Gene: AKT1 (v-akt murine thymoma viral oncogene homolog 1)  Homo sapiens
Symbol: AKT1
Name: v-akt murine thymoma viral oncogene homolog 1
Description: The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AKT; CWS6; MGC99656; OTTHUMP00000244411; OTTHUMP00000244432; OTTHUMP00000244433; OTTHUMP00000244434; OTTHUMP00000244435; OTTHUMP00000244438; OTTHUMP00000244439; PKB; PKB alpha; PKB-ALPHA; PRKBA; protein kinase B; protein kinase B alpha; proto-oncogene c-Akt; RAC; rac protein kinase alpha; RAC-ALPHA; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha
Orthologs: Mus musculus : Akt1 (thymoma viral proto-oncogene 1)  MGI
Rattus norvegicus : Akt1 (v-akt murine thymoma viral oncogene homolog 1)
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_11486,226,645 - 86,250,896-NCBI
Human Genome Assembly HuRef1485,432,617 - 85,464,212-NCBI
Human Genome Assembly GRCh3714105,235,686 - 105,262,080-NCBI
Human Genome Assembly Build 3614104,306,731 - 104,333,125-NCBI
Human Cytogenetic Map14q32.32 NCBI
Human Genome Assembly14104,306,752 - 104,330,608 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

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