BMP4 (bone morphogenetic protein 4)

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Keyword

Gene: BMP4 (bone morphogenetic protein 4) Homo sapiens

Symbol:

BMP4

Name:

bone morphogenetic protein 4

Description:

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

BMP-2B; BMP-4; BMP2B; BMP2B1; bone morphogenetic protein 2B; bone morphogenetic protein 4; MCOPS6; OFC11; OTTHUMP00000178992; ZYME

Orthologs:

Mus musculus : Bmp4 (bone morphogenetic protein 4) MGI
Rattus norvegicus : Bmp4 (bone morphogenetic protein 4)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	14	35,400,454 - 35,407,554	-	NCBI
Human Genome Assembly HuRef	14	34,579,652 - 34,586,754	-	NCBI
Human Genome Assembly GRCh37	14	54,416,454 - 54,423,554	-	NCBI
Human Genome Assembly Build 36	14	53,486,204 - 53,493,304	-	NCBI
Human Cytogenetic Map	14	q22-q23		NCBI
Human Genome Assembly	14	53,486,206 - 53,491,020		NCBI