ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1)

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Keyword

Gene: ABCB1 (ATP-binding cassette, sub-family B (MDR/TAP), member 1) Homo sapiens

Symbol:

ABCB1

Name:

ATP-binding cassette, sub-family B (MDR/TAP), member 1

Description:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

ABC20; ATP-binding cassette sub-family B member 1; ATP-binding cassette, subfamily B, member 1; CD243; CLCS; colchicin sensitivity; doxorubicin resistance; GP170; MDR1; MGC163296; multidrug resistance protein 1; OTTHUMP00000205790; P-glycoprotein 1; P-GP; PGY1

Orthologs:

Mus musculus : Abcb1a (ATP-binding cassette, sub-family B (MDR/TAP), member 1A) MGI
Rattus norvegicus : Abcb1a (ATP-binding cassette, sub-family B (MDR/TAP), member 1A)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	7	90,440,411 - 90,649,881	-	NCBI
Human Alternate Assembly CRA_TCAGchr7v2	7	86,464,691 - 86,673,953	-	NCBI
Human Genome Assembly HuRef	7	81,744,182 - 81,952,578	-	NCBI
Human Genome Assembly GRCh37	7	87,133,179 - 87,342,639	-	NCBI
Human Genome Assembly Build 36	7	86,970,884 - 87,180,500	-	NCBI
Human Cytogenetic Map	7	q21.12		NCBI
Human Genome Assembly	7	86,777,598 - 86,987,215		NCBI