MAP2K5 (mitogen-activated protein kinase kinase 5) - Rat Genome Database

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Gene: MAP2K5 (mitogen-activated protein kinase kinase 5) Homo sapiens
Analyze
Symbol: MAP2K5
Name: mitogen-activated protein kinase kinase 5
RGD ID: 735708
HGNC Page HGNC:6845
Description: Predicted to enable MAP kinase kinase activity. Predicted to be involved in several processes, including negative regulation of apoptotic process; negative regulation of cell migration involved in sprouting angiogenesis; and regulation of gene expression. Predicted to act upstream of or within heart development. Predicted to be located in spindle. Biomarker of prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: dual specificity mitogen-activated protein kinase kinase 5; HsT17454; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAPK/ERK kinase 5; MAPKK 5; MAPKK5; MEK 5; MEK5; PRKMK5
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381567,542,703 - 67,807,114 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1567,542,703 - 67,807,117 (+)EnsemblGRCh38hg38GRCh38
GRCh371567,835,041 - 68,099,452 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361565,622,075 - 65,886,506 (+)NCBINCBI36Build 36hg18NCBI36
Build 341565,719,944 - 65,886,505NCBI
Celera1544,722,555 - 44,987,508 (+)NCBICelera
Cytogenetic Map15q23NCBI
HuRef1544,669,592 - 44,933,408 (+)NCBIHuRef
CHM1_11567,952,970 - 68,217,538 (+)NCBICHM1_1
T2T-CHM13v2.01565,364,709 - 65,628,974 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (EXP)
acetylsalicylic acid  (EXP)
afimoxifene  (EXP)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
arecoline  (ISO)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
butanal  (EXP)
carbamazepine  (EXP)
CGP 52608  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
cis-caffeic acid  (EXP)
clofibrate  (ISO)
clozapine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
dexamethasone  (EXP)
diclofenac  (EXP)
dorsomorphin  (EXP)
fipronil  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
genistein  (ISO)
haloperidol  (ISO)
hesperidin  (EXP)
hydrogen peroxide  (EXP)
indometacin  (EXP)
L-methionine  (ISO)
methamphetamine  (EXP)
methoxychlor  (ISO)
methylmercury chloride  (EXP)
methylseleninic acid  (EXP)
N(4)-hydroxycytidine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
oxaliplatin  (ISO)
oxytocin  (EXP)
paracetamol  (EXP,ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
potassium chromate  (EXP)
resveratrol  (EXP)
rutin  (ISO)
SB 431542  (EXP)
silicon dioxide  (EXP)
sodium arsenate  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
sulfates  (EXP)
tert-butyl hydroperoxide  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (ISO)
topotecan  (ISO)
trans-caffeic acid  (EXP)
troglitazone  (ISO)
undecane  (ISO)
urethane  (EXP)
valproic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
spindle  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion. Mehta PB, etal., Oncogene. 2003 Mar 6;22(9):1381-9.
3. Activated MEK5 induces serial assembly of sarcomeres and eccentric cardiac hypertrophy. Nicol RL, etal., EMBO J. 2001 Jun 1;20(11):2757-67.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Activation of the MEK5/ERK5 cascade is responsible for biliary dysgenesis in a rat model of Caroli's disease. Sato Y, etal., Am J Pathol. 2005 Jan;166(1):49-60.
8. IRAK1 deletion disrupts cardiac Toll/IL-1 signaling and protects against contractile dysfunction. Thomas JA, etal., Am J Physiol Heart Circ Physiol. 2003 Aug;285(2):H597-606.
9. Regulation of cellular functions by the ERK5 signalling pathway. Wang X and Tournier C, Cell Signal. 2006 Jun;18(6):753-60. Epub 2006 Jan 6.
Additional References at PubMed
PMID:7499418   PMID:7759517   PMID:8889548   PMID:9384584   PMID:9790194   PMID:10531364   PMID:10593883   PMID:11073940   PMID:11158308   PMID:11520859   PMID:12219026   PMID:12477932  
PMID:12628002   PMID:12659851   PMID:12813044   PMID:12842996   PMID:14583600   PMID:14702039   PMID:14743216   PMID:15075238   PMID:15378007   PMID:15489334   PMID:15805119   PMID:16728640  
PMID:16730941   PMID:16758967   PMID:16861740   PMID:17474147   PMID:17637780   PMID:17872495   PMID:18071319   PMID:18588859   PMID:19223043   PMID:19279021   PMID:19294699   PMID:19605361  
PMID:19822783   PMID:19903815   PMID:19913121   PMID:20396431   PMID:20551324   PMID:20628086   PMID:20935630   PMID:20936779   PMID:21166929   PMID:21516116   PMID:21767578   PMID:21779176  
PMID:21820407   PMID:21861603   PMID:21873635   PMID:21900206   PMID:21925394   PMID:21988832   PMID:22344219   PMID:22594783   PMID:22658674   PMID:22939624   PMID:23563607   PMID:23950888  
PMID:24205826   PMID:24436253   PMID:24861553   PMID:24975362   PMID:25142570   PMID:25231870   PMID:25241761   PMID:25637721   PMID:25662172   PMID:26498236   PMID:27160304   PMID:27878304  
PMID:28205554   PMID:28319085   PMID:28329290   PMID:28514442   PMID:28540300   PMID:28596290   PMID:29798820   PMID:29892012   PMID:30021884   PMID:30132833   PMID:30442718   PMID:31005259  
PMID:31515488   PMID:31969375   PMID:31980649   PMID:32296183   PMID:32707033   PMID:33232597   PMID:33961781   PMID:34079125   PMID:34108663   PMID:34245854   PMID:34681917   PMID:34857952  
PMID:35713705   PMID:35831314   PMID:36736316   PMID:36968222   PMID:37278562   PMID:37704626  


Genomics

Comparative Map Data
MAP2K5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381567,542,703 - 67,807,114 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1567,542,703 - 67,807,117 (+)EnsemblGRCh38hg38GRCh38
GRCh371567,835,041 - 68,099,452 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361565,622,075 - 65,886,506 (+)NCBINCBI36Build 36hg18NCBI36
Build 341565,719,944 - 65,886,505NCBI
Celera1544,722,555 - 44,987,508 (+)NCBICelera
Cytogenetic Map15q23NCBI
HuRef1544,669,592 - 44,933,408 (+)NCBIHuRef
CHM1_11567,952,970 - 68,217,538 (+)NCBICHM1_1
T2T-CHM13v2.01565,364,709 - 65,628,974 (+)NCBIT2T-CHM13v2.0
Map2k5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39963,071,050 - 63,288,964 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl963,071,050 - 63,285,184 (-)EnsemblGRCm39 Ensembl
GRCm38963,163,768 - 63,381,682 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl963,163,768 - 63,377,902 (-)EnsemblGRCm38mm10GRCm38
MGSCv37963,011,577 - 63,225,659 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36962,961,776 - 63,175,858 (-)NCBIMGSCv36mm8
Celera960,383,063 - 60,597,534 (-)NCBICelera
Cytogenetic Map9B- CNCBI
cM Map933.96NCBI
Map2k5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8872,520,616 - 72,748,395 (-)NCBIGRCr8
mRatBN7.2863,625,220 - 63,852,090 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl863,625,221 - 63,851,983 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx869,140,369 - 69,367,101 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0867,412,831 - 67,639,556 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0865,282,951 - 65,509,687 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0868,055,976 - 68,282,656 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl868,055,972 - 68,282,590 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0867,784,868 - 68,010,809 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4867,313,472 - 67,542,723 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1867,332,521 - 67,559,107 (-)NCBI
Celera863,038,974 - 63,262,592 (-)NCBICelera
Cytogenetic Map8q24NCBI
Map2k5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554508,203,569 - 8,458,258 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554508,207,577 - 8,458,258 (-)NCBIChiLan1.0ChiLan1.0
MAP2K5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21656,797,445 - 57,064,491 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11560,970,950 - 61,238,196 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01546,493,139 - 46,760,271 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11564,761,465 - 65,029,655 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1564,761,394 - 65,029,655 (+)Ensemblpanpan1.1panPan2
MAP2K5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13031,665,032 - 31,920,792 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3031,664,564 - 31,920,751 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3031,599,952 - 31,856,489 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03031,860,861 - 32,117,463 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3031,861,062 - 32,117,422 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13031,790,015 - 32,045,842 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03031,850,721 - 32,107,484 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03032,096,413 - 32,353,048 (+)NCBIUU_Cfam_GSD_1.0
Map2k5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640109,643,236 - 109,880,510 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647127,491,342 - 27,728,607 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647127,491,255 - 27,728,572 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAP2K5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1165,458,258 - 165,740,297 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11165,458,263 - 165,733,452 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21183,148,368 - 183,197,101 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAP2K5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12615,694,760 - 15,956,814 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2615,693,811 - 15,956,918 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048125,513,002 - 125,773,972 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map2k5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247815,224,724 - 5,489,488 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247815,224,722 - 5,489,517 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MAP2K5
32 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_145160.2(MAP2K5):c.1075-4271C>T single nucleotide variant Lung cancer [RCV000099631] Chr15:67743960 [GRCh38]
Chr15:68036298 [GRCh37]
Chr15:15q23		 uncertain significance
GRCh38/hg38 15q22.33-23(chr15:67194581-69086285)x1 copy number loss See cases [RCV000053218] Chr15:67194581..69086285 [GRCh38]
Chr15:67486919..69378625 [GRCh37]
Chr15:65273973..67165679 [NCBI36]
Chr15:15q22.33-23		 pathogenic
GRCh38/hg38 15q22.2-26.3(chr15:59828460-101920998)x3 copy number gain See cases [RCV000142915] Chr15:59828460..101920998 [GRCh38]
Chr15:60120659..102461201 [GRCh37]
Chr15:57907951..100278724 [NCBI36]
Chr15:15q22.2-26.3		 pathogenic
GRCh37/hg19 15q22.31-26.3(chr15:64637227-102509910)x3 copy number gain See cases [RCV000240602] Chr15:64637227..102509910 [GRCh37]
Chr15:15q22.31-26.3		 pathogenic
GRCh37/hg19 15q22.1-26.3(chr15:59297293-102480888)x3 copy number gain not provided [RCV000415836] Chr15:59297293..102480888 [GRCh37]
Chr15:15q22.1-26.3		 likely pathogenic
GRCh37/hg19 15q15.1-26.3(chr15:41745084-102354798)x4 copy number gain See cases [RCV000447123] Chr15:41745084..102354798 [GRCh37]
Chr15:15q15.1-26.3		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:20733395-102511616)x4 copy number gain See cases [RCV000447765] Chr15:20733395..102511616 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)x3 copy number gain See cases [RCV000510717] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112) copy number gain See cases [RCV000512019] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
Single allele duplication not provided [RCV000677926] Chr15:31115047..102354857 [GRCh37]
Chr15:15q13.2-26.3		 pathogenic
GRCh37/hg19 15q22.31-23(chr15:66861081-69213575)x1 copy number loss not provided [RCV000683701] Chr15:66861081..69213575 [GRCh37]
Chr15:15q22.31-23		 pathogenic
GRCh37/hg19 15q23(chr15:67787064-67885311)x0 copy number loss not provided [RCV000738807] Chr15:67787064..67885311 [GRCh37]
Chr15:15q23		 benign
GRCh37/hg19 15q23(chr15:67819115-67869147)x0 copy number loss not provided [RCV000738808] Chr15:67819115..67869147 [GRCh37]
Chr15:15q23		 benign
GRCh37/hg19 15q23(chr15:67852405-67869147)x1 copy number loss not provided [RCV000738809] Chr15:67852405..67869147 [GRCh37]
Chr15:15q23		 benign
GRCh37/hg19 15q23(chr15:67868647-67869147)x1 copy number loss not provided [RCV000738810] Chr15:67868647..67869147 [GRCh37]
Chr15:15q23		 benign
GRCh37/hg19 15q11.1-26.3(chr15:20016811-102493540)x3 copy number gain not provided [RCV000751155] Chr15:20016811..102493540 [GRCh37]
Chr15:15q11.1-26.3		 pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20071673-102461162)x3 copy number gain not provided [RCV000751156] Chr15:20071673..102461162 [GRCh37]
Chr15:15q11.1-26.3		 pathogenic
NM_145160.3(MAP2K5):c.469G>A (p.Ala157Thr) single nucleotide variant Inborn genetic diseases [RCV003244030] Chr15:67592963 [GRCh38]
Chr15:67885301 [GRCh37]
Chr15:15q23		 uncertain significance
NM_145160.3(MAP2K5):c.849C>T (p.Asp283=) single nucleotide variant not provided [RCV000880002] Chr15:67692480 [GRCh38]
Chr15:67984818 [GRCh37]
Chr15:15q23		 benign
NM_145160.3(MAP2K5):c.184+7C>T single nucleotide variant not provided [RCV000908486] Chr15:67550089 [GRCh38]
Chr15:67842427 [GRCh37]
Chr15:15q23		 benign
GRCh37/hg19 15q22.33-23(chr15:67369118-70481307)x1 copy number loss not provided [RCV000846047] Chr15:67369118..70481307 [GRCh37]
Chr15:15q22.33-23		 pathogenic
GRCh37/hg19 15q22.31-23(chr15:67172682-68053940)x1 copy number loss not provided [RCV001006705] Chr15:67172682..68053940 [GRCh37]
Chr15:15q22.31-23		 pathogenic
NM_145160.3(MAP2K5):c.586-8A>G single nucleotide variant not provided [RCV000957308] Chr15:67646223 [GRCh38]
Chr15:67938561 [GRCh37]
Chr15:15q23		 benign
NC_000015.9:g.(?_32964879)_(91358519_?)dup duplication Bloom syndrome [RCV001343104]|Familial colorectal cancer [RCV001325176] Chr15:32964879..91358519 [GRCh37]
Chr15:15q13.3-26.1		 uncertain significance
NC_000015.9:g.(?_66161924)_(69018313_?)dup duplication Neuronal ceroid lipofuscinosis [RCV003120802]|not provided [RCV002045713] Chr15:66161924..69018313 [GRCh37]
Chr15:15q22.31-23		 uncertain significance|no classifications from unflagged records
NM_145160.3(MAP2K5):c.797C>T (p.Ala266Val) single nucleotide variant Inborn genetic diseases [RCV002906688] Chr15:67658613 [GRCh38]
Chr15:67950951 [GRCh37]
Chr15:15q23		 uncertain significance
NM_145160.3(MAP2K5):c.373C>T (p.Arg125Trp) single nucleotide variant Inborn genetic diseases [RCV002992515] Chr15:67586855 [GRCh38]
Chr15:67879193 [GRCh37]
Chr15:15q23		 uncertain significance
NM_145160.3(MAP2K5):c.1331A>G (p.Gln444Arg) single nucleotide variant Inborn genetic diseases [RCV002934808] Chr15:67806734 [GRCh38]
Chr15:68099072 [GRCh37]
Chr15:15q23		 uncertain significance
NM_145160.3(MAP2K5):c.755A>G (p.Tyr252Cys) single nucleotide variant Inborn genetic diseases [RCV002896361] Chr15:67658571 [GRCh38]
Chr15:67950909 [GRCh37]
Chr15:15q23		 uncertain significance
NM_145160.3(MAP2K5):c.670A>G (p.Ile224Val) single nucleotide variant Inborn genetic diseases [RCV003254348] Chr15:67646403 [GRCh38]
Chr15:67938741 [GRCh37]
Chr15:15q23		 uncertain significance
GRCh37/hg19 15q22.33-26.1(chr15:67358491-91644328)x3 copy number gain not provided [RCV003222839] Chr15:67358491..91644328 [GRCh37]
Chr15:15q22.33-26.1		 pathogenic
NM_145160.3(MAP2K5):c.1037T>C (p.Phe346Ser) single nucleotide variant Inborn genetic diseases [RCV003266001] Chr15:67703401 [GRCh38]
Chr15:67995739 [GRCh37]
Chr15:15q23		 uncertain significance
GRCh37/hg19 15q23(chr15:67881929-68241646)x1 copy number loss not provided [RCV003483237] Chr15:67881929..68241646 [GRCh37]
Chr15:15q23		 uncertain significance
NM_145160.3(MAP2K5):c.1074+1G>A single nucleotide variant not provided [RCV003887767] Chr15:67727946 [GRCh38]
Chr15:68020284 [GRCh37]
Chr15:15q23		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2763
Count of miRNA genes:818
Interacting mature miRNAs:953
Transcripts:ENST00000178640, ENST00000340972, ENST00000354498, ENST00000395476, ENST00000439036, ENST00000557869, ENST00000558021, ENST00000558274, ENST00000558392, ENST00000559262, ENST00000560086, ENST00000560591
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D15S1015  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371567,839,381 - 67,839,471UniSTSGRCh37
Build 361565,626,435 - 65,626,525RGDNCBI36
Celera1544,726,915 - 44,727,005RGD
Cytogenetic Map15q23UniSTS
HuRef1544,673,931 - 44,674,035UniSTS
Marshfield Genetic Map1566.9UniSTS
Marshfield Genetic Map1566.9RGD
Genethon Genetic Map1566.4UniSTS
Stanford-G3 RH Map152172.0UniSTS
GeneMap99-GB4 RH Map15232.98UniSTS
Whitehead-YAC Contig Map15 UniSTS
NCBI RH Map15421.0UniSTS
GeneMap99-G3 RH Map152167.0UniSTS
D15S1242  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371567,903,729 - 67,903,849UniSTSGRCh37
Build 361565,690,783 - 65,690,903RGDNCBI36
Celera1544,791,064 - 44,791,184RGD
Cytogenetic Map15q23UniSTS
HuRef1544,737,930 - 44,738,050UniSTS
Stanford-G3 RH Map152271.0UniSTS
NCBI RH Map15408.6UniSTS
RH102019  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371568,054,207 - 68,054,396UniSTSGRCh37
Build 361565,841,261 - 65,841,450RGDNCBI36
Celera1544,942,330 - 44,942,519RGD
Cytogenetic Map15q23UniSTS
HuRef1544,888,226 - 44,888,415UniSTS
GeneMap99-GB4 RH Map15230.25UniSTS
G63218  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371568,016,011 - 68,016,284UniSTSGRCh37
Build 361565,803,065 - 65,803,338RGDNCBI36
Celera1544,904,133 - 44,904,406RGD
Cytogenetic Map15q23UniSTS
HuRef1544,850,088 - 44,850,361UniSTS
TNG Radiation Hybrid Map1526078.0UniSTS
SHGC-147756  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371568,054,460 - 68,054,769UniSTSGRCh37
Build 361565,841,514 - 65,841,823RGDNCBI36
Celera1544,942,583 - 44,942,892RGD
Cytogenetic Map15q23UniSTS
HuRef1544,888,479 - 44,888,788UniSTS
TNG Radiation Hybrid Map1526138.0UniSTS
SHGC-156118  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371567,840,277 - 67,840,620UniSTSGRCh37
Build 361565,627,331 - 65,627,674RGDNCBI36
Celera1544,727,811 - 44,728,154RGD
Cytogenetic Map15q23UniSTS
HuRef1544,674,713 - 44,675,056UniSTS
TNG Radiation Hybrid Map1524957.0UniSTS
SHGC-172623  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371568,030,948 - 68,031,258UniSTSGRCh37
Build 361565,818,002 - 65,818,312RGDNCBI36
Celera1544,919,071 - 44,919,381RGD
Cytogenetic Map15q23UniSTS
HuRef1544,865,026 - 44,865,336UniSTS
TNG Radiation Hybrid Map1526112.0UniSTS
BCD1447  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371567,947,533 - 67,947,626UniSTSGRCh37
Build 361565,734,587 - 65,734,680RGDNCBI36
Celera1544,835,615 - 44,835,708RGD
Cytogenetic Map15q23UniSTS
HuRef1544,781,672 - 44,781,765UniSTS
GeneMap99-GB4 RH Map15236.81UniSTS
D15S1220  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371567,934,270 - 67,934,426UniSTSGRCh37
Build 361565,721,324 - 65,721,480RGDNCBI36
Celera1544,822,364 - 44,822,520RGD
Cytogenetic Map15q23UniSTS
HuRef1544,768,421 - 44,768,577UniSTS
Whitehead-RH Map15226.7UniSTS
Whitehead-YAC Contig Map15 UniSTS
SHGC-34905  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371568,086,853 - 68,086,953UniSTSGRCh37
Build 361565,873,907 - 65,874,007RGDNCBI36
Celera1544,974,911 - 44,975,011RGD
Cytogenetic Map15q23UniSTS
HuRef1544,920,808 - 44,920,908UniSTS
Stanford-G3 RH Map152207.0UniSTS
GeneMap99-GB4 RH Map15230.25UniSTS
Whitehead-RH Map15231.7UniSTS
NCBI RH Map15417.7UniSTS
GeneMap99-G3 RH Map152202.0UniSTS
STS-H66629  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371568,086,780 - 68,086,951UniSTSGRCh37
Build 361565,873,834 - 65,874,005RGDNCBI36
Celera1544,974,838 - 44,975,009RGD
Cytogenetic Map15q23UniSTS
HuRef1544,920,735 - 44,920,906UniSTS
GeneMap99-GB4 RH Map15232.98UniSTS
AFM276YB5  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371567,882,082 - 67,882,184UniSTSGRCh37
Build 361565,669,136 - 65,669,238RGDNCBI36
Celera1544,769,623 - 44,769,721RGD
Cytogenetic Map15q23UniSTS
HuRef1544,716,527 - 44,716,625UniSTS
Whitehead-YAC Contig Map15 UniSTS
RH67871  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371568,099,291 - 68,099,422UniSTSGRCh37
Build 361565,886,345 - 65,886,476RGDNCBI36
Celera1544,987,347 - 44,987,478RGD
Cytogenetic Map15q23UniSTS
HuRef1544,933,244 - 44,933,375UniSTS
GeneMap99-GB4 RH Map15234.89UniSTS
MARC_7855-7856:996688103:1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371567,984,859 - 67,985,889UniSTSGRCh37
Build 361565,771,913 - 65,772,943RGDNCBI36
Celera1544,872,996 - 44,874,026RGD
HuRef1544,819,039 - 44,820,069UniSTS
WI-19238  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15q23UniSTS
GeneMap99-GB4 RH Map15232.07UniSTS
Whitehead-RH Map15228.4UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1293 1031 851 70 732 38 3299 886 1862 171 1116 963 38 753 2036 3
Low 1143 1948 874 553 1211 427 1057 1307 1864 247 341 647 135 451 752 1 1
Below cutoff 2 11 1 7 2 8 1 3 3 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001206804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_145160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011521787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011521788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017022414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_024449988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047432856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378445 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378447 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001751355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007064474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_008488992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC009292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC016355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC103753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK024766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK057521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK293459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK315435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI460343 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM682675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT006780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DN998338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HH961878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF456084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U71087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U71088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000178640   ⟹   ENSP00000178640
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1567,542,703 - 67,807,114 (+)Ensembl
RefSeq Acc Id: ENST00000340972   ⟹   ENSP00000342101
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1567,640,553 - 67,807,113 (+)Ensembl
RefSeq Acc Id: ENST00000354498   ⟹   ENSP00000346493
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1567,548,998 - 67,807,111 (+)Ensembl
RefSeq Acc Id: ENST00000395476   ⟹   ENSP00000378859
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1567,543,331 - 67,807,117 (+)Ensembl
RefSeq Acc Id: ENST00000439036   ⟹   ENSP00000390196
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1567,563,300 - 67,641,489 (+)Ensembl
RefSeq Acc Id: ENST00000557869   ⟹   ENSP00000483771
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1567,703,358 - 67,769,929 (+)Ensembl
RefSeq Acc Id: ENST00000558021
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1567,748,368 - 67,769,905 (+)Ensembl
RefSeq Acc Id: ENST00000558274
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1567,717,997 - 67,806,732 (+)Ensembl
RefSeq Acc Id: ENST00000558392
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1567,585,742 - 67,807,083 (+)Ensembl
RefSeq Acc Id: ENST00000559262   ⟹   ENSP00000480580
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1567,585,890 - 67,679,956 (+)Ensembl
RefSeq Acc Id: ENST00000560086
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1567,546,153 - 67,550,075 (+)Ensembl
RefSeq Acc Id: ENST00000560591
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1567,543,263 - 67,659,356 (+)Ensembl
RefSeq Acc Id: NM_001206804   ⟹   NP_001193733
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381567,549,094 - 67,807,114 (+)NCBI
GRCh371567,835,021 - 68,099,455 (+)ENTREZGENE
HuRef1544,669,592 - 44,933,408 (+)ENTREZGENE
CHM1_11567,959,291 - 68,217,538 (+)NCBI
T2T-CHM13v2.01565,371,112 - 65,628,974 (+)NCBI
Sequence:
RefSeq Acc Id: NM_002757   ⟹   NP_002748
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381567,542,703 - 67,807,114 (+)NCBI
GRCh371567,835,021 - 68,099,455 (+)ENTREZGENE
Build 361565,622,075 - 65,886,506 (+)NCBI Archive
HuRef1544,669,592 - 44,933,408 (+)ENTREZGENE
CHM1_11567,952,970 - 68,217,538 (+)NCBI
T2T-CHM13v2.01565,364,709 - 65,628,974 (+)NCBI
Sequence:
RefSeq Acc Id: NM_145160   ⟹   NP_660143
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381567,542,703 - 67,807,114 (+)NCBI
GRCh371567,835,021 - 68,099,455 (+)ENTREZGENE
Build 361565,622,075 - 65,886,506 (+)NCBI Archive
HuRef1544,669,592 - 44,933,408 (+)ENTREZGENE
CHM1_11567,952,970 - 68,217,538 (+)NCBI
T2T-CHM13v2.01565,364,709 - 65,628,974 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011521787   ⟹   XP_011520089
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381567,542,703 - 67,679,689 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011521788   ⟹   XP_011520090
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381567,542,703 - 67,682,123 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017022414   ⟹   XP_016877903
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381567,542,703 - 67,664,282 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047432856   ⟹   XP_047288812
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381567,549,094 - 67,682,123 (+)NCBI
RefSeq Acc Id: XM_054378445   ⟹   XP_054234420
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01565,364,709 - 65,501,675 (+)NCBI
RefSeq Acc Id: XM_054378446   ⟹   XP_054234421
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01565,364,709 - 65,504,218 (+)NCBI
RefSeq Acc Id: XM_054378447   ⟹   XP_054234422
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01565,364,709 - 65,486,264 (+)NCBI
RefSeq Acc Id: XM_054378448   ⟹   XP_054234423
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01565,371,112 - 65,504,220 (+)NCBI
RefSeq Acc Id: XR_007064474
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381567,542,703 - 67,693,560 (+)NCBI
RefSeq Acc Id: XR_008488992
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01565,364,709 - 65,515,533 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001193733 (Get FASTA)   NCBI Sequence Viewer  
  NP_002748 (Get FASTA)   NCBI Sequence Viewer  
  NP_660143 (Get FASTA)   NCBI Sequence Viewer  
  XP_011520089 (Get FASTA)   NCBI Sequence Viewer  
  XP_011520090 (Get FASTA)   NCBI Sequence Viewer  
  XP_016877903 (Get FASTA)   NCBI Sequence Viewer  
  XP_047288812 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234420 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234421 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234422 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234423 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB16851 (Get FASTA)   NCBI Sequence Viewer  
  AAB16852 (Get FASTA)   NCBI Sequence Viewer  
  AAH08838 (Get FASTA)   NCBI Sequence Viewer  
  AAP35426 (Get FASTA)   NCBI Sequence Viewer  
  BAG37823 (Get FASTA)   NCBI Sequence Viewer  
  BAG51927 (Get FASTA)   NCBI Sequence Viewer  
  BAG56954 (Get FASTA)   NCBI Sequence Viewer  
  CAG47025 (Get FASTA)   NCBI Sequence Viewer  
  CBX51412 (Get FASTA)   NCBI Sequence Viewer  
  EAW77799 (Get FASTA)   NCBI Sequence Viewer  
  EAW77800 (Get FASTA)   NCBI Sequence Viewer  
  EAW77801 (Get FASTA)   NCBI Sequence Viewer  
  EAW77802 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000178640
  ENSP00000178640.5
  ENSP00000342101.4
  ENSP00000346493
  ENSP00000346493.5
  ENSP00000378859
  ENSP00000378859.2
  ENSP00000390196.1
  ENSP00000480580.1
  ENSP00000483771.1
GenBank Protein Q13163 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_660143   ⟸   NM_145160
- Peptide Label: isoform A
- UniProtKB: Q92961 (UniProtKB/Swiss-Prot),   B4DE43 (UniProtKB/Swiss-Prot),   Q92962 (UniProtKB/Swiss-Prot),   Q13163 (UniProtKB/Swiss-Prot),   B2RD76 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_002748   ⟸   NM_002757
- Peptide Label: isoform B
- UniProtKB: B2RD76 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001193733   ⟸   NM_001206804
- Peptide Label: isoform C
- UniProtKB: B2RD76 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011520090   ⟸   XM_011521788
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_011520089   ⟸   XM_011521787
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_016877903   ⟸   XM_017022414
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSP00000390196   ⟸   ENST00000439036
RefSeq Acc Id: ENSP00000483771   ⟸   ENST00000557869
RefSeq Acc Id: ENSP00000480580   ⟸   ENST00000559262
RefSeq Acc Id: ENSP00000178640   ⟸   ENST00000178640
RefSeq Acc Id: ENSP00000346493   ⟸   ENST00000354498
RefSeq Acc Id: ENSP00000342101   ⟸   ENST00000340972
RefSeq Acc Id: ENSP00000378859   ⟸   ENST00000395476
RefSeq Acc Id: XP_047288812   ⟸   XM_047432856
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054234421   ⟸   XM_054378446
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054234420   ⟸   XM_054378445
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054234422   ⟸   XM_054378447
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054234423   ⟸   XM_054378448
- Peptide Label: isoform X4
Protein Domains
PB1   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q13163-F1-model_v2 AlphaFold Q13163 1-448 view protein structure

Promoters
RGD ID:6792247
Promoter ID:HG_KWN:21733
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000354498,   NM_002757,   OTTHUMT00000257041,   UC002AQT.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361565,621,296 - 65,622,812 (+)MPROMDB
RGD ID:7229907
Promoter ID:EPDNEW_H20699
Type:initiation region
Name:MAP2K5_2
Description:mitogen-activated protein kinase kinase 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20700  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381567,541,658 - 67,541,718EPDNEW
RGD ID:7229909
Promoter ID:EPDNEW_H20700
Type:initiation region
Name:MAP2K5_1
Description:mitogen-activated protein kinase kinase 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20699  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381567,542,715 - 67,542,775EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6845 AgrOrtholog
COSMIC MAP2K5 COSMIC
Ensembl Genes ENSG00000137764 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000178640 ENTREZGENE
  ENST00000178640.10 UniProtKB/Swiss-Prot
  ENST00000340972.8 UniProtKB/TrEMBL
  ENST00000354498 ENTREZGENE
  ENST00000354498.9 UniProtKB/Swiss-Prot
  ENST00000395476 ENTREZGENE
  ENST00000395476.6 UniProtKB/Swiss-Prot
  ENST00000439036.5 UniProtKB/TrEMBL
  ENST00000557869.2 UniProtKB/TrEMBL
  ENST00000559262.5 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000137764 GTEx
HGNC ID HGNC:6845 ENTREZGENE
Human Proteome Map MAP2K5 Human Proteome Map
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PB1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PB1_MAP2K5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5607 UniProtKB/Swiss-Prot
NCBI Gene 5607 ENTREZGENE
OMIM 602520 OMIM
PANTHER DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30590 PharmGKB
PROSITE PB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PB1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP CAD & PB1 domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087WWX7_HUMAN UniProtKB/TrEMBL
  A0A087X0Z8_HUMAN UniProtKB/TrEMBL
  A6NK28_HUMAN UniProtKB/TrEMBL
  B2RD76 ENTREZGENE, UniProtKB/TrEMBL
  B4DE43 ENTREZGENE
  H7BZL1_HUMAN UniProtKB/TrEMBL
  MP2K5_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q92961 ENTREZGENE
  Q92962 ENTREZGENE
UniProt Secondary B4DE43 UniProtKB/Swiss-Prot
  Q92961 UniProtKB/Swiss-Prot
  Q92962 UniProtKB/Swiss-Prot