GADD45A (growth arrest and DNA-damage-inducible, alpha)

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Keyword

Gene: GADD45A (growth arrest and DNA-damage-inducible, alpha) Homo sapiens

Symbol:

GADD45A

Name:

growth arrest and DNA-damage-inducible, alpha

Description:

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

DDIT-1; DDIT1; DNA damage-inducible transcript 1 protein; DNA damage-inducible transcript-1; DNA-damage-inducible transcript 1; GADD45; growth arrest and DNA damage-inducible protein GADD45 alpha; growth arrest and dna-damage-inducible 45 alpha; growth arrest and DNA-damage-inducible 45 alpha; OTTHUMP00000010979; OTTHUMP00000010981

Orthologs:

Mus musculus : Gadd45a (growth arrest and DNA-damage-inducible 45 alpha) MGI
Rattus norvegicus : Gadd45a (growth arrest and DNA-damage-inducible, alpha)

Related Pseudogenes:

GADD45AP1

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	1	68,222,867 - 68,226,028	+	NCBI
Human Genome Assembly HuRef	1	66,261,120 - 66,264,281	+	NCBI
Human Genome Assembly GRCh37	1	68,150,860 - 68,154,021	+	NCBI
Human Genome Assembly Build 36	1	67,923,471 - 67,926,607	+	NCBI
Human Cytogenetic Map	1	p31.2		NCBI
Human Genome Assembly	1	67,862,903 - 67,866,040		NCBI