Gene: AACS (acetoacetyl-CoA synthetase)
Homo sapiens
Symbol:
AACS
Name:
acetoacetyl-CoA synthetase
Description:
ENCODES a protein that exhibits acetoacetate-CoA ligase activity (inferred); ATP binding (inferred); butyrate-CoA ligase activity (inferred); INVOLVED IN adipose tissue development (inferred); cellular response to cholesterol (inferred); cellular response to glucose stimulus (inferred); PARTICIPATES IN butanoate metabolic pathway; ketone bodies metabolic pathway; ASSOCIATED WITH Diabetes Mellitus, Experimental (ortholog); Obesity (ortholog); FOUND IN cytosol (inferred); INTERACTS WITH cyclosporin A; isotretinoin; 2,3,7,8-tetrachlorodibenzodioxine (ortholog)
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
acetoacetate-CoA ligase; acetoacetyl-CoA synthetase; ACSF1; acyl-CoA synthetase family member 1; FLJ12389; FLJ41251; homolog of C. elegans supressor of ras 5 (sur-5); OTTHUMP00000239025; protein sur-5 homolog; SUR-5
Orthologs:
Mus musculus : Aacs
(acetoacetyl-CoA synthetase)
MGI
Aacs
(acetoacetyl-CoA synthetase)
Related Pseudogenes:
AACSP1
Latest Assembly:
Human Genome Assembly GRCh37
Position:
Map Chr Position Strand Source Human Alternate Assembly CHM1_1 12 125,365,065 - 125,443,159 + NCBI Human Genome Assembly HuRef 12 122,513,724 - 122,591,469 + NCBI Human Genome Assembly GRCh37 12 125,549,925 - 125,627,871 + NCBI Human Celera Assembly 12 125,154,148 - 125,231,815 + NCBI Human Genome Assembly Build 36 12 124,115,878 - 124,193,824 + NCBI Human Cytogenetic Map 12 q24.31 NCBI Human Genome Assembly 12 124,074,886 - 124,152,745 NCBI
Model
Gene-Chemical Interaction Annotations
2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1332110 6480464 Tetrachlorodibenzodioxin results in decreased expression of AACS mRNA CTD PMID:18295293 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:708522 6480464 Tetrachlorodibenzodioxin results in decreased expression of AACS mRNA CTD PMID:21215274 2,4-dinitrotoluene affects expression ISO RGD:708522 6480464 2,4-dinitrotoluene affects the expression of AACS mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO RGD:708522 6480464 2,6-dinitrotoluene affects the expression of AACS mRNA CTD PMID:21346803 2-amino-2-deoxy-D-glucopyranose increases expression ISO RGD:1332110 6480464 Glucosamine results in increased expression of AACS mRNA CTD PMID:17178593 2-methoxyethanol increases expression ISO RGD:708522 6480464 methyl cellosolve results in increased expression of AACS mRNA CTD PMID:21061450 4,4'-diaminodiphenylmethane increases expression ISO RGD:1332110 6480464 4,4'-diaminodiphenylmethane results in increased expression of AACS mRNA CTD PMID:18648102 aldehydo-D-glucosamine increases expression ISO RGD:1332110 6480464 Glucosamine results in increased expression of AACS mRNA CTD PMID:17178593 ammonium chloride affects expression ISO RGD:708522 6480464 Ammonium Chloride affects the expression of AACS mRNA CTD PMID:16483693 benzo[a]pyrene decreases expression ISO RGD:1332110 6480464 Benzo(a)pyrene results in decreased expression of AACS mRNA CTD PMID:21715664 benzo[a]pyrene decreases expression ISO RGD:1332110 6480464 Benzo(a)pyrene results in decreased expression of AACS mRNA CTD PMID:19770486 more ... benzo[a]pyrene multiple interactions ISO RGD:1332110 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of AACS mRNA] CTD PMID:22228805 benzo[a]pyrene decreases expression ISO RGD:1332110 6480464 Benzo(a)pyrene results in decreased expression of AACS mRNA CTD PMID:19770486 PMID:21715664 benzo[a]pyrene decreases expression ISO RGD:1332110 6480464 Benzo(a)pyrene results in decreased expression of AACS mRNA CTD PMID:21715664 PMID:19770486 benzo[a]pyrene multiple interactions ISO RGD:1332110 6480464 [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of AACS mRNA CTD PMID:21715664 beta-D-glucosamine increases expression ISO RGD:1332110 6480464 Glucosamine results in increased expression of AACS mRNA CTD PMID:17178593 bisphenol A increases expression ISO RGD:1332110 6480464 bisphenol A results in increased expression of AACS mRNA CTD PMID:21932408 cocaine affects expression ISO RGD:708522 6480464 Cocaine affects the expression of AACS mRNA CTD PMID:20187946 copper atom decreases expression ISO RGD:1332110 6480464 Copper results in decreased expression of AACS mRNA CTD PMID:17205981 copper(0) decreases expression ISO RGD:1332110 6480464 Copper results in decreased expression of AACS mRNA CTD PMID:17205981 cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of AACS mRNA CTD PMID:20106945 dibutyl phthalate increases expression ISO RGD:1332110 6480464 Dibutyl Phthalate results in increased expression of AACS mRNA CTD PMID:21266533 dibutyl phthalate increases expression ISO RGD:1332110 6480464 Dibutyl Phthalate results in increased expression of AACS mRNA CTD PMID:17361019 PMID:21266533 dibutyl phthalate decreases expression ISO RGD:708522 6480464 Dibutyl Phthalate results in decreased expression of AACS mRNA CTD PMID:21266533 isotretinoin decreases expression EXP 6480464 Isotretinoin results in decreased expression of AACS mRNA CTD PMID:20436886 paracetamol affects expression ISO RGD:1332110 6480464 Acetaminophen affects the expression of AACS mRNA CTD PMID:17562736 phenobarbital decreases expression ISO RGD:1332110 6480464 Phenobarbital results in decreased expression of AACS mRNA CTD PMID:19270015 phenobarbital increases expression ISO RGD:1332110 6480464 Phenobarbital results in increased expression of AACS mRNA CTD PMID:23091169 pirinixic acid decreases expression ISO RGD:1332110 6480464 pirinixic acid results in decreased expression of AACS mRNA CTD PMID:18445702 pirinixic acid increases expression ISO RGD:1332110 6480464 pirinixic acid results in increased expression of AACS mRNA CTD PMID:18301758 pregnenolone 16alpha-carbonitrile increases expression ISO RGD:1332110 6480464 Pregnenolone Carbonitrile results in increased expression of AACS mRNA CTD PMID:22698814 pregnenolone 16alpha-carbonitrile multiple interactions ISO RGD:1332110 6480464 NR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of AACS mRNA] CTD PMID:22698814 tamoxifen affects expression ISO RGD:1332110 6480464 Tamoxifen affects the expression of AACS mRNA CTD PMID:20937368 testosterone increases expression ISO RGD:1332110 6480464 Testosterone results in increased expression of AACS mRNA CTD PMID:16579987 valproic acid affects expression ISO RGD:1332110 6480464 Valproic Acid affects the expression of AACS mRNA CTD PMID:17292431 valproic acid increases expression ISO RGD:1332110 6480464 Valproic Acid results in increased expression of AACS mRNA CTD PMID:21427059
Biological Process adipose tissue development IEA Ensembl:ENSRNOP00000001292 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 cellular response to cholesterol IEA Ensembl:ENSRNOP00000001292 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 cellular response to glucose stimulus IEA Ensembl:ENSRNOP00000001292 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 cellular response to testosterone stimulus IEA Ensembl:ENSRNOP00000001292 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 fatty acid metabolic process IEA UniProtKB-KW:KW-0276 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 liver development IEA Ensembl:ENSRNOP00000001292 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of insulin secretion IEA Ensembl:ENSRNOP00000001292 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 response to drug IEA Ensembl:ENSRNOP00000001292 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 response to ethanol IEA Ensembl:ENSRNOP00000001292 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 response to nutrient IEA Ensembl:ENSRNOP00000001292 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 response to oleic acid IEA Ensembl:ENSRNOP00000001292 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 response to purine-containing compound IEA Ensembl:ENSRNOP00000001292 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 response to starvation IEA Ensembl:ENSRNOP00000001292 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 white fat cell differentiation IEA Ensembl:ENSRNOP00000001292 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 Cellular Component cytosol IEA UniProtKB-SubCell:SL-0091 2290271 GO_REF:0000039 UniProtKB GO_REF:0000039 Molecular Function acetoacetate-CoA ligase activity IEA EC:6.2.1.16 2290271 GO_REF:0000003 UniProtKB GO_REF:0000003 ATP binding IEA UniProtKB-KW:KW-0067 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 butyrate-CoA ligase activity IEA Ensembl:ENSRNOP00000001292 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 catalytic activity IEA InterPro:IPR000873 2290271 GO_REF:0000002 InterPro GO_REF:0000002
1331644 AASTH7_H Allergic/atopic asthma related QTL 7 (human) 2.29 Reversible airflow obstruction asthma score 12 74133886 133812422 Human 1559248 SAPOA1_H Serum apolipoprotein A level QTL 1 (human) 2.02 Apolipoprotein level apolipoprotein A-I 12 95712415 133789251 Human 1643452 BW104_H Body weight QTL 104 (human) 1.89 .005 Body fat amount abdominal visceral 12 102789645 128789645 Human 2292994 PRSTS146_H Prostate tumor susceptibility QTL 146 (human) 5.69 .000022 Prostate tumor susceptibility 12 103060538 129060538 Human 1331642 AASTH6_H Allergic/atopic asthma related QTL 6 (human) 2.46 .0004 Reversible airflow obstruction post-bronchodilator FEV1 12 103082760 129082760 Human 1357293 AASTH20_H Allergic/atopic asthma related QTL 20 (human) 1.13 Reversible airflow obstruction post-bronchodilator FEV1 12 103082760 129082760 Human 1643266 BW201_H Body weight QTL 201 (human) 3.79 .00001 Body fat amount percent body fat 12 103082760 129082760 Human 1643270 BW198_H Body weight QTL 198 (human) 3.57 .00003 Body weight BMI 12 103082760 129082760 Human 1643277 BW203_H Body weight QTL 203 (human) 3.05 .00009 Body morphometry waist circumference 12 103082760 129082760 Human 1643313 BW234_H Body weight QTL 234 (human) 1.08 Body weight body mass index 12 103082760 129082760 Human 2314720 INSUL18_H Insulin level QTL 18(human) 2 .106 Insulin level 12 103082760 129082760 Human 1298449 UAE2_H Urinary albumin excretion QTL 2 (human) 2 .005 Urinary albumin excretion urine albumin:creatinine ratio (ACR) 12 103232104 129232104 Human 2289480 SLEP16_H Serum leptin level QTL 16 (human) 2.06 Hormone level leptin 12 106170388 132170388 Human 2316666 GLUCO252_H Glucose level QTL 252 (human) 3.65 Glucose level 12 107147609 133147609 Human 1643308 BW235_H Body weight QTL 235 (human) 1.86 Body weight body mass index 12 107188584 133188584 Human 1643411 BW278_H Body Weight QTL 278 (human) 1.79 .002 Body weight 12 107188584 133188584 Human 2293466 PRSTS305_H Prostate tumor susceptibility QTL 305 (human) .024 Prostate tumor susceptibility 12 107188584 133188584 Human 1643468 SLIPL18_H Serum lipid level QTL 18 (human) 2.6 .02 Lipid level 12 114961269 133812422 Human 2314558 GLUCO46_H Glucose level QTL 46 (human) 1.1 Glucose level 12 114961269 133812422 Human 2289606 BW476_H Body weight QTL 476 (human) 2.9 Body fat amount abdominal 12 116060455 131962898 Human 2316044 GLUCO197_H Glucose level QTL 197 (human) .03 Glucose level 12 116082709 126625403 Human 1576338 MYI6_H Myocardial infarction susceptibility QTL 6 (human) 5.62 Myocardial infarction susceptibility early-onset 12 117397776 133812422 Human 1576332 MYI14_H Myocardial infarction susceptibility QTL 14 (human) 4.44 Myocardial infarction susceptibility early-onset 12 117397776 133812422 Human 2293368 PRSTS218_H Prostate tumor susceptibility QTL 218 (human) 1.05 Prostate tumor susceptibility 12 117397776 133812422 Human 2293401 PRSTS216_H Prostate tumor susceptibility QTL 216 (human) 1.76 Prostate tumor susceptibility 12 117397776 133812422 Human 2293420 PRSTS217_H Prostate tumor susceptibility QTL 217 (human) 1.89 Prostate tumor susceptibility 12 117397776 133812422 Human 2289471 BW218_H Body weight QTL 218 (human) 1.96 Body fat amount percent fat 12 119170322 126625403 Human 2289628 BW500_H Body weight QTL 500 (human) 3.8 Body fat amount percent fat 12 120188466 127961399 Human 2289630 BW501_H Body weight QTL 501 (human) 2.4 Body fat amount percent fat 12 120188466 127961399 Human 2289632 BW502_H Body weight QTL 502 (human) 1.5 Body fat amount percent fat 12 120188466 127961399 Human 2314793 GLUCO112_H Glucose level QTL 112 (human) 2.24 Glucose level 12 120188466 130397814 Human
Gene-Chemical Interaction Annotations
