MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4)

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Keyword

Gene: MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4) Homo sapiens

Symbol:

MAP4K4

Name:

mitogen-activated protein kinase kinase kinase kinase 4

Description:

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

FLH21957; FLJ10410; FLJ20373; FLJ90111; hepatocyte progenitor kinase-like/germinal center kinase-like kinase; HGK; HPK/GCK-like kinase HGK; KIAA0687; MAPK/ERK kinase kinase kinase 4; MEK kinase kinase 4; MEKKK 4; MEKKK4; mitogen-activated protein kinase kinase kinase kinase 4; nck-interacting kinase; NIK; OTTHUMP00000207902; OTTHUMP00000207903; OTTHUMP00000207971; OTTHUMP00000207972; OTTHUMP00000207973; OTTHUMP00000207974; Ste20 group protein kinase HGK

Orthologs:

Mus musculus : Map4k4 (mitogen-activated protein kinase kinase kinase kinase 4) MGI
Rattus norvegicus : Map4k4 (mitogen-activated protein kinase kinase kinase kinase 4)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	2	101,970,112 - 102,166,466	+	NCBI
Human Genome Assembly HuRef	2	96,077,883 - 96,275,019	+	NCBI
Human Genome Assembly GRCh37	2	102,314,165 - 102,511,152	+	NCBI
Human Genome Assembly Build 36	2	101,680,920 - 101,877,584	+	NCBI
Human Cytogenetic Map	2	q11.2-q12		NCBI
Human Genome Assembly	2	101,773,005 - 101,969,669		NCBI