Gene: PARP1 (poly (ADP-ribose) polymerase 1)  Homo sapiens
Symbol: PARP1
Name: poly (ADP-ribose) polymerase 1
Description: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); ADP-ribosyltransferase diphtheria toxin-like 1; ADP-ribosyltransferase NAD(+); ADPRT; ADPRT 1; ADPRT1; ARTD1; NAD(+) ADP-ribosyltransferase 1; OTTHUMP00000035663; pADPRT-1; PARP; PARP-1; poly (ADP-ribose) polymerase family, member 1; poly [ADP-ribose] polymerase 1; poly(ADP-ribose) polymerase; poly(ADP-ribose) synthetase; poly(ADP-ribosyl)transferase; poly[ADP-ribose] synthase 1; PPOL
Orthologs: Mus musculus : Parp1 (poly (ADP-ribose) polymerase family, member 1)  MGI
Rattus norvegicus : Parp1 (poly (ADP-ribose) polymerase 1)
Related Pseudogenes: PARP1P1   PARP1P2  
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_11233,343,826 - 233,391,238-NCBI
Human Genome Assembly HuRef1197,065,678 - 197,113,094-NCBI
Human Genome Assembly GRCh371226,548,392 - 226,595,801-NCBI
Human Genome Assembly Build 361224,615,015 - 224,662,424-NCBI
Human Cytogenetic Map1q41-q42 NCBI
Human Genome Assembly1222,855,240 - 222,902,526 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

Annotation    (Toggle Detail/Summary View)

Disease Annotations
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RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
  
More on PARP1
Entrez Gene
Ensembl Gene
Genome Browser: (hg18) (hg19)
HGNC Report
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 1345118
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2013-04-30
Status: ACTIVE



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