MMP8 (matrix metallopeptidase 8) - Rat Genome Database

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Gene: MMP8 (matrix metallopeptidase 8) Homo sapiens
Analyze
Symbol: MMP8
Name: matrix metallopeptidase 8
RGD ID: 1351878
HGNC Page HGNC:7175
Description: Enables serine-type endopeptidase activity and tumor necrosis factor binding activity. Involved in endodermal cell differentiation; positive regulation of tumor necrosis factor production; and proteolysis. Located in extracellular space. Implicated in breast cancer and carotid artery disease. Biomarker of COVID-19; aortic aneurysm (multiple); arthritis (multiple); breast cancer; and female reproductive organ cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CLG1; collagenase 2; HNC; matrix metalloproteinase 8 (neutrophil collagenase); matrix metalloproteinase-8; MMP-8; neutrophil collagenase; PMN leukocyte collagenase; PMNL collagenase; PMNL-CL
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,711,796 - 102,724,954 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,711,796 - 102,727,050 (-)EnsemblGRCh38hg38GRCh38
GRCh3711102,582,527 - 102,595,685 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611102,088,540 - 102,100,868 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411102,088,539 - 102,100,868NCBI
Celera1199,743,725 - 99,756,878 (-)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,509,472 - 98,522,626 (-)NCBIHuRef
CHM1_111102,465,498 - 102,478,648 (-)NCBICHM1_1
T2T-CHM13v2.011102,713,966 - 102,727,115 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
1,10-phenanthroline  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3-hydroxypicolinic acid  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
all-trans-retinoic acid  (EXP)
aluminium oxide  (EXP)
ammonium chloride  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
calcitriol  (EXP)
carbon nanotube  (ISO)
carvedilol  (ISO)
CGP 52608  (EXP)
chlordecone  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cyclophosphamide  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzofurans  (ISO)
diclofenac  (ISO)
dieckol  (EXP)
dioxygen  (ISO)
doxycycline  (EXP)
ethyl methanesulfonate  (EXP)
ethylenediaminetetraacetic acid  (EXP)
fasudil  (ISO)
fentin chloride  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
genistein  (ISO)
graphene oxide  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (EXP)
megestrol acetate  (ISO)
metacetamol  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorohexanesulfonic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
pioglitazone  (ISO)
pirinixic acid  (ISO)
prinomastat  (EXP)
progesterone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetracycline  (EXP)
tetraphene  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
XL147  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Identification of new therapeutic targets by genome-wide analysis of gene expression in the ipsilateral cortex of aged rats after stroke. Buga AM, etal., PLoS One. 2012;7(12):e50985. doi: 10.1371/journal.pone.0050985. Epub 2012 Dec 12.
2. Plasma MMP1 and MMP8 expression in breast cancer: protective role of MMP8 against lymph node metastasis. Decock J, etal., BMC Cancer. 2008 Mar 20;8:77.
3. Association of matrix metalloproteinase-8 gene variation with breast cancer prognosis. Decock J, etal., Cancer Res. 2007 Nov 1;67(21):10214-21.
4. Inflammation Profiling of Critically Ill Coronavirus Disease 2019 Patients. Fraser DD, etal., Crit Care Explor. 2020 Jun 22;2(6):e0144. doi: 10.1097/CCE.0000000000000144. eCollection 2020 Jun.
5. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
6. Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome. Ikonomidis JS, etal., Circulation. 2006 Jul 4;114(1 Suppl):I365-70.
7. Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat. Peterson JT, etal., Cardiovasc Res. 2000 May;46(2):307-15.
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Matrix metalloproteinase 2 is associated with stable and matrix metalloproteinases 8 and 9 with vulnerable carotid atherosclerotic lesions: a study in human endarterectomy specimen pointing to a role for different extracellular matrix metalloproteinase inducer glycosylation forms. Sluijter JP, etal., Stroke. 2006 Jan;37(1):235-9. Epub 2005 Dec 8.
11. Cytokine-regulated expression of collagenase-2 (MMP-8) is involved in the progression of ovarian cancer. Stadlmann S, etal., Eur J Cancer. 2003 Nov;39(17):2499-505.
12. MMP profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis. Tchetverikov I, etal., Ann Rheum Dis. 2004 Jul;63(7):881-3.
13. Enhanced production and activation of matrix metalloproteinase-7 (matrilysin) in human endometrial carcinomas. Ueno H, etal., Int J Cancer. 1999 Oct 22;84(5):470-7.
14. Matrix metalloproteinase-8 and -9 are increased at the site of abdominal aortic aneurysm rupture. Wilson WR, etal., Circulation. 2006 Jan 24;113(3):438-45.
Additional References at PubMed
PMID:1330697   PMID:1646048   PMID:1662606   PMID:2159879   PMID:2164002   PMID:2169256   PMID:2169766   PMID:2176876   PMID:7656015   PMID:7998967   PMID:8137810   PMID:8216228  
PMID:8307185   PMID:8631924   PMID:8639592   PMID:8921407   PMID:9042108   PMID:9249047   PMID:9578462   PMID:9655333   PMID:9688535   PMID:9737711   PMID:10353844   PMID:10419448  
PMID:10859319   PMID:10922468   PMID:10949161   PMID:10986281   PMID:11329013   PMID:11400153   PMID:11731274   PMID:12054629   PMID:12101112   PMID:12117418   PMID:12149192   PMID:12477932  
PMID:14550288   PMID:15042023   PMID:15187163   PMID:15367487   PMID:15489334   PMID:15661397   PMID:15888067   PMID:16134994   PMID:16192646   PMID:16242329   PMID:16259988   PMID:16872847  
PMID:16877349   PMID:16928431   PMID:16940985   PMID:17178858   PMID:17418871   PMID:17473191   PMID:17567680   PMID:17584650   PMID:17728507   PMID:17932311   PMID:18278188   PMID:18428024  
PMID:18626311   PMID:18700005   PMID:18768525   PMID:18818748   PMID:18980523   PMID:19019335   PMID:19064570   PMID:19074885   PMID:19094243   PMID:19124506   PMID:19159011   PMID:19180518  
PMID:19330028   PMID:19358835   PMID:19442604   PMID:19460733   PMID:19527514   PMID:19674746   PMID:19708869   PMID:19745165   PMID:19751716   PMID:19834535   PMID:19880617   PMID:19913121  
PMID:19995403   PMID:20042585   PMID:20140262   PMID:20184870   PMID:20356362   PMID:20371206   PMID:20442866   PMID:20452482   PMID:20453486   PMID:20484597   PMID:20485444   PMID:20587546  
PMID:20621951   PMID:20626027   PMID:20628086   PMID:20659259   PMID:20673868   PMID:20708200   PMID:20809029   PMID:20889295   PMID:21048031   PMID:21196908   PMID:21432777   PMID:21437624  
PMID:21515330   PMID:21642878   PMID:21697883   PMID:21784671   PMID:21857935   PMID:21872914   PMID:21873635   PMID:21906737   PMID:21920499   PMID:21925226   PMID:21994255   PMID:22092455  
PMID:22113040   PMID:22179173   PMID:22257687   PMID:22311494   PMID:22382449   PMID:22487237   PMID:22808470   PMID:23054081   PMID:23154389   PMID:23259856   PMID:23313321   PMID:23442769  
PMID:23512982   PMID:23535732   PMID:23632023   PMID:23845380   PMID:23851508   PMID:23851938   PMID:23865360   PMID:23953866   PMID:23962148   PMID:23967183   PMID:24065531   PMID:24099107  
PMID:24164993   PMID:24170307   PMID:24267248   PMID:24283658   PMID:24651234   PMID:24784232   PMID:24828408   PMID:25016699   PMID:25034366   PMID:25049354   PMID:25087078   PMID:25109362  
PMID:25319807   PMID:25545245   PMID:25550459   PMID:25607396   PMID:25633268   PMID:25635689   PMID:25712810   PMID:25841875   PMID:26132583   PMID:26339374   PMID:26418236   PMID:26462905  
PMID:26492282   PMID:26577236   PMID:26773532   PMID:26872724   PMID:26898119   PMID:26923392   PMID:27296149   PMID:27313452   PMID:27377304   PMID:27442388   PMID:27503909   PMID:27561093  
PMID:27579896   PMID:27631232   PMID:27797337   PMID:27843200   PMID:28278213   PMID:28283184   PMID:28330493   PMID:28344315   PMID:28423488   PMID:28445942   PMID:28652424   PMID:28734574  
PMID:28745526   PMID:28772283   PMID:29078079   PMID:29102926   PMID:29212897   PMID:29215835   PMID:29263043   PMID:29275297   PMID:29292194   PMID:29453088   PMID:29532899   PMID:29564945  
PMID:29599337   PMID:29808017   PMID:29929486   PMID:29987050   PMID:30170451   PMID:30192205   PMID:30194163   PMID:30194384   PMID:30300896   PMID:30313082   PMID:30328228   PMID:30626536  
PMID:30755371   PMID:31067818   PMID:31263835   PMID:31444693   PMID:31590330   PMID:31638929   PMID:31771979   PMID:31881666   PMID:32108279   PMID:32234890   PMID:32790178   PMID:32801681  
PMID:32818670   PMID:32944879   PMID:33143325   PMID:33219886   PMID:33275619   PMID:33275641   PMID:33375174   PMID:33556788   PMID:33556789   PMID:33567492   PMID:33894037   PMID:33902302  
PMID:33961781   PMID:34043679   PMID:34353321   PMID:34419758   PMID:34448550   PMID:34550870   PMID:34571507   PMID:34800007   PMID:34857952   PMID:35163727   PMID:35328734   PMID:35329310  
PMID:35769040   PMID:36040233   PMID:36273042   PMID:36282475   PMID:36438922   PMID:37877535   PMID:38031100   PMID:38326622   PMID:38419037   PMID:38433295  


Genomics

Comparative Map Data
MMP8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811102,711,796 - 102,724,954 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11102,711,796 - 102,727,050 (-)EnsemblGRCh38hg38GRCh38
GRCh3711102,582,527 - 102,595,685 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611102,088,540 - 102,100,868 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411102,088,539 - 102,100,868NCBI
Celera1199,743,725 - 99,756,878 (-)NCBICelera
Cytogenetic Map11q22.2NCBI
HuRef1198,509,472 - 98,522,626 (-)NCBIHuRef
CHM1_111102,465,498 - 102,478,648 (-)NCBICHM1_1
T2T-CHM13v2.011102,713,966 - 102,727,115 (-)NCBIT2T-CHM13v2.0
Mmp8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3997,558,430 - 7,568,487 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl97,558,457 - 7,568,486 (+)EnsemblGRCm39 Ensembl
GRCm3897,558,429 - 7,568,486 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl97,558,456 - 7,568,485 (+)EnsemblGRCm38mm10GRCm38
MGSCv3797,558,429 - 7,568,486 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3697,558,460 - 7,568,485 (+)NCBIMGSCv36mm8
Celera94,948,941 - 4,958,998 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
Mmp8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8813,008,873 - 13,018,729 (+)NCBIGRCr8
mRatBN7.284,724,009 - 4,733,864 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl84,724,029 - 4,733,520 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx88,683,788 - 8,692,660 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.086,981,565 - 6,990,437 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.084,983,774 - 4,992,630 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.085,768,808 - 5,777,741 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl85,768,811 - 5,778,702 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.085,771,659 - 5,780,576 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.484,402,124 - 4,410,976 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.184,402,123 - 4,410,976 (+)NCBI
Celera86,283,716 - 6,292,568 (+)NCBICelera
Cytogenetic Map8q11NCBI
Mmp8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554125,928,997 - 5,939,012 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554125,928,997 - 5,939,012 (-)NCBIChiLan1.0ChiLan1.0
MMP8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29103,503,121 - 103,516,444 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111104,591,436 - 104,604,786 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01197,650,408 - 97,663,731 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111101,143,372 - 101,156,695 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11101,143,268 - 101,156,736 (-)Ensemblpanpan1.1panPan2
MMP8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1529,036,381 - 29,047,180 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl529,035,820 - 29,046,808 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha528,984,875 - 28,995,648 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0529,087,831 - 29,098,581 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl529,087,795 - 29,098,209 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1529,122,825 - 29,133,583 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0529,002,064 - 29,012,820 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0529,177,264 - 29,188,014 (+)NCBIUU_Cfam_GSD_1.0
Mmp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494786,297,496 - 86,305,565 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365515,228,950 - 5,238,948 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365515,228,950 - 5,238,948 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl933,384,033 - 33,396,947 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1933,384,034 - 33,397,637 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2937,330,738 - 37,343,699 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MMP8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1194,097,620 - 94,110,114 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl194,097,896 - 94,109,432 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604331,764,839 - 31,777,953 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624878164,171 - 175,654 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624878124,396 - 174,584 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MMP8
36 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
MMP8, HAPLOTYPE, TGG single nucleotide variant Preterm premature rupture of membranes [RCV000018648] Chr11:11q21-q22 pathogenic
GRCh38/hg38 11q14.1-22.3(chr11:78232836-106779420)x1 copy number loss See cases [RCV000052710] Chr11:78232836..106779420 [GRCh38]
Chr11:77943882..106650146 [GRCh37]
Chr11:77621530..106155356 [NCBI36]
Chr11:11q14.1-22.3		 pathogenic
GRCh38/hg38 11q14.1-22.2(chr11:85242847-102920097)x1 copy number loss See cases [RCV000052711] Chr11:85242847..102920097 [GRCh38]
Chr11:84953891..102738968 [GRCh37]
Chr11:84631539..102296037 [NCBI36]
Chr11:11q14.1-22.2		 pathogenic
GRCh38/hg38 11q22.1-25(chr11:100348599-135040246)x3 copy number gain See cases [RCV000053638] Chr11:100348599..135040246 [GRCh38]
Chr11:100219331..134910140 [GRCh37]
Chr11:99724541..134415350 [NCBI36]
Chr11:11q22.1-25		 pathogenic
Single allele deletion Intellectual disability [RCV001293382] Chr11:118359328..118372573 [GRCh37]
Chr11:11p15.3-q23.3		 pathogenic
GRCh38/hg38 11q22.1-22.3(chr11:98357901-106059146)x1 copy number loss See cases [RCV000136574] Chr11:98357901..106059146 [GRCh38]
Chr11:98228629..105929873 [GRCh37]
Chr11:97733839..105435083 [NCBI36]
Chr11:11q22.1-22.3		 pathogenic
GRCh38/hg38 11q22.1-22.3(chr11:101452984-104044105)x3 copy number gain See cases [RCV000136846] Chr11:101452984..104044105 [GRCh38]
Chr11:101323715..103914833 [GRCh37]
Chr11:100828925..103420043 [NCBI36]
Chr11:11q22.1-22.3		 pathogenic
GRCh38/hg38 11q14.3-22.3(chr11:91086659-109595582)x1 copy number loss See cases [RCV000138038] Chr11:91086659..109595582 [GRCh38]
Chr11:90819827..109466308 [GRCh37]
Chr11:90459475..108971518 [NCBI36]
Chr11:11q14.3-22.3		 pathogenic
GRCh37/hg19 11p13-q25(chr11:32799481-134938470)x3 copy number gain MISSED ABORTION [RCV002282973] Chr11:32799481..134938470 [GRCh37]
Chr11:11p13-q25		 pathogenic
NM_002424.3(MMP8):c.1348C>T (p.Gln450Ter) single nucleotide variant not specified [RCV000454562] Chr11:102713404 [GRCh38]
Chr11:102584135 [GRCh37]
Chr11:11q22.2		 likely benign
NM_002424.3(MMP8):c.259A>G (p.Lys87Glu) single nucleotide variant not specified [RCV000455192] Chr11:102722517 [GRCh38]
Chr11:102593248 [GRCh37]
Chr11:11q22.2		 benign
NM_002424.3(MMP8):c.95C>T (p.Thr32Ile) single nucleotide variant not specified [RCV000455827] Chr11:102724761 [GRCh38]
Chr11:102595492 [GRCh37]
Chr11:11q22.2		 benign
GRCh37/hg19 11q14.2-22.3(chr11:88152458-109414650)x1 copy number loss See cases [RCV000510457] Chr11:88152458..109414650 [GRCh37]
Chr11:11q14.2-22.3		 pathogenic
GRCh37/hg19 11q22.1-22.3(chr11:98515900-104970876)x1 copy number loss See cases [RCV000511844] Chr11:98515900..104970876 [GRCh37]
Chr11:11q22.1-22.3		 likely pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470) copy number gain See cases [RCV000511729] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:230616-134938470)x3 copy number gain See cases [RCV000510881] Chr11:230616..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
NM_002424.3(MMP8):c.691C>T (p.Pro231Ser) single nucleotide variant Inborn genetic diseases [RCV003244583] Chr11:102718507 [GRCh38]
Chr11:102589238 [GRCh37]
Chr11:11q22.2		 uncertain significance
GRCh37/hg19 11q22.2-22.3(chr11:102578709-107230611)x1 copy number loss not provided [RCV000683366] Chr11:102578709..107230611 [GRCh37]
Chr11:11q22.2-22.3		 likely pathogenic
GRCh37/hg19 11q13.4-23.3(chr11:71588805-116680918)x3 copy number gain not provided [RCV000683374] Chr11:71588805..116680918 [GRCh37]
Chr11:11q13.4-23.3		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:198510-134934063)x3 copy number gain not provided [RCV000737348] Chr11:198510..134934063 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11p15.5-q25(chr11:70864-134938470)x3 copy number gain not provided [RCV000749874] Chr11:70864..134938470 [GRCh37]
Chr11:11p15.5-q25		 pathogenic
GRCh37/hg19 11q14.1-23.2(chr11:80053454-113316236)x1 copy number loss not provided [RCV000737595] Chr11:80053454..113316236 [GRCh37]
Chr11:11q14.1-23.2		 pathogenic
NM_002424.3(MMP8):c.78A>G (p.Lys26=) single nucleotide variant not provided [RCV000900437] Chr11:102724778 [GRCh38]
Chr11:102595509 [GRCh37]
Chr11:11q22.2		 benign
NM_002424.3(MMP8):c.651T>C (p.His217=) single nucleotide variant not provided [RCV000921452] Chr11:102718547 [GRCh38]
Chr11:102589278 [GRCh37]
Chr11:11q22.2		 likely benign
NM_002424.3(MMP8):c.785-4C>T single nucleotide variant not provided [RCV000898257] Chr11:102716423 [GRCh38]
Chr11:102587154 [GRCh37]
Chr11:11q22.2		 likely benign
NM_002424.3(MMP8):c.450G>A (p.Arg150=) single nucleotide variant not provided [RCV000973482] Chr11:102721660 [GRCh38]
Chr11:102592391 [GRCh37]
Chr11:11q22.2		 benign
NM_002424.3(MMP8):c.241G>A (p.Glu81Lys) single nucleotide variant not provided [RCV000954964] Chr11:102722535 [GRCh38]
Chr11:102593266 [GRCh37]
Chr11:11q22.2		 likely benign
NM_002424.3(MMP8):c.898G>A (p.Asp300Asn) single nucleotide variant not provided [RCV000918844] Chr11:102716306 [GRCh38]
Chr11:102587037 [GRCh37]
Chr11:11q22.2		 likely benign
NM_002424.3(MMP8):c.1329C>T (p.Tyr443=) single nucleotide variant not provided [RCV000960119] Chr11:102713423 [GRCh38]
Chr11:102584154 [GRCh37]
Chr11:11q22.2		 benign
NM_002424.3(MMP8):c.178G>A (p.Val60Ile) single nucleotide variant not provided [RCV000960120] Chr11:102722598 [GRCh38]
Chr11:102593329 [GRCh37]
Chr11:11q22.2		 benign
NM_002424.3(MMP8):c.903-6C>T single nucleotide variant not provided [RCV000879428] Chr11:102715443 [GRCh38]
Chr11:102586174 [GRCh37]
Chr11:11q22.2		 benign
NM_002424.3(MMP8):c.1387A>G (p.Asn463Asp) single nucleotide variant not provided [RCV000886302] Chr11:102713365 [GRCh38]
Chr11:102584096 [GRCh37]
Chr11:11q22.2		 benign
NM_002424.3(MMP8):c.353G>A (p.Arg118Gln) single nucleotide variant not provided [RCV000956998] Chr11:102721757 [GRCh38]
Chr11:102592488 [GRCh37]
Chr11:11q22.2		 benign
NM_002424.3(MMP8):c.903-3T>C single nucleotide variant not provided [RCV000956997] Chr11:102715440 [GRCh38]
Chr11:102586171 [GRCh37]
Chr11:11q22.2		 benign
GRCh37/hg19 11q22.1-22.3(chr11:99059204-103281943)x3 copy number gain not provided [RCV002472738] Chr11:99059204..103281943 [GRCh37]
Chr11:11q22.1-22.3		 uncertain significance
GRCh37/hg19 11q22.1-22.3(chr11:98770072-104602846)x1 copy number loss not provided [RCV002472602] Chr11:98770072..104602846 [GRCh37]
Chr11:11q22.1-22.3		 likely pathogenic
NC_000011.9:g.(?_94153285)_(111965700_?)del deletion Ataxia-telangiectasia syndrome [RCV001389105] Chr11:94153285..111965700 [GRCh37]
Chr11:11q21-23.1		 pathogenic
GRCh37/hg19 11q22.2(chr11:102308740-102676879) copy number gain not specified [RCV002052953] Chr11:102308740..102676879 [GRCh37]
Chr11:11q22.2		 uncertain significance
GRCh37/hg19 11q14.1-23.3(chr11:85422071-118022671)x1 copy number loss not provided [RCV001832892] Chr11:85422071..118022671 [GRCh37]
Chr11:11q14.1-23.3		 uncertain significance
NC_000011.9:g.(?_101323686)_(103349981_?)del deletion Jeune thoracic dystrophy [RCV001942288]|not provided [RCV001942287] Chr11:101323686..103349981 [GRCh37]
Chr11:11q22.1-22.3		 pathogenic|no classifications from unflagged records
NC_000011.9:g.(?_101374735)_(103349981_?)dup duplication not provided [RCV003122918] Chr11:101374735..103349981 [GRCh37]
Chr11:11q22.1-22.3		 uncertain significance
GRCh37/hg19 11q22.1-22.3(chr11:101371503-109306519)x1 copy number loss not provided [RCV002472494] Chr11:101371503..109306519 [GRCh37]
Chr11:11q22.1-22.3		 pathogenic
NM_002424.3(MMP8):c.1118G>A (p.Ser373Asn) single nucleotide variant Inborn genetic diseases [RCV002817321] Chr11:102714628 [GRCh38]
Chr11:102585359 [GRCh37]
Chr11:11q22.2		 uncertain significance
GRCh37/hg19 11q14.1-22.3(chr11:81478509-104667040)x1 copy number loss not provided [RCV002475722] Chr11:81478509..104667040 [GRCh37]
Chr11:11q14.1-22.3		 pathogenic
NM_002424.3(MMP8):c.290G>A (p.Gly97Asp) single nucleotide variant Inborn genetic diseases [RCV002686481] Chr11:102722486 [GRCh38]
Chr11:102593217 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002424.3(MMP8):c.320A>C (p.Lys107Thr) single nucleotide variant Inborn genetic diseases [RCV002777337] Chr11:102722456 [GRCh38]
Chr11:102593187 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002424.3(MMP8):c.450G>C (p.Arg150Ser) single nucleotide variant Inborn genetic diseases [RCV002839797] Chr11:102721660 [GRCh38]
Chr11:102592391 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002424.3(MMP8):c.980C>T (p.Thr327Ile) single nucleotide variant Inborn genetic diseases [RCV002778306] Chr11:102715360 [GRCh38]
Chr11:102586091 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002424.3(MMP8):c.305C>T (p.Thr102Ile) single nucleotide variant Inborn genetic diseases [RCV002661153] Chr11:102722471 [GRCh38]
Chr11:102593202 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002424.3(MMP8):c.58G>A (p.Ala20Thr) single nucleotide variant Inborn genetic diseases [RCV002799830] Chr11:102724798 [GRCh38]
Chr11:102595529 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002424.3(MMP8):c.379G>T (p.Ala127Ser) single nucleotide variant Inborn genetic diseases [RCV002803251] Chr11:102721731 [GRCh38]
Chr11:102592462 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002424.3(MMP8):c.337T>G (p.Leu113Val) single nucleotide variant Inborn genetic diseases [RCV002873293] Chr11:102722439 [GRCh38]
Chr11:102593170 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002424.3(MMP8):c.109C>G (p.Leu37Val) single nucleotide variant Inborn genetic diseases [RCV002874440] Chr11:102722667 [GRCh38]
Chr11:102593398 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002424.3(MMP8):c.908T>C (p.Phe303Ser) single nucleotide variant Inborn genetic diseases [RCV002916847] Chr11:102715432 [GRCh38]
Chr11:102586163 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002424.3(MMP8):c.874C>T (p.Arg292Cys) single nucleotide variant Inborn genetic diseases [RCV002672469] Chr11:102716330 [GRCh38]
Chr11:102587061 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002424.3(MMP8):c.1064A>G (p.Tyr355Cys) single nucleotide variant Inborn genetic diseases [RCV002961749] Chr11:102714682 [GRCh38]
Chr11:102585413 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002424.3(MMP8):c.868A>G (p.Thr290Ala) single nucleotide variant Inborn genetic diseases [RCV002897911] Chr11:102716336 [GRCh38]
Chr11:102587067 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002424.3(MMP8):c.763G>A (p.Asp255Asn) single nucleotide variant Inborn genetic diseases [RCV002677911] Chr11:102718435 [GRCh38]
Chr11:102589166 [GRCh37]
Chr11:11q22.2		 likely benign
NM_002424.3(MMP8):c.1009G>T (p.Asp337Tyr) single nucleotide variant Inborn genetic diseases [RCV003280726] Chr11:102715331 [GRCh38]
Chr11:102586062 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002424.3(MMP8):c.1096T>A (p.Ser366Thr) single nucleotide variant Inborn genetic diseases [RCV003200270] Chr11:102714650 [GRCh38]
Chr11:102585381 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002424.3(MMP8):c.530A>G (p.Asn177Ser) single nucleotide variant Inborn genetic diseases [RCV003185340] Chr11:102721493 [GRCh38]
Chr11:102592224 [GRCh37]
Chr11:11q22.2		 uncertain significance
NM_002424.3(MMP8):c.929T>C (p.Leu310Pro) single nucleotide variant not provided [RCV003396039] Chr11:102715411 [GRCh38]
Chr11:102586142 [GRCh37]
Chr11:11q22.2		 likely benign
GRCh37/hg19 11q21-22.3(chr11:97147292-102979905)x3 copy number gain not provided [RCV003484850] Chr11:97147292..102979905 [GRCh37]
Chr11:11q21-22.3		 uncertain significance
Single allele duplication not provided [RCV003448710] Chr11:102134973..134945611 [GRCh37]
Chr11:11q22.2-25		 pathogenic
NM_002424.3(MMP8):c.1041C>T (p.Asn347=) single nucleotide variant not provided [RCV003396038] Chr11:102714705 [GRCh38]
Chr11:102585436 [GRCh37]
Chr11:11q22.2		 likely benign
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1920
Count of miRNA genes:759
Interacting mature miRNAs:851
Transcripts:ENST00000236826, ENST00000438475, ENST00000528662, ENST00000531168, ENST00000532799, ENST00000533258
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
GDB:197833  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,583,363 - 102,583,534UniSTSGRCh37
Build 3611102,088,573 - 102,088,744RGDNCBI36
Celera1199,744,562 - 99,744,733RGD
Cytogenetic Map11q22.3UniSTS
HuRef1198,510,309 - 98,510,480UniSTS
MMP8_926  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,583,300 - 102,584,006UniSTSGRCh37
Build 3611102,088,510 - 102,089,216RGDNCBI36
Celera1199,744,499 - 99,745,205RGD
HuRef1198,510,246 - 98,510,952UniSTS
D11S4330  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh3711102,583,935 - 102,584,036UniSTSGRCh37
Build 3611102,089,145 - 102,089,246RGDNCBI36
Celera1199,745,134 - 99,745,235RGD
Cytogenetic Map11q22.3UniSTS
HuRef1198,510,881 - 98,510,982UniSTS
Stanford-G3 RH Map114492.0UniSTS
NCBI RH Map11886.3UniSTS
GeneMap99-G3 RH Map114492.0UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 12 13 1
Medium 5 634 1 752 54 2 3 2 103 4 2
Low 92 372 214 55 288 46 399 110 256 15 69 529 11 421 127 2
Below cutoff 1390 1490 1029 336 318 200 2533 1464 2463 135 956 624 138 725 1774

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001304441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001304442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011542834 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011542835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011542836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017017771 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047426965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047426966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054368836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054368837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054368838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054368839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF059679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK303511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL597614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP000647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW468376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC074989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC144094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG213446 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG218770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ141306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DW009698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000236826   ⟹   ENSP00000236826
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,711,796 - 102,724,954 (-)Ensembl
RefSeq Acc Id: ENST00000438475   ⟹   ENSP00000401004
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,713,130 - 102,724,781 (-)Ensembl
RefSeq Acc Id: ENST00000528662   ⟹   ENSP00000431431
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,712,632 - 102,727,050 (-)Ensembl
RefSeq Acc Id: ENST00000531168   ⟹   ENSP00000433812
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,722,500 - 102,724,952 (-)Ensembl
RefSeq Acc Id: ENST00000532799   ⟹   ENSP00000431938
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,722,543 - 102,724,954 (-)Ensembl
RefSeq Acc Id: ENST00000533258   ⟹   ENSP00000437173
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11102,721,469 - 102,724,941 (-)Ensembl
RefSeq Acc Id: NM_001304441   ⟹   NP_001291370
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,711,796 - 102,724,954 (-)NCBI
CHM1_111102,465,498 - 102,478,648 (-)NCBI
T2T-CHM13v2.011102,713,966 - 102,727,115 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001304442   ⟹   NP_001291371
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,711,796 - 102,724,954 (-)NCBI
CHM1_111102,465,498 - 102,478,648 (-)NCBI
T2T-CHM13v2.011102,713,966 - 102,727,115 (-)NCBI
Sequence:
RefSeq Acc Id: NM_002424   ⟹   NP_002415
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,711,796 - 102,724,954 (-)NCBI
GRCh3711102,582,526 - 102,595,734 (-)NCBI
Build 3611102,088,540 - 102,100,868 (-)NCBI Archive
HuRef1198,509,472 - 98,522,626 (-)ENTREZGENE
CHM1_111102,465,498 - 102,478,648 (-)NCBI
T2T-CHM13v2.011102,713,966 - 102,727,115 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011542834   ⟹   XP_011541136
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,711,796 - 102,724,954 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011542835   ⟹   XP_011541137
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,711,796 - 102,724,954 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047426965   ⟹   XP_047282921
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,711,796 - 102,724,954 (-)NCBI
RefSeq Acc Id: XM_047426966   ⟹   XP_047282922
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,713,755 - 102,724,954 (-)NCBI
RefSeq Acc Id: XM_054368836   ⟹   XP_054224811
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.011102,713,966 - 102,727,115 (-)NCBI
RefSeq Acc Id: XM_054368837   ⟹   XP_054224812
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.011102,713,966 - 102,727,115 (-)NCBI
RefSeq Acc Id: XM_054368838   ⟹   XP_054224813
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.011102,713,966 - 102,727,115 (-)NCBI
RefSeq Acc Id: XM_054368839   ⟹   XP_054224814
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.011102,715,925 - 102,727,115 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_002415   ⟸   NM_002424
- Peptide Label: isoform 1 preproprotein
- UniProtKB: Q45F99 (UniProtKB/Swiss-Prot),   P22894 (UniProtKB/Swiss-Prot),   A8K9E4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001291371   ⟸   NM_001304442
- Peptide Label: isoform 2
- UniProtKB: B4E0I2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001291370   ⟸   NM_001304441
- Peptide Label: isoform 2
- UniProtKB: B4E0I2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011541136   ⟸   XM_011542834
- Peptide Label: isoform X1
- UniProtKB: A8K9E4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011541137   ⟸   XM_011542835
- Peptide Label: isoform X2
- UniProtKB: B4E0I2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000401004   ⟸   ENST00000438475
RefSeq Acc Id: ENSP00000433812   ⟸   ENST00000531168
RefSeq Acc Id: ENSP00000431938   ⟸   ENST00000532799
RefSeq Acc Id: ENSP00000437173   ⟸   ENST00000533258
RefSeq Acc Id: ENSP00000236826   ⟸   ENST00000236826
RefSeq Acc Id: ENSP00000431431   ⟸   ENST00000528662
RefSeq Acc Id: XP_047282921   ⟸   XM_047426965
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047282922   ⟸   XM_047426966
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054224811   ⟸   XM_054368836
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054224813   ⟸   XM_054368838
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054224812   ⟸   XM_054368837
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054224814   ⟸   XM_054368839
- Peptide Label: isoform X3
Protein Domains
Peptidase metallopeptidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P22894-F1-model_v2 AlphaFold P22894 1-467 view protein structure

Promoters
RGD ID:7221919
Promoter ID:EPDNEW_H16705
Type:initiation region
Name:MMP8_1
Description:matrix metallopeptidase 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811102,724,954 - 102,725,014EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:7175 AgrOrtholog
COSMIC MMP8 COSMIC
Ensembl Genes ENSG00000118113 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000236826 ENTREZGENE
  ENST00000236826.8 UniProtKB/Swiss-Prot
  ENST00000438475 ENTREZGENE
  ENST00000438475.2 UniProtKB/TrEMBL
  ENST00000528662.6 UniProtKB/TrEMBL
  ENST00000531168.1 UniProtKB/TrEMBL
  ENST00000532799.1 UniProtKB/TrEMBL
  ENST00000533258.5 UniProtKB/TrEMBL
Gene3D-CATH 2.110.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000118113 GTEx
HGNC ID HGNC:7175 ENTREZGENE
Human Proteome Map MMP8 Human Proteome Map
InterPro Hemopexin-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin-like_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hemopexin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  M10A_MMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10_metallopeptidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M10A_Zn_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidoglycan-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:4317 UniProtKB/Swiss-Prot
NCBI Gene 4317 ENTREZGENE
OMIM 120355 OMIM
PANTHER MATRIX METALLOPROTEINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10201:SF137 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hemopexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_M10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PG_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA30888 PharmGKB
PIRSF Peptidase_M10A_matrix UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS MATRIXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYSTEINE_SWITCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMOPEXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEMOPEXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART SM00120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnMc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47090 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50923 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K9E4 ENTREZGENE, UniProtKB/TrEMBL
  B4E0I2 ENTREZGENE, UniProtKB/TrEMBL
  E9PIY7_HUMAN UniProtKB/TrEMBL
  E9PJB3_HUMAN UniProtKB/TrEMBL
  E9PL87_HUMAN UniProtKB/TrEMBL
  H7C1M3_HUMAN UniProtKB/TrEMBL
  MMP8_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q45F99 ENTREZGENE
UniProt Secondary Q45F99 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-03 MMP8  matrix metallopeptidase 8  MMP8  matrix metallopeptidase 8 (neutrophil collagenase)  Symbol and/or name change 5135510 APPROVED