(+)-catechin multiple interactions EXP 6480464 Catechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of H2AX protein] CTD PMID:21882252 (+)-dexrazoxane multiple interactions ISO H2ax (Mus musculus) 6480464 Dexrazoxane inhibits the reaction [Cyclophosphamide results in increased expression of H2AX protein] CTD PMID:37690746 (-)-ephedrine multiple interactions ISO H2ax (Rattus norvegicus) 6480464 [Caffeine co-treated with Ephedrine] results in increased phosphorylation of H2AX protein CTD PMID:15537744 (-)-epigallocatechin 3-gallate multiple interactions ISO H2ax (Mus musculus) 6480464 epigallocatechin gallate inhibits the reaction [epigallocatechin gallate results in increased phosphorylation of H2AX protein] CTD PMID:25528115 (-)-epigallocatechin 3-gallate increases expression ISO H2ax (Mus musculus) 6480464 epigallocatechin gallate results in increased expression of H2AX protein CTD PMID:25585349 and PMID:29175576 (-)-epigallocatechin 3-gallate increases phosphorylation ISO H2ax (Mus musculus) 6480464 epigallocatechin gallate results in increased phosphorylation of H2AX protein CTD PMID:25528115 (1->4)-beta-D-glucan multiple interactions ISO H2ax (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of H2AX mRNA CTD PMID:36331819 (S)-nicotine multiple interactions EXP 6480464 Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein modified form] CTD PMID:23907605 1,10-phenanthroline multiple interactions EXP 6480464 [Copper binds to phthalic acid binds to 1 and 10-phenanthroline] which results in increased expression of H2AX protein modified form CTD PMID:22659117 1,2-dimethylhydrazine increases expression ISO H2ax (Rattus norvegicus) 6480464 1 and 2-Dimethylhydrazine results in increased expression of H2AX protein CTD PMID:32387197 1,2-dimethylhydrazine multiple interactions ISO H2ax (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of H2AX mRNA CTD PMID:22206623 1,3-benzothiazole-2-thiol multiple interactions EXP 6480464 1-aminobenzotriazole inhibits the reaction [captax results in increased expression of H2AX protein] more ... CTD PMID:35279910 1,3-benzothiazole-2-thiol increases expression EXP 6480464 captax results in increased expression of H2AX protein CTD PMID:35279910 1,3-dinitrobenzene decreases expression ISO H2ax (Rattus norvegicus) 6480464 3-dinitrobenzene results in decreased expression of H2AX mRNA CTD PMID:21983209 1,4-benzoquinone increases phosphorylation EXP 6480464 quinone results in increased phosphorylation of H2AX protein CTD PMID:18835433 1,4-benzoquinone multiple interactions ISO H2ax (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [quinone analog results in increased expression of H2AX protein modified form] more ... CTD PMID:33961949 1,4-benzoquinone increases expression ISO H2ax (Mus musculus) 6480464 quinone analog results in increased expression of H2AX protein modified form CTD PMID:33961949 1,4-benzoquinone increases phosphorylation ISO H2ax (Mus musculus) 6480464 quinone results in increased phosphorylation of H2AX protein CTD PMID:31340051 1,4-dioxane increases expression ISO H2ax (Mus musculus) 6480464 1 and 4-dioxane results in increased expression of H2AX protein CTD PMID:33693819 1,4-dioxane increases expression ISO H2ax (Rattus norvegicus) 6480464 1 and 4-dioxane results in increased expression of H2AX protein CTD PMID:37258237 1-fluoro-2,4-dinitrobenzene increases expression EXP 6480464 Dinitrofluorobenzene results in increased expression of H2AX mRNA CTD PMID:23999411 1-naphthyl isothiocyanate affects expression ISO H2ax (Rattus norvegicus) 6480464 1-Naphthylisothiocyanate affects the expression of H2AX protein CTD PMID:26011634 17alpha-ethynylestradiol increases expression ISO H2ax (Mus musculus) 6480464 Ethinyl Estradiol results in increased expression of H2AX mRNA CTD PMID:12072388 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of H2AX mRNA more ... CTD PMID:16462019 more ... 17beta-estradiol affects expression ISO H2ax (Rattus norvegicus) 6480464 Estradiol affects the expression of H2AX mRNA CTD PMID:32145629 17beta-estradiol increases expression ISO H2ax (Mus musculus) 6480464 Estradiol results in increased expression of H2AX protein modified form CTD PMID:31939680 17beta-estradiol increases expression ISO H2ax (Rattus norvegicus) 6480464 Estradiol results in increased expression of H2AX protein CTD PMID:23788033 17beta-estradiol multiple interactions ISO H2ax (Rattus norvegicus) 6480464 Fulvestrant inhibits the reaction [Estradiol results in increased expression of H2AX protein] CTD PMID:23788033 17beta-estradiol multiple interactions EXP 6480464 Estradiol promotes the reaction [PCB 180 metabolite results in increased phosphorylation of H2AX protein] and Fulvestrant inhibits the reaction [Estradiol results in increased expression of H2AX protein modified form] CTD PMID:26148434 and PMID:31939680 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one multiple interactions EXP 6480464 [ATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AX protein]] which results in increased expression of ERG mRNA more ... CTD PMID:21134073 and PMID:23272087 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases expression EXP 6480464 Metribolone results in increased expression of H2AX protein CTD PMID:23272087 1H-pyrazole increases expression ISO H2ax (Mus musculus) 6480464 pyrazole results in increased expression of H2AX mRNA CTD PMID:17945193 2,2',4,4'-Tetrabromodiphenyl ether affects expression ISO H2ax (Mus musculus) 6480464 2 more ... CTD PMID:30294300 2,2'-bipyridine multiple interactions EXP 6480464 [Copper binds to phthalic acid binds to 2 and 2'-Dipyridyl] which results in increased expression of H2AX protein modified form CTD PMID:22659117 2,3',4,4',5-Pentachlorobiphenyl increases expression ISO H2ax (Mus musculus) 6480464 2 more ... CTD PMID:31388691 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO H2ax (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of H2AX mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO H2ax (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in decreased expression of H2AX mRNA CTD PMID:33387578 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO H2ax (Mus musculus) 6480464 NFE2L2 gene mutant form promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of H2AX protein] and Tetrachlorodibenzodioxin promotes the reaction [NFE2L2 gene mutant form results in increased expression of H2AX protein] CTD PMID:21846477 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO H2ax (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of H2AX protein CTD PMID:21846477 and PMID:33823233 2,3-dimethoxynaphthalene-1,4-dione increases expression EXP 6480464 2 more ... CTD PMID:19031421 2,4,6-trinitrotoluene affects expression ISO H2ax (Rattus norvegicus) 6480464 Trinitrotoluene affects the expression of H2AX mRNA CTD PMID:21346803 2,4-diaminotoluene decreases expression ISO H2ax (Mus musculus) 6480464 2 and 4-diaminotoluene results in decreased expression of H2AX mRNA CTD PMID:20713471 2,4-diaminotoluene increases phosphorylation EXP 6480464 2 and 4-diaminotoluene results in increased phosphorylation of H2AX protein CTD PMID:34510228 2,4-dibromophenol multiple interactions ISO H2ax (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [2 more ... CTD PMID:33961949 2,4-dibromophenol increases expression ISO H2ax (Mus musculus) 6480464 2 and 4-dibromophenol metabolite results in increased expression of H2AX protein modified form CTD PMID:33961949 2-acetamidofluorene increases expression ISO H2ax (Rattus norvegicus) 6480464 2-Acetylaminofluorene results in increased expression of H2AX protein CTD PMID:26338220 2-acetamidofluorene increases phosphorylation EXP 6480464 2-Acetylaminofluorene results in increased phosphorylation of H2AX protein CTD PMID:34510228 2-Amino-3-methyl-9H-pyrido[2,3-b]indole increases expression EXP 6480464 2-amino-3-methyl-9H-pyrido(2 and 3-b)indole results in increased expression of H2AX protein modified form CTD PMID:28160022 2-Amino-9H-pyrido[2,3-b]indole increases expression EXP 6480464 2-amino-9H-pyrido(2 and 3-b)indole results in increased expression of H2AX protein modified form CTD PMID:28160022 2-deoxy-D-glucose decreases expression EXP 6480464 Deoxyglucose results in decreased expression of H2AX protein CTD PMID:23363784 2-methoxy-17beta-estradiol increases expression EXP 6480464 2-Methoxyestradiol results in increased expression of H2AX protein modified form CTD PMID:23967052 2-nitroanisole increases expression ISO H2ax (Rattus norvegicus) 6480464 2-nitroanisole results in increased expression of H2AX protein CTD PMID:26338220 2-nitrofluorene increases expression ISO H2ax (Rattus norvegicus) 6480464 2-nitrofluorene results in increased expression of H2AX mRNA CTD PMID:15890375 2-nitropropane increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 2-nitropropane results in increased phosphorylation of H2AX protein CTD PMID:37527026 2-palmitoylglycerol increases expression EXP 6480464 2-palmitoylglycerol results in increased expression of H2AX mRNA CTD PMID:37199045 2-phenylethylamine multiple interactions EXP 6480464 [NAT2 protein results in increased susceptibility to phenethylamine] which results in increased expression of H2AX protein CTD PMID:36138126 2-tert-butylhydroquinone multiple interactions ISO H2ax (Rattus norvegicus) 6480464 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of H2AX protein] CTD PMID:28583816 2-tert-butylhydroquinone multiple interactions EXP 6480464 2-tert-butylhydroquinone inhibits the reaction [hydroquinone results in increased expression of H2AX protein] CTD PMID:35123993 2-tert-butylhydroquinone increases expression EXP 6480464 2-tert-butylhydroquinone results in increased expression of H2AX protein CTD PMID:35123993 3,3',4,4',5-pentachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:31733235 3,3',4,4',5-pentachlorobiphenyl multiple interactions EXP 6480464 2 more ... CTD PMID:31733235 3,3',4,4'-tetrachlorobiphenyl multiple interactions EXP 6480464 2 more ... CTD PMID:31733235 3,3',4,4'-tetrachlorobiphenyl increases expression EXP 6480464 3 more ... CTD PMID:31733235 3,3',5-triiodo-L-thyronine increases phosphorylation EXP 6480464 Triiodothyronine analog results in increased phosphorylation of H2AX protein CTD PMID:22383522 3,3',5-triiodo-L-thyronine multiple interactions EXP 6480464 Triiodothyronine analog promotes the reaction [Cisplatin results in increased expression of H2AX protein] CTD PMID:22383522 3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine increases expression EXP 6480464 3 more ... CTD PMID:28160022 3,4-methylenedioxymethamphetamine multiple interactions EXP 6480464 [NAT2 protein results in increased susceptibility to N-Methyl-3 and 4-methylenedioxyamphetamine] which results in increased expression of H2AX protein CTD PMID:36138126 3-Amino-1-methyl-5H-pyrido[4,3-b]indole increases expression EXP 6480464 3-amino-1-methyl-5H-pyrido(4 and 3-b)indole results in increased expression of H2AX protein modified form CTD PMID:28160022 3-methyl-3H-imidazo[4,5-f]quinolin-2-amine increases expression EXP 6480464 2-amino-3-methylimidazo(4 and 5-f)quinoline results in increased expression of H2AX protein modified form CTD PMID:28160022 3-methyl-3H-imidazo[4,5-f]quinolin-2-amine increases phosphorylation EXP 6480464 2-amino-3-methylimidazo(4 and 5-f)quinoline results in increased phosphorylation of H2AX protein CTD PMID:34510228 3-methyladenine multiple interactions EXP 6480464 3-methyladenine inhibits the reaction [Aflatoxin B1 results in increased expression of H2AX protein] CTD PMID:34396909 4,4'-sulfonyldiphenol multiple interactions EXP 6480464 [bisphenol S co-treated with cylindrospermopsin] results in increased expression of H2AX protein CTD PMID:32244372 4,4'-sulfonyldiphenol multiple interactions ISO H2ax (Rattus norvegicus) 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of H2AX mRNA CTD PMID:36041667 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein] more ... CTD PMID:21882252 more ... 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression EXP 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein modified form CTD PMID:34784199 and PMID:35435490 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression ISO H2ax (Rattus norvegicus) 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX mRNA CTD PMID:15890375 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases phosphorylation EXP 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of H2AX protein CTD PMID:26231820 4-chloroaniline increases phosphorylation EXP 6480464 4-chloroaniline results in increased phosphorylation of H2AX protein CTD PMID:34510228 4-hydroxynon-2-enal multiple interactions ISO H2ax (Mus musculus) 6480464 POLH protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein] more ... CTD PMID:22331492 4-hydroxynon-2-enal increases expression EXP 6480464 4-hydroxy-2-nonenal results in increased expression of H2AX protein CTD PMID:34503147 4-hydroxynon-2-enal multiple interactions EXP 6480464 [procymidone co-treated with iprodione co-treated with cyprodinil co-treated with fludioxonil co-treated with cyhalothrin co-treated with 4-hydroxy-2-nonenal] results in increased expression of H2AX protein CTD PMID:34503147 4-hydroxynon-2-enal increases phosphorylation ISO H2ax (Mus musculus) 6480464 4-hydroxy-2-nonenal results in increased phosphorylation of H2AX protein CTD PMID:22331492 4-methoxy-TEMPO multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [4-methoxy-2 more ... CTD PMID:28993908 4-methoxy-TEMPO increases phosphorylation EXP 6480464 4-methoxy-2 more ... CTD PMID:28993908 4-Nerolidylcatechol increases phosphorylation EXP 6480464 4-nerolidylcatechol results in increased phosphorylation of H2AX protein CTD PMID:22372875 4-nitroquinoline N-oxide increases expression EXP 6480464 4-Nitroquinoline-1-oxide results in increased expression of H2AX protein CTD PMID:32087850 4-nitroquinoline N-oxide increases phosphorylation EXP 6480464 4-Nitroquinoline-1-oxide results in increased phosphorylation of H2AX protein CTD PMID:34510228 4-nonylphenol increases phosphorylation EXP 6480464 4-nonylphenol results in increased phosphorylation of H2AX protein CTD PMID:32466334 4-tert-Octylphenol increases phosphorylation EXP 6480464 4-tert-octylphenol results in increased phosphorylation of H2AX protein CTD PMID:32466334 4-vinylcyclohexene dioxide increases expression EXP 6480464 4-vinyl-1-cyclohexene dioxide results in increased expression of H2AX protein CTD PMID:37182589 5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid multiple interactions EXP 6480464 pyridoxal phosphate-6-azophenyl-2' and 4'-disulfonic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form]] CTD PMID:32941855 5-aza-2'-deoxycytidine affects localization EXP 6480464 Decitabine affects the localization of H2AX protein CTD PMID:17991895 5-aza-2'-deoxycytidine increases expression EXP 6480464 Decitabine results in increased expression of H2AX protein CTD PMID:17991895 and PMID:18223691 5-aza-2'-deoxycytidine multiple interactions EXP 6480464 ATM protein affects the reaction [Decitabine results in increased expression of H2AX protein] more ... CTD PMID:17991895 and PMID:19732952 5-aza-2'-deoxycytidine increases phosphorylation EXP 6480464 Decitabine results in increased phosphorylation of H2AX protein CTD PMID:19215824 and PMID:19732952 5-azacytidine increases expression EXP 6480464 Azacitidine results in increased expression of H2AX protein CTD PMID:17991895 5-azacytidine multiple interactions ISO H2ax (Rattus norvegicus) 6480464 Azacitidine inhibits the reaction [potassium bromate results in increased phosphorylation of H2AX protein] CTD PMID:25015661 5-chloro-7-iodoquinolin-8-ol increases phosphorylation EXP 6480464 Clioquinol results in increased phosphorylation of H2AX protein CTD PMID:22627294 5-fluorouracil multiple interactions EXP 6480464 [Fluorouracil co-treated with olaparib] results in increased phosphorylation of H2AX protein more ... CTD PMID:15016801 more ... 5-fluorouracil increases phosphorylation EXP 6480464 Fluorouracil results in increased phosphorylation of H2AX protein CTD PMID:26544897 and PMID:34510228 5-fluorouracil affects expression EXP 6480464 Fluorouracil affects the expression of H2AX mRNA CTD PMID:16584549 6-propyl-2-thiouracil increases expression ISO H2ax (Rattus norvegicus) 6480464 Propylthiouracil results in increased expression of H2AX mRNA CTD PMID:24780913 680C91 decreases expression EXP 6480464 TDO inhibitor LM10 results in decreased expression of H2AX protein modified form CTD PMID:26651356 7,12-dimethyltetraphene increases expression ISO H2ax (Rattus norvegicus) 6480464 9 more ... CTD PMID:23969067 7,12-dimethyltetraphene increases phosphorylation EXP 6480464 9 more ... CTD PMID:34510228 7,12-dimethyltetraphene multiple interactions ISO H2ax (Mus musculus) 6480464 A gene mutant form affects the reaction [9 more ... CTD PMID:25448685 7,12-dimethyltetraphene increases expression ISO H2ax (Mus musculus) 6480464 9 more ... CTD PMID:25448685 and PMID:32553695 7,9-dihydro-1H-purine-2,6,8(3H)-trione multiple interactions ISO H2ax (Mus musculus) 6480464 CASP1 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AX protein] and NLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AX protein] CTD PMID:23619996 7,9-dihydro-1H-purine-2,6,8(3H)-trione increases phosphorylation ISO H2ax (Mus musculus) 6480464 Uric Acid results in increased phosphorylation of H2AX protein CTD PMID:23619996 9-aminoacridine multiple interactions EXP 6480464 [Aminacrine results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein] CTD PMID:26928355 9-aminoacridine decreases phosphorylation EXP 6480464 Aminacrine results in decreased phosphorylation of H2AX protein CTD PMID:26928355 [6]-Shogaol multiple interactions EXP 6480464 shogaol analog inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AX protein] CTD PMID:23899529 ABT-737 multiple interactions EXP 6480464 [ABT-737 co-treated with hydroquinone] results in increased expression of H2AX protein CTD PMID:28843007 acetylsalicylic acid decreases expression EXP 6480464 Aspirin results in decreased expression of H2AX protein CTD PMID:23363784 acrolein increases expression EXP 6480464 Acrolein results in increased expression of H2AX protein CTD PMID:34958888 acrylamide increases expression ISO H2ax (Mus musculus) 6480464 Acrylamide results in increased expression of H2AX protein CTD PMID:36599426 and PMID:36997053 acrylonitrile increases expression ISO H2ax (Mus musculus) 6480464 Acrylonitrile results in increased expression of H2AX protein CTD PMID:35429547 actinomycin D increases expression EXP 6480464 Dactinomycin results in increased expression of H2AX protein CTD PMID:31226288 adenosine multiple interactions EXP 6480464 Adenosine promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 adenosine 5'-monophosphate multiple interactions EXP 6480464 Adenosine Monophosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 ADP multiple interactions EXP 6480464 Adenosine Diphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] more ... CTD PMID:32941855 aflatoxin B1 multiple interactions EXP 6480464 2 more ... CTD PMID:28882572 more ... aflatoxin B1 increases expression ISO H2ax (Mus musculus) 6480464 Aflatoxin B1 results in increased expression of H2AX protein CTD PMID:34396909 aflatoxin B1 increases expression EXP 6480464 Aflatoxin B1 analog results in increased expression of H2AX protein more ... CTD PMID:31154085 more ... aflatoxin B1 increases methylation EXP 6480464 Aflatoxin B1 results in increased methylation of H2AX polyA tail CTD PMID:30157460 aflatoxin B1 increases phosphorylation ISO H2ax (Mus musculus) 6480464 Aflatoxin B1 results in increased phosphorylation of H2AX protein CTD PMID:19770486 aflatoxin B1 decreases expression ISO H2ax (Rattus norvegicus) 6480464 Aflatoxin B1 results in decreased expression of H2AX mRNA CTD PMID:15890375 aflatoxin B1 increases phosphorylation EXP 6480464 Aflatoxin B1 results in increased phosphorylation of H2AX protein CTD PMID:28882572 and PMID:34510228 Aflatoxin G1 multiple interactions ISO H2ax (Mus musculus) 6480464 aflatoxin G1 results in increased expression of and results in increased localization of H2AX protein and TNFRSF1B protein inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein] CTD PMID:36997055 Aflatoxin G1 increases phosphorylation EXP 6480464 aflatoxin G1 results in increased phosphorylation of H2AX protein CTD PMID:36997055 Aflatoxin G1 multiple interactions EXP 6480464 CYP2E1 promotes the reaction [aflatoxin G1 results in increased expression of H2AX protein] more ... CTD PMID:23907605 and PMID:36997055 Aflatoxin G1 increases expression EXP 6480464 aflatoxin G1 results in increased expression of H2AX protein modified form CTD PMID:23907605 aldehydo-D-glucose multiple interactions ISO H2ax (Mus musculus) 6480464 Glucose promotes the reaction [Bupivacaine results in increased expression of H2AX protein] CTD PMID:31672611 aldehydo-D-glucose increases expression ISO H2ax (Mus musculus) 6480464 Glucose results in increased expression of H2AX protein CTD PMID:31672611 alizarin multiple interactions EXP 6480464 alizarin inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein] CTD PMID:37515497 all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of H2AX mRNA CTD PMID:16249480 and PMID:33167477 all-trans-retinoic acid increases expression ISO H2ax (Mus musculus) 6480464 Tretinoin results in increased expression of H2AX protein CTD PMID:33823233 alternariol increases expression EXP 6480464 alternariol results in increased expression of H2AX protein modified form CTD PMID:26341179 alvocidib affects expression EXP 6480464 alvocidib affects the expression of H2AX protein CTD PMID:15078984 alvocidib multiple interactions EXP 6480464 alvocidib inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein] CTD PMID:37515497 amsacrine multiple interactions EXP 6480464 ATM protein promotes the reaction [Amsacrine results in increased phosphorylation of H2AX protein] CTD PMID:37451322 amsacrine increases phosphorylation EXP 6480464 Amsacrine results in increased phosphorylation of H2AX protein CTD PMID:37451322 anthocyanin increases phosphorylation EXP 6480464 Anthocyanins results in increased phosphorylation of H2AX protein CTD PMID:27444805 anthra[1,9-cd]pyrazol-6(2H)-one multiple interactions EXP 6480464 pyrazolanthrone inhibits the reaction [4-methoxy-2 more ... CTD PMID:25619392 and PMID:28993908 aphidicolin multiple interactions EXP 6480464 Aphidicolin inhibits the reaction [Docetaxel results in increased expression of H2AX protein] CTD PMID:20878124 aristolochic acid A increases expression ISO H2ax (Mus musculus) 6480464 aristolochic acid I results in increased expression of H2AX protein CTD PMID:31602497 aristolochic acid A increases expression EXP 6480464 aristolochic acid I results in increased expression of H2AX mRNA CTD PMID:33212167 aristolochic acid A multiple interactions ISO H2ax (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [aristolochic acid I results in increased expression of H2AX protein] CTD PMID:36863539 aristolochic acid A increases expression ISO H2ax (Rattus norvegicus) 6480464 aristolochic acid I results in increased expression of H2AX protein CTD PMID:36863539 aristolochic acid A multiple interactions ISO H2ax (Mus musculus) 6480464 TRP53 protein affects the reaction [aristolochic acid I results in increased expression of H2AX protein] CTD PMID:31602497 arsane increases expression EXP 6480464 Arsenic results in increased expression of H2AX mRNA and Arsenic results in increased expression of H2AX protein CTD PMID:29161537 more ... arsane increases expression ISO H2ax (Mus musculus) 6480464 Arsenic results in increased expression of H2AX protein CTD PMID:34998823 arsane multiple interactions EXP 6480464 [arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of H2AX protein more ... CTD PMID:31822296 more ... arsane multiple interactions ISO H2ax (Rattus norvegicus) 6480464 [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Zinc deficiency] results in increased expression of H2AX protein CTD PMID:31542844 arsenic atom increases expression EXP 6480464 Arsenic results in increased expression of H2AX mRNA and Arsenic results in increased expression of H2AX protein CTD PMID:29161537 more ... arsenic atom increases expression ISO H2ax (Mus musculus) 6480464 Arsenic results in increased expression of H2AX protein CTD PMID:34998823 arsenic atom multiple interactions ISO H2ax (Rattus norvegicus) 6480464 [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Zinc deficiency] results in increased expression of H2AX protein CTD PMID:31542844 arsenic atom multiple interactions EXP 6480464 [arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of H2AX protein more ... CTD PMID:31822296 more ... arsenic trichloride multiple interactions EXP 6480464 [arsenic trichloride results in increased abundance of Arsenic] which results in increased expression of H2AX protein and [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in increased expression of H2AX protein CTD PMID:35809665 arsenite(3-) multiple interactions EXP 6480464 arsenite promotes the reaction [G3BP1 protein binds to H2AX mRNA] CTD PMID:32406909 arsenous acid multiple interactions EXP 6480464 [Arsenic Trioxide co-treated with ruxolitinib] results in increased phosphorylation of H2AX protein more ... CTD PMID:18636201 more ... arsenous acid increases expression ISO H2ax (Rattus norvegicus) 6480464 Arsenic Trioxide results in increased expression of H2AX protein CTD PMID:23337567 arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of H2AX protein and Arsenic Trioxide results in increased expression of H2AX protein modified form CTD PMID:28265077 more ... arsenous acid increases expression ISO H2ax (Mus musculus) 6480464 Arsenic Trioxide results in increased expression of H2AX protein modified form CTD PMID:28265077 arsenous acid increases phosphorylation EXP 6480464 Arsenic Trioxide results in increased phosphorylation of H2AX protein CTD PMID:16891316 and PMID:23861973 arsenous acid multiple interactions ISO H2ax (Rattus norvegicus) 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Arsenic Trioxide results in increased expression of H2AX protein] CTD PMID:23337567 artesunate increases phosphorylation EXP 6480464 Artesunate results in increased phosphorylation of H2AX protein CTD PMID:31664825 artesunate multiple interactions EXP 6480464 APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of H2AX protein] CTD PMID:31664825 ATP multiple interactions EXP 6480464 Adenosine Triphosphate promotes the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] more ... CTD PMID:32941855 atrazine affects expression ISO H2ax (Mus musculus) 6480464 Atrazine affects the expression of H2AX protein modified form CTD PMID:26518232 auramine O increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 Benzophenoneidum results in increased phosphorylation of H2AX protein CTD PMID:37527026 azathioprine decreases expression EXP 6480464 Azathioprine results in decreased expression of H2AX mRNA CTD PMID:22623647 Benz[c]acridine increases expression EXP 6480464 benz(c)acridine metabolite results in increased expression of H2AX protein CTD PMID:31051210 benzene increases expression ISO H2ax (Mus musculus) 6480464 Benzene results in increased expression of H2AX mRNA CTD PMID:15120971 and PMID:15122651 benzene increases phosphorylation ISO H2ax (Mus musculus) 6480464 Benzene results in increased phosphorylation of H2AX protein CTD PMID:35963423 benzidine increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 benzidine results in increased phosphorylation of H2AX protein CTD PMID:37527026 benzidine multiple interactions EXP 6480464 [NAT1 polymorphism affects the susceptibility to benzidine] which affects the expression of H2AX CTD PMID:37097310 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene metabolite results in increased expression of H2AX protein more ... CTD PMID:21873372 more ... benzo[a]pyrene increases expression ISO H2ax (Rattus norvegicus) 6480464 Benzo(a)pyrene results in increased expression of H2AX protein modified form CTD PMID:34283317 benzo[a]pyrene increases expression ISO H2ax (Mus musculus) 6480464 Benzo(a)pyrene metabolite results in increased expression of H2AX protein modified form CTD PMID:32553695 benzo[a]pyrene increases phosphorylation ISO H2ax (Mus musculus) 6480464 Benzo(a)pyrene results in increased phosphorylation of H2AX protein CTD PMID:19770486 and PMID:33393179 benzo[a]pyrene increases methylation EXP 6480464 Benzo(a)pyrene results in increased methylation of H2AX promoter CTD PMID:27901495 benzo[a]pyrene increases phosphorylation EXP 6480464 Benzo(a)pyrene results in increased phosphorylation of H2AX protein CTD PMID:20888899 more ... benzo[a]pyrene multiple interactions ISO H2ax (Mus musculus) 6480464 pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein] CTD PMID:33393179 benzo[a]pyrene multiple interactions EXP 6480464 2 more ... CTD PMID:20888899 more ... benzo[a]pyrene diol epoxide I increases expression EXP 6480464 7 more ... CTD PMID:19150397 benzo[a]pyrene diol epoxide I increases phosphorylation ISO H2ax (Mus musculus) 6480464 7 more ... CTD PMID:22331492 benzo[a]pyrene diol epoxide I multiple interactions ISO H2ax (Mus musculus) 6480464 POLH protein affects the reaction [7 more ... CTD PMID:22331492 benzo[a]pyrene diol epoxide I decreases expression EXP 6480464 7 more ... CTD PMID:20382639 benzo[a]pyrene diol epoxide I multiple interactions EXP 6480464 [Hydrogen Peroxide co-treated with 7 more ... CTD PMID:18848825 benzo[a]pyrene diol epoxide I affects phosphorylation EXP 6480464 7 more ... CTD PMID:18848825 benzo[e]pyrene increases methylation EXP 6480464 benzo(e)pyrene results in increased methylation of H2AX polyA tail CTD PMID:30157460 Benzo[ghi]perylene multiple interactions EXP 6480464 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [1 and 12-benzoperylene results in increased expression of H2AX protein] CTD PMID:35182551 Benzo[ghi]perylene increases phosphorylation EXP 6480464 1 and 12-benzoperylene results in increased phosphorylation of H2AX protein CTD PMID:37150498 Benzo[ghi]perylene increases expression EXP 6480464 1 and 12-benzoperylene results in increased expression of H2AX protein CTD PMID:31518672 and PMID:35182551 berberine increases expression EXP 6480464 Berberine results in increased expression of H2AX protein modified form CTD PMID:23747414 berberine decreases expression EXP 6480464 Berberine results in decreased expression of H2AX mRNA and Berberine results in decreased expression of H2AX protein CTD PMID:23363784 and PMID:27311644 berberine multiple interactions EXP 6480464 TOP2A protein affects the reaction [Berberine results in increased expression of H2AX protein modified form] CTD PMID:23747414 beta-hexachlorocyclohexane increases phosphorylation EXP 6480464 beta-hexachlorocyclohexane results in increased phosphorylation of H2AX protein CTD PMID:33207735 biphenyl-4-amine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [4-biphenylamine results in increased expression of H2AX protein] more ... CTD PMID:32433928 more ... biphenyl-4-amine increases expression EXP 6480464 4-biphenylamine results in increased expression of H2AX protein CTD PMID:32433928 more ... bis(2-chloroethyl) sulfide increases expression EXP 6480464 Mustard Gas results in increased expression of H2AX protein modified form CTD PMID:25102026 bis(2-chloroethyl) sulfide decreases expression EXP 6480464 Mustard Gas results in decreased expression of H2AX mRNA CTD PMID:33491125 bis(2-chloroethyl) sulfide multiple interactions EXP 6480464 pifithrin promotes the reaction [Mustard Gas results in increased phosphorylation of H2AX protein] CTD PMID:25448276 bis(2-chloroethyl) sulfide increases phosphorylation EXP 6480464 Mustard Gas results in increased phosphorylation of H2AX protein CTD PMID:20435105 and PMID:25448276 bis(2-ethylhexyl) phthalate increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 Diethylhexyl Phthalate results in increased phosphorylation of H2AX protein CTD PMID:30543897 bis(2-ethylhexyl) phthalate increases phosphorylation ISO H2ax (Mus musculus) 6480464 Diethylhexyl Phthalate results in increased phosphorylation of H2AX protein CTD PMID:36423848 bis(2-ethylhexyl) phthalate decreases expression ISO H2ax (Rattus norvegicus) 6480464 Diethylhexyl Phthalate results in decreased expression of H2AX protein CTD PMID:37258237 bis(2-ethylhexyl) phthalate increases phosphorylation EXP 6480464 Diethylhexyl Phthalate results in increased phosphorylation of H2AX protein CTD PMID:30543897 bis(2-ethylhexyl) phthalate multiple interactions EXP 6480464 Diethylhexyl Phthalate inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form] more ... CTD PMID:30543897 and PMID:30720231 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of H2AX mRNA more ... CTD PMID:16462019 more ... bisphenol A affects expression ISO H2ax (Rattus norvegicus) 6480464 bisphenol A affects the expression of H2AX mRNA CTD PMID:32145629 bisphenol A increases expression ISO H2ax (Mus musculus) 6480464 bisphenol A results in increased expression of H2AX mRNA CTD PMID:32156529 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of H2AX mRNA CTD PMID:30903817 bisphenol A increases phosphorylation EXP 6480464 bisphenol A results in increased phosphorylation of H2AX protein CTD PMID:29128613 and PMID:32466334 bisphenol A decreases expression ISO H2ax (Mus musculus) 6480464 bisphenol A results in decreased expression of H2AX mRNA CTD PMID:30245210 bisphenol A multiple interactions ISO H2ax (Rattus norvegicus) 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of H2AX mRNA more ... CTD PMID:23788033 more ... bisphenol A multiple interactions ISO H2ax (Mus musculus) 6480464 bisphenol A inhibits the reaction [[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] which results in increased expression of H2AX protein] more ... CTD PMID:25693136 and PMID:33239236 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of H2AX mRNA and bisphenol A results in decreased expression of H2AX protein CTD PMID:29275510 and PMID:34186270 bisphenol A increases expression ISO H2ax (Rattus norvegicus) 6480464 bisphenol A results in increased expression of H2AX protein CTD PMID:23788033 bisphenol A increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 bisphenol A results in increased phosphorylation of H2AX protein CTD PMID:29128613 bisphenol A multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [bisphenol A results in increased phosphorylation of H2AX protein] more ... CTD PMID:23227178 more ... Bisphenol B increases expression ISO H2ax (Mus musculus) 6480464 bisphenol B results in increased expression of H2AX protein CTD PMID:33392205 Bisphenol B increases expression EXP 6480464 bisphenol B results in increased expression of H2AX protein CTD PMID:34186270 bisphenol F increases expression ISO H2ax (Mus musculus) 6480464 bisphenol F results in increased expression of H2AX protein CTD PMID:29102535 bisphenol F increases expression EXP 6480464 bisphenol F results in increased expression of H2AX protein CTD PMID:34186270 bisphenol F multiple interactions ISO H2ax (Rattus norvegicus) 6480464 [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of H2AX mRNA CTD PMID:36041667 bisphenol F multiple interactions EXP 6480464 [bisphenol F co-treated with cylindrospermopsin] results in increased expression of H2AX protein CTD PMID:32244372 bleomycin A2 increases expression EXP 6480464 Bleomycin results in increased expression of H2AX protein CTD PMID:25130544 bortezomib multiple interactions EXP 6480464 [Bortezomib co-treated with romidepsin] results in increased phosphorylation of H2AX protein more ... CTD PMID:15173094 and PMID:16778179 bortezomib decreases phosphorylation EXP 6480464 Bortezomib results in decreased phosphorylation of H2AX protein CTD PMID:32482060 bortezomib multiple interactions ISO H2ax (Rattus norvegicus) 6480464 Bortezomib inhibits the reaction [Doxorubicin results in increased expression of H2AX protein] and Bortezomib inhibits the reaction [Etoposide results in increased expression of H2AX protein] CTD PMID:17875725 bortezomib increases expression EXP 6480464 Bortezomib results in increased expression of H2AX protein modified form CTD PMID:16778179 and PMID:18790767 bromoethene increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 vinyl bromide results in increased phosphorylation of H2AX protein CTD PMID:37527026 bupivacaine multiple interactions ISO H2ax (Mus musculus) 6480464 Glucose promotes the reaction [Bupivacaine results in increased expression of H2AX protein] CTD PMID:31672611 bupivacaine increases expression ISO H2ax (Mus musculus) 6480464 Bupivacaine results in increased expression of H2AX protein CTD PMID:31672611 busulfan increases phosphorylation EXP 6480464 Busulfan results in increased phosphorylation of H2AX protein CTD PMID:18339423 busulfan multiple interactions EXP 6480464 [Clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased expression of H2AX protein CTD PMID:20933509 Butylbenzyl phthalate multiple interactions ISO H2ax (Mus musculus) 6480464 Nicotinamide Mononucleotide inhibits the reaction [butylbenzyl phthalate results in increased phosphorylation of H2AX protein] CTD PMID:36756972 Butylbenzyl phthalate increases phosphorylation ISO H2ax (Mus musculus) 6480464 butylbenzyl phthalate results in increased phosphorylation of H2AX protein CTD PMID:36756972 butyric acid increases expression ISO H2ax (Rattus norvegicus) 6480464 Butyric Acid results in increased expression of H2AX protein CTD PMID:25070040 butyric acid multiple interactions EXP 6480464 Butyric Acid promotes the reaction [Benzo(a)pyrene results in increased expression of and results in increased phosphorylation of H2AX protein] CTD PMID:36399157 butyric acid decreases expression ISO H2ax (Rattus norvegicus) 6480464 Butyric Acid results in decreased expression of H2AX mRNA CTD PMID:12800193 cadmium atom increases expression ISO H2ax (Rattus norvegicus) 6480464 Cadmium results in increased expression of H2AX protein CTD PMID:27658547 cadmium atom multiple interactions ISO H2ax (Rattus norvegicus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of H2AX protein and Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of H2AX protein] CTD PMID:33031904 cadmium dichloride increases expression ISO H2ax (Rattus norvegicus) 6480464 Cadmium Chloride results in increased expression of H2AX protein CTD PMID:22457795 cadmium dichloride increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 Cadmium Chloride results in increased phosphorylation of H2AX protein CTD PMID:37451666 cadmium dichloride multiple interactions ISO H2ax (Rattus norvegicus) 6480464 [Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of H2AX protein more ... CTD PMID:33031904 and PMID:37451666 cadmium dichloride affects expression ISO H2ax (Mus musculus) 6480464 Cadmium Chloride affects the expression of H2AX mRNA CTD PMID:18974090 caffeine multiple interactions EXP 6480464 Caffeine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of H2AX protein] more ... CTD PMID:15975956 more ... caffeine multiple interactions ISO H2ax (Rattus norvegicus) 6480464 [Caffeine co-treated with Ephedrine] results in increased phosphorylation of H2AX protein CTD PMID:15537744 calciol decreases expression EXP 6480464 Cholecalciferol results in decreased expression of H2AX protein CTD PMID:23363784 calcitriol decreases expression EXP 6480464 Calcitriol results in decreased expression of H2AX mRNA CTD PMID:21592394 calcitriol multiple interactions EXP 6480464 [salinomycin co-treated with Calcitriol] results in decreased expression of H2AX mRNA and [Testosterone co-treated with Calcitriol] results in decreased expression of H2AX mRNA CTD PMID:21592394 and PMID:35914560 camptothecin increases expression EXP 6480464 Camptothecin results in increased expression of H2AX protein and Camptothecin results in increased expression of H2AX protein modified form CTD PMID:21227924 more ... camptothecin increases expression ISO H2ax (Rattus norvegicus) 6480464 Camptothecin results in increased expression of H2AX protein CTD PMID:17875725 camptothecin increases expression ISO H2ax (Mus musculus) 6480464 Camptothecin results in increased expression of H2AX protein CTD PMID:17875725 camptothecin increases phosphorylation EXP 6480464 Camptothecin results in increased phosphorylation of H2AX protein CTD PMID:21646468 and PMID:32482060 camptothecin multiple interactions EXP 6480464 3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased expression of H2AX protein modified form] more ... CTD PMID:21227924 more ... cannabidiol increases expression EXP 6480464 Cannabidiol results in increased expression of H2AX protein modified form CTD PMID:27769052 cannabidiol multiple interactions EXP 6480464 Cannabidiol promotes the reaction [Dronabinol results in increased expression of H2AX protein modified form] and Dronabinol promotes the reaction [Cannabidiol results in increased expression of H2AX protein modified form] CTD PMID:27769052 capsaicin increases localization EXP 6480464 Capsaicin results in increased localization of H2AX protein CTD PMID:22226932 carbamate ester multiple interactions EXP 6480464 Carbamates analog results in increased phosphorylation of and results in increased activity of H2AX protein CTD PMID:19376255 carbamate ester increases phosphorylation EXP 6480464 Carbamates analog results in increased phosphorylation of H2AX protein CTD PMID:19111005 carbamazepine increases expression EXP 6480464 Carbamazepine results in increased expression of H2AX protein CTD PMID:36995427 carbon nanotube increases expression ISO H2ax (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25554681 carbon nanotube increases expression EXP 6480464 Nanotubes and Carbon results in increased expression of H2AX protein CTD PMID:32493873 carboplatin increases expression EXP 6480464 Carboplatin results in increased expression of H2AX protein CTD PMID:22302033 carboplatin multiple interactions EXP 6480464 palbociclib inhibits the reaction [Carboplatin results in increased expression of H2AX protein] CTD PMID:22302033 carmustine decreases expression EXP 6480464 Carmustine results in decreased expression of H2AX mRNA CTD PMID:15980968 carmustine increases phosphorylation EXP 6480464 Carmustine results in increased phosphorylation of H2AX protein CTD PMID:20472715 carmustine multiple interactions EXP 6480464 MDM4 protein promotes the reaction [Carmustine affects the localization of H2AX protein] and MDM4 protein promotes the reaction [Carmustine results in increased phosphorylation of H2AX protein] CTD PMID:20472715 carmustine affects localization EXP 6480464 Carmustine affects the localization of H2AX protein CTD PMID:20472715 carteolol increases phosphorylation EXP 6480464 Carteolol results in increased phosphorylation of H2AX protein CTD PMID:37120125 celecoxib multiple interactions EXP 6480464 Celecoxib inhibits the reaction [Etoposide results in increased phosphorylation of H2AX protein] CTD PMID:21745461 CGP 52608 multiple interactions EXP 6480464 CGP 52608 promotes the reaction [RORA protein binds to H2AX gene] CTD PMID:28238834 chlorambucil increases phosphorylation EXP 6480464 Chlorambucil analog results in increased phosphorylation of H2AX protein and Chlorambucil results in increased phosphorylation of H2AX protein CTD PMID:16861886 and PMID:32482060 chlordecone increases expression ISO H2ax (Mus musculus) 6480464 Chlordecone results in increased expression of H2AX protein modified form CTD PMID:31084621 chlorite multiple interactions ISO H2ax (Rattus norvegicus) 6480464 chlorite promotes the reaction [Bromates results in increased phosphorylation of H2AX protein] CTD PMID:21864635 chloropicrin increases phosphorylation EXP 6480464 chloropicrin results in increased phosphorylation of H2AX protein CTD PMID:31884112 chloropicrin multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [chloropicrin results in increased phosphorylation of H2AX protein] CTD PMID:31884112 chloroprene increases expression ISO H2ax (Mus musculus) 6480464 Chloroprene results in increased expression of H2AX mRNA CTD PMID:23125180 chlorpyrifos increases expression EXP 6480464 Chlorpyrifos results in increased expression of H2AX protein CTD PMID:32156659 chlorpyrifos multiple interactions EXP 6480464 [Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in increased expression of H2AX protein CTD PMID:34830855 chlorpyrifos decreases expression ISO H2ax (Mus musculus) 6480464 Chlorpyrifos results in decreased expression of H2AX mRNA CTD PMID:37019170 cholesterol increases phosphorylation ISO H2ax (Mus musculus) 6480464 Cholesterol results in increased phosphorylation of H2AX protein CTD PMID:33239236 cholesterol multiple interactions ISO H2ax (Mus musculus) 6480464 bisphenol A promotes the reaction [Cholesterol results in increased phosphorylation of H2AX protein] and Resveratrol inhibits the reaction [bisphenol A promotes the reaction [Cholesterol results in increased phosphorylation of H2AX protein]] CTD PMID:33239236 choline multiple interactions ISO H2ax (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased phosphorylation of H2AX protein CTD PMID:20548288 chromium(6+) increases ubiquitination EXP 6480464 chromium hexavalent ion results in increased ubiquitination of H2AX protein CTD PMID:25288669 chromium(6+) increases phosphorylation ISO H2ax (Mus musculus) 6480464 chromium hexavalent ion results in increased phosphorylation of H2AX protein CTD PMID:25288669 chromium(6+) multiple interactions ISO H2ax (Mus musculus) 6480464 [sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of H2AX protein more ... CTD PMID:25288669 and PMID:35643323 chromium(6+) increases ubiquitination ISO H2ax (Mus musculus) 6480464 chromium hexavalent ion results in increased ubiquitination of H2AX protein CTD PMID:25288669 chromium(6+) increases expression ISO H2ax (Mus musculus) 6480464 chromium hexavalent ion results in increased expression of H2AX protein CTD PMID:25352572 chromium(6+) multiple interactions EXP 6480464 ATR protein affects the reaction [chromium hexavalent ion results in increased phosphorylation of H2AX protein] and ATR protein affects the reaction [chromium hexavalent ion results in increased ubiquitination of H2AX protein] CTD PMID:25288669 chromium(6+) increases phosphorylation EXP 6480464 chromium hexavalent ion results in increased phosphorylation of H2AX protein CTD PMID:25288669 chromone increases expression EXP 6480464 4-chromone analog results in increased expression of H2AX protein modified form CTD PMID:30256521 Cinobufagin increases expression EXP 6480464 cinobufagin results in increased expression of H2AX protein CTD PMID:35427566 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of H2AX mRNA more ... CTD PMID:21500194 more ... cisplatin increases phosphorylation ISO H2ax (Mus musculus) 6480464 Cisplatin results in increased phosphorylation of H2AX protein CTD PMID:21285353 more ... cisplatin increases expression ISO H2ax (Mus musculus) 6480464 Cisplatin results in increased expression of H2AX protein and Cisplatin results in increased expression of H2AX protein modified form CTD PMID:26723870 and PMID:26739623 cisplatin multiple interactions ISO H2ax (Rattus norvegicus) 6480464 Lovastatin inhibits the reaction [Cisplatin results in increased expression of H2AX protein modified form] CTD PMID:26739623 cisplatin increases expression ISO H2ax (Rattus norvegicus) 6480464 Cisplatin results in increased expression of H2AX protein modified form CTD PMID:26739623 cisplatin multiple interactions ISO H2ax (Mus musculus) 6480464 erdosteine inhibits the reaction [Cisplatin results in increased phosphorylation of H2AX protein] more ... CTD PMID:21324906 more ... cisplatin increases phosphorylation EXP 6480464 Cisplatin results in increased phosphorylation of H2AX protein CTD PMID:20145152 more ... cisplatin multiple interactions EXP 6480464 (+)-JQ1 compound promotes the reaction [Cisplatin results in increased expression of H2AX protein] more ... CTD PMID:20145152 more ... clofarabine multiple interactions EXP 6480464 [Clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased expression of H2AX protein CTD PMID:20933509 cobalt dichloride multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [cobaltous chloride promotes the reaction [nickel chloride results in increased phosphorylation of H2AX protein]] more ... CTD PMID:22172632 cobalt dichloride decreases expression ISO H2ax (Rattus norvegicus) 6480464 cobaltous chloride results in decreased expression of H2AX mRNA CTD PMID:24386269 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of H2AX mRNA CTD PMID:19376846 cobalt dichloride increases phosphorylation EXP 6480464 cobaltous chloride results in increased phosphorylation of H2AX protein CTD PMID:22172632 copper atom multiple interactions EXP 6480464 [Copper binds to phthalic acid binds to 1 more ... CTD PMID:22659117 and PMID:35809665 copper atom increases expression EXP 6480464 Copper results in increased expression of H2AX protein CTD PMID:35809665 copper(0) multiple interactions EXP 6480464 [Copper binds to phthalic acid binds to 1 more ... CTD PMID:22659117 and PMID:35809665 copper(0) increases expression EXP 6480464 Copper results in increased expression of H2AX protein CTD PMID:35809665 copper(II) sulfate decreases expression EXP 6480464 Copper Sulfate results in decreased expression of H2AX mRNA CTD PMID:19549813 coumestrol multiple interactions EXP 6480464 [Coumestrol co-treated with 2 more ... CTD PMID:19167446 coumestrol increases expression EXP 6480464 Coumestrol results in increased expression of H2AX mRNA and Coumestrol results in increased expression of H2AX protein modified form CTD PMID:19167446 and PMID:28986287 crizotinib increases phosphorylation EXP 6480464 Crizotinib results in increased phosphorylation of H2AX protein CTD PMID:31639374 crizotinib multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Crizotinib results in increased phosphorylation of H2AX protein] CTD PMID:31639374 CU-O LINKAGE increases expression EXP 6480464 cupric oxide analog results in increased expression of H2AX protein CTD PMID:27270449 CU-O LINKAGE decreases expression EXP 6480464 cupric oxide results in decreased expression of H2AX mRNA CTD PMID:22077320 curcumin multiple interactions EXP 6480464 [Curcumin co-treated with Metribolone] results in increased phosphorylation of H2AX protein and [Isoflavones co-treated with Curcumin] results in increased phosphorylation of H2AX protein CTD PMID:21134073 curcumin increases phosphorylation EXP 6480464 Curcumin results in increased phosphorylation of H2AX protein CTD PMID:19401701 and PMID:21134073 CX-5461 increases expression EXP 6480464 CX 5461 results in increased expression of H2AX protein CTD PMID:28211448 cyclophosphamide increases phosphorylation EXP 6480464 Cyclophosphamide results in increased phosphorylation of H2AX protein CTD PMID:32482060 and PMID:34510228 cyclophosphamide increases expression ISO H2ax (Mus musculus) 6480464 Cyclophosphamide results in increased expression of H2AX protein CTD PMID:37690746 cyclophosphamide increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 Cyclophosphamide results in increased phosphorylation of H2AX protein CTD PMID:33211169 cyclophosphamide multiple interactions ISO H2ax (Mus musculus) 6480464 Dexrazoxane inhibits the reaction [Cyclophosphamide results in increased expression of H2AX protein] CTD PMID:37690746 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of H2AX mRNA CTD PMID:20106945 more ... cyhalothrin multiple interactions EXP 6480464 [fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AX protein more ... CTD PMID:22389207 and PMID:34503147 cylindrospermopsin increases expression EXP 6480464 cylindrospermopsin results in increased expression of H2AX protein CTD PMID:30905859 and PMID:32244372 cylindrospermopsin multiple interactions EXP 6480464 [4 more ... CTD PMID:32244372 cypermethrin increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 cypermethrin results in increased phosphorylation of H2AX protein CTD PMID:35512476 cyprodinil increases phosphorylation EXP 6480464 cyprodinil results in increased phosphorylation of H2AX protein CTD PMID:22389207 cyprodinil multiple interactions EXP 6480464 [fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AX protein more ... CTD PMID:22389207 and PMID:34503147 cytarabine increases phosphorylation EXP 6480464 Cytarabine results in increased phosphorylation of H2AX protein CTD PMID:19628630 and PMID:34510228 D-glucose multiple interactions ISO H2ax (Mus musculus) 6480464 Glucose promotes the reaction [Bupivacaine results in increased expression of H2AX protein] CTD PMID:31672611 D-glucose increases expression ISO H2ax (Mus musculus) 6480464 Glucose results in increased expression of H2AX protein CTD PMID:31672611 daunorubicin affects expression EXP 6480464 Daunorubicin affects the expression of H2AX mRNA CTD PMID:27780733 daunorubicin increases expression EXP 6480464 Daunorubicin results in increased expression of H2AX protein CTD PMID:34963561 decabromodiphenyl ether increases expression ISO H2ax (Mus musculus) 6480464 decabromobiphenyl ether results in increased expression of H2AX mRNA and decabromobiphenyl ether results in increased expression of H2AX protein CTD PMID:34936917 dexamethasone multiple interactions EXP 6480464 [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of H2AX mRNA CTD PMID:26424790 diallyl trisulfide decreases expression EXP 6480464 diallyl trisulfide results in decreased expression of H2AX mRNA CTD PMID:34995734 diarsenic trioxide multiple interactions ISO H2ax (Rattus norvegicus) 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Arsenic Trioxide results in increased expression of H2AX protein] CTD PMID:23337567 diarsenic trioxide increases expression ISO H2ax (Rattus norvegicus) 6480464 Arsenic Trioxide results in increased expression of H2AX protein CTD PMID:23337567 diarsenic trioxide increases expression ISO H2ax (Mus musculus) 6480464 Arsenic Trioxide results in increased expression of H2AX protein modified form CTD PMID:28265077 diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of H2AX protein and Arsenic Trioxide results in increased expression of H2AX protein modified form CTD PMID:28265077 more ... diarsenic trioxide increases phosphorylation EXP 6480464 Arsenic Trioxide results in increased phosphorylation of H2AX protein CTD PMID:16891316 and PMID:23861973 diarsenic trioxide multiple interactions EXP 6480464 [Arsenic Trioxide co-treated with ruxolitinib] results in increased phosphorylation of H2AX protein more ... CTD PMID:18636201 more ... diazinon multiple interactions EXP 6480464 [Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in increased expression of H2AX protein CTD PMID:34830855 dibenz[a,h]anthracene increases expression EXP 6480464 1 more ... CTD PMID:31051210 Dibenz[a,j]acridine increases expression EXP 6480464 dibenzacridine metabolite results in increased expression of H2AX protein CTD PMID:31051210 Dibenz[c,h]acridine increases expression EXP 6480464 dibenz(c and h)acridine metabolite results in increased expression of H2AX protein CTD PMID:31051210 dibenziodolium multiple interactions EXP 6480464 diphenyleneiodonium inhibits the reaction [Aflatoxin B1 results in increased expression of H2AX protein] and diphenyleneiodonium inhibits the reaction [niraparib results in increased expression of H2AX protein] CTD PMID:34396909 dibenzo[a,l]pyrene multiple interactions EXP 6480464 2-(morpholin-4-yl)benzo(h)chromen-4-one inhibits the reaction [dibenzo(a and l)pyrene results in increased phosphorylation of H2AX protein] CTD PMID:31838185 dibenzo[a,l]pyrene increases phosphorylation EXP 6480464 dibenzo(a and l)pyrene results in increased phosphorylation of H2AX protein CTD PMID:31838185 dibutyl phthalate decreases expression ISO H2ax (Mus musculus) 6480464 Dibutyl Phthalate results in decreased expression of H2AX mRNA CTD PMID:17361019 and PMID:21266533 dichlorine increases expression ISO H2ax (Mus musculus) 6480464 Chlorine results in increased expression of H2AX protein CTD PMID:36690086 diclofenac increases expression EXP 6480464 Diclofenac results in increased expression of H2AX protein CTD PMID:32087850 diepoxybutane multiple interactions ISO H2ax (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [diepoxybutane results in increased expression of H2AX protein modified form] CTD PMID:25633853 diepoxybutane increases expression ISO H2ax (Mus musculus) 6480464 diepoxybutane results in increased expression of H2AX protein modified form CTD PMID:25633853 diethylstilbestrol increases expression ISO H2ax (Rattus norvegicus) 6480464 Diethylstilbestrol results in increased expression of H2AX mRNA CTD PMID:15890375 dihydroxyacetone increases expression EXP 6480464 Dihydroxyacetone results in increased expression of H2AX protein CTD PMID:32506039 dimethoate multiple interactions EXP 6480464 [Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in increased expression of H2AX protein CTD PMID:34830855 dimethocaine multiple interactions EXP 6480464 [NAT2 protein results in increased susceptibility to dimethocaine] which results in increased expression of H2AX protein CTD PMID:36138126 dioxygen decreases expression EXP 6480464 Oxygen deficiency results in decreased expression of H2AX mRNA CTD PMID:26516004 dioxygen multiple interactions EXP 6480464 Oxygen deficiency inhibits the reaction [ferric oxide analog results in increased expression of H2AX protein] and Oxygen deficiency inhibits the reaction [nickel monoxide analog results in increased expression of H2AX protein] CTD PMID:27270449 disodium selenite increases expression EXP 6480464 Sodium Selenite results in increased expression of H2AX mRNA CTD PMID:18175754 disodium selenite increases expression ISO H2ax (Mus musculus) 6480464 Sodium Selenite results in increased expression of H2AX protein CTD PMID:37142062 Disperse Blue 1 increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 Disperse Blue 1 results in increased phosphorylation of H2AX protein CTD PMID:33211169 disulfiram multiple interactions EXP 6480464 Disulfiram inhibits the reaction [captax results in increased expression of H2AX protein] more ... CTD PMID:28300663 more ... disulfiram increases expression EXP 6480464 Disulfiram results in increased expression of H2AX protein CTD PMID:34830855 dorsomorphin increases phosphorylation EXP 6480464 dorsomorphin results in increased phosphorylation of H2AX protein CTD PMID:23274516 dorsomorphin multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [dorsomorphin results in increased phosphorylation of H2AX protein] CTD PMID:23274516 doxorubicin multiple interactions EXP 6480464 [TP53 protein affects the susceptibility to Doxorubicin] which affects the expression of H2AX mRNA more ... CTD PMID:15489221 more ... doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of H2AX mRNA CTD PMID:29803840 and PMID:36634904 doxorubicin increases expression ISO H2ax (Mus musculus) 6480464 Doxorubicin results in increased expression of H2AX protein and Doxorubicin results in increased expression of H2AX protein modified form CTD PMID:17875725 and PMID:28710503 doxorubicin multiple interactions ISO H2ax (Rattus norvegicus) 6480464 4 more ... CTD PMID:17875725 more ... doxorubicin increases expression ISO H2ax (Rattus norvegicus) 6480464 Doxorubicin results in increased expression of H2AX protein and Doxorubicin results in increased expression of H2AX protein modified form CTD PMID:17875725 more ... doxorubicin increases phosphorylation ISO H2ax (Mus musculus) 6480464 Doxorubicin results in increased phosphorylation of H2AX protein CTD PMID:22712078 and PMID:31368505 doxorubicin multiple interactions ISO H2ax (Mus musculus) 6480464 Lovastatin inhibits the reaction [Doxorubicin results in increased expression of H2AX protein modified form] more ... CTD PMID:17875725 more ... doxorubicin affects expression EXP 6480464 Doxorubicin affects the expression of H2AX mRNA CTD PMID:27780733 doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of H2AX mRNA more ... CTD PMID:22302033 more ... doxorubicin increases phosphorylation EXP 6480464 Doxorubicin results in increased phosphorylation of H2AX protein CTD PMID:15489221 more ... dronedarone increases phosphorylation EXP 6480464 Dronedarone results in increased phosphorylation of H2AX protein CTD PMID:29616291 dronedarone multiple interactions EXP 6480464 CYP2D6 protein inhibits the reaction [Dronedarone results in increased phosphorylation of H2AX protein] more ... CTD PMID:29616291 Echimidine increases expression EXP 6480464 echimidine results in increased expression of H2AX protein CTD PMID:31154085 elemental selenium increases expression EXP 6480464 Selenium results in increased expression of H2AX mRNA CTD PMID:19244175 ellipticine multiple interactions EXP 6480464 [ellipticine binds to FTL protein] which results in increased expression of H2AX protein modified form CTD PMID:30914192 ellipticine increases expression EXP 6480464 ellipticine results in increased expression of H2AX protein modified form CTD PMID:30914192 emodin increases expression EXP 6480464 Emodin results in increased expression of H2AX protein and Emodin results in increased expression of H2AX protein modified form CTD PMID:20855424 more ... emodin multiple interactions EXP 6480464 TOP2A affects the reaction [Emodin results in increased expression of H2AX protein modified form] CTD PMID:20855424 enilconazole multiple interactions EXP 6480464 [Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in increased expression of H2AX protein CTD PMID:34830855 Enterolactone multiple interactions EXP 6480464 [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of H2AX mRNA CTD PMID:19167446 entinostat increases phosphorylation EXP 6480464 entinostat results in increased phosphorylation of H2AX protein CTD PMID:34665271 epothilone A multiple interactions EXP 6480464 [epothilone A co-treated with Metformin] results in increased expression of H2AX mRNA CTD PMID:29117515 epothilone A increases expression EXP 6480464 epothilone A results in increased expression of H2AX mRNA CTD PMID:29117515 erdosteine multiple interactions ISO H2ax (Mus musculus) 6480464 erdosteine inhibits the reaction [Cisplatin results in increased phosphorylation of H2AX protein] CTD PMID:26193055 erlotinib hydrochloride multiple interactions EXP 6480464 Erlotinib Hydrochloride promotes the reaction [Resveratrol results in increased expression of H2AX protein modified form] and Resveratrol promotes the reaction [Erlotinib Hydrochloride results in increased expression of H2AX protein modified form] CTD PMID:25895606 erlotinib hydrochloride increases expression EXP 6480464 Erlotinib Hydrochloride results in increased expression of H2AX protein modified form CTD PMID:25895606 erucifoline increases expression EXP 6480464 erucifoline results in increased expression of H2AX protein CTD PMID:31154085 estragole increases expression ISO H2ax (Rattus norvegicus) 6480464 estragole results in increased expression of H2AX protein modified form CTD PMID:29054680 ethanol increases phosphorylation EXP 6480464 Ethanol results in increased phosphorylation of H2AX protein CTD PMID:24374569 ethanol increases expression ISO H2ax (Mus musculus) 6480464 Ethanol results in increased expression of H2AX mRNA more ... CTD PMID:34192554 more ... ethanol increases expression EXP 6480464 Ethanol results in increased expression of H2AX mRNA more ... CTD PMID:34192554 and PMID:34405320 ethanol multiple interactions EXP 6480464 CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of H2AX protein modified form]] more ... CTD PMID:34192554 and PMID:34405320 ethanol multiple interactions ISO H2ax (Mus musculus) 6480464 [BRCA1 gene mutant form results in increased susceptibility to Ethanol] which results in increased phosphorylation of H2AX protein more ... CTD PMID:26629949 more ... ethanol increases phosphorylation ISO H2ax (Mus musculus) 6480464 Ethanol results in increased phosphorylation of H2AX protein CTD PMID:26629949 ethyl methanesulfonate increases expression EXP 6480464 Ethyl Methanesulfonate results in increased expression of H2AX protein CTD PMID:35395335 and PMID:36995427 Ethylenethiourea increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 Ethylenethiourea results in increased phosphorylation of H2AX protein CTD PMID:37527026 etoposide increases phosphorylation EXP 6480464 Etoposide results in increased phosphorylation of H2AX protein CTD PMID:20978201 more ... etoposide decreases response to substance ISO H2ax (Mus musculus) 6480464 H2AX protein results in decreased susceptibility to Etoposide CTD PMID:21555580 etoposide increases expression ISO H2ax (Mus musculus) 6480464 Etoposide results in increased expression of H2AX protein CTD PMID:17875725 more ... etoposide increases expression ISO H2ax (Rattus norvegicus) 6480464 Etoposide results in increased expression of H2AX protein CTD PMID:17875725 etoposide multiple interactions ISO H2ax (Mus musculus) 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Etoposide results in increased expression of H2AX protein] more ... CTD PMID:17875725 more ... etoposide multiple interactions ISO H2ax (Rattus norvegicus) 6480464 4 more ... CTD PMID:17875725 etoposide increases expression EXP 6480464 Etoposide results in increased expression of H2AX protein and Etoposide results in increased expression of H2AX protein modified form CTD PMID:22302033 more ... etoposide multiple interactions EXP 6480464 Celecoxib inhibits the reaction [Etoposide results in increased phosphorylation of H2AX protein] more ... CTD PMID:21745461 more ... fenbendazole increases expression EXP 6480464 Fenbendazole analog results in increased expression of H2AX protein and Fenbendazole results in increased expression of H2AX protein CTD PMID:35569513 fenthion increases expression EXP 6480464 Fenthion results in increased expression of H2AX protein CTD PMID:33221015 ferric oxide multiple interactions EXP 6480464 Oxygen deficiency inhibits the reaction [ferric oxide analog results in increased expression of H2AX protein] CTD PMID:27270449 ferric oxide increases expression EXP 6480464 ferric oxide analog results in increased expression of H2AX protein CTD PMID:27270449 flavanones multiple interactions EXP 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one promotes the reaction [Flavanones results in increased phosphorylation of H2AX protein] more ... CTD PMID:21616090 flavanones increases phosphorylation EXP 6480464 Flavanones results in increased phosphorylation of H2AX protein CTD PMID:21616090 flavokawain B increases phosphorylation EXP 6480464 flavokawain B results in increased phosphorylation of H2AX protein CTD PMID:30025493 fludioxonil multiple interactions EXP 6480464 [fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AX protein more ... CTD PMID:22389207 and PMID:34503147 fludioxonil increases phosphorylation EXP 6480464 fludioxonil results in increased phosphorylation of H2AX protein CTD PMID:22389207 fluoranthene multiple interactions ISO H2ax (Mus musculus) 6480464 [1-methylanthracene co-treated with fluoranthene] results in decreased expression of H2AX mRNA CTD PMID:28329830 fluoranthene multiple interactions EXP 6480464 [fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of H2AX protein and [pyrene co-treated with fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of H2AX protein CTD PMID:33249052 flutamide increases expression ISO H2ax (Rattus norvegicus) 6480464 Flutamide results in increased expression of H2AX mRNA CTD PMID:24793618 folic acid multiple interactions ISO H2ax (Mus musculus) 6480464 [1 more ... CTD PMID:20548288 and PMID:22206623 folic acid affects phosphorylation ISO H2ax (Mus musculus) 6480464 Folic Acid deficiency affects the phosphorylation of H2AX protein CTD PMID:28471487 fomepizole multiple interactions EXP 6480464 Fomepizole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein] CTD PMID:28300663 formaldehyde increases expression EXP 6480464 Formaldehyde results in increased expression of H2AX protein CTD PMID:22479348 fotemustine increases expression EXP 6480464 fotemustine results in increased expression of H2AX protein modified form CTD PMID:25125662 FR900359 affects phosphorylation EXP 6480464 FR900359 affects the phosphorylation of H2AX protein CTD PMID:37730182 fructose multiple interactions ISO H2ax (Mus musculus) 6480464 [Dietary Fats co-treated with Cholesterol more ... CTD PMID:37271273 fulvestrant multiple interactions ISO H2ax (Rattus norvegicus) 6480464 Fulvestrant inhibits the reaction [bisphenol A results in increased expression of H2AX protein] and Fulvestrant inhibits the reaction [Estradiol results in increased expression of H2AX protein] CTD PMID:23788033 fulvestrant multiple interactions ISO H2ax (Mus musculus) 6480464 Fulvestrant inhibits the reaction [4 more ... CTD PMID:36098747 fulvestrant multiple interactions EXP 6480464 Fulvestrant inhibits the reaction [Estradiol results in increased expression of H2AX protein modified form] more ... CTD PMID:31939680 fumonisin B1 decreases expression EXP 6480464 fumonisin B1 results in decreased expression of H2AX protein CTD PMID:25800559 furan increases methylation ISO H2ax (Rattus norvegicus) 6480464 furan results in increased methylation of H2AX gene CTD PMID:22079235 GDP multiple interactions EXP 6480464 Guanosine Diphosphate inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 gemcitabine increases expression EXP 6480464 Gemcitabine results in increased expression of H2AX protein and Gemcitabine results in increased expression of H2AX protein modified form CTD PMID:20798217 more ... gemcitabine multiple interactions EXP 6480464 PIF1 protein inhibits the reaction [Gemcitabine results in increased expression of H2AX protein] and Thymidine inhibits the reaction [PIF1 protein inhibits the reaction [Gemcitabine results in increased expression of H2AX protein]] CTD PMID:37183367 genistein multiple interactions EXP 6480464 ATM protein affects the reaction [Genistein results in increased phosphorylation of H2AX protein] CTD PMID:15177039 genistein increases expression EXP 6480464 Genistein results in increased expression of H2AX mRNA CTD PMID:16474171 genistein increases phosphorylation EXP 6480464 Genistein results in increased phosphorylation of H2AX protein CTD PMID:15177039 gentamycin increases expression ISO H2ax (Rattus norvegicus) 6480464 Gentamicins results in increased expression of H2AX mRNA CTD PMID:33387578 Gingerenone A increases expression EXP 6480464 gingerenone A results in increased expression of H2AX protein CTD PMID:35326237 Gingerenone A multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [gingerenone A results in increased expression of H2AX protein] CTD PMID:35326237 ginsenoside Rg1 multiple interactions EXP 6480464 ginsenoside Rg1 promotes the reaction [Doxorubicin results in increased expression of H2AX mRNA] CTD PMID:34783124 Glu-P-1 increases expression EXP 6480464 2-amino-6-methyldipyrido(1 more ... CTD PMID:28160022 Glu-P-2 increases expression EXP 6480464 Glu-P-2 results in increased expression of H2AX protein modified form CTD PMID:28160022 glucose increases expression ISO H2ax (Mus musculus) 6480464 Glucose results in increased expression of H2AX protein CTD PMID:31672611 glucose multiple interactions ISO H2ax (Mus musculus) 6480464 Glucose promotes the reaction [Bupivacaine results in increased expression of H2AX protein] CTD PMID:31672611 glutathione multiple interactions ISO H2ax (Mus musculus) 6480464 Glutathione inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of H2AX protein] CTD PMID:21722719 glutathione multiple interactions EXP 6480464 Glutathione inhibits the reaction [rubimaillin results in increased phosphorylation of H2AX protein] CTD PMID:35007525 glycerol 2-phosphate multiple interactions EXP 6480464 [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of H2AX mRNA CTD PMID:26424790 glyphosate increases expression ISO H2ax (Mus musculus) 6480464 Glyphosate results in increased expression of H2AX protein modified form CTD PMID:31352102 GSK690693 multiple interactions EXP 6480464 GSK690693 inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein] CTD PMID:34784199 GTP multiple interactions EXP 6480464 Guanosine Triphosphate inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 guanosine multiple interactions EXP 6480464 Guanosine inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 Heliotrine increases expression EXP 6480464 heliotrine results in increased expression of H2AX protein CTD PMID:31154085 hexachlorobenzene increases expression EXP 6480464 Hexachlorobenzene results in increased expression of H2AX protein CTD PMID:32156659 hydrazine increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 hydrazine results in increased phosphorylation of H2AX protein CTD PMID:37527026 hydrogen peroxide multiple interactions EXP 6480464 [ERCC6 protein affects the susceptibility to Hydrogen Peroxide] which affects the expression of H2AX protein more ... CTD PMID:18848825 more ... hydrogen peroxide multiple interactions ISO H2ax (Mus musculus) 6480464 [Hydrogen Peroxide co-treated with N-(oxo-5 more ... CTD PMID:31494107 hydrogen peroxide increases expression ISO H2ax (Rattus norvegicus) 6480464 Hydrogen Peroxide results in increased expression of H2AX protein CTD PMID:17875725 hydrogen peroxide increases expression ISO H2ax (Mus musculus) 6480464 Hydrogen Peroxide results in increased expression of H2AX protein CTD PMID:17875725 hydrogen peroxide increases phosphorylation EXP 6480464 Hydrogen Peroxide results in increased phosphorylation of H2AX protein CTD PMID:25460656 and PMID:28300663 hydrogen peroxide increases expression EXP 6480464 Hydrogen Peroxide results in increased expression of H2AX mRNA more ... CTD PMID:25972194 more ... hydrogen peroxide decreases expression EXP 6480464 Hydrogen Peroxide results in decreased expression of H2AX protein modified form CTD PMID:27655674 hydroquinone multiple interactions EXP 6480464 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [hydroquinone results in increased expression of H2AX protein] more ... CTD PMID:17875398 more ... hydroquinone multiple interactions ISO H2ax (Mus musculus) 6480464 FAU protein affects the reaction [hydroquinone results in increased expression of H2AX protein] CTD PMID:22687461 hydroquinone increases expression ISO H2ax (Mus musculus) 6480464 hydroquinone results in increased expression of H2AX protein CTD PMID:22687461 and PMID:23940708 hydroquinone increases phosphorylation EXP 6480464 hydroquinone results in increased phosphorylation of H2AX protein CTD PMID:18835433 hydroquinone affects localization EXP 6480464 hydroquinone affects the localization of H2AX protein modified form CTD PMID:20036648 hydroquinone increases expression EXP 6480464 hydroquinone results in increased expression of H2AX protein and hydroquinone results in increased expression of H2AX protein alternative form CTD PMID:21267443 more ... hydroxyurea increases expression EXP 6480464 Hydroxyurea results in increased expression of H2AX protein and Hydroxyurea results in increased expression of H2AX protein modified form CTD PMID:21840268 more ... hydroxyurea increases phosphorylation EXP 6480464 Hydroxyurea results in increased phosphorylation of H2AX protein CTD PMID:32466334 and PMID:32482060 hydroxyurea increases phosphorylation ISO H2ax (Mus musculus) 6480464 Hydroxyurea results in increased phosphorylation of H2AX protein CTD PMID:29228353 hydroxyurea multiple interactions ISO H2ax (Mus musculus) 6480464 TRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased phosphorylation of H2AX protein] CTD PMID:29228353 IDP multiple interactions EXP 6480464 Inosine Diphosphate inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 imiquimod decreases expression ISO H2ax (Mus musculus) 6480464 Imiquimod results in decreased expression of H2AX mRNA CTD PMID:21878529 indicine increases expression EXP 6480464 indicine analog results in increased expression of H2AX protein CTD PMID:31154085 inosine multiple interactions EXP 6480464 Inosine inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 intermedine increases expression EXP 6480464 intermedine analog results in increased expression of H2AX protein CTD PMID:31154085 iprodione multiple interactions EXP 6480464 [fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AX protein more ... CTD PMID:22389207 more ... irinotecan increases expression EXP 6480464 Irinotecan metabolite results in increased expression of H2AX mRNA more ... CTD PMID:15956246 and PMID:30612311 irinotecan multiple interactions EXP 6480464 [Irinotecan co-treated with rucaparib] results in increased expression of H2AX protein CTD PMID:30612311 iron(2+) sulfate (anhydrous) increases expression ISO H2ax (Rattus norvegicus) 6480464 ferrous sulfate results in increased expression of H2AX protein CTD PMID:28583816 iron(2+) sulfate (anhydrous) multiple interactions ISO H2ax (Rattus norvegicus) 6480464 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of H2AX protein] CTD PMID:28583816 isocyanates increases phosphorylation EXP 6480464 Isocyanates analog results in increased phosphorylation of H2AX protein CTD PMID:19111005 isocyanates increases phosphorylation ISO H2ax (Mus musculus) 6480464 [Isocyanates results in increased phosphorylation of ATM protein] which results in increased phosphorylation of H2AX protein CTD PMID:19197993 isocyanates increases expression EXP 6480464 Isocyanates results in increased expression of H2AX protein CTD PMID:19283680 isoflavones multiple interactions EXP 6480464 [Isoflavones co-treated with Curcumin] results in increased phosphorylation of H2AX protein CTD PMID:21134073 isoprenaline increases expression ISO H2ax (Mus musculus) 6480464 Isoproterenol results in increased expression of H2AX mRNA CTD PMID:21335049 isotretinoin decreases expression EXP 6480464 Isotretinoin results in decreased expression of H2AX mRNA CTD PMID:20436886 jacobine increases expression EXP 6480464 jacobine analog results in increased expression of H2AX protein and jacobine results in increased expression of H2AX protein CTD PMID:31154085 kaempferol increases phosphorylation EXP 6480464 kaempferol results in increased phosphorylation of H2AX protein CTD PMID:19028473 kaempferol increases expression EXP 6480464 kaempferol results in increased expression of H2AX protein CTD PMID:35063459 kaempferol increases expression ISO H2ax (Mus musculus) 6480464 kaempferol results in increased expression of H2AX protein CTD PMID:24595819 L-ascorbic acid multiple interactions EXP 6480464 [Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of H2AX mRNA and [Ascorbic Acid results in increased reduction of Vitamin K 3] which results in increased phosphorylation of H2AX protein CTD PMID:19482829 and PMID:26424790 L-methionine multiple interactions ISO H2ax (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased phosphorylation of H2AX protein CTD PMID:20548288 lapatinib increases expression EXP 6480464 Lapatinib results in increased expression of H2AX protein CTD PMID:37788138 lapatinib multiple interactions EXP 6480464 CYP3A5 protein inhibits the reaction [Lapatinib results in increased expression of H2AX protein] and CYP3A7 protein inhibits the reaction [Lapatinib results in increased expression of H2AX protein] CTD PMID:37788138 Lasiocarpine increases phosphorylation EXP 6480464 lasiocarpine results in increased phosphorylation of H2AX protein CTD PMID:31289892 Lasiocarpine multiple interactions EXP 6480464 [CYP3A4 protein results in increased metabolism of lasiocarpine] which results in increased phosphorylation of H2AX protein CTD PMID:31103741 Lasiocarpine increases expression EXP 6480464 lasiocarpine results in increased expression of H2AX protein CTD PMID:31154085 Lasiocarpine increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 lasiocarpine results in increased phosphorylation of H2AX protein CTD PMID:31289892 lead diacetate multiple interactions EXP 6480464 [lead acetate results in increased abundance of Lead] which results in increased phosphorylation of H2AX protein and PPIF protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased phosphorylation of H2AX protein] CTD PMID:31874198 lead(0) multiple interactions EXP 6480464 [lead acetate results in increased abundance of Lead] which results in increased phosphorylation of H2AX protein and PPIF protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased phosphorylation of H2AX protein] CTD PMID:31874198 leflunomide decreases expression EXP 6480464 Leflunomide results in decreased expression of H2AX mRNA CTD PMID:28988120 leptomycin B multiple interactions EXP 6480464 leptomycin B promotes the reaction [Bortezomib results in increased expression of H2AX protein modified form] CTD PMID:16778179 Licochalcone B increases expression EXP 6480464 licochalcone B results in increased expression of H2AX mRNA CTD PMID:33647349 Licochalcone B increases phosphorylation EXP 6480464 licochalcone B results in increased phosphorylation of H2AX protein CTD PMID:35948134 Liensinine increases phosphorylation EXP 6480464 liensinine results in increased phosphorylation of H2AX protein CTD PMID:37423554 Longikaurin A increases expression EXP 6480464 longikaurin A results in increased expression of H2AX protein modified form CTD PMID:28801140 lovastatin multiple interactions EXP 6480464 Lovastatin inhibits the reaction [Cisplatin results in increased phosphorylation of H2AX protein] CTD PMID:21356574 lovastatin multiple interactions ISO H2ax (Mus musculus) 6480464 Lovastatin inhibits the reaction [Cisplatin results in increased expression of H2AX protein modified form] more ... CTD PMID:22712078 more ... lovastatin multiple interactions ISO H2ax (Rattus norvegicus) 6480464 Lovastatin inhibits the reaction [Cisplatin results in increased expression of H2AX protein modified form] CTD PMID:26739623 luteolin multiple interactions EXP 6480464 CYP1A1 protein promotes the reaction [Luteolin results in increased expression of H2AX protein] and CYP1A2 protein promotes the reaction [Luteolin results in increased expression of H2AX protein] CTD PMID:33727136 luteolin increases expression EXP 6480464 Luteolin results in increased expression of H2AX protein CTD PMID:33727136 LY294002 multiple interactions EXP 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein] CTD PMID:34784199 mancozeb multiple interactions EXP 6480464 [Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in increased expression of H2AX protein CTD PMID:34830855 maneb multiple interactions EXP 6480464 [Maneb co-treated with mancozeb co-treated with iprodione co-treated with enilconazole co-treated with Chlorpyrifos co-treated with Diazinon co-treated with Dimethoate] results in increased expression of H2AX protein CTD PMID:34830855 manumycin A multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [manumycin results in increased phosphorylation of H2AX protein] CTD PMID:19409983 manumycin A increases phosphorylation EXP 6480464 manumycin results in increased phosphorylation of H2AX protein CTD PMID:19409983 mechlorethamine increases expression ISO H2ax (Mus musculus) 6480464 Mechlorethamine results in increased expression of H2AX protein modified form CTD PMID:25891025 mechlorethamine increases expression ISO H2ax (Rattus norvegicus) 6480464 Mechlorethamine results in increased expression of H2AX protein modified form CTD PMID:33971176 MeIQ increases expression EXP 6480464 2-amino-3 more ... CTD PMID:28160022 MeIQx increases expression EXP 6480464 2-amino-3 more ... CTD PMID:28160022 melatonin multiple interactions ISO H2ax (Mus musculus) 6480464 Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of H2AX protein] CTD PMID:35643323 melphalan multiple interactions EXP 6480464 [N-(oxo-5 more ... CTD PMID:25351371 menadione multiple interactions EXP 6480464 [Ascorbic Acid results in increased reduction of Vitamin K 3] which results in increased phosphorylation of H2AX protein CTD PMID:19482829 menaquinone increases phosphorylation EXP 6480464 Vitamin K 2 results in increased phosphorylation of H2AX protein CTD PMID:29432837 mestranol decreases expression ISO H2ax (Mus musculus) 6480464 Mestranol results in decreased expression of H2AX mRNA and Mestranol results in decreased expression of H2AX protein CTD PMID:36098747 mestranol multiple interactions ISO H2ax (Mus musculus) 6480464 Fulvestrant inhibits the reaction [Mestranol results in decreased expression of H2AX protein] CTD PMID:36098747 metformin decreases expression EXP 6480464 Metformin results in decreased expression of H2AX protein CTD PMID:23363784 metformin increases expression EXP 6480464 Metformin results in increased expression of H2AX mRNA CTD PMID:29117515 metformin multiple interactions EXP 6480464 [epothilone A co-treated with Metformin] results in increased expression of H2AX mRNA CTD PMID:29117515 methapyrilene increases expression ISO H2ax (Rattus norvegicus) 6480464 Methapyrilene results in increased expression of H2AX mRNA CTD PMID:15890375 methapyrilene increases methylation EXP 6480464 Methapyrilene results in increased methylation of H2AX polyA tail CTD PMID:30157460 methotrexate affects response to substance EXP 6480464 H2AX protein affects the susceptibility to Methotrexate CTD PMID:16217747 methotrexate increases phosphorylation EXP 6480464 Methotrexate results in increased phosphorylation of H2AX protein CTD PMID:21114963 methoxsalen multiple interactions EXP 6480464 Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein modified form] CTD PMID:23907605 methoxychlor increases phosphorylation EXP 6480464 Methoxychlor results in increased phosphorylation of H2AX protein CTD PMID:32466334 methyl methanesulfonate increases expression EXP 6480464 Methyl Methanesulfonate results in increased expression of H2AX protein CTD PMID:32087850 methyl methanesulfonate increases phosphorylation EXP 6480464 Methyl Methanesulfonate results in increased phosphorylation of H2AX protein CTD PMID:34510228 methyllycaconitine multiple interactions EXP 6480464 methyllycaconitine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein] CTD PMID:34784199 miconazole increases expression ISO H2ax (Mus musculus) 6480464 Miconazole results in increased expression of H2AX mRNA CTD PMID:27462272 microcystin-LR increases expression EXP 6480464 cyanoginosin LR results in increased expression of H2AX protein CTD PMID:36435412 mitomycin C increases phosphorylation EXP 6480464 Mitomycin results in increased phosphorylation of H2AX protein CTD PMID:21386838 more ... mitomycin C increases expression EXP 6480464 Mitomycin results in increased expression of H2AX protein and Mitomycin results in increased expression of H2AX protein modified form CTD PMID:29928969 and PMID:32087850 mitoxantrone increases expression EXP 6480464 Mitoxantrone results in increased expression of H2AX protein CTD PMID:24994473 mitoxantrone increases phosphorylation EXP 6480464 Mitoxantrone results in increased phosphorylation of H2AX protein CTD PMID:19738048 mitoxantrone multiple interactions ISO H2ax (Rattus norvegicus) 6480464 Poly(ADP-ribose) Polymerase Inhibitors affects the reaction [Mitoxantrone results in increased expression of H2AX protein] CTD PMID:29913208 mitoxantrone increases expression ISO H2ax (Rattus norvegicus) 6480464 Mitoxantrone results in increased expression of H2AX protein CTD PMID:29913208 mono(2-ethylhexyl) phthalate increases phosphorylation ISO H2ax (Mus musculus) 6480464 mono-(2-ethylhexyl)phthalate results in increased phosphorylation of H2AX protein CTD PMID:36174712 monocrotaline increases expression EXP 6480464 Monocrotaline results in increased expression of H2AX protein CTD PMID:31154085 myricetin multiple interactions EXP 6480464 myricetin inhibits the reaction [Doxorubicin results in increased expression of H2AX protein] CTD PMID:32107588 N,N-bis(2-hydroxypropyl)nitrosamine increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 diisopropanolnitrosamine results in increased phosphorylation of H2AX protein CTD PMID:33211169 N,N-dimethylformamide increases expression EXP 6480464 Dimethylformamide results in increased expression of H2AX protein CTD PMID:26387567 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [2 more ... CTD PMID:15173094 more ... N-acetyl-L-cysteine increases expression EXP 6480464 Acetylcysteine results in increased expression of H2AX protein CTD PMID:31715134 and PMID:35123993 N-acetyl-L-cysteine multiple interactions ISO H2ax (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [2 more ... CTD PMID:24614525 more ... N-acetyl-L-cysteine multiple interactions ISO H2ax (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased phosphorylation of H2AX protein] more ... CTD PMID:26079211 more ... N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AX protein]] CTD PMID:21227924 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO H2ax (Rattus norvegicus) 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Doxorubicin results in increased expression of H2AX protein] and benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Etoposide results in increased expression of H2AX protein] CTD PMID:17875725 N-butyl-N-(4-hydroxybutyl)nitrosamine increases expression ISO H2ax (Rattus norvegicus) 6480464 Butylhydroxybutylnitrosamine results in increased expression of H2AX protein CTD PMID:26338220 and PMID:35771629 N-ethyl-N-nitrosourea increases phosphorylation EXP 6480464 Ethylnitrosourea results in increased phosphorylation of H2AX protein CTD PMID:34510228 N-methyl-4-phenylpyridinium decreases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of H2AX mRNA CTD PMID:24810058 N-methyl-N'-nitro-N-nitrosoguanidine increases expression EXP 6480464 Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form CTD PMID:26921499 and PMID:27233451 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions EXP 6480464 [[Methylnitronitrosoguanidine results in increased phosphorylation of and results in increased stability of and results in increased expression of E2F3 protein] which results in increased expression of RRM2 mRNA] inhibits the reaction [Methylnitronitrosoguanidine results in increased expression of H2AX protein modified form] more ... CTD PMID:26921499 N-methyl-N-nitrosourea increases expression EXP 6480464 Methylnitrosourea results in increased expression of H2AX protein modified form CTD PMID:27233451 N-nitroso-N-methyl-4-aminobutyric acid multiple interactions EXP 6480464 [CYP2A6 protein results in increased metabolism of 4-(N-nitroso-N-methylamino)butyric acid] which results in increased expression of H2AX protein CTD PMID:35882637 N-Nitrosodiethanolamine increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 N-nitrosodiethanolamine results in increased phosphorylation of H2AX protein CTD PMID:37527026 N-nitrosodiethylamine increases expression ISO H2ax (Mus musculus) 6480464 Diethylnitrosamine results in increased expression of H2AX protein modified form CTD PMID:27746196 N-nitrosodiethylamine increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 Diethylnitrosamine results in increased phosphorylation of H2AX protein CTD PMID:37527026 N-nitrosodiethylamine multiple interactions EXP 6480464 [CYP2A6 protein results in increased metabolism of Diethylnitrosamine] which results in increased expression of H2AX protein CTD PMID:35882637 N-nitrosodiethylamine increases expression ISO H2ax (Rattus norvegicus) 6480464 Diethylnitrosamine results in increased expression of H2AX protein CTD PMID:26589970 and PMID:37258237 N-nitrosodimethylamine increases expression ISO H2ax (Rattus norvegicus) 6480464 Dimethylnitrosamine results in increased expression of H2AX mRNA CTD PMID:15890375 N-nitrosodimethylamine increases phosphorylation EXP 6480464 Dimethylnitrosamine results in increased phosphorylation of H2AX protein CTD PMID:34510228 N-Nitrosomethylethylamine increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 methylethylnitrosamine results in increased phosphorylation of H2AX protein CTD PMID:37527026 N-Nitrosopyrrolidine decreases expression EXP 6480464 N-Nitrosopyrrolidine results in decreased expression of H2AX mRNA CTD PMID:32234424 N-Phenyl-1-naphthylamine increases expression EXP 6480464 N-phenyl-1-naphthylamine results in increased expression of H2AX protein CTD PMID:35279910 n-propyl gallate decreases phosphorylation EXP 6480464 Propyl Gallate results in decreased phosphorylation of H2AX protein CTD PMID:26928355 n-propyl gallate multiple interactions EXP 6480464 [Propyl Gallate results in decreased phosphorylation of H2AX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein] CTD PMID:26928355 nickel atom increases expression EXP 6480464 Nickel results in increased expression of H2AX mRNA CTD PMID:25583101 nickel dichloride decreases expression EXP 6480464 nickel chloride results in decreased expression of H2AX mRNA CTD PMID:17312168 nickel dichloride increases expression EXP 6480464 nickel chloride results in increased expression of H2AX protein modified form CTD PMID:28552779 nickel dichloride multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [cobaltous chloride promotes the reaction [nickel chloride results in increased phosphorylation of H2AX protein]] more ... CTD PMID:22172632 nickel dichloride increases phosphorylation EXP 6480464 nickel chloride results in increased phosphorylation of H2AX protein CTD PMID:22172632 nicotine multiple interactions EXP 6480464 Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of H2AX protein modified form] CTD PMID:23907605 nimesulide multiple interactions EXP 6480464 nimesulide inhibits the reaction [Etoposide results in increased phosphorylation of H2AX protein] CTD PMID:21745461 nimustine increases phosphorylation EXP 6480464 Nimustine results in increased phosphorylation of H2AX protein CTD PMID:26418950 niraparib multiple interactions EXP 6480464 diphenyleneiodonium inhibits the reaction [niraparib results in increased expression of H2AX protein] CTD PMID:34396909 niraparib increases expression EXP 6480464 niraparib results in increased expression of H2AX protein CTD PMID:34396909 nitenpyram increases expression EXP 6480464 nitenpyram results in increased expression of H2AX mRNA CTD PMID:35568224 nitrogen mustard multiple interactions EXP 6480464 MGMT protein affects the reaction [Nitrogen Mustard Compounds results in increased expression of H2AX protein] and Nitrogen Mustard Compounds results in decreased expression of and results in increased phosphorylation of H2AX protein CTD PMID:27342729 nitrogen mustard increases expression EXP 6480464 Nitrogen Mustard Compounds results in increased expression of H2AX mRNA and Nitrogen Mustard Compounds results in increased expression of H2AX protein CTD PMID:27342729 Nitrosoheptamethyleneimine increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 N-nitrosoheptamethyleneimine results in increased phosphorylation of H2AX protein CTD PMID:37527026 NMN zwitterion multiple interactions ISO H2ax (Mus musculus) 6480464 Nicotinamide Mononucleotide inhibits the reaction [butylbenzyl phthalate results in increased phosphorylation of H2AX protein] CTD PMID:36756972 nocodazole increases expression EXP 6480464 Nocodazole results in increased expression of H2AX protein modified form CTD PMID:26914363 NORCANTHARIDIN multiple interactions EXP 6480464 Paclitaxel promotes the reaction [norcantharidin results in increased expression of H2AX protein modified form] CTD PMID:34272796 NORCANTHARIDIN increases expression EXP 6480464 norcantharidin results in increased expression of H2AX protein modified form CTD PMID:34272796 norethisterone increases phosphorylation EXP 6480464 Norethindrone results in increased phosphorylation of H2AX protein CTD PMID:15905198 NS-398 multiple interactions EXP 6480464 N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Etoposide results in increased phosphorylation of H2AX protein] CTD PMID:21745461 NSC 23766 multiple interactions ISO H2ax (Mus musculus) 6480464 NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of H2AX protein modified form] CTD PMID:28710503 O-methyleugenol increases expression ISO H2ax (Rattus norvegicus) 6480464 methyleugenol results in increased expression of H2AX protein CTD PMID:26011634 o-toluidine increases expression EXP 6480464 2-toluidine results in increased expression of H2AX protein CTD PMID:35279910 ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of H2AX mRNA CTD PMID:19287073 ochratoxin A increases expression ISO H2ax (Rattus norvegicus) 6480464 ochratoxin A results in increased expression of H2AX mRNA and ochratoxin A results in increased expression of H2AX protein modified form CTD PMID:23358140 and PMID:24243707 ochratoxin A increases expression EXP 6480464 ochratoxin A results in increased expression of H2AX protein CTD PMID:28286205 olaparib multiple interactions EXP 6480464 (+)-JQ1 compound promotes the reaction [olaparib results in increased expression of H2AX protein] more ... CTD PMID:26544897 and PMID:29567272 olaparib increases expression EXP 6480464 olaparib results in increased expression of H2AX protein CTD PMID:29567272 olaparib increases phosphorylation EXP 6480464 olaparib results in increased phosphorylation of H2AX protein CTD PMID:25531448 otosenine increases expression EXP 6480464 otosenine results in increased expression of H2AX protein CTD PMID:31154085 ouabain increases phosphorylation EXP 6480464 Ouabain results in increased phosphorylation of H2AX protein CTD PMID:31436044 oxaliplatin affects localization EXP 6480464 Oxaliplatin affects the localization of H2AX protein modified form CTD PMID:19735649 oxaliplatin multiple interactions ISO H2ax (Rattus norvegicus) 6480464 [Oxaliplatin co-treated with Topotecan] results in decreased expression of H2AX mRNA CTD PMID:25729387 oxaliplatin multiple interactions EXP 6480464 [pifithrin results in decreased phosphorylation of TP53 protein] inhibits the reaction [Oxaliplatin results in increased expression of H2AX protein modified form] more ... CTD PMID:19735649 more ... oxaliplatin increases expression EXP 6480464 Oxaliplatin results in increased expression of H2AX protein modified form CTD PMID:19735649 oxybenzone multiple interactions EXP 6480464 Fulvestrant inhibits the reaction [oxybenzone results in increased expression of H2AX protein modified form] CTD PMID:31939680 oxybenzone increases expression ISO H2ax (Mus musculus) 6480464 oxybenzone results in increased expression of H2AX protein modified form CTD PMID:31939680 oxybenzone increases expression EXP 6480464 oxybenzone results in increased expression of H2AX protein modified form CTD PMID:31939680 ozone multiple interactions ISO H2ax (Mus musculus) 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased expression of H2AX mRNA and [Air Pollutants results in increased abundance of Ozone] which results in increased expression of H2AX mRNA CTD PMID:34911549 p-tert-Amylphenol increases phosphorylation EXP 6480464 4-tert-octylphenol results in increased phosphorylation of H2AX protein CTD PMID:32466334 paclitaxel increases expression EXP 6480464 Paclitaxel results in increased expression of H2AX protein and Paclitaxel results in increased expression of H2AX protein modified form CTD PMID:18451153 more ... paclitaxel multiple interactions EXP 6480464 Paclitaxel promotes the reaction [norcantharidin results in increased expression of H2AX protein modified form] and palbociclib inhibits the reaction [Paclitaxel results in increased expression of H2AX protein] CTD PMID:22302033 and PMID:34272796 palbociclib multiple interactions EXP 6480464 Doxorubicin inhibits the reaction [palbociclib results in decreased phosphorylation of H2AX protein] more ... CTD PMID:22302033 and PMID:22751436 palbociclib decreases phosphorylation EXP 6480464 palbociclib results in decreased phosphorylation of H2AX protein CTD PMID:22751436 palmatine increases expression EXP 6480464 palmatine results in increased expression of H2AX protein modified form CTD PMID:23747414 panobinostat increases expression EXP 6480464 Panobinostat results in increased expression of H2AX protein CTD PMID:22923501 panobinostat multiple interactions EXP 6480464 manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Resveratrol promotes the reaction [Panobinostat results in increased expression of H2AX protein]] more ... CTD PMID:22923501 and PMID:23681230 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of H2AX mRNA and Acetaminophen results in increased expression of H2AX protein CTD PMID:21420995 more ... paracetamol multiple interactions EXP 6480464 2-(2 more ... CTD PMID:33971260 paracetamol affects expression ISO H2ax (Mus musculus) 6480464 Acetaminophen affects the expression of H2AX mRNA CTD PMID:17562736 paracetamol decreases expression ISO H2ax (Rattus norvegicus) 6480464 Acetaminophen results in decreased expression of H2AX mRNA and Acetaminophen results in decreased expression of H2AX protein CTD PMID:26011634 and PMID:33387578 paracetamol increases expression ISO H2ax (Mus musculus) 6480464 Acetaminophen results in increased expression of H2AX protein modified form CTD PMID:29540258 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of H2AX mRNA CTD PMID:25458485 paraquat multiple interactions ISO H2ax (Mus musculus) 6480464 ATG7 protein affects the reaction [Paraquat results in increased expression of H2AX protein] and ST2825 inhibits the reaction [Paraquat results in increased expression of H2AX protein] CTD PMID:28012437 and PMID:34811946 paraquat increases expression ISO H2ax (Mus musculus) 6480464 Paraquat results in increased expression of H2AX protein CTD PMID:28012437 and PMID:34811946 pectolinarigenin multiple interactions EXP 6480464 TOP2A protein affects the reaction [pectolinarigenin results in increased expression of H2AX protein] CTD PMID:37393350 pectolinarigenin increases expression EXP 6480464 pectolinarigenin results in increased expression of H2AX protein CTD PMID:37393350 pentachlorophenol increases expression ISO H2ax (Mus musculus) 6480464 Pentachlorophenol results in increased expression of H2AX mRNA CTD PMID:23892564 pentamidine affects localization EXP 6480464 Pentamidine affects the localization of H2AX protein modified form CTD PMID:20144237 perfluorooctane-1-sulfonic acid multiple interactions ISO H2ax (Mus musculus) 6480464 [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of H2AX mRNA CTD PMID:36331819 phenanthridone multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [phenanthridone results in increased expression of H2AX protein modified form] and TXNRD1 protein inhibits the reaction [phenanthridone results in increased expression of H2AX protein modified form] CTD PMID:29416738 phenanthridone increases expression EXP 6480464 phenanthridone results in increased expression of H2AX protein modified form CTD PMID:29416738 phenformin decreases expression ISO H2ax (Rattus norvegicus) 6480464 Phenformin results in decreased expression of H2AX mRNA CTD PMID:31324951 phenobarbital affects expression EXP 6480464 Phenobarbital affects the expression of H2AX mRNA CTD PMID:19159669 phenobarbital increases expression ISO H2ax (Mus musculus) 6480464 Phenobarbital results in increased expression of H2AX mRNA CTD PMID:19363144 and PMID:23091169 phenol affects localization EXP 6480464 Phenol affects the localization of H2AX protein modified form CTD PMID:20096274 PhIP increases expression EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased expression of H2AX protein modified form CTD PMID:28160022 PhIP increases phosphorylation EXP 6480464 2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased phosphorylation of H2AX protein CTD PMID:32466334 and PMID:34510228 phosphoramide mustard increases expression ISO H2ax (Rattus norvegicus) 6480464 phosphoramide mustard results in increased expression of H2AX protein CTD PMID:21439308 phosphoramide mustard increases expression ISO H2ax (Mus musculus) 6480464 phosphoramide mustard results in increased expression of H2AX protein CTD PMID:21439308 phosphoramide mustard multiple interactions ISO H2ax (Rattus norvegicus) 6480464 phosphoramide mustard results in increased phosphorylation of and results in increased expression of H2AX protein CTD PMID:25497287 phthalic acid multiple interactions EXP 6480464 [Copper binds to phthalic acid binds to 1 more ... CTD PMID:22659117 pifithrin-? multiple interactions ISO H2ax (Mus musculus) 6480464 pifithrin promotes the reaction [2 more ... CTD PMID:33961949 pifithrin-? multiple interactions EXP 6480464 [pifithrin results in decreased phosphorylation of TP53 protein] inhibits the reaction [Oxaliplatin results in increased expression of H2AX protein modified form] more ... CTD PMID:19732952 more ... pinocembrin multiple interactions ISO H2ax (Mus musculus) 6480464 pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein] CTD PMID:33393179 pinocembrin multiple interactions EXP 6480464 pinocembrin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AX protein] CTD PMID:33393179 piperonyl butoxide increases expression ISO H2ax (Rattus norvegicus) 6480464 Piperonyl Butoxide results in increased expression of H2AX mRNA CTD PMID:15890375 pirinixic acid decreases expression ISO H2ax (Mus musculus) 6480464 pirinixic acid results in decreased expression of H2AX mRNA CTD PMID:17426115 pirinixic acid increases expression ISO H2ax (Rattus norvegicus) 6480464 pirinixic acid results in increased expression of H2AX mRNA CTD PMID:15890375 and PMID:19162173 piroxicam decreases expression EXP 6480464 Piroxicam results in decreased expression of H2AX mRNA CTD PMID:21858171 poly(vinylpyrrolidone) multiple interactions EXP 6480464 [Silver co-treated with Povidone] results in increased expression of H2AX protein modified form CTD PMID:27387714 potassium bromate multiple interactions ISO H2ax (Rattus norvegicus) 6480464 Azacitidine inhibits the reaction [potassium bromate results in increased phosphorylation of H2AX protein] and trichostatin A inhibits the reaction [potassium bromate results in increased phosphorylation of H2AX protein] CTD PMID:25015661 potassium bromate multiple interactions ISO H2ax (Mus musculus) 6480464 [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] which results in increased expression of H2AX protein and bisphenol A inhibits the reaction [[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] which results in increased expression of H2AX protein] CTD PMID:25693136 potassium bromate increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 potassium bromate results in increased phosphorylation of H2AX protein CTD PMID:25015661 potassium dichromate increases expression EXP 6480464 Potassium Dichromate results in increased expression of H2AX protein modified form CTD PMID:29391238 potassium dichromate multiple interactions EXP 6480464 EHMT2 protein promotes the reaction [Potassium Dichromate results in increased expression of H2AX protein modified form] more ... CTD PMID:29391238 Pranoprofen increases expression EXP 6480464 pyranoprofen results in increased expression of H2AX protein CTD PMID:31765691 procymidone multiple interactions EXP 6480464 [fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AX protein more ... CTD PMID:22389207 and PMID:34503147 promethazine decreases expression ISO H2ax (Rattus norvegicus) 6480464 Promethazine results in decreased expression of H2AX protein CTD PMID:26011634 propiconazole increases expression ISO H2ax (Mus musculus) 6480464 propiconazole results in increased expression of H2AX mRNA CTD PMID:19363144 and PMID:21278054 propylparaben increases expression EXP 6480464 propylparaben results in increased expression of H2AX protein modified form CTD PMID:31939680 propylparaben multiple interactions EXP 6480464 Fulvestrant inhibits the reaction [propylparaben results in increased expression of H2AX protein modified form] CTD PMID:31939680 protein kinase inhibitor increases phosphorylation EXP 6480464 Protein Kinase Inhibitors results in increased phosphorylation of H2AX protein CTD PMID:21878655 pterostilbene multiple interactions EXP 6480464 [Resveratrol co-treated with pterostilbene] results in decreased expression of H2AX protein modified form more ... CTD PMID:26459286 and PMID:34405320 pterostilbene multiple interactions ISO H2ax (Mus musculus) 6480464 CCN1 protein inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of H2AX protein modified form]] more ... CTD PMID:34405320 pyrene multiple interactions EXP 6480464 [pyrene co-treated with Benzo(a)pyrene] results in increased expression of H2AX protein and [pyrene co-treated with fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of H2AX protein CTD PMID:33249052 pyrimethamine increases phosphorylation EXP 6480464 Pyrimethamine results in increased phosphorylation of H2AX protein CTD PMID:19435820 pyrrolidine dithiocarbamate multiple interactions EXP 6480464 pyrrolidine dithiocarbamic acid inhibits the reaction [TNF protein promotes the reaction [aflatoxin G1 results in increased phosphorylation of H2AX protein]] CTD PMID:36997055 quercetin multiple interactions EXP 6480464 Quercetin inhibits the reaction [Cisplatin results in increased expression of H2AX protein modified form] CTD PMID:24999622 quercetin increases expression ISO H2ax (Mus musculus) 6480464 Quercetin results in increased expression of H2AX protein CTD PMID:24595819 quercetin multiple interactions ISO H2ax (Rattus norvegicus) 6480464 Quercetin inhibits the reaction [Doxorubicin results in increased expression of H2AX protein modified form] CTD PMID:24902966 quercetin increases phosphorylation EXP 6480464 Quercetin results in increased phosphorylation of H2AX protein CTD PMID:15177039 quizartinib multiple interactions EXP 6480464 quizartinib affects the reaction [RGFP966 results in increased phosphorylation of H2AX protein] more ... CTD PMID:34665271 quizartinib increases phosphorylation EXP 6480464 quizartinib results in increased phosphorylation of H2AX protein CTD PMID:34665271 rac-1,2-dichloropropane multiple interactions EXP 6480464 1-aminobenzotriazole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AX protein] more ... CTD PMID:28300663 rac-1,2-dichloropropane multiple interactions ISO H2ax (Mus musculus) 6480464 NFE2L2 gene mutant form inhibits the reaction [propylene dichloride results in increased expression of H2AX protein] and propylene dichloride results in increased expression of and results in increased phosphorylation of H2AX protein CTD PMID:37326970 rac-1,2-dichloropropane increases phosphorylation ISO H2ax (Mus musculus) 6480464 propylene dichloride results in increased phosphorylation of H2AX protein CTD PMID:28300663 rac-1,2-dichloropropane increases phosphorylation EXP 6480464 propylene dichloride results in increased phosphorylation of H2AX protein CTD PMID:28300663 razoxane multiple interactions ISO H2ax (Rattus norvegicus) 6480464 Razoxane inhibits the reaction [Doxorubicin results in increased expression of H2AX protein] and Razoxane inhibits the reaction [Etoposide results in increased expression of H2AX protein] CTD PMID:17875725 reactive oxygen species decreases response to substance ISO H2ax (Mus musculus) 6480464 H2AX protein results in decreased susceptibility to Reactive Oxygen Species CTD PMID:21555580 remdesivir increases expression EXP 6480464 remdesivir results in increased expression of H2AX protein CTD PMID:35417658 resorcinol increases expression EXP 6480464 resorcinol results in increased expression of H2AX mRNA CTD PMID:22623647 resveratrol multiple interactions EXP 6480464 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Resveratrol results in increased phosphorylation of H2AX protein] more ... CTD PMID:15975956 more ... resveratrol multiple interactions ISO H2ax (Mus musculus) 6480464 Resveratrol inhibits the reaction [bisphenol A promotes the reaction [Cholesterol results in increased phosphorylation of H2AX protein]] CTD PMID:33239236 resveratrol decreases expression EXP 6480464 Resveratrol results in decreased expression of H2AX protein and Resveratrol results in decreased expression of H2AX protein modified form CTD PMID:23363784 and PMID:26459286 resveratrol increases response to substance EXP 6480464 H2AX protein results in increased susceptibility to Resveratrol CTD PMID:25619392 resveratrol increases phosphorylation EXP 6480464 Resveratrol results in increased phosphorylation of H2AX protein CTD PMID:15975956 more ... resveratrol increases expression EXP 6480464 Resveratrol results in increased expression of H2AX protein and Resveratrol results in increased expression of H2AX protein modified form CTD PMID:22923501 more ... Retrorsine increases expression EXP 6480464 retrorsine results in increased expression of H2AX protein CTD PMID:31154085 ribavirin increases expression EXP 6480464 Ribavirin results in increased expression of H2AX protein modified form CTD PMID:32112805 riddelliine increases expression EXP 6480464 riddelliine results in increased expression of H2AX protein CTD PMID:31154085 riddelliine increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 riddelliine results in increased phosphorylation of H2AX protein CTD PMID:31289892 riddelliine increases phosphorylation EXP 6480464 riddelliine results in increased phosphorylation of H2AX protein CTD PMID:31289892 romidepsin multiple interactions EXP 6480464 [Bortezomib co-treated with romidepsin] results in increased phosphorylation of H2AX protein more ... CTD PMID:15173094 and PMID:34665271 romidepsin increases phosphorylation EXP 6480464 romidepsin results in increased phosphorylation of H2AX protein CTD PMID:34665271 rotenone increases phosphorylation ISO H2ax (Mus musculus) 6480464 Rotenone results in increased phosphorylation of H2AX protein CTD PMID:23619996 rotenone multiple interactions EXP 6480464 [PSME4 protein affects the susceptibility to Rotenone] which results in decreased expression of H2AX protein modified form CTD PMID:32368861 rotenone multiple interactions ISO H2ax (Mus musculus) 6480464 CASP1 gene mutant form inhibits the reaction [Rotenone results in increased phosphorylation of H2AX protein] and NLRP3 gene mutant form inhibits the reaction [Rotenone results in increased phosphorylation of H2AX protein] CTD PMID:23619996 rotenone decreases response to substance ISO H2ax (Mus musculus) 6480464 H2AX protein results in decreased susceptibility to Rotenone CTD PMID:21555580 rubimaillin multiple interactions EXP 6480464 Glutathione inhibits the reaction [rubimaillin results in increased phosphorylation of H2AX protein] CTD PMID:35007525 rubimaillin increases phosphorylation ISO H2ax (Mus musculus) 6480464 rubimaillin results in increased phosphorylation of H2AX protein CTD PMID:35007525 rubimaillin increases phosphorylation EXP 6480464 rubimaillin results in increased phosphorylation of H2AX protein CTD PMID:35007525 rucaparib affects expression EXP 6480464 rucaparib affects the expression of H2AX protein CTD PMID:30612311 rucaparib multiple interactions EXP 6480464 [Irinotecan co-treated with rucaparib] results in increased expression of H2AX protein more ... CTD PMID:30612311 and PMID:32927276 ruxolitinib multiple interactions EXP 6480464 [Arsenic Trioxide co-treated with ruxolitinib] results in increased phosphorylation of H2AX protein CTD PMID:30012499 Salinomycin multiple interactions EXP 6480464 [salinomycin co-treated with Calcitriol] results in decreased expression of H2AX mRNA CTD PMID:35914560 Salinomycin decreases expression EXP 6480464 salinomycin results in decreased expression of H2AX mRNA CTD PMID:35914560 Satratoxin H increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 satratoxin H results in increased phosphorylation of H2AX protein CTD PMID:22863859 selenium atom increases expression EXP 6480464 Selenium results in increased expression of H2AX mRNA CTD PMID:19244175 selenocystine increases phosphorylation EXP 6480464 selenocystine results in increased phosphorylation of H2AX protein CTD PMID:35863474 selenocystine increases phosphorylation ISO H2ax (Mus musculus) 6480464 selenocystine results in increased phosphorylation of H2AX protein CTD PMID:35863474 selinexor multiple interactions EXP 6480464 [selinexor co-treated with INCB057643] results in increased expression of H2AX protein CTD PMID:37899423 selinexor increases expression EXP 6480464 selinexor results in increased expression of H2AX protein CTD PMID:37899423 senecionine increases expression EXP 6480464 senecionine results in increased expression of H2AX protein CTD PMID:31154085 seneciphylline increases expression EXP 6480464 seneciphylline results in increased expression of H2AX protein CTD PMID:31154085 Senkirkine increases expression EXP 6480464 senkirkine results in increased expression of H2AX protein CTD PMID:31154085 silibinin increases phosphorylation EXP 6480464 Silybin results in increased phosphorylation of H2AX protein CTD PMID:16777994 silibinin multiple interactions EXP 6480464 Caffeine inhibits the reaction [Silybin results in increased phosphorylation of H2AX protein] CTD PMID:16777994 silicon dioxide increases expression EXP 6480464 Silicon Dioxide results in increased expression of H2AX mRNA and Silicon Dioxide results in increased expression of H2AX protein modified form CTD PMID:25351596 and PMID:28757444 silicon dioxide increases expression ISO H2ax (Mus musculus) 6480464 Silicon Dioxide results in increased expression of H2AX mRNA CTD PMID:29341224 silicon dioxide increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 Silicon Dioxide results in increased phosphorylation of H2AX protein CTD PMID:23178243 silicon dioxide increases phosphorylation ISO H2ax (Mus musculus) 6480464 Silicon Dioxide results in increased phosphorylation of H2AX protein CTD PMID:23619996 silicon dioxide multiple interactions EXP 6480464 PARP1 protein inhibits the reaction [Silicon Dioxide results in increased expression of H2AX protein modified form] CTD PMID:28757444 silver atom multiple interactions EXP 6480464 [Silver analog co-treated with poly(N-vinylpyrrolidine)] results in increased expression of H2AX protein and [Silver co-treated with Povidone] results in increased expression of H2AX protein modified form CTD PMID:26028148 and PMID:27387714 silver(0) multiple interactions EXP 6480464 [Silver analog co-treated with poly(N-vinylpyrrolidine)] results in increased expression of H2AX protein and [Silver co-treated with Povidone] results in increased expression of H2AX protein modified form CTD PMID:26028148 and PMID:27387714 simvastatin increases phosphorylation EXP 6480464 Simvastatin results in increased phosphorylation of H2AX protein CTD PMID:20499237 sirolimus decreases expression EXP 6480464 Sirolimus results in decreased expression of H2AX protein CTD PMID:23363784 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of H2AX mRNA more ... CTD PMID:22706169 more ... sodium arsenite multiple interactions ISO H2ax (Rattus norvegicus) 6480464 [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Zinc deficiency] results in increased expression of H2AX protein CTD PMID:31542844 sodium arsenite increases phosphorylation ISO H2ax (Mus musculus) 6480464 sodium arsenite results in increased phosphorylation of H2AX protein CTD PMID:30456849 sodium arsenite decreases expression ISO H2ax (Mus musculus) 6480464 sodium arsenite results in decreased expression of H2AX mRNA CTD PMID:16014739 sodium arsenite increases expression ISO H2ax (Mus musculus) 6480464 sodium arsenite results in increased expression of H2AX protein modified form CTD PMID:25787150 sodium arsenite increases phosphorylation EXP 6480464 sodium arsenite results in increased phosphorylation of H2AX protein CTD PMID:20375080 more ... sodium chromate multiple interactions EXP 6480464 MUS81 protein mutant form inhibits the reaction [sodium chromate(VI) results in increased expression of H2AX protein modified form] CTD PMID:28318385 sodium chromate multiple interactions ISO H2ax (Mus musculus) 6480464 [sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of H2AX protein and Melatonin inhibits the reaction [[sodium chromate(VI) results in increased abundance of chromium hexavalent ion] which results in increased expression of H2AX protein] CTD PMID:35643323 sodium chromate increases expression EXP 6480464 sodium chromate(VI) results in increased expression of H2AX protein modified form CTD PMID:28318385 sodium dichromate decreases expression ISO H2ax (Mus musculus) 6480464 sodium bichromate results in decreased expression of H2AX mRNA CTD PMID:31558096 sodium fluoride increases expression ISO H2ax (Mus musculus) 6480464 Sodium Fluoride results in increased expression of H2AX protein CTD PMID:27548804 sodium fluoride decreases expression ISO H2ax (Mus musculus) 6480464 Sodium Fluoride results in decreased expression of H2AX protein CTD PMID:28918527 sodium nitrite increases expression ISO H2ax (Mus musculus) 6480464 Sodium Nitrite results in increased expression of H2AX protein modified form CTD PMID:31476334 Sodium salicylate increases expression EXP 6480464 Sodium Salicylate results in increased expression of H2AX mRNA CTD PMID:29117515 sterigmatocystin increases expression EXP 6480464 Sterigmatocystin results in increased expression of H2AX protein modified form CTD PMID:26914363 sulindac multiple interactions EXP 6480464 [Arsenic Trioxide co-treated with Sulindac] results in increased phosphorylation of H2AX protein CTD PMID:18636201 sunitinib decreases expression EXP 6480464 Sunitinib results in decreased expression of H2AX mRNA CTD PMID:31533062 T-2 toxin multiple interactions EXP 6480464 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [T-2 Toxin results in increased activity of H2AX protein] CTD PMID:20150440 T-2 toxin increases activity EXP 6480464 T-2 Toxin results in increased activity of H2AX protein CTD PMID:20150440 temozolomide multiple interactions EXP 6480464 [Temozolomide co-treated with Resveratrol] results in increased phosphorylation of H2AX protein CTD PMID:23522185 temozolomide decreases response to substance ISO H2ax (Mus musculus) 6480464 H2AX protein results in decreased susceptibility to Temozolomide CTD PMID:21555580 temozolomide increases phosphorylation EXP 6480464 Temozolomide results in increased phosphorylation of H2AX protein CTD PMID:23522185 and PMID:26418950 TEMPO increases expression ISO H2ax (Mus musculus) 6480464 TEMPO results in increased expression of H2AX protein CTD PMID:25882087 terbufos increases expression EXP 6480464 terbufos results in increased expression of H2AX protein CTD PMID:33221015 tert-butyl hydroperoxide decreases expression EXP 6480464 tert-Butylhydroperoxide results in decreased expression of H2AX mRNA CTD PMID:15336504 tert-butyl hydroperoxide increases phosphorylation EXP 6480464 tert-Butylhydroperoxide results in increased phosphorylation of H2AX protein CTD PMID:33207735 testosterone multiple interactions EXP 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of H2AX mRNA CTD PMID:21592394 testosterone multiple interactions ISO H2ax (Rattus norvegicus) 6480464 [bisphenol A co-treated with Testosterone] results in increased expression of H2AX mRNA CTD PMID:26496021 testosterone decreases expression EXP 6480464 Testosterone results in decreased expression of H2AX mRNA CTD PMID:21592394 tetrachloromethane increases expression ISO H2ax (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of H2AX mRNA CTD PMID:31919559 tetrachloromethane multiple interactions ISO H2ax (Mus musculus) 6480464 ATM protein inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of H2AX protein] CTD PMID:36526012 tetrachloromethane increases phosphorylation ISO H2ax (Mus musculus) 6480464 Carbon Tetrachloride results in increased phosphorylation of H2AX protein CTD PMID:36526012 tetraphene increases expression EXP 6480464 benz(a)anthracene metabolite results in increased expression of H2AX protein CTD PMID:31051210 thallium(I) acetate increases expression EXP 6480464 thallium acetate results in increased expression of H2AX protein CTD PMID:36745568 thapsigargin increases expression EXP 6480464 Thapsigargin results in increased expression of H2AX mRNA CTD PMID:19442820 thapsigargin decreases phosphorylation EXP 6480464 Thapsigargin results in decreased phosphorylation of H2AX protein CTD PMID:32482060 Theaflavin 3,3'-digallate decreases expression EXP 6480464 theaflavin-3 and 3'-digallate results in decreased expression of H2AX protein CTD PMID:34925699 thioacetamide increases expression ISO H2ax (Rattus norvegicus) 6480464 Thioacetamide results in increased expression of H2AX mRNA and Thioacetamide results in increased expression of H2AX protein CTD PMID:26011634 more ... thymidine multiple interactions EXP 6480464 Thymidine inhibits the reaction [PIF1 protein inhibits the reaction [Gemcitabine results in increased expression of H2AX protein]] CTD PMID:37183367 thymoquinone increases phosphorylation EXP 6480464 thymoquinone results in increased phosphorylation of H2AX protein CTD PMID:31298468 Tiron increases phosphorylation EXP 6480464 1 more ... CTD PMID:22785532 Tiron multiple interactions EXP 6480464 1 more ... CTD PMID:22785532 titanium dioxide increases expression ISO H2ax (Mus musculus) 6480464 titanium dioxide results in increased expression of H2AX mRNA CTD PMID:23557971 Tomentosin increases expression EXP 6480464 tomentosin results in increased expression of H2AX protein CTD PMID:30917517 Tomentosin increases phosphorylation EXP 6480464 tomentosin results in increased phosphorylation of H2AX protein CTD PMID:27922187 Tomentosin multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [tomentosin results in increased expression of H2AX protein] CTD PMID:30917517 topotecan increases phosphorylation EXP 6480464 Topotecan results in increased phosphorylation of H2AX protein CTD PMID:16432175 topotecan increases expression EXP 6480464 Topotecan results in increased expression of H2AX protein modified form CTD PMID:23376119 topotecan multiple interactions ISO H2ax (Rattus norvegicus) 6480464 [Oxaliplatin co-treated with Topotecan] results in decreased expression of H2AX mRNA CTD PMID:25729387 topotecan multiple interactions ISO H2ax (Mus musculus) 6480464 APAF1 promotes the reaction [Topotecan results in increased phosphorylation of H2AX protein] and TRP53 inhibits the reaction [Topotecan results in increased phosphorylation of H2AX protein] CTD PMID:19812371 topotecan increases phosphorylation ISO H2ax (Mus musculus) 6480464 Topotecan results in increased phosphorylation of H2AX protein CTD PMID:19812371 topotecan multiple interactions EXP 6480464 [veliparib co-treated with Topotecan] results in increased expression of H2AX protein CTD PMID:21795476 toxaphene decreases expression ISO H2ax (Rattus norvegicus) 6480464 Toxaphene results in decreased expression of H2AX mRNA CTD PMID:23153324 triadimefon increases expression ISO H2ax (Mus musculus) 6480464 triadimefon results in increased expression of H2AX mRNA CTD PMID:19363144 tributylstannane increases expression ISO H2ax (Rattus norvegicus) 6480464 tributyltin results in increased expression of H2AX protein modified form CTD PMID:26079211 tributylstannane increases expression EXP 6480464 tributyltin results in increased expression of H2AX protein modified form CTD PMID:31401084 tributylstannane increases phosphorylation EXP 6480464 tributyltin results in increased phosphorylation of H2AX protein CTD PMID:36319700 tributylstannane increases phosphorylation ISO H2ax (Mus musculus) 6480464 tributyltin results in increased phosphorylation of H2AX protein CTD PMID:36319700 tributylstannane multiple interactions EXP 6480464 2-(2 more ... CTD PMID:31401084 and PMID:36319700 tributylstannane multiple interactions ISO H2ax (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [tributyltin results in increased expression of H2AX protein modified form] and Phycocyanin inhibits the reaction [tributyltin results in increased expression of H2AX protein modified form] CTD PMID:26079211 trichloroethene increases phosphorylation EXP 6480464 Trichloroethylene results in increased phosphorylation of H2AX protein CTD PMID:29722447 trichloroethene decreases expression ISO H2ax (Rattus norvegicus) 6480464 Trichloroethylene results in decreased expression of H2AX mRNA CTD PMID:33387578 trichloroethene multiple interactions EXP 6480464 1-aminobenzotriazole inhibits the reaction [Trichloroethylene results in increased phosphorylation of H2AX protein] more ... CTD PMID:29722447 trichloroethene increases phosphorylation ISO H2ax (Mus musculus) 6480464 Trichloroethylene results in increased phosphorylation of H2AX protein CTD PMID:29722447 trichostatin A affects expression EXP 6480464 trichostatin A affects the expression of H2AX mRNA CTD PMID:28542535 trichostatin A multiple interactions ISO H2ax (Rattus norvegicus) 6480464 trichostatin A inhibits the reaction [potassium bromate results in increased phosphorylation of H2AX protein] CTD PMID:25015661 triciribine increases expression EXP 6480464 triciribine results in increased expression of H2AX mRNA CTD PMID:29117515 trimellitic anhydride increases expression ISO H2ax (Mus musculus) 6480464 trimellitic anhydride results in increased expression of H2AX mRNA CTD PMID:19042947 triphenyl phosphate increases expression EXP 6480464 triphenyl phosphate results in increased expression of H2AX protein CTD PMID:36372259 triphenyl phosphate increases expression ISO H2ax (Mus musculus) 6480464 triphenyl phosphate results in increased expression of H2AX protein CTD PMID:37149271 Triptolide increases expression ISO H2ax (Mus musculus) 6480464 triptolide results in increased expression of H2AX mRNA CTD PMID:32835833 Triptolide increases expression EXP 6480464 triptolide results in increased expression of H2AX protein CTD PMID:36990132 Triptolide increases phosphorylation EXP 6480464 triptolide results in increased phosphorylation of H2AX protein CTD PMID:31218727 troglitazone decreases expression EXP 6480464 Troglitazone results in decreased expression of H2AX mRNA CTD PMID:19140230 trovafloxacin multiple interactions EXP 6480464 [TNF protein co-treated with trovafloxacin] results in increased expression of H2AX protein modified form more ... CTD PMID:25748550 trovafloxacin decreases expression ISO H2ax (Mus musculus) 6480464 trovafloxacin results in decreased expression of H2AX mRNA CTD PMID:35537566 trovafloxacin increases phosphorylation ISO H2ax (Mus musculus) 6480464 trovafloxacin results in increased phosphorylation of H2AX protein CTD PMID:24817034 trovafloxacin increases expression EXP 6480464 trovafloxacin results in increased expression of H2AX protein modified form CTD PMID:25748550 UDP multiple interactions EXP 6480464 Uridine Diphosphate inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 usnic acid multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [usnic acid results in increased expression of H2AX protein] and NFE2L2 protein inhibits the reaction [usnic acid results in increased expression of H2AX protein modified form] CTD PMID:27369375 and PMID:31715134 usnic acid increases expression EXP 6480464 usnic acid results in increased expression of H2AX protein and usnic acid results in increased expression of H2AX protein modified form CTD PMID:27369375 and PMID:31715134 UTP multiple interactions EXP 6480464 Uridine Triphosphate inhibits the reaction [Cesium-137 results in increased expression of and affects the localization of H2AX protein modified form] CTD PMID:32941855 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of H2AX mRNA CTD PMID:25979313 valproic acid decreases expression ISO H2ax (Mus musculus) 6480464 Valproic Acid results in decreased expression of H2AX mRNA and Valproic Acid results in decreased expression of H2AX protein CTD PMID:21427059 and PMID:21708246 valproic acid increases expression ISO H2ax (Mus musculus) 6480464 Valproic Acid results in increased expression of H2AX protein CTD PMID:21708246 vancomycin decreases expression ISO H2ax (Mus musculus) 6480464 Vancomycin results in decreased expression of H2AX mRNA CTD PMID:18930951 veliparib increases expression EXP 6480464 [veliparib results in increased expression of PARP1 protein] which results in increased expression of H2AX protein more ... CTD PMID:17505006 more ... veliparib multiple interactions EXP 6480464 [veliparib co-treated with Topotecan] results in increased expression of H2AX protein more ... CTD PMID:21227924 more ... versicolorin A increases expression EXP 6480464 versicolorin A results in increased expression of H2AX protein CTD PMID:32106047 and PMID:33984424 versicolorin A multiple interactions EXP 6480464 [Aflatoxin B1 co-treated with versicolorin A] results in increased expression of H2AX protein and versicolorin A promotes the reaction [Aflatoxin B1 results in increased expression of H2AX protein] CTD PMID:33984424 vincristine multiple interactions EXP 6480464 [CEP 33779 results in increased susceptibility to Vincristine] which results in increased phosphorylation of H2AX protein and [NVP-BSK805 results in increased susceptibility to Vincristine] which results in increased phosphorylation of H2AX protein CTD PMID:28669723 vorinostat increases activity EXP 6480464 Vorinostat results in increased activity of H2AX protein CTD PMID:20460513 vorinostat increases phosphorylation EXP 6480464 Vorinostat results in increased phosphorylation of H2AX protein CTD PMID:20531243 vorinostat increases expression EXP 6480464 Vorinostat results in increased expression of H2AX protein and Vorinostat results in increased expression of H2AX protein modified form CTD PMID:20679231 and PMID:22923501 vorinostat multiple interactions EXP 6480464 Resveratrol promotes the reaction [Vorinostat results in increased expression of H2AX protein] CTD PMID:22923501 wogonin increases expression EXP 6480464 wogonin results in increased expression of H2AX protein CTD PMID:32671444 wogonin multiple interactions EXP 6480464 wogonin inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein] CTD PMID:37515497 wortmannin multiple interactions EXP 6480464 Wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein] more ... CTD PMID:17991895 more ... Xanthatin increases expression EXP 6480464 xanthatin results in increased expression of H2AX protein modified form CTD PMID:29074359 yttrium chloride increases phosphorylation ISO H2ax (Rattus norvegicus) 6480464 yttrium chloride results in increased phosphorylation of H2AX protein CTD PMID:35088107 yttrium chloride multiple interactions ISO H2ax (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [yttrium chloride results in increased phosphorylation of H2AX protein] CTD PMID:35088107 zearalenone increases expression ISO H2ax (Mus musculus) 6480464 Zearalenone results in increased expression of H2AX protein modified form CTD PMID:28089945 more ... zearalenone decreases expression ISO H2ax (Mus musculus) 6480464 Zearalenone results in decreased expression of H2AX protein CTD PMID:35504548 zebularine increases expression EXP 6480464 pyrimidin-2-one beta-ribofuranoside results in increased expression of H2AX protein CTD PMID:17991895 zidovudine increases phosphorylation EXP 6480464 Zidovudine results in increased phosphorylation of H2AX protein CTD PMID:34510228 zinc atom increases expression EXP 6480464 Zinc deficiency results in increased expression of H2AX mRNA CTD PMID:18356318 zinc atom multiple interactions ISO H2ax (Rattus norvegicus) 6480464 [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Zinc deficiency] results in increased expression of H2AX protein CTD PMID:31542844 zinc dichloride increases expression EXP 6480464 zinc chloride results in increased expression of H2AX mRNA CTD PMID:18947441 zinc oxide increases activity ISO H2ax (Mus musculus) 6480464 Zinc Oxide analog results in increased activity of H2AX protein CTD PMID:24614525 zinc oxide multiple interactions ISO H2ax (Mus musculus) 6480464 Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased activity of H2AX protein] CTD PMID:24614525 zinc(0) increases expression EXP 6480464 Zinc deficiency results in increased expression of H2AX mRNA CTD PMID:18356318 zinc(0) multiple interactions ISO H2ax (Rattus norvegicus) 6480464 [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Zinc deficiency] results in increased expression of H2AX protein CTD PMID:31542844 zoledronic acid increases expression EXP 6480464 Zoledronic Acid results in increased expression of H2AX mRNA CTD PMID:20977926
