Gene: CYP1A2 (cytochrome P450, family 1, subfamily A, polypeptide 2)  Homo sapiens
Symbol: CYP1A2
Name: cytochrome P450, family 1, subfamily A, polypeptide 2
Description: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: aryl hydrocarbon hydroxylase; CP12; CYPIA2; cytochrome P(3)450; cytochrome P450 1A2; cytochrome P450 4; cytochrome p450, 1a2; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2; cytochrome P450-P3; dioxin-inducible P3-450; flavoprotein-linked monooxygenase; microsomal monooxygenase; P3-450; P450 form 4; P450(PA); xenobiotic monooxygenase
Orthologs: Mus musculus : Cyp1a2 (cytochrome P450, family 1, subfamily a, polypeptide 2)  MGI
Rattus norvegicus : Cyp1a2 (cytochrome P450, family 1, subfamily a, polypeptide 2)
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_11555,092,226 - 55,099,982+NCBI
Human Genome Assembly HuRef1551,838,984 - 51,846,743+NCBI
Human Genome Assembly GRCh371575,041,184 - 75,048,941+NCBI
Human Genome Assembly Build 361572,828,237 - 72,835,994+NCBI
Human Cytogenetic Map15q24.1 NCBI
Human Genome Assembly1572,828,236 - 72,835,994 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

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