Gene: TLR2 (toll-like receptor 2)  Homo sapiens Symbol: TLR2 Name: toll-like receptor 2 Description: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008] Type: protein-coding RefSeq Status: REVIEWED Also known as: CD282; TIL4; toll-like receptor 2; toll/interleukin 1 receptor-like 4; toll/interleukin-1 receptor-like protein 4 Orthologs: Mus musculus : Tlr2 (toll-like receptor 2)  MGI Rattus norvegicus : Tlr2 (toll-like receptor 2) Latest Assembly: Human Genome Assembly GRCh37 Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 4 154,390,697 - 154,412,500 + NCBI Human Genome Assembly HuRef 4 150,336,457 - 150,358,268 + NCBI Human Genome Assembly GRCh37 4 154,605,441 - 154,627,243 + NCBI Human Genome Assembly Build 36 4 154,824,891 - 154,846,693 + NCBI Human Cytogenetic Map 4 q32   NCBI Human Genome Assembly 4 154,966,670 - 154,984,135   NCBI Model Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Acute Kidney Injury   ISS RGD:1551003 7207898 associated with Sepsis RGD   Acute Tubulointerstitial Nephritis   ISS RGD:1551003 7207900   RGD   Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis   ISS RGD:1551003 7240543   RGD   Arthritis, Experimental   ISS RGD:735138 7241099   RGD   Aspergillosis   ISS RGD:1551003 4145322 mRNA:increased expression:lung RGD   Asthma   ISS RGD:1551003 4145334   RGD   Asthma   ISS RGD:1551003 4145343   RGD   Asthma Susceptibility IAGP   4145352 DNA:SNP: :rs7656411 (human) RGD   Asthma Susceptibility IAGP   4144228 DNA:SNP: :596T>C (human) RGD   Asthma Susceptibility IAGP   4144171 DNA:SNP: :rs4696480 (human) RGD   Asthma   IAGP   2312679 DNA:SNP: :rs3804100 (human) RGD   Brain Injuries   ISS RGD:735138 2312713 mRNA:increased expression:brain RGD   Carotid Stenosis Treatment ISS RGD:735138 7241095   RGD   Colorectal Neoplasms   IEA   7240710   OMIM   Cough   IEP   7240539 protein:decreased expression:sputum, macrophage RGD   Diabetes Mellitus, Experimental   ISS RGD:735138 2312491   RGD   Diabetes Mellitus, Experimental   ISS RGD:1551003 2312684   RGD   Diabetes Mellitus, Type 1 No_Association IAGP   2312687 DNA:SNP: :1350T>C (human) RGD   Diabetes Mellitus, Type 1   IAGP   2312686 DNA:SNP: :1350T>C (human) RGD   Diabetes Mellitus, Type 1   ISS RGD:1551003 2312684   RGD   Diabetes Mellitus, Type 1   IEP   2312683 protein:increased expression:monocyte RGD   Diabetes Mellitus, Type 1   IAGP   2312679 DNA:SNP: :rs3804100 (human) RGD   Diabetic Nephropathies   ISS RGD:1551003 7241083 associated with Diabetes Mellitus, Experimental RGD   Dyslipidemias   ISS RGD:1551003 7241091   RGD   Encephalomyelitis, Autoimmune, Experimental   ISS RGD:735138 2312575 protein:increased expression:spinal cord RGD   Endotoxemia Treatment ISS RGD:735138 7241094   RGD   Enterocolitis, Necrotizing   ISS RGD:735138 5128779 mRNA:increased expression:ileum RGD   Fever   ISS RGD:735138 7241096   RGD   Gastroesophageal Reflux   IEP   7240539 protein:decreased expression:sputum, macrophage RGD   Glomerulonephritis   ISS RGD:1551003 7241071   RGD   Gram-Positive Bacterial Infections   ISS RGD:1551003 7240560   RGD   Inflammation   ISS RGD:1551003 7240558 associated with Ureteral Obstruction RGD   Inflammation   ISS RGD:735138 4889539   RGD   Inflammation   ISS RGD:1551003 4889537 associated with Respiratory Hypersensitivity RGD   Influenza, Human   IEP   4145339 protein:increased expression:monocyte RGD   Kidney Failure, Chronic   IEP   7240546   RGD   Kidney Reperfusion Injury   ISS RGD:1551003 7240552   RGD   Kidney Reperfusion Injury   ISS RGD:1551003 7241087   RGD   Kidney Reperfusion Injury Treatment ISS RGD:1551003 7207894   RGD   Kidney Reperfusion Injury Severity ISS RGD:1551003 7207896   RGD   Kidney Reperfusion Injury Treatment ISS RGD:735138 7207892   RGD   Leprosy   IEA   7240710   OMIM   Leptospirosis   ISS RGD:1551003 7240557   RGD   Liver Cirrhosis, Experimental Treatment ISS RGD:735138 7241092   RGD   Lung Diseases   IAGP   4145340 associated with Mycobacterium avium-intracellulare Infection;DNA:polymorphism:intron (human) RGD   Lung Diseases   ISS RGD:735138 4145321 associated with Hyperoxia;mRNA, protein:increased expression:lung RGD   Lung Diseases   ISS RGD:735138 4145303 Acute Lung Injury;mRNA:increased expression:lung RGD   Lung Diseases   ISS RGD:735138 2312725 associated with Pancreatitis, Acute Necrotizing RGD   MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO   IEA   7240710   OMIM   Myocardial Reperfusion Injury   ISS RGD:735138 2312688   RGD   Neuritis, Autoimmune, Experimental Severity ISS RGD:735138 2312712   RGD   Obesity   ISS RGD:1551003 2312681   RGD   Pancreatitis   ISS RGD:735138 2312507   RGD   Pancreatitis, Acute Necrotizing   ISS RGD:735138 2312724 mRNA:increased expression:liver RGD   Pneumonia Susceptibility ISS RGD:1551003 4145330   RGD   Pneumonia, Bacterial   ISS RGD:1551003 4145337   RGD   Pneumonia, Bacterial   ISS RGD:735138 4889533   RGD   Pneumonia, Pneumococcal   ISS RGD:1551003 4145321   RGD   Pneumonia, Pneumocystis   ISS RGD:1551003 4145341   RGD   Prostatic Neoplasms   IAGP   7207899 DNA:deletion:promoter:−196_−174del (human) RGD   Pulmonary Emphysema   ISS RGD:1551003 4145342 protein:increased expression:alveolar macrophage RGD   Pulmonary Fibrosis   ISS RGD:1551003 4144177   RGD   Pulmonary Fibrosis   ISS RGD:1551003 4145324 associated with Pneumonia RGD   Renal Fibrosis   ISS RGD:735138 7207895 associated with Ureteral Obstruction RGD   Renal Insufficiency   ISS RGD:735138 7241085   RGD   Reperfusion Injury   ISS RGD:735138 2312727 mRNA, protein:increased expression:kidney RGD   Respiratory Syncytial Virus Infections   ISS RGD:1551003 4889534   RGD   Rhinitis No_Association IAGP   4145356 associated with Sinusitis;DNA:SNPs: :multiple (human) RGD   Rhinitis Susceptibility IAGP   4145354 DNA:SNPs: :597T>C, 1350T>C (human) RGD   Sarcoidosis, Pulmonary   IEP   4145301 mRNA:decreased expression:alveolar macrophage RGD   Sepsis   ISS RGD:735138 2312732   RGD   Sepsis   ISS RGD:735138 1302750 associated with Burns;mRNA:increased expression:liver, lung, kidney RGD   Sepsis   ISS RGD:735138 2312497 associated with Liver Diseases;mRNA:increased expression:liver RGD   Streptococcal Infections Severity ISS RGD:1551003 7240559   RGD   Transplant Rejection   IEP   7240551 kidney RGD   Transplant Rejection   ISS RGD:1551003 7207901   RGD   Transplant Rejection   IAGP   7240554 liver;DNA:SNP: :p.R753Q (human) RGD   Transplant Rejection   ISS RGD:1551003 7240555   RGD   Transplant Rejection   ISS RGD:735138 7240551 kidney RGD   Tuberculosis   IEA   7240710   OMIM   Tuberculosis, Pulmonary Susceptibility IAGP   4145323 DNA:SNP: :rs1816702 (human) RGD   Tuberculosis, Pulmonary   IAGP   4145320 DNA:polymorphisms: :multiple (human) RGD   Tuberculosis, Pulmonary Susceptibility IAGP   4145304 DNA:polymorphism:intron (human) RGD   Tuberculosis, Pulmonary   IEP   4145355 mRNA, protein:increased expression:blood, T cell RGD   Urinary Bladder Neoplasms   IAGP   7207893 DNA:deletion:promoter:−196_−174del (human) RGD   Urinary Tract Infections Susceptibility IAGP   7240561 DNA:polymorphism: :p.R753Q (human) RGD   Wallerian Degeneration   ISS RGD:1551003 2312723   RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (+)-pilocarpine increases expression ISO RGD:1551003 6480464 Pilocarpine results in increased expression of TLR2 mRNA CTD PMID:15193289 (-)-citrinin increases expression ISO RGD:1551003 6480464 Citrinin results in increased expression of TLR2 mRNA CTD PMID:22771370 1-chloro-2,4,6-trinitrobenzene multiple interactions ISO RGD:1551003 6480464 TLR2 protein affects the reaction [TLR4 protein results in increased susceptibility to Picryl Chloride] CTD PMID:18725520 17alpha-ethynylestradiol increases expression ISO RGD:735138 6480464 Ethinyl Estradiol results in increased expression of TLR2 mRNA CTD PMID:17557909 17beta-estradiol multiple interactions EXP   6480464 [Progesterone co-treated with Estradiol] results in increased expression of TLR2 mRNA CTD PMID:17404688 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1551003 6480464 Tetrachlorodibenzodioxin affects the expression of TLR2 mRNA CTD PMID:21570461 adapalene decreases expression EXP   6480464 adapalene results in decreased expression of TLR2 protein CTD PMID:17518990 aflatoxin B1 increases expression ISO RGD:1551003 6480464 Aflatoxin B1 results in increased expression of TLR2 protein CTD PMID:22445859 all-trans-retinol increases expression EXP   6480464 Vitamin A results in increased expression of TLR2 mRNA CTD PMID:17033190 ammonium hexachloroplatinate affects expression EXP   6480464 ammonium hexachloroplatinate affects the expression of TLR2 mRNA CTD PMID:19110044 astemizole decreases expression ISO RGD:735138 6480464 Astemizole results in decreased expression of TLR2 mRNA CTD PMID:20221588 benzene increases expression EXP   6480464 Benzene results in increased expression of TLR2 mRNA CTD PMID:15929907 benzo[a]pyrene increases expression ISO RGD:1551003 6480464 Benzo(a)pyrene results in increased expression of TLR2 mRNA CTD PMID:22228805 bis(2-chloroethyl) sulfide increases expression ISO RGD:1551003 6480464 Mustard Gas results in increased expression of TLR2 mRNA CTD PMID:18955075 bisdemethoxycurcumin multiple interactions EXP   6480464 [bis(4-hydroxycinnamoyl)methane analog co-treated with APP protein] results in increased expression of TLR2 mRNA; more ... CTD PMID:22029407 bisphenol A decreases expression EXP   6480464 bisphenol A results in decreased expression of TLR2 mRNA CTD PMID:20678512 cadmium dichloride decreases expression ISO RGD:1551003 6480464 Cadmium Chloride results in decreased expression of TLR2 mRNA CTD PMID:20061341 cefaloridine increases expression ISO RGD:735138 6480464 Cephaloridine results in increased expression of TLR2 mRNA CTD PMID:18500788 cerium trichloride increases expression ISO RGD:1551003 6480464 cerous chloride results in increased expression of TLR2 protein; more ... CTD PMID:21656643 chitosan multiple interactions EXP   6480464 Chitosan inhibits the reaction [Lipopolysaccharides results in decreased expression of TLR2 mRNA] CTD PMID:21329777 chitosan decreases expression EXP   6480464 Chitosan results in decreased expression of TLR2 mRNA CTD PMID:21329777 ciguatoxin CTX1B affects expression ISO RGD:1551003 6480464 Ciguatoxins affects the expression of TLR2 mRNA CTD PMID:18353800 cisplatin increases expression EXP   6480464 Cisplatin results in increased expression of TLR2 protein CTD PMID:16803524 cobalt atom multiple interactions EXP   6480464 [tungsten carbide co-treated with Cobalt] results in decreased expression of TLR2 mRNA CTD PMID:18078969 cortisol increases expression EXP   6480464 Hydrocortisone results in increased expression of TLR2 mRNA CTD PMID:17033190 curcumin multiple interactions ISO RGD:735138 6480464 Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]; more ... CTD PMID:22683883 cyclosporin A increases expression EXP   6480464 Cyclosporine results in increased expression of TLR2 mRNA CTD PMID:20106945 D-glucose decreases expression EXP   6480464 Glucose results in decreased expression of TLR2 protein CTD PMID:20200188 diarsenic trioxide decreases expression EXP   6480464 arsenic trioxide results in decreased expression of TLR2 mRNA CTD PMID:20471514 diarsenic trioxide multiple interactions EXP   6480464 bortezomib inhibits the reaction [arsenic trioxide results in decreased expression of TLR2 mRNA] CTD PMID:20471514 dopamine increases expression ISO RGD:735138 6480464 Dopamine results in increased expression of TLR2 mRNA CTD PMID:21983523 doxorubicin multiple interactions ISO RGD:1551003 6480464 TLR2 gene mutant form inhibits the reaction [Doxorubicin results in increased activity of RELA protein]; more ... CTD PMID:15505089 doxorubicin decreases response to substance ISO RGD:1551003 6480464 TLR2 gene mutant form results in decreased susceptibility to Doxorubicin CTD PMID:15505089 fenoldopam increases expression ISO RGD:735138 6480464 Fenoldopam results in increased expression of TLR2 mRNA CTD PMID:21983523 ferulic acid multiple interactions ISO RGD:1551003 6480464 ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]; more ... CTD PMID:21291945 fonofos increases methylation EXP   6480464 Fonofos results in increased methylation of TLR2 promoter CTD PMID:22847954 furan increases methylation ISO RGD:735138 6480464 furan results in increased methylation of TLR2 gene CTD PMID:22079235 glucose decreases expression EXP   6480464 Glucose results in decreased expression of TLR2 protein CTD PMID:20200188 glutathione decreases expression EXP   6480464 Glutathione results in decreased expression of TLR2 mRNA CTD PMID:22385246 hexamethylene diisocyanate affects expression EXP   6480464 1,6-hexamethylene diisocyanate affects the expression of TLR2 mRNA CTD PMID:19110044 histamine multiple interactions EXP   6480464 Histamine promotes the reaction [TLR2 results in increased expression of PTGS2]; more ... CTD PMID:20040740 hydroxycitronellal increases expression EXP   6480464 hydroxycitronellal results in increased expression of TLR2 mRNA CTD PMID:17936526 isoeugenol increases expression EXP   6480464 isoeugenol results in increased expression of TLR2 mRNA CTD PMID:17936526 lycopene multiple interactions EXP   6480464 lycopene inhibits the reaction [HMGB1 protein results in increased expression of TLR2 protein]; more ... CTD PMID:22429818 muramyl dipeptide increases activity EXP   6480464 Acetylmuramyl-Alanyl-Isoglutamine analog results in increased activity of TLR2 protein CTD PMID:15905553 muramyl dipeptide increases response to substance ISO RGD:1551003 6480464 TLR2 protein results in increased susceptibility to Acetylmuramyl-Alanyl-Isoglutamine analog CTD PMID:15905553 muramyl dipeptide increases activity ISO RGD:1551003 6480464 Acetylmuramyl-Alanyl-Isoglutamine analog results in increased activity of TLR2 protein CTD PMID:15905553 N-acetyl-L-cysteine decreases expression EXP   6480464 Acetylcysteine results in decreased expression of TLR2 mRNA CTD PMID:22385246 N-nitrosodiethylamine multiple interactions ISO RGD:735138 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of TLR2 mRNA CTD PMID:18164116 nitroprusside multiple interactions ISO RGD:1551003 6480464 [Nitroprusside co-treated with TNFA co-treated with IFNG] results in increased expression of TLR2 mRNA CTD PMID:15153526 ozone multiple interactions ISO RGD:1551003 6480464 [Lipopolysaccharides co-treated with Ozone] results in increased expression of TLR2 mRNA CTD PMID:16864405 ozone decreases response to substance ISO RGD:1551003 6480464 TLR2 gene mutant form results in decreased susceptibility to Ozone CTD PMID:17626835 ozone multiple interactions ISO RGD:1551003 6480464 TLR2 gene mutant form inhibits the reaction [Ozone results in increased expression of CXCL1 mRNA]; more ... CTD PMID:17626835 ozone increases expression ISO RGD:1551003 6480464 Ozone results in increased expression of TLR2 mRNA CTD PMID:17626835 paracetamol affects expression ISO RGD:1551003 6480464 Acetaminophen affects the expression of TLR2 mRNA CTD PMID:17562736 parathion increases methylation EXP   6480464 Parathion results in increased methylation of TLR2 promoter CTD PMID:22847954 phenobarbital affects expression EXP   6480464 Phenobarbital affects the expression of TLR2 mRNA CTD PMID:19159669 pirinixic acid multiple interactions ISO RGD:1551003 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of TLR2 mRNA CTD PMID:19710929 progesterone multiple interactions EXP   6480464 [Progesterone co-treated with Estradiol] results in increased expression of TLR2 mRNA CTD PMID:17404688 progesterone increases expression EXP   6480464 Progesterone results in increased expression of TLR2 mRNA CTD PMID:17404688 propiconazole increases expression ISO RGD:1551003 6480464 propiconazole results in increased expression of TLR2 mRNA CTD PMID:21278054 propiconazole increases expression ISO RGD:1551003 6480464 propiconazole results in increased expression of TLR2 mRNA CTD PMID:21278054 PMID:22334560 prostaglandin E2 multiple interactions EXP   6480464 Histamine promotes the reaction [[TLR2 results in increased expression of PTGS2] which results in increased chemical synthesis of Dinoprostone] CTD PMID:20040740 silicon dioxide increases expression ISO RGD:735138 6480464 Silicon Dioxide results in increased expression of TLR2 mRNA CTD PMID:21602193 simvastatin increases expression EXP   6480464 Simvastatin results in increased expression of TLR2 protein CTD PMID:16387846 simvastatin multiple interactions EXP   6480464 Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 protein] CTD PMID:16443229 sodium dichromate decreases expression ISO RGD:735138 6480464 sodium bichromate results in decreased expression of TLR2 mRNA CTD PMID:22561333 sodium dodecyl sulfate increases expression EXP   6480464 Sodium Dodecyl Sulfate results in increased expression of TLR2 mRNA CTD PMID:17936526 sulfasalazine multiple interactions ISO RGD:1551003 6480464 Sulfasalazine inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA] CTD PMID:12888452 sulindac multiple interactions ISO RGD:735138 6480464 [Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of TLR2 mRNA CTD PMID:20371263 terbufos increases methylation EXP   6480464 terbufos results in increased methylation of TLR2 promoter CTD PMID:22847954 tetrachloromethane increases expression ISO RGD:1551003 6480464 Carbon Tetrachloride results in increased expression of TLR2 mRNA; more ... CTD PMID:21291945 tetrachloromethane multiple interactions ISO RGD:735138 6480464 Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]; more ... CTD PMID:22683883 tetrachloromethane increases expression ISO RGD:735138 6480464 Carbon Tetrachloride results in increased expression of TLR2 mRNA; more ... CTD PMID:22683883 tetrachloromethane multiple interactions ISO RGD:1551003 6480464 ferulic acid inhibits the reaction [Carbon Tetrachloride results in increased expression of TLR2 mRNA]; more ... CTD PMID:21291945 titanium atom multiple interactions ISO RGD:735138 6480464 [Lipopolysaccharides co-treated with Titanium] results in increased expression of TLR2 mRNA CTD PMID:21308757 trimellitic anhydride affects expression EXP   6480464 trimellitic anhydride affects the expression of TLR2 mRNA CTD PMID:19110044 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) cell surface pattern recognition receptor signaling pathway   IEA Ensembl:ENSMUSP00000029623 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 cellular response to bacterial lipopeptide   TAS   2290271 PMID:15356140 BHF-UCL PMID:15356140 cellular response to diacyl bacterial lipopeptide   IDA   2290271 PMID:19931471 MGI PMID:19931471 cellular response to lipoteichoic acid   IDA   2290271 PMID:12594207 MGI PMID:12594207 cellular response to peptidoglycan   IEA Ensembl:ENSMUSP00000029623 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 cellular response to triacyl bacterial lipopeptide   IDA   2290271 PMID:19931471 MGI PMID:19931471 chloramphenicol transport   IEA Ensembl:ENSMUSP00000029623 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 defense response to Gram-positive bacterium   IEA Ensembl:ENSMUSP00000029623 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 detection of diacyl bacterial lipopeptide   IDA   2290271 PMID:19931471 MGI PMID:19931471 detection of triacyl bacterial lipopeptide   IDA   2290271 PMID:19931471 MGI PMID:19931471 I-kappaB phosphorylation   IDA   2290271 PMID:19740627 BHF-UCL PMID:19740627 immune response   TAS   2290271 PMID:10426995 PINC PMID:10426995 induction by symbiont of defense-related host nitric oxide production   IEA Ensembl:ENSMUSP00000029623 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 induction of apoptosis   TAS   2290271 PMID:10426996 PINC PMID:10426996 inflammatory response   IEA UniProtKB-KW:KW-0395 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 innate immune response   TAS   2290271 PMID:15356140 BHF-UCL PMID:15356140 innate immune response   TAS   2290271 Reactome:REACT_6802 Reactome Reactome:REACT_6802 lipopolysaccharide-mediated signaling pathway   TAS   2290271 PMID:11518816 GOC PMID:11518816 MyD88-dependent toll-like receptor signaling pathway   TAS   2290271 Reactome:REACT_6788 Reactome Reactome:REACT_6788 negative regulation of growth of symbiont in host   IEA Ensembl:ENSMUSP00000029623 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of interleukin-12 production   IEA Ensembl:ENSMUSP00000029623 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of interleukin-17 production   IEA Ensembl:ENSMUSP00000029623 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of chemokine production   IDA   2290271 PMID:19740627 BHF-UCL PMID:19740627 positive regulation of cytokine secretion   IEA Ensembl:ENSMUSP00000029623 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of inflammatory response   IC GO:0042346 2290271 PMID:19740627 BHF-UCL PMID:19740627 positive regulation of interferon-beta production   ISS UniProtKB:Q9QUN7 2290271 GO_REF:0000024 BHF-UCL GO_REF:0000024 positive regulation of interleukin-12 production   ISS UniProtKB:Q9QUN7 2290271 GO_REF:0000024 BHF-UCL GO_REF:0000024 positive regulation of interleukin-18 production   ISS UniProtKB:Q9QUN7 2290271 GO_REF:0000024 BHF-UCL GO_REF:0000024 positive regulation of interleukin-6 production   IDA   2290271 PMID:19740627 BHF-UCL PMID:19740627 positive regulation of interleukin-8 production   IDA   2290271 PMID:17128265 BHF-UCL PMID:17128265 positive regulation of interleukin-8 production   IDA   2290271 PMID:19740627 BHF-UCL PMID:19740627 positive regulation of leukocyte migration   IEA Ensembl:ENSMUSP00000029623 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of macrophage cytokine production   IEA Ensembl:ENSMUSP00000029623 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of NF-kappaB import into nucleus   IDA   2290271 PMID:19740627 BHF-UCL PMID:19740627 positive regulation of NF-kappaB transcription factor activity   IDA   2290271 PMID:12594207 MGI PMID:12594207 positive regulation of nitric oxide biosynthetic process   IEA Ensembl:ENSMUSP00000029623 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of nitric-oxide synthase biosynthetic process   ISS UniProtKB:Q9QUN7 2290271 GO_REF:0000024 BHF-UCL GO_REF:0000024 positive regulation of toll-like receptor signaling pathway   IDA   2290271 PMID:17128265 BHF-UCL PMID:17128265 positive regulation of transcription from RNA polymerase II promoter   ISS UniProtKB:Q9QUN7 2290271 GO_REF:0000024 BHF-UCL GO_REF:0000024 positive regulation of tumor necrosis factor biosynthetic process   IEA Ensembl:ENSMUSP00000029623 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of tumor necrosis factor production   ISS UniProtKB:Q9QUN7 2290271 GO_REF:0000024 BHF-UCL GO_REF:0000024 positive regulation of Wnt receptor signaling pathway   IMP   2290271 PMID:16601243 BHF-UCL PMID:16601243 response to molecule of fungal origin   IEA Ensembl:ENSMUSP00000029623 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 signal transduction   TAS   2290271 PMID:11044375 UniProtKB PMID:11044375 toll-like receptor 2 signaling pathway   TAS   2290271 Reactome:REACT_7980 Reactome Reactome:REACT_7980 toll-like receptor 4 signaling pathway   TAS   2290271 Reactome:REACT_6890 Reactome Reactome:REACT_6890 toll-like receptor 4 signaling pathway   TAS   2290271 Reactome:REACT_6894 Reactome Reactome:REACT_6894 toll-like receptor signaling pathway   TAS   2290271 Reactome:REACT_6966 Reactome Reactome:REACT_6966 toll-like receptor TLR1:TLR2 signaling pathway   TAS   2290271 Reactome:REACT_8005 Reactome Reactome:REACT_8005 toll-like receptor TLR6:TLR2 signaling pathway   TAS   2290271 Reactome:REACT_8006 Reactome Reactome:REACT_8006 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) cell surface   IDA   2290271 PMID:12443841 UniProtKB PMID:12443841 cytoplasm   IDA   2290271 PMID:19740627 BHF-UCL PMID:19740627 external side of plasma membrane   IEA Ensembl:ENSMUSP00000029623 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 integral to plasma membrane   TAS   2290271 PMID:9435236 PINC PMID:9435236 plasma membrane   TAS   2290271 Reactome:REACT_6856 Reactome Reactome:REACT_6856 plasma membrane   TAS   2290271 Reactome:REACT_150418 Reactome Reactome:REACT_150418 plasma membrane   TAS   2290271 Reactome:REACT_121383 Reactome Reactome:REACT_121383 plasma membrane   TAS   2290271 Reactome:REACT_121298 Reactome Reactome:REACT_121298 plasma membrane   TAS   2290271 Reactome:REACT_120882 Reactome Reactome:REACT_120882 plasma membrane   TAS   2290271 Reactome:REACT_120733 Reactome Reactome:REACT_120733 plasma membrane   TAS   2290271 Reactome:REACT_6833 Reactome Reactome:REACT_6833 plasma membrane   TAS   2290271 Reactome:REACT_6797 Reactome Reactome:REACT_6797 plasma membrane   TAS   2290271 Reactome:REACT_6794 Reactome Reactome:REACT_6794 plasma membrane   TAS   2290271 Reactome:REACT_6736 Reactome Reactome:REACT_6736 plasma membrane   TAS   2290271 Reactome:REACT_25221 Reactome Reactome:REACT_25221 plasma membrane   TAS   2290271 Reactome:REACT_25213 Reactome Reactome:REACT_25213 plasma membrane   TAS   2290271 Reactome:REACT_25097 Reactome Reactome:REACT_25097 plasma membrane   TAS   2290271 Reactome:REACT_115718 Reactome Reactome:REACT_115718 plasma membrane   IDA   2290271 PMID:19740627 BHF-UCL PMID:19740627 plasma membrane   TAS   2290271 Reactome:REACT_7984 Reactome Reactome:REACT_7984 plasma membrane   TAS   2290271 Reactome:REACT_7951 Reactome Reactome:REACT_7951 plasma membrane   TAS   2290271 Reactome:REACT_6975 Reactome Reactome:REACT_6975 plasma membrane   TAS   2290271 Reactome:REACT_6929 Reactome Reactome:REACT_6929 plasma membrane   TAS   2290271 Reactome:REACT_6862 Reactome Reactome:REACT_6862 Toll-like receptor 1-Toll-like receptor 2 protein complex   IDA   2290271 PMID:17889651 MGI PMID:17889651 Toll-like receptor 2-Toll-like receptor 6 protein complex   IEA Ensembl:ENSMUSP00000029623 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) diacyl lipopeptide binding   IEA Ensembl:ENSMUSP00000029623 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 Gram-positive bacterial cell surface binding   IDA   2290271 PMID:11521063 UniProtKB PMID:11521063 lipopolysaccharide receptor activity   TAS   2290271 PMID:11518816 UniProtKB PMID:11518816 lipoteichoic acid binding   IEA Ensembl:ENSMUSP00000029623 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 pattern recognition receptor activity   IDA   2290271 PMID:10384090 UniProtKB PMID:10384090 peptidoglycan binding   IDA   2290271 PMID:11986301 UniProtKB PMID:11986301 protein binding   IPI UniProtKB:Q676U5 2290271 PMID:23376921 UniProtKB PMID:23376921 protein binding   IPI UniProtKB:C3PTT6 2290271 PMID:20802527 IntAct PMID:20802527 protein binding   IPI UniProtKB:P58753 2290271 PMID:19509286 BHF-UCL PMID:19509286 protein binding   IPI UniProtKB:Q15654 2290271 PMID:15657077 UniProtKB PMID:15657077 protein binding   IPI UniProtKB:Q9H0E2 2290271 PMID:11441107 UniProtKB PMID:11441107 protein binding   IPI UniProtKB:Q9H0E2 2290271 PMID:10854325 UniProtKB PMID:10854325 protein heterodimerization activity   IDA   2290271 PMID:17889651 MGI PMID:17889651 receptor activity   IDA   2290271 PMID:11672593 UniProtKB PMID:11672593 transmembrane signaling receptor activity   IEA InterPro:IPR017241 2290271 GO_REF:0000002 InterPro GO_REF:0000002 triacyl lipopeptide binding   IDA   2290271 PMID:17889651 MGI PMID:17889651 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Entamoeba histolyca infection pathway   IEA RGD:1353654 6907045   KEGG hsa:05146 Leishmania infection pathway   IEA RGD:1353654 6907045   KEGG hsa:05140 measles infection pathway   IEA RGD:1353654 6907045   KEGG hsa:05162 Mycobacterium tuberculosis infection pathway   IEA RGD:1353654 6907045   KEGG hsa:05152 Plasmodium infection pathway   IEA RGD:1353654 6907045   KEGG hsa:05144 rheumatoid arthritis pathway   IEA RGD:1353654 6907045   KEGG hsa:05323 Toll-like receptor signaling pathway   ISS RGD:735138 1643119   RGD   Toll-like receptor signaling pathway   IEA RGD:1353654 6907045   KEGG hsa:04620 Toll-like receptor signaling pathway   ISS RGD:735138 5684896   RGD   Toll-like receptor signaling pathway   TAS   5685014   RGD   Toxoplasma gondii infection pathway   IEA RGD:1353654 6907045   KEGG hsa:05145 Trypanosoma cruzi infection pathway   IEA RGD:1353654 6907045   KEGG hsa:05142 External Database Links KEGG Pathway Amoebiasis Chagas disease (American trypanosomiasis) Hepatitis B Herpes simplex infection Legionellosis Leishmaniasis Malaria Measles Phagosome PI3K-Akt signaling pathway Rheumatoid arthritis Toll-like receptor signaling pathway Toxoplasmosis Tuberculosis Pathway Interaction Database Endogenous TLR signaling (PID:200208) Disease Annotations Acute Kidney Injury  (ISS) Acute Tubulointerstitial Nephritis  (ISS) Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISS) Arthritis, Experimental  (ISS) Aspergillosis  (ISS) Asthma  (IAGP,ISS) Brain Injuries  (ISS) Carotid Stenosis  (ISS) Colorectal Neoplasms  (IEA) Cough  (IEP) Diabetes Mellitus, Experimental  (ISS) Diabetes Mellitus, Type 1  (IAGP,IEP,ISS) Diabetic Nephropathies  (ISS) Dyslipidemias  (ISS) Encephalomyelitis, Autoimmune, Experimental  (ISS) Endotoxemia  (ISS) Enterocolitis, Necrotizing  (ISS) Fever  (ISS) Gastroesophageal Reflux  (IEP) Glomerulonephritis  (ISS) Gram-Positive Bacterial Infections  (ISS) Inflammation  (ISS) Influenza, Human  (IEP) Kidney Failure, Chronic  (IEP) Kidney Reperfusion Injury  (ISS) Leprosy  (IEA) Leptospirosis  (ISS) Liver Cirrhosis, Experimental  (ISS) Lung Diseases  (IAGP,ISS) MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO  (IEA) Myocardial Reperfusion Injury  (ISS) Neuritis, Autoimmune, Experimental  (ISS) Obesity  (ISS) Pancreatitis  (ISS) Pancreatitis, Acute Necrotizing  (ISS) Pneumonia  (ISS) Pneumonia, Bacterial  (ISS) Pneumonia, Pneumococcal  (ISS) Pneumonia, Pneumocystis  (ISS) Prostatic Neoplasms  (IAGP) Pulmonary Emphysema  (ISS) Pulmonary Fibrosis  (ISS) Renal Fibrosis  (ISS) Renal Insufficiency  (ISS) Reperfusion Injury  (ISS) Respiratory Syncytial Virus Infections  (ISS) Rhinitis  (IAGP) Sarcoidosis, Pulmonary  (IEP) Sepsis  (ISS) Streptococcal Infections  (ISS) Transplant Rejection  (IAGP,IEP,ISS) Tuberculosis  (IEA) Tuberculosis, Pulmonary  (IAGP,IEP) Urinary Bladder Neoplasms  (IAGP) Urinary Tract Infections  (IAGP) Wallerian Degeneration  (ISS) Gene-Chemical Interaction Annotations (+)-pilocarpine  (ISO) (-)-citrinin  (ISO) 1-chloro-2,4,6-trinitrobenzene  (ISO) 17alpha-ethynylestradiol  (ISO) 17beta-estradiol  (EXP) 2,3,7,8-tetrachlorodibenzodioxine  (ISO) adapalene  (EXP) aflatoxin B1  (ISO) all-trans-retinol  (EXP) ammonium hexachloroplatinate  (EXP) astemizole  (ISO) benzene  (EXP) benzo[a]pyrene  (ISO) bis(2-chloroethyl) sulfide  (ISO) bisdemethoxycurcumin  (EXP) bisphenol A  (EXP) cadmium dichloride  (ISO) cefaloridine  (ISO) cerium trichloride  (ISO) chitosan  (EXP) ciguatoxin CTX1B  (ISO) cisplatin  (EXP) cobalt atom  (EXP) cortisol  (EXP) curcumin  (ISO) cyclosporin A  (EXP) D-glucose  (EXP) diarsenic trioxide  (EXP) dopamine  (ISO) doxorubicin  (ISO) fenoldopam  (ISO) ferulic acid  (ISO) fonofos  (EXP) furan  (ISO) glucose  (EXP) glutathione  (EXP) hexamethylene diisocyanate  (EXP) histamine  (EXP) hydroxycitronellal  (EXP) isoeugenol  (EXP) lycopene  (EXP) muramyl dipeptide  (EXP,ISO) N-acetyl-L-cysteine  (EXP) N-nitrosodiethylamine  (ISO) nitroprusside  (ISO) ozone  (ISO) paracetamol  (ISO) parathion  (EXP) phenobarbital  (EXP) pirinixic acid  (ISO) progesterone  (EXP) propiconazole  (ISO) prostaglandin E2  (EXP) silicon dioxide  (ISO) simvastatin  (EXP) sodium dichromate  (ISO) sodium dodecyl sulfate  (EXP) sulfasalazine  (ISO) sulindac  (ISO) terbufos  (EXP) tetrachloromethane  (ISO) titanium atom  (ISO) trimellitic anhydride  (EXP) Gene Ontology Annotations Biological Process cell surface pattern recognition receptor signaling pathway  (IEA) cellular response to bacterial lipopeptide  (TAS) cellular response to diacyl bacterial lipopeptide  (IDA) cellular response to lipoteichoic acid  (IDA) cellular response to peptidoglycan  (IEA) cellular response to triacyl bacterial lipopeptide  (IDA) chloramphenicol transport  (IEA) defense response to Gram-positive bacterium  (IEA) detection of diacyl bacterial lipopeptide  (IDA) detection of triacyl bacterial lipopeptide  (IDA) I-kappaB phosphorylation  (IDA) immune response  (TAS) induction by symbiont of defense-related host nitric oxide production  (IEA) induction of apoptosis  (TAS) inflammatory response  (IEA) innate immune response  (TAS) lipopolysaccharide-mediated signaling pathway  (TAS) MyD88-dependent toll-like receptor signaling pathway  (TAS) negative regulation of growth of symbiont in host  (IEA) negative regulation of interleukin-12 production  (IEA) negative regulation of interleukin-17 production  (IEA) positive regulation of chemokine production  (IDA) positive regulation of cytokine secretion  (IEA) positive regulation of inflammatory response  (IC) positive regulation of interferon-beta production  (ISS) positive regulation of interleukin-12 production  (ISS) positive regulation of interleukin-18 production  (ISS) positive regulation of interleukin-6 production  (IDA) positive regulation of interleukin-8 production  (IDA) positive regulation of leukocyte migration  (IEA) positive regulation of macrophage cytokine production  (IEA) positive regulation of NF-kappaB import into nucleus  (IDA) positive regulation of NF-kappaB transcription factor activity  (IDA) positive regulation of nitric oxide biosynthetic process  (IEA) positive regulation of nitric-oxide synthase biosynthetic process  (ISS) positive regulation of toll-like receptor signaling pathway  (IDA) positive regulation of transcription from RNA polymerase II promoter  (ISS) positive regulation of tumor necrosis factor biosynthetic process  (IEA) positive regulation of tumor necrosis factor production  (ISS) positive regulation of Wnt receptor signaling pathway  (IMP) response to molecule of fungal origin  (IEA) signal transduction  (TAS) toll-like receptor 2 signaling pathway  (TAS) toll-like receptor 4 signaling pathway  (TAS) toll-like receptor signaling pathway  (TAS) toll-like receptor TLR1:TLR2 signaling pathway  (TAS) toll-like receptor TLR6:TLR2 signaling pathway  (TAS) Cellular Component cell surface  (IDA) cytoplasm  (IDA) external side of plasma membrane  (IEA) integral to plasma membrane  (TAS) plasma membrane  (IDA,TAS) Toll-like receptor 1-Toll-like receptor 2 protein complex  (IDA) Toll-like receptor 2-Toll-like receptor 6 protein complex  (IEA) Molecular Function diacyl lipopeptide binding  (IEA) Gram-positive bacterial cell surface binding  (IDA) lipopolysaccharide receptor activity  (TAS) lipoteichoic acid binding  (IEA) pattern recognition receptor activity  (IDA) peptidoglycan binding  (IDA) protein binding  (IPI) protein heterodimerization activity  (IDA) receptor activity  (IDA) transmembrane signaling receptor activity  (IEA) triacyl lipopeptide binding  (IDA) Molecular Pathway Annotations Entamoeba histolyca infection pathway  (IEA) Leishmania infection pathway  (IEA) measles infection pathway  (IEA) Mycobacterium tuberculosis infection pathway  (IEA) Plasmodium infection pathway  (IEA) rheumatoid arthritis pathway  (IEA) Toll-like receptor signaling pathway  (IEA,ISS,TAS) Toxoplasma gondii infection pathway  (IEA) Trypanosoma cruzi infection pathway  (IEA) External Database Links KEGG Pathway Amoebiasis Chagas disease (American trypanosomiasis) Hepatitis B Herpes simplex infection Legionellosis Leishmaniasis Malaria Measles Phagosome PI3K-Akt signaling pathway Rheumatoid arthritis Toll-like receptor signaling pathway Toxoplasmosis Tuberculosis Pathway Interaction Database Endogenous TLR signaling (PID:200208) References - curated 1. Amura CR, etal., Mol Immunol. 2012 Oct;52(3-4):249-57. doi: 10.1016/j.molimm.2012.05.020. Epub 2012 Jun 27. 2. Andersson A, etal., J Leukoc Biol. 2008 Nov;84(5):1248-55. Epub 2008 Jul 21. 3. Bjornvold M, etal., Genes Immun. 2009 Mar;10(2):181-7. Epub 2009 Jan 15. 4. Boivin A, etal., J Neurosci. 2007 Nov 14;27(46):12565-76. 5. Braga TT, etal., Mol Med. 2012 Oct 24;18:1231-9. doi: 10.2119/molmed.2012.00131. 6. Brown HJ, etal., J Immunol. 2006 Aug 1;177(3):1925-31. 7. Brown RA, etal., Transplantation. 2010 Apr 15;89(7):811-5. doi: 10.1097/TP.0b013e3181cbac18. 8. Buckland KF, etal., Inflamm Res. 2008 Aug;57(8):379-87. 9. Caricilli AM, etal., J Endocrinol. 2008 Dec;199(3):399-406. Epub 2008 Sep 11. 10. Castoldi A, etal., PLoS One. 2012;7(5):e37584. doi: 10.1371/journal.pone.0037584. Epub 2012 May 24. 11. Chassin C, etal., J Immunol. 2009 Aug 15;183(4):2669-77. doi: 10.4049/jimmunol.0900506. Epub 2009 Jul 27. 12. Chen G, etal., Ann Clin Lab Sci. 2008 Winter;38(1):65-74. 13. Chen X, etal., J Infect Dis. 2009 Aug 1;200(3):399-408. 14. Chen YC, etal., BMC Med Genet. 2010 Jan 30;11:17. 15. Correa-Costa M, etal., PLoS One. 2011;6(12):e29004. doi: 10.1371/journal.pone.0029004. Epub 2011 Dec 14. 16. Dessing MC, etal., PLoS One. 2009 Nov 24;4(11):e7993. 17. Devaraj S, etal., Arterioscler Thromb Vasc Biol. 2011 Aug;31(8):1796-804. doi: 10.1161/ATVBAHA.111.228924. Epub 2011 May 26. 18. Devaraj S, etal., J Clin Endocrinol Metab. 2008 Feb;93(2):578-83. Epub 2007 Nov 20. 19. Du T, etal., Diabetes Res Clin Pract. 2009 Feb;83(2):208-14. Epub 2008 Nov 17. 20. Farrar CA, etal., FASEB J. 2012 Feb;26(2):799-807. doi: 10.1096/fj.11-195396. Epub 2011 Oct 31. 21. Forte A, etal., Cardiovasc Drugs Ther. 2012 Feb;26(1):9-21. doi: 10.1007/s10557-011-6359-8. 22. Froy O, etal., Mol Immunol. 2007 Feb;44(5):796-802. Epub 2006 Jun 5. 23. Fuchs B, etal., Int Arch Allergy Immunol. 2010;152(2):131-9. Epub 2009 Dec 16. 24. Gao HK, etal., Inflamm Res. 2009 Mar 10. 25. GOA_HUMAN data from the GO Consortium 26. Guo LH, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):1156-62. Epub 2006 Sep 1. 27. Hajishengallis G, etal., J Immunol. 2008 Sep 15;181(6):4141-9. 28. Hoffmann U, etal., Nephrol Dial Transplant. 2011 Mar;26(3):1080-7. doi: 10.1093/ndt/gfq420. Epub 2010 Jul 13. 29. Hubschle T, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R180-7. Epub 2005 Sep 8. 30. Jing K and Sun M, Zhongguo Dang Dai Er Ke Za Zhi. 2011 Dec;13(12):985-8. 31. Kajiya T, etal., J Infect. 2008 Sep;57(3):249-59. Epub 2008 Jul 26. 32. Kang I, etal., Eur Arch Otorhinolaryngol. 2010 Mar;267(3):385-9. Epub 2009 Sep 18. 33. Kerber-Momot T, etal., Inflammation. 2010 Feb;33(1):58-64. 34. Kerkhof M, etal., Thorax. 2010 Aug;65(8):690-7. 35. Khan AM, etal., Peptides. 2012 Dec;38(2):395-403. doi: 10.1016/j.peptides.2012.09.023. Epub 2012 Sep 28. 36. Kim BS, etal., Transplantation. 2005 May 27;79(10):1370-7. 37. Kim HS, etal., Immunity. 2007 Aug;27(2):321-33. Epub 2007 Aug 16. 38. Knorr C, etal., Brain Res. 2008 Apr 18;1205:36-46. Epub 2008 Feb 21. 39. Koc M, etal., Nephrol Dial Transplant. 2011 Mar;26(3):955-63. doi: 10.1093/ndt/gfq500. Epub 2010 Aug 20. 40. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34. 41. Leemans JC, etal., PLoS One. 2009 May 27;4(5):e5704. doi: 10.1371/journal.pone.0005704. 42. Leendertse M, etal., J Immunol. 2008 Apr 1;180(7):4865-74. 43. Li HY, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2003 Mar;15(3):139-42. 44. Lim SW, etal., Transplantation. 2005 Sep 15;80(5):691-9. 45. Liu Y, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G442-50. Epub 2009 Jul 16. 46. Lu ZQ, etal., Zhonghua Yi Xue Za Zhi. 2009 Jan 13;89(2):138-41. 47. Mandal RK, etal., Mol Biol Rep. 2012 Jul;39(7):7263-9. doi: 10.1007/s11033-012-1556-5. Epub 2012 Feb 6. 48. Murawski MR, etal., J Virol. 2009 Feb;83(3):1492-500. Epub 2008 Nov 19. 49. Park Y, etal., Ann N Y Acad Sci. 2004 Dec;1037:170-4. 50. Paul-Clark MJ, etal., Am J Respir Crit Care Med. 2009 Feb 15;179(4):299-306. Epub 2008 Nov 14. 51. Paun A, etal., Int J Radiat Oncol Biol Phys. 2010 Jul 15;77(4):1198-205. 52. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 53. Puliti M, etal., Infect Immun. 2009 Apr;77(4):1524-31. doi: 10.1128/IAI.00965-08. Epub 2009 Jan 29. 54. Qian FH, etal., J Investig Allergol Clin Immunol. 2010;20(4):340-6. 55. RGD automated import pipeline for gene-chemical interactions 56. RGD Automated Pipelines 57. Rusai K, etal., Pediatr Nephrol. 2010 May;25(5):853-60. doi: 10.1007/s00467-009-1422-4. Epub 2010 Feb 4. 58. Santin I, etal., Ann N Y Acad Sci. 2006 Oct;1079:268-72. 59. Sawa H, etal., Hepatogastroenterology. 2008 Nov-Dec;55(88):2247-51. 60. Singh V, etal., Arch Med Res. 2013 Jan;44(1):54-61. doi: 10.1016/j.arcmed.2012.10.008. Epub 2012 Nov 6. 61. Smit LA, etal., Am J Respir Crit Care Med. 2009 Mar 1;179(5):363-8. Epub 2008 Dec 18. 62. Summers SA, etal., Arthritis Rheum. 2011 Apr;63(4):1124-35. doi: 10.1002/art.30208. 63. Tabel Y, etal., Int J Immunogenet. 2007 Dec;34(6):399-405. 64. Tang CW, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2011 Feb;34(2):123-7. 65. Tewfik MA, etal., J Otolaryngol Head Neck Surg. 2008 Aug;37(4):552-8. 66. Tokairin Y, etal., Respirology. 2008 May;13(3):324-32. 67. Tomofuji T, etal., Lipids Health Dis. 2013 Jan 8;12(1):1. 68. Tu CT, etal., Food Chem Toxicol. 2012 Sep;50(9):3343-51. doi: 10.1016/j.fct.2012.05.050. Epub 2012 Jun 7. 69. Velez DR, etal., Int J Tuberc Lung Dis. 2009 Sep;13(9):1068-76. 70. Wang S, etal., Dis Model Mech. 2010 Jan-Feb;3(1-2):92-103. doi: 10.1242/dmm.003533. Epub 2009 Dec 28. 71. Wang SH, etal., Microbes Infect. 2008 Apr;10(4):334-41. Epub 2007 Dec 28. 72. Welsch J, etal., Innate Immun. 2012 Jun;18(3):541-59. doi: 10.1177/1753425911426892. Epub 2011 Oct 31. 73. Wiken M, etal., Respir Res. 2010 Sep 2;11:121. 74. Wolfs TG, etal., J Immunol. 2002 Feb 1;168(3):1286-93. 75. Wu HS, etal., Hepatobiliary Pancreat Dis Int. 2005 Nov;4(4):609-13. 76. Wu Q, etal., Am J Respir Crit Care Med. 2008 Apr 1;177(7):720-9. Epub 2008 Jan 17. 77. Xue Y, etal., Clin Chem Lab Med. 2010 Jun;48(6):785-9. 78. Yang HZ, etal., J Immunol. 2009 Jan 1;182(1):692-702. 79. Yang JX, etal., Chin Med J (Engl). 2009 Sep 5;122(17):2017-21. 80. Yao YM, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2003 Nov;15(11):646-50. 81. Yim JJ, etal., Hum Immunol. 2008 Sep;69(9):572-6. Epub 2008 Jul 3. 82. Zhang L, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2006 Mar;18(3):161-4. 83. Zhang ZY, etal., Neuroscience. 2009 Mar 3;159(1):136-42. Epub 2009 Jan 1. 84. Zheng XY, etal., Chin J Integr Med. 2012 Dec;18(12):918-24. doi: 10.1007/s11655-012-1295-1. Epub 2012 Dec 13. 85. Zhu W, etal., Mol Biol Rep. 2012 Apr;39(4):3667-73. doi: 10.1007/s11033-011-1141-3. Epub 2011 Jul 3. 86. Zuo WQ, etal., Zhonghua Er Ke Za Zhi. 2010 Jan;48(1):19-23. References - uncurated PubMed 10384090   10395652   10426995   10426996   10548109   10854325   10963608   11035751   11044375   11081518   11101877   11160242   11222859   11276206   11441107   11476982   11477091   11518816   11521063   11561001   11672593   11724772   11751856   11782555   11836257   11842086   11867630   11867688   11877429   11894098   11912201   11932927   11986301   12023360   12061629   12077222   12089142   12163593   12171914   12207338   12270725   12356755   12397021   12437972   12438323   12443841   12445799   12471095   12477932   12525572   12538701   12540550   12588460   12594207   12630564   12646604   12651614   12663765   12734363   12734376   12810071   12816980   12817025   12860988   12874236   12941697   12942028   12946842   12958190   12966099   12975352   14500665   14551607   14607814   14625308   14651524   14662888   14673018   14694183   14706103   14706104   14707104   14709406   14738464   14966134   14979495   14981245   14987294   15007072   15007351   15007364   15041961   15044215   15064239   15107846   15138193   15146245   15146246   15146415   15148609   15155685   15173186   15175649   15210811   15214053   15247273   15247281   15272059   15276183   15305230   15319868   15321997   15322009   15342637   15356140   15385480   15456896   15489334   15489631   15496409   15501775   15516360   15521019   15539529   15583145   15585865   15657077   15670752   15670766   15696084   15717270   15726416   15728506   15731031   15731043   15731050   15753758   15760452   15760459   15778388   15790341   15793154   15814732   15864780   15875151   15910421   15919371   15950961   15955814   15968536   16002719   16004610   16024789   16034117   16035096   16081826   16107886   16115866   16146574   16177110   16179594   16213463   16230348   16239565   16242370   16267105   16270639   16283346   16290232   16293622   16336272   16371473   16374251   16437124   16439361   16443229   16455995   16478769   16482509   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17567674   17588655   17595233   17599732   17600044   17624834   17629003   17640874   17651447   17652449   17667860   17669234   17675516   17676990   17703412   17709420   17711514   17713436   17728249   17854755   17855767   17855803   17872459   17877764   17878165   17878330   17889651   17892476   17908769   17913539   17914947   17916356   17916440   17928056   17934735   17934843   17942642   17956467   17964520   17967853   17974158   17984211   18006661   18025115   18028450   18040078   18054497   18056480   18062119   18067993   18073264   18089358   18159247   18167552   18175935   18177245   18180796   18191935   18195069   18201568   18218857   18219831   18221795   18234309   18249133   18266466   18268386   18275280   18292749   18295348   18312481   18325643   18349186   18354224   18359883   18368233   18369480   18394314   18406368   18411230   18414649   18419772   18423053   18424702   18438411   18441280   18442320   18445187   18451040   18454672   18458086   18458151   18461142   18474641   18495130   18516040   18547625   18549457   18559343   18565796   18566366   18571457   18583567   18596023   18618036   18625015   18641349   18650783   18651887   18676680   18678660   18680520   18684966   18686608   18704103   18714935   18722665   18755634   18765807   18769358   18773284   18776592   18802114   18809506   18810425   18813073   18818748   18832719   18846558   18925411   18930806   18942754   18946062   18952897   18975326   18978205   18983769   19001446   19012493   19014987   19015258   19016779   19019335   19029192   19033535   19050632   19061090   19071087   19103770   19106411   19111445   19120068   19120486   19120490   19120971   19121950   19124728   19134118   19139093   19139198   19141294   19148938   19164296   19167431   19170196   19172872   19195606   19196344   19197942   19200604   19220214   19247692   19254290   19258923   19265130   19275590   19279330   19280717   19299164   19306954   19317913   19336475   19342676   19378782   19381722   19392987   19401382   19401779   19407153   19412702   19420105   19423540   19447045   19454663   19454721   19455302   19458089   19493410   19503839   19505919   19509286   19509287   19522765   19527514   19528164   19539691   19541348   19542461   19543380   19543401   19545686   19554026   19564644   19573080   19574958   19592497   19596998   19597734   19617348   19622038   19625176   19627277   19631014   19635908   19638314   19648269   19684606   19686607   19692168   19693643   19701803   19740627   19758322   19766998   19771447   19771452   19773279   19796535   19804908   19810822   19812189   19814623   19819943   19830732   19835594   19843711   19844258   19849713   19855253   19874421   19888805   19913121   19915052   19917706   19924287   19931471   19933854   19948716   19948975   19948979   19950169   19953283   19953876   19995893   20002809   20007698   20011697   20016852   20020500   20024498   20041977   20044219   20056178   20056792   20057905   20063104   20067962   20085599   20092701   20098705   20100933   20109309   20113368   20120936   20147631   20153491   20154223   20167866   20169003   20174873   20194452   20196868   20198307   20207250   20222908   20227302   20232093   20233331   20237496   20307689   20337891   20338659   20348427   20348497   20357716   20363151   20375602   20379614   20382708   20384861   20388081   20388552   20400509   20402671   20404927   20406964   20438785   20441518   20441696   20448286   20452482   20454607   20456615   20463618   20463690   20472010   20473500   20483368   20492495   20492496   20497180   20497485   20500688   20503287   20520770   20525885   20534434   20549240   20560984   20568250   20577092   20577149   20578945   20581745   20595247   20598754   20599261   20601596   20604744   20614721   20616112   20626741   20628086   20634913   20646321   20646366   20646633   20650298   20673868   20686034   20713893   20714796   20726329   20730440   20740673   20797905   20799043   20800577   20802527   20805788   20818954   20818961   20819778   20821041   20835611   20849532   20861605   20877569   20927103   20933500   20937339   20940109   20946179   20947433   20977567   21048031   21055975   21060793   21078852   21097451   21105983   21107351   21128061   21134221   21148810   21163333   21167252   21168672   21173310   21178007   21179035   21188584   21191086   21206505   21220755   21224062   21239179   21246489   21276007   21281869   21298446   21303685   21320563   21321205   21330474   21343392   21356257   21371045   21398611   21406030   21417682   21424379   21425908   21426724   21437199   21438704   21443084   21447101   21454596   21455638   21460227   21468605   21474333   21481769   21483768   21493395   21500195   21515468   21518510   21544941   21563293   21570715   21570717   21573018   21600098   21621299   21625017   21646294   21673343   21705332   21709150   21721932   21768114   21768203   21775336   21775683   21783307   21789185   21789730   21794115   21825064   21827211   21829704   21834467   21841130   21843566   21845735   21846836   21848584   21858161   21883620   21887520   21897866   21899704   21902816   21905008   21923667   21949112   21950140   21952587   21956671   21960283   21978687   21982724   21989233   21994405   21998742   22003201   22021706   22022564   22030478   22032785   22041559   22057691   22067623   22095710   22100911   22105995   22126586   22128242   22133017   22133266   22166855   22182736   22186927   22198949   22210918   22216191   22219347   22219617   22221660   22227093   22229967   22230402   22251071   22280448   22292031   22295065   22303480   22305616   22309608   22330637   22336003   22359280   22372604   22402138   22442665   22466961   22467654   22468087   22491449   22496225   22521894   22523426   22555189   22556042   22560646   22561467   22608210   22613713   22623652   22662111   22673208   22697069   22707717   22737215   22777994   22778396   22792230   22795952   22815694   22825445   22844428   22848741   22865347   22870312   22952638   22964787   22982459   22992740   23026048   23028414   23068105   23079657   23091345   23133361   23166414   23211828   23230212   23233677   23244658   23255565   23285751   9435236   9596645   9751057 RGD Disease Portals TLR2 has been annotated in the following RGD Disease Portals. Biological Process Cancer Diseases Cancer Pathways Biological Process Cardiovascular Diseases Cardiovascular Pathways Diabetes Diseases Diabetes Pathways Biological Process Immune and Inflammatory Diseases Immune and Inflammatory Pathways Neurological Diseases Neurological Pathways Biological Process Obesity Diseases Obesity Pathways Biological Process Respiratory Diseases Respiratory Pathways Genomics Comparative Map Data TLR2   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 4 154,390,697 - 154,412,500 + NCBI Human Genome Assembly HuRef 4 150,336,457 - 150,358,268 + NCBI Human Genome Assembly GRCh37 4 154,605,441 - 154,627,243 + NCBI Human Genome Assembly Build 36 4 154,824,891 - 154,846,693 + NCBI Human Cytogenetic Map 4 q32   NCBI Human Genome Assembly 4 154,966,670 - 154,984,135   NCBI Tlr2   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 3 83,836,272 - 83,841,608 - NCBI Mouse cM Map 3   - NCBI Mouse Celera Assembly 3 83,852,064 - 83,857,400 - NCBI Mouse Genome Assembly Build 37 3 83,640,194 - 83,645,530 - NCBI Mouse Genome Assembly Build 36.1 3 83,640,194 - 83,645,689 - NCBI Mouse Cytogenetic Map 3 E3   NCBI Tlr2   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 2 q34   NCBI RGSC Genome Assembly v5.0 2 202,253,256 - 202,258,683 - NCBI RGSC Genome Assembly v3.4 2 175,607,990 - 175,613,992 - NCBI Rat Celera Assembly 2 163,202,040 - 163,207,399 - NCBI Genome Assembly 3.1 2 175,558,096 - 175,564,098 - NCBI Position Markers G34296   Map Chr Position Strand Source Human Genome Assembly HuRef 4 150,357,526 - 150,357,718   UniSTS Human Genome Assembly GRCh37 4 154,626,501 - 154,626,693   UniSTS Human Celera Assembly 4 151,950,988 - 151,951,180   RGD Human Genome Assembly Build 36 4 154,845,951 - 154,846,143   RGD Human Cytogenetic Map 4 q32   UniSTS D4S660   Map Chr Position Strand Source Human TNG Radiation Hybrid Map 4 92560.0   UniSTS Human Genome Assembly HuRef 4 150,349,379 - 150,349,535   UniSTS Human Genome Assembly GRCh37 4 154,618,362 - 154,618,518   UniSTS Human Celera Assembly 4 151,942,849 - 151,943,005   RGD Human Genome Assembly Build 36 4 154,837,812 - 154,837,968   RGD Human Cytogenetic Map 4 q32   UniSTS PMC128073P3   Map Chr Position Strand Source Human Genome Assembly HuRef 4 150,355,159 - 150,355,450   UniSTS Human Genome Assembly GRCh37 4 154,624,134 - 154,624,425   UniSTS Human Celera Assembly 4 151,948,621 - 151,948,912   RGD Human Genome Assembly Build 36 4 154,843,584 - 154,843,875   RGD Human Cytogenetic Map 4 q32   UniSTS PMC201071P1   Map Chr Position Strand Source Human Genome Assembly HuRef 4 150,331,976 - 150,332,051   UniSTS Human Genome Assembly HuRef 4 150,357,040 - 150,357,115   UniSTS Human Genome Assembly GRCh37 4 154,626,015 - 154,626,090   UniSTS Human Genome Assembly GRCh37 4 154,600,967 - 154,601,042   UniSTS Human Celera Assembly 4 151,950,502 - 151,950,577   UniSTS Human Celera Assembly 4 151,925,453 - 151,925,528   RGD Human Genome Assembly Build 36 4 154,820,417 - 154,820,492   RGD Human Cytogenetic Map 4 q32   UniSTS PMC37511P1   Map Chr Position Strand Source Human Genome Assembly HuRef 4 150,356,738 - 150,357,084   UniSTS Human Genome Assembly GRCh37 4 154,625,713 - 154,626,059   UniSTS Human Celera Assembly 4 151,950,200 - 151,950,546   RGD Human Genome Assembly Build 36 4 154,845,163 - 154,845,509   RGD Human Cytogenetic Map 4 q32   UniSTS PMC55404P2   Map Chr Position Strand Source Human Genome Assembly HuRef 4 150,355,309 - 150,355,564   UniSTS Human Genome Assembly GRCh37 4 154,624,284 - 154,624,539   UniSTS Human Celera Assembly 4 151,948,771 - 151,949,026   RGD Human Genome Assembly Build 36 4 154,843,734 - 154,843,989   RGD Human Cytogenetic Map 4 q32   UniSTS PMC97725P1   Map Chr Position Strand Source Human Genome Assembly HuRef 4 150,357,058 - 150,357,487   UniSTS Human Genome Assembly GRCh37 4 154,626,033 - 154,626,462   UniSTS Human Celera Assembly 4 151,950,520 - 151,950,949   RGD Human Genome Assembly Build 36 4 154,845,483 - 154,845,912   RGD Human Cytogenetic Map 4 q32   UniSTS PMC98129P1   Map Chr Position Strand Source Human Genome Assembly HuRef 4 150,355,275 - 150,355,640   UniSTS Human Genome Assembly GRCh37 4 154,624,250 - 154,624,615   UniSTS Human Celera Assembly 4 151,948,737 - 151,949,102   RGD Human Genome Assembly Build 36 4 154,843,700 - 154,844,065   RGD Human Cytogenetic Map 4 q32   UniSTS PMC98226P1   Map Chr Position Strand Source Human Genome Assembly HuRef 4 150,356,936 - 150,357,413   UniSTS Human Genome Assembly GRCh37 4 154,625,911 - 154,626,388   UniSTS Human Celera Assembly 4 151,950,398 - 151,950,875   RGD Human Genome Assembly Build 36 4 154,845,361 - 154,845,838   RGD Human Cytogenetic Map 4 q32   UniSTS PMC98510P1   Map Chr Position Strand Source Human Genome Assembly HuRef 4 150,357,062 - 150,357,444   UniSTS Human Genome Assembly GRCh37 4 154,626,037 - 154,626,419   UniSTS Human Celera Assembly 4 151,950,524 - 151,950,906   RGD Human Genome Assembly Build 36 4 154,845,487 - 154,845,869   RGD Human Cytogenetic Map 4 q32   UniSTS AF368419   Map Chr Position Strand Source Human Genome Assembly HuRef 4 150,357,236 - 150,357,353   UniSTS Human Genome Assembly GRCh37 4 154,626,211 - 154,626,328   UniSTS Human Celera Assembly 4 151,950,698 - 151,950,815   RGD Human Genome Assembly Build 36 4 154,845,661 - 154,845,778   RGD TLR2_1084.2   Map Chr Position Strand Source Human Genome Assembly HuRef 4 150,356,931 - 150,357,765   UniSTS Human Genome Assembly GRCh37 4 154,625,906 - 154,626,740   UniSTS Human Celera Assembly 4 151,950,393 - 151,951,227   RGD Human Genome Assembly Build 36 4 154,845,356 - 154,846,190   RGD D4S841   Map Chr Position Strand Source Human TNG Radiation Hybrid Map 4 92556.0   UniSTS Human Genome Assembly HuRef 4 150,349,126 - 150,349,294   UniSTS Human Genome Assembly GRCh37 4 154,618,109 - 154,618,277   UniSTS Human Celera Assembly 4 151,942,596 - 151,942,764   RGD Human Genome Assembly Build 36 4 154,837,559 - 154,837,727   RGD Human Cytogenetic Map 4 q32   UniSTS D4S575   Map Chr Position Strand Source Human Genome Assembly HuRef 4 150,349,817 - 150,349,965   UniSTS Human Genome Assembly GRCh37 4 154,618,800 - 154,618,948   UniSTS Human Celera Assembly 4 151,943,287 - 151,943,435   RGD Human Genome Assembly Build 36 4 154,838,250 - 154,838,398   RGD Human Cytogenetic Map 4 q32   UniSTS SHGC4-1535   Map Chr Position Strand Source Human TNG Radiation Hybrid Map 4 92564.0   UniSTS Human Genome Assembly HuRef 4 150,357,553 - 150,357,715   UniSTS Human Genome Assembly GRCh37 4 154,626,528 - 154,626,690   UniSTS Human Celera Assembly 4 151,951,015 - 151,951,177   RGD Human Genome Assembly Build 36 4 154,845,978 - 154,846,140   RGD Human Cytogenetic Map 4 q32   UniSTS SHGC-33147   Map Chr Position Strand Source Human GeneMap99-G3 RH Map 4 8389.0   UniSTS Human Whitehead-RH Map 4 686.3   UniSTS Human GeneMap99-GB4 RH Map 4 638.84   UniSTS Human Stanford-G3 RH Map 4 8464.0   UniSTS Human TNG Radiation Hybrid Map 4 92564.0   UniSTS Human Genome Assembly HuRef 4 150,357,417 - 150,357,566   UniSTS Human Genome Assembly GRCh37 4 154,626,392 - 154,626,541   UniSTS Human Celera Assembly 4 151,950,879 - 151,951,028   RGD Human Genome Assembly Build 36 4 154,845,842 - 154,845,991   RGD Human Cytogenetic Map 4 q32   UniSTS TLR2   Map Chr Position Strand Source Human Genome Assembly HuRef 4 150,357,065 - 150,357,293   UniSTS Human Genome Assembly HuRef 4 150,332,001 - 150,332,229   UniSTS Human Genome Assembly GRCh37 4 154,600,992 - 154,601,220   UniSTS Human Genome Assembly GRCh37 4 154,626,040 - 154,626,268   UniSTS Human Celera Assembly 4 151,925,478 - 151,925,706   UniSTS Human Celera Assembly 4 151,950,527 - 151,950,755   UniSTS QTLs in Region (Human Genome Assembly GRCh37) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 1331636 COPD13_H Chronic obstructive pulmonary disease QTL 13 (human) 1.56 Chronic airflow obstruction post-BD FEV1 minus pre-BD FEV1 4 57681817 183160300 Human 2289563 BW441_H Body weight QTL 441 (human) 2.66 .0005 Body weight BMI 4 99434973 185151317 Human 1559222 SAPOA2_H Serum apolipoprotein A level QTL 2 (human) 2.35 Apolipoprotein level apolipoprotein A-II level 4 108376545 190440336 Human 1643293 BW197_H Body weight QTL 197 (human) 1.71 .002 Body weight BMI 4 128751555 154751555 Human 1643443 SLIPL3_H Serum lipid level QTL 3 (human) 2.07 .001 Lipid level 4 130501052 156501052 Human 1643249 BW135_H Body weight QTL 135 (human) 1.92 Body weight 4 130501052 156501052 Human 1643255 BW128_H Body Weight QTL 128 (human) .88 .022 Body weight body mass index 4 130501052 156501052 Human 1559360 BW79_H Body weight QTL 79 (human) 1.89 .005 Body weight body mass index 4 145336879 171336879 Human 2292886 MYI20_H Myocardial infarction susceptibility QTL 20 (human) Myocardial infarction susceptibility early-onset 4 145336879 171336879 Human 2292901 MYI21_H Myocardial infarction susceptibility QTL 21 (human) Myocardial infarction susceptibility early-onset 4 145336879 171336879 Human 2314741 GLUCO78_H Glucose level QTL 78 (human) .66 .01 Glucose level non-insulin dependent 4 145353344 171353344 Human 1358214 AASTH29_H Allergic/Atopic asthma related QTL 29 (human) 2.12 Serum IgE titer reversible airflow obstruction 4 150391020 176391020 Human Sequence Nucleotide Sequences Nucleotide RefSeqs NG_016229 (Get FASTA) Search GEO for Microarray Profiles   NM_003264 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AB445624 (Get FASTA) Search GEO for Microarray Profiles   ABBA01070142 (Get FASTA) Search GEO for Microarray Profiles   AC106865 (Get FASTA) Search GEO for Microarray Profiles   AF051152 (Get FASTA) Search GEO for Microarray Profiles   AF424049 (Get FASTA) Search GEO for Microarray Profiles   AF502291 (Get FASTA) Search GEO for Microarray Profiles   AK125659 (Get FASTA) Search GEO for Microarray Profiles   AMYH01014629 (Get FASTA) Search GEO for Microarray Profiles   AW614989 (Get FASTA) Search GEO for Microarray Profiles   BC033756 (Get FASTA) Search GEO for Microarray Profiles   BI769109 (Get FASTA) Search GEO for Microarray Profiles   CH471056 (Get FASTA) Search GEO for Microarray Profiles   DQ012265 (Get FASTA) Search GEO for Microarray Profiles   DQ012266 (Get FASTA) Search GEO for Microarray Profiles   DQ012267 (Get FASTA) Search GEO for Microarray Profiles   DQ012268 (Get FASTA) Search GEO for Microarray Profiles   DQ012269 (Get FASTA) Search GEO for Microarray Profiles   DQ012270 (Get FASTA) Search GEO for Microarray Profiles   DQ012271 (Get FASTA) Search GEO for Microarray Profiles   U88878 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_003264 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_003255 Peptide Label: precursor Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 4 154,390,697 - 154,412,500 + NCBI Human Genome Assembly HuRef 4 150,336,457 - 150,358,268 + ENTREZGENE Human Genome Assembly GRCh37 4 154,605,441 - 154,627,243 + ENTREZGENE Human Genome Assembly Build 36 4 154,824,891 - 154,846,693 + NCBI Archive Protein Sequences Protein RefSeqs NP_003255 (Get FASTA) GenBank Protein AAC34133 (Get FASTA)   AAC34377 (Get FASTA)   AAH33756 (Get FASTA)   AAM23001 (Get FASTA)   AAY85644 (Get FASTA)   AAY85645 (Get FASTA)   AAY85646 (Get FASTA)   AAY85647 (Get FASTA)   AAY85648 (Get FASTA)   AAY85649 (Get FASTA)   AAY85650 (Get FASTA)   ABM84931 (Get FASTA)   ABW03649 (Get FASTA)   BAG54231 (Get FASTA)   BAG55021 (Get FASTA)   EAX04952 (Get FASTA)   EAX04953 (Get FASTA)   O60603 (Get FASTA) Promoters RGD ID: 6802742 Promoter ID: HG_KWN:49310 Type: CpG-Island SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: CD4+TCell,   Lymphoblastoid Transcripts: NM_003264,   UC003INO.1,   UC003INP.1,   UC003INR.1 Position: Map Chr Position Strand Source Human Genome Assembly Build 36 4 154,824,694 - 154,825,194 + MPROMDB Additional Information External Database Links Database Acc Id Source(s) COSMIC TLR2 COSMIC Entrez Gene 7097 ENTREZGENE Germonline ENSG00000137462 HGNC ID 11848 ENTREZGENE HomoloGene Group ID 20695 ENTREZGENE HPRD ID 04323 ENTREZGENE InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot   Leu-rich_rpt UniProtKB/Swiss-Prot   Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot   TIR_dom UniProtKB/Swiss-Prot   TLR2 UniProtKB/Swiss-Prot   Toll-like_receptor UniProtKB/Swiss-Prot IPI IPI00019006 UniProtKB/Swiss-Prot KEGG Report hsa:7097 ENTREZGENE, UniProtKB/Swiss-Prot OMIM 114500 OMIM   246300 OMIM   603028 OMIM   607948 OMIM PANTHER PTHR24365:SF17 UniProtKB/Swiss-Prot Pfam TIR UniProtKB/Swiss-Prot PharmGKB PA36550 PharmGKB PIRSF Toll-like_receptor UniProtKB/Swiss-Prot PROSITE LRR UniProtKB/Swiss-Prot   TIR UniProtKB/Swiss-Prot SMART LRR_TYP UniProtKB/Swiss-Prot   LRRCT UniProtKB/Swiss-Prot   TIR UniProtKB/Swiss-Prot Superfamily-SCOP TIR UniProtKB/Swiss-Prot UniGene Hs.519033 ENTREZGENE UniProt B3KWR9_HUMAN UniProtKB/TrEMBL   TLR2_HUMAN UniProtKB/Swiss-Prot Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2011-08-16 TLR2  toll-like receptor 2  TLR2  toll-like receptor 2  Symbol and/or name change 39860 APPROVED

More on TLR2 Entrez Gene Ensembl Gene Genome Browser: (hg18) (hg19) HGNC Report NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 1353654 Created: 2005-03-08 Species: Homo sapiens Last Modified: 2013-04-30 Status: ACTIVE