Annotation (Toggle Detail/Summary View) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | axon guidance | | TAS | | 2290271 | Reactome:REACT_18266 | Reactome | Reactome:REACT_18266 | epidermal growth factor receptor signaling pathway | | TAS | | 2290271 | PMID:9873047 | UniProtKB | PMID:9873047 | histone H2A-S1 phosphorylation | | IDA | | 2290271 | PMID:15010469 | UniProtKB | PMID:15010469 | histone H3-S10 phosphorylation | | IMP | | 2290271 | PMID:12773393 | UniProtKB | PMID:12773393 | histone H3-S28 phosphorylation | | IMP | | 2290271 | PMID:12773393 | UniProtKB | PMID:12773393 | histone phosphorylation | | TAS | | 2290271 | PMID:20018936 | BHF-UCL | PMID:20018936 | histone phosphorylation | | IDA | | 2290271 | PMID:9873047 | UniProtKB | PMID:9873047 | inflammatory response | | IEA | UniProtKB-KW:KW-0395 | 2290271 | GO_REF:0000037 | UniProtKB | GO_REF:0000037 | innate immune response | | TAS | | 2290271 | Reactome:REACT_6802 | Reactome | Reactome:REACT_6802 | interleukin-1-mediated signaling pathway | | IMP | | 2290271 | PMID:20018936 | BHF-UCL | PMID:20018936 | intracellular protein kinase cascade | | IDA | | 2290271 | PMID:9687510 | UniProtKB | PMID:9687510 | intracellular protein kinase cascade | | IEA | Ensembl:ENSMUSP00000042987 | 2290271 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | MyD88-dependent toll-like receptor signaling pathway | | TAS | | 2290271 | Reactome:REACT_27215 | Reactome | Reactome:REACT_27215 | MyD88-dependent toll-like receptor signaling pathway | | TAS | | 2290271 | Reactome:REACT_6788 | Reactome | Reactome:REACT_6788 | MyD88-independent toll-like receptor signaling pathway | | TAS | | 2290271 | Reactome:REACT_6782 | Reactome | Reactome:REACT_6782 | MyD88-independent toll-like receptor signaling pathway | | TAS | | 2290271 | Reactome:REACT_6809 | Reactome | Reactome:REACT_6809 | negative regulation of cytokine production | | TAS | | 2290271 | PMID:18508628 | UniProtKB | PMID:18508628 | negative regulation of transcription, DNA-dependent | | IDA | | 2290271 | PMID:15010469 | UniProtKB | PMID:15010469 | neurotrophin TRK receptor signaling pathway | | TAS | | 2290271 | Reactome:REACT_11061 | Reactome | Reactome:REACT_11061 | positive regulation of CREB transcription factor activity | | TAS | | 2290271 | PMID:18508628 | UniProtKB | PMID:18508628 | positive regulation of histone acetylation | | IMP | | 2290271 | PMID:20018936 | BHF-UCL | PMID:20018936 | positive regulation of histone phosphorylation | | IMP | | 2290271 | PMID:20018936 | BHF-UCL | PMID:20018936 | positive regulation of NF-kappaB transcription factor activity | | IMP | | 2290271 | PMID:12628924 | UniProtKB | PMID:12628924 | positive regulation of NF-kappaB transcription factor activity | | IMP | | 2290271 | PMID:18511904 | UniProtKB | PMID:18511904 | positive regulation of transcription from RNA polymerase II promoter | | IMP | | 2290271 | PMID:20018936 | BHF-UCL | PMID:20018936 | protein phosphorylation | | IDA | | 2290271 | PMID:9687510 | UniProtKB | PMID:9687510 | regulation of transcription, DNA-dependent | | IMP | | 2290271 | PMID:12763138 | UniProtKB | PMID:12763138 | regulation of transcription, DNA-dependent | | IEA | Ensembl:ENSMUSP00000042987 | 2290271 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | regulation of transcription, DNA-dependent | | IDA | | 2290271 | PMID:9687510 | UniProtKB | PMID:9687510 | response to external stimulus | | IEP | | 2290271 | PMID:9873047 | UniProtKB | PMID:9873047 | response to stress | | IEP | | 2290271 | PMID:9873047 | UniProtKB | PMID:9873047 | stress-activated MAPK cascade | | TAS | | 2290271 | Reactome:REACT_21308 | Reactome | Reactome:REACT_21308 | toll-like receptor 10 signaling pathway | | TAS | | 2290271 | Reactome:REACT_9027 | Reactome | Reactome:REACT_9027 | toll-like receptor 2 signaling pathway | | TAS | | 2290271 | Reactome:REACT_7980 | Reactome | Reactome:REACT_7980 | toll-like receptor 3 signaling pathway | | TAS | | 2290271 | Reactome:REACT_6783 | Reactome | Reactome:REACT_6783 | toll-like receptor 4 signaling pathway | | TAS | | 2290271 | Reactome:REACT_6890 | Reactome | Reactome:REACT_6890 | toll-like receptor 4 signaling pathway | | TAS | | 2290271 | Reactome:REACT_6894 | Reactome | Reactome:REACT_6894 | toll-like receptor 5 signaling pathway | | TAS | | 2290271 | Reactome:REACT_9061 | Reactome | Reactome:REACT_9061 | toll-like receptor 9 signaling pathway | | TAS | | 2290271 | Reactome:REACT_9047 | Reactome | Reactome:REACT_9047 | toll-like receptor signaling pathway | | TAS | | 2290271 | Reactome:REACT_6966 | Reactome | Reactome:REACT_6966 | toll-like receptor signaling pathway | | TAS | | 2290271 | Reactome:REACT_9020 | Reactome | Reactome:REACT_9020 | toll-like receptor TLR1:TLR2 signaling pathway | | TAS | | 2290271 | Reactome:REACT_8005 | Reactome | Reactome:REACT_8005 | toll-like receptor TLR6:TLR2 signaling pathway | | TAS | | 2290271 | Reactome:REACT_8006 | Reactome | Reactome:REACT_8006 | TRIF-dependent toll-like receptor signaling pathway | | TAS | | 2290271 | Reactome:REACT_25281 | Reactome | Reactome:REACT_25281 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Bladder cancer |
| Circadian entrainment | |
| MAPK signaling pathway | |
| Neurotrophin signaling pathway | |
| Pathway Interaction Database | ErbB1 downstream signaling (PID:200133) |
| LPA4-mediated signaling events (PID:200047) | |
| Signaling mediated by p38-alpha and p38-beta (PID:200180) | |
| Trk receptor signaling mediated by the MAPK pathway (PID:200213) | |
Gene-Chemical Interaction Annotations
|
|
|
Gene Ontology Annotations
|
|
|
|
|
Molecular Pathway Annotations
|
|
| External Database Links | |
| KEGG Pathway | Bladder cancer |
| Circadian entrainment | |
| MAPK signaling pathway | |
| Neurotrophin signaling pathway | |
| Pathway Interaction Database | ErbB1 downstream signaling (PID:200133) |
| LPA4-mediated signaling events (PID:200047) | |
| Signaling mediated by p38-alpha and p38-beta (PID:200180) | |
| Trk receptor signaling mediated by the MAPK pathway (PID:200213) | |
References - curated| 1. |
Gaestel M Nat Rev Mol Cell Biol. 2006 Feb;7(2):120-30. |
| 2. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 3. |
RGD automated import pipeline for gene-chemical interactions |
References - uncurated| PubMed | 10469656 |
| 10521505 | |
| 10635333 | |
| 10702687 | |
| 10880354 | |
| 10978317 | |
| 11018520 | |
| 11157753 | |
| 11297520 | |
| 11350938 | |
| 11500364 | |
| 11777913 | |
| 11909979 | |
| 11994045 | |
| 12421349 | |
| 12477932 | |
| 12569367 | |
| 12576423 | |
| 12628924 | |
| 12690113 | |
| 12763138 | |
| 12773393 | |
| 12807421 | |
| 14551213 | |
| 14578350 | |
| 14963018 | |
| 15010469 | |
| 15133024 | |
| 15276183 | |
| 15302935 | |
| 15489334 | |
| 15568999 | |
| 15797222 | |
| 16223362 | |
| 16479592 | |
| 16532028 | |
| 16543895 | |
| 16762916 | |
| 17117922 | |
| 17495961 | |
| 17512525 | |
| 18424438 | |
| 18508628 | |
| 18511904 | |
| 19015318 | |
| 19197368 | |
| 19251839 | |
| 19633291 | |
| 19672773 | |
| 19706715 | |
| 19933278 | |
| 20044958 | |
| 20089855 | |
| 20129940 | |
| 20198339 | |
| 20200978 | |
| 20354165 | |
| 20379614 | |
| 20406806 | |
| 20408143 | |
| 20433920 | |
| 20596523 | |
| 20805296 | |
| 20864036 | |
| 20936779 | |
| 21282660 | |
| 21832049 | |
| 21900206 | |
| 21988832 | |
| 22312446 | |
| 22504420 | |
| 22626465 | |
| 22939624 | |
| 9343414 | |
| 9687510 | |
| 9872331 | |
| 9873047 |
RGD Disease Portals| RPS6KA5 has been annotated in the following RGD Disease Portals. |
|||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
![]() |
| ||||
Comparative Map Data| RPS6KA5 (Homo sapiens) |
|
|||||||||||||||||||||||||||||||||||
| Rps6ka5 (Mus musculus) |
|
|||||||||||||||||||||||||||||||||||
| Rps6ka5 (Rattus norvegicus) |
|
Position Markers| G35600 |
|
||||||||||||||||||||||||||||||||||||||||
| G35963 |
|
||||||||||||||||||||||||||||||||||||||||
| RH93294 |
|
||||||||||||||||||||||||||||||||||||||||
| RH101942 |
|
||||||||||||||||||||||||||||||||||||||||
| SHGC-81746 |
|
||||||||||||||||||||||||||||||||||||||||
| G63724 |
|
||||||||||||||||||||||||||||||||||||||||
| G35701 |
|
||||||||||||||||||||||||||||||||||||||||
| G35828 |
|
||||||||||||||||||||||||||||||||||||||||
| RH66186 |
|
QTLs in Region (Human Genome Assembly GRCh37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_004755 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_182398 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | ABBA01030488 | (Get FASTA) | Search GEO for Microarray Profiles |
| ABBA01030489 | (Get FASTA) | Search GEO for Microarray Profiles | |
| ABBA01030490 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF074393 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF080000 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF090421 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK295266 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK309925 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AL050099 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AL121784 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AL133454 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AL159191 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AMYH01005948 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AMYH01005949 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC017187 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BF593074 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BG699153 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH471061 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_004755 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_004746 | |||||||||||||||||||||||||
| Peptide Label: | isoform a | |||||||||||||||||||||||||
| Position: |
|
| RefSeq Acc Id: | NM_182398 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_872198 | |||||||||||||||||||||||||
| Peptide Label: | isoform b | |||||||||||||||||||||||||
| Position: |
|
Protein Sequences| Protein RefSeqs | NP_004746 | (Get FASTA) |
| NP_872198 | (Get FASTA) | |
| GenBank Protein | AAC31171 | (Get FASTA) |
| AAC69577 | (Get FASTA) | |
| AAD23915 | (Get FASTA) | |
| AAH17187 | (Get FASTA) | |
| BAH12021 | (Get FASTA) | |
| CAB43270 | (Get FASTA) | |
| EAW81439 | (Get FASTA) | |
| EAW81440 | (Get FASTA) | |
| O75582 | (Get FASTA) |
Promoters| RGD ID: | 6791768 | ||||||||||
| Promoter ID: | HG_KWN:19998 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | CD4+TCell, CD4+TCell_12Hour, CD4+TCell_2Hour, HeLa_S3, Jurkat, K562, Lymphoblastoid, NB4 | ||||||||||
| Transcripts: | NM_004755, NM_182398, UC010ATT.1 | ||||||||||
| Position: |
|
External Database Links| Database | Acc Id | Source(s) |
| COSMIC | RPS6KA5 | COSMIC |
| Ensembl Genes | ENSG00000100784 | ENTREZGENE |
| Ensembl Protein | ENSP00000261991 | ENTREZGENE |
| ENSP00000402787 | ENTREZGENE | |
| Ensembl Transcript | ENST00000261991 | ENTREZGENE |
| ENST00000418736 | ENTREZGENE | |
| Entrez Gene | 9252 | ENTREZGENE |
| Germonline | ENSG00000100784 | |
| HGNC ID | 10434 | ENTREZGENE |
| HomoloGene Group ID | 48302 | ENTREZGENE |
| HPRD ID | 06789 | ENTREZGENE |
| InterPro | AGC-kinase_C | UniProtKB/Swiss-Prot |
| Kinase-like_dom | UniProtKB/Swiss-Prot | |
| Pkinase_C | UniProtKB/Swiss-Prot | |
| Prot_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot | |
| Ribosomal_S6_kinase_II | UniProtKB/Swiss-Prot | |
| Ser/Thr_kinase_AS | UniProtKB/Swiss-Prot | |
| Ser/Thr_kinase_dom | UniProtKB/Swiss-Prot | |
| IPI | IPI00335101 | UniProtKB/Swiss-Prot |
| IPI01011281 | UniProtKB/TrEMBL | |
| KEGG Report | hsa:9252 | ENTREZGENE, UniProtKB/Swiss-Prot |
| OMIM | 603607 | OMIM |
| Pfam | Pkinase | UniProtKB/Swiss-Prot |
| Pkinase_C | UniProtKB/Swiss-Prot | |
| PharmGKB | PA34849 | PharmGKB |
| PIRSF | Ribsml_S6_kin_2 | UniProtKB/Swiss-Prot |
| PROSITE | AGC_KINASE_CTER | UniProtKB/Swiss-Prot |
| PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_ST | UniProtKB/Swiss-Prot | |
| SMART | S_TK_X | UniProtKB/Swiss-Prot |
| S_TKc | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Kinase_like | UniProtKB/Swiss-Prot |
| UniGene | Hs.510225 | ENTREZGENE |
| UniProt | B7Z2Y5_HUMAN | UniProtKB/TrEMBL |
| G3V2D1_HUMAN | UniProtKB/TrEMBL | |
| G3V4D7_HUMAN | UniProtKB/TrEMBL | |
| H0YJE1_HUMAN | UniProtKB/TrEMBL | |
| KS6A5_HUMAN | UniProtKB/Swiss-Prot | |
| Q9UG98_HUMAN | UniProtKB/TrEMBL |
| More on RPS6KA5 | |||
![]() |
Entrez Gene | ||
![]() |
Ensembl Gene | ||
|
|
||
![]() |
HGNC Report | ||
![]() |
NCBI Map Viewer | ||
![]() |
Vista | ||
![]() |
Vista + UCSC | ||
| RGD Object Information | |
| RGD ID: | 1318046 |
| Created: | 2005-01-12 |
| Species: | Homo sapiens |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




