Gene: EGF (epidermal growth factor)  Homo sapiens Symbol: EGF Name: epidermal growth factor Description: This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010] Type: protein-coding RefSeq Status: REVIEWED Also known as: beta-urogastrone; epidermal growth factor; HOMG4; OTTHUMP00000162922; OTTHUMP00000219721; OTTHUMP00000219722; pro-epidermal growth factor; URG Orthologs: Mus musculus : Egf (epidermal growth factor)  MGI Rattus norvegicus : Egf (epidermal growth factor) Latest Assembly: Human Genome Assembly GRCh37 Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 4 110,628,399 - 110,728,472 + NCBI Human Genome Assembly HuRef 4 106,566,131 - 106,666,223 + NCBI Human Genome Assembly GRCh37 4 110,834,040 - 110,934,118 + NCBI Human Genome Assembly Build 36 4 111,053,499 - 111,152,868 + NCBI Human Cytogenetic Map 4 q25   NCBI Human Genome Assembly 4 111,191,653 - 111,291,023   NCBI Model Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Acute Kidney Injury   IEP   6906908   RGD   AIDS-Associated Nephropathy   IEP   6906909   RGD   Carcinoma, Pancreatic Ductal Disease_progression IEP   2317644 protein:increased expression: : RGD   Diabetic Nephropathies   IEP   6906912   RGD   Enterocolitis, Necrotizing   ISS RGD:2542 2317627   RGD   Gallbladder Neoplasms Susceptibility IAGP   2317641 DNA:SNP: :+61A>G (rs4444903)(human) RGD   Gallbladder Neoplasms   IEP   2317646   RGD   Hypomagnesemia 4, Renal   IEA   7240710   OMIM   Hypomagnesemia primary   IAGP   6906911   RGD   Lupus Nephritis   IEP   5688301   RGD   Pancreatic Neoplasms   TAS   5490965   RGD   Pancreatic Neoplasms Disease_progression IEP   2317650 protein:increased expression:pancreas RGD   Pancreatitis   IEP   2317638 protein:decreased expression:serum RGD   Pneumonia Resistance ISS RGD:10510 6906904   RGD   Reperfusion Injury Resistance IED   6906916   RGD   Wounds and Injuries   ISS RGD:2542 6906918   RGD   Zollinger-Ellison Syndrome   IED   2317668 protein:increased expression:saliva RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (+)-taxifolin decreases expression EXP   6480464 taxifolin results in decreased expression of EGF mRNA CTD PMID:17541156 (-)-epigallocatechin 3-gallate multiple interactions EXP   6480464 epigallocatechin gallate inhibits the reaction [EGF protein binds to EGFR protein]; more ... CTD PMID:17616711 (-)-epigallocatechin 3-gallate decreases expression EXP   6480464 epigallocatechin gallate results in decreased expression of EGF mRNA CTD PMID:20346928 PMID:20706672 (-)-epigallocatechin 3-gallate decreases expression EXP   6480464 epigallocatechin gallate results in decreased expression of EGF mRNA CTD PMID:20346928 (R)-noradrenaline multiple interactions ISO RGD:2542 6480464 [EGF protein co-treated with Norepinephrine] results in increased expression of MYC mRNA CTD PMID:12632255 1-chloro-2,4-dinitrobenzene decreases expression EXP   6480464 Dinitrochlorobenzene results in decreased expression of EGF mRNA CTD PMID:20146380 11-deoxycorticosterone multiple interactions ISO RGD:2542 6480464 4,5-dianilinophthalimide inhibits the reaction [EGF protein results in increased susceptibility to Desoxycorticosterone]; more ... CTD PMID:11751714 11-deoxycorticosterone increases response to substance ISO RGD:2542 6480464 EGF protein results in increased susceptibility to Desoxycorticosterone CTD PMID:11751714 17alpha-ethynylestradiol increases response to substance ISO RGD:2542 6480464 Ethinyl Estradiol results in increased susceptibility to EGF protein CTD PMID:2786453 17beta-estradiol multiple interactions EXP   6480464 EGF protein inhibits the reaction [[Estradiol co-treated with EGFR protein] results in increased expression of SIAH2 mRNA]; more ... CTD PMID:18629630 17beta-estradiol multiple interactions EXP   6480464 Estradiol promotes the reaction [EGF protein results in increased phosphorylation of EGFR protein]; more ... CTD PMID:21185374 17beta-estradiol multiple interactions ISO RGD:2542 6480464 Cycloheximide promotes the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA]; more ... CTD PMID:12632255 17beta-estradiol multiple interactions EXP   6480464 Estradiol inhibits the reaction [EGF protein results in increased expression of PLAUR protein] CTD PMID:19395996 17beta-estradiol multiple interactions EXP   6480464 Estradiol promotes the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; more ... CTD PMID:16901965 17beta-estradiol affects activity EXP   6480464 Estradiol affects the activity of EGF protein CTD PMID:19395996 17beta-estradiol multiple interactions EXP   6480464 EGF protein promotes the reaction [Estradiol results in increased phosphorylation of EGFR protein] CTD PMID:20005069 17beta-estradiol multiple interactions EXP   6480464 EGF protein promotes the reaction [Estradiol results in increased expression of OLFM4 mRNA]; more ... CTD PMID:21048224 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP   6480464 Tetrachlorodibenzodioxin results in increased expression of EGF mRNA CTD PMID:20044593 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:2542 6480464 geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]] CTD PMID:9605431 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10510 6480464 [TGFA protein co-treated with EGF protein] affects the susceptibility to Tetrachlorodibenzodioxin CTD PMID:12520078 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:10510 6480464 Tetrachlorodibenzodioxin results in decreased expression of EGF protein CTD PMID:2260090 PMID:9787404 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10510 6480464 Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein] CTD PMID:6309801 PMID:9664232 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP   6480464 Tetrachlorodibenzodioxin results in increased expression of EGF protein CTD PMID:9787404 2,3,7,8-tetrachlorodibenzodioxine affects response to substance ISO RGD:10510 6480464 EGF protein affects the susceptibility to Tetrachlorodibenzodioxin CTD PMID:12520078 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10510 6480464 CSK protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]]; more ... CTD PMID:9664232 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10510 6480464 Tretinoin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of EGF protein] CTD PMID:2260090 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP   6480464 Tetrachlorodibenzodioxin results in increased expression of EGF mRNA CTD PMID:20044593 PMID:9787404 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:2542 6480464 Tetrachlorodibenzodioxin results in decreased expression of EGF mRNA CTD PMID:18796159 more ... 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10510 6480464 Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein] CTD PMID:6309801 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:2542 6480464 Tetrachlorodibenzodioxin results in decreased expression of EGF mRNA CTD PMID:18796159 PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP   6480464 Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein] CTD PMID:2033054 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10510 6480464 AG 1879 inhibits the reaction [EGF protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG protein]]]; more ... CTD PMID:16971554 2,3,7,8-tetrachlorodibenzodioxine affects response to substance ISO RGD:10510 6480464 EGF gene mutant form affects the susceptibility to Tetrachlorodibenzodioxin CTD PMID:11399798 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:10510 6480464 Tetrachlorodibenzodioxin results in decreased expression of EGF mRNA CTD PMID:19759094 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10510 6480464 AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of EGF mRNA] CTD PMID:19759094 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:2542 6480464 Tetrachlorodibenzodioxin results in decreased expression of EGF mRNA CTD PMID:18796159 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:10510 6480464 Tetrachlorodibenzodioxin results in increased expression of EGF mRNA CTD PMID:20044593 2,3,7,8-tetrachlorodibenzodioxine decreases activity ISO RGD:10510 6480464 Tetrachlorodibenzodioxin results in decreased activity of EGF protein CTD PMID:20486776 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10510 6480464 Tetrachlorodibenzodioxin inhibits the reaction [EGF protein results in increased expression of AQP1 mRNA]; more ... CTD PMID:15667827 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10510 6480464 [Tetrachlorodibenzodioxin co-treated with EGF protein] results in increased expression of CDKN1B protein; more ... CTD PMID:20486776 2,3,7,8-tetrachlorodibenzodioxine decreases response to substance ISO RGD:10510 6480464 EGF protein results in decreased susceptibility to Tetrachlorodibenzodioxin CTD PMID:14514962 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10510 6480464 [Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of AHR mRNA]; more ... CTD PMID:16054899 2,4-dinitrotoluene affects expression ISO RGD:2542 6480464 2,4-dinitrotoluene affects the expression of EGF mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO RGD:2542 6480464 2,6-dinitrotoluene affects the expression of EGF mRNA CTD PMID:21346803 2-acetamidofluorene multiple interactions ISO RGD:2542 6480464 2-Acetylaminofluorene affects the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:10900465 2-acetamidofluorene decreases localization ISO RGD:2542 6480464 2-Acetylaminofluorene results in decreased localization of EGF protein CTD PMID:10900465 3,3',4,4',5-pentachlorobiphenyl decreases expression ISO RGD:2542 6480464 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of EGF mRNA CTD PMID:20959002 3,3',5-triiodo-L-thyronine multiple interactions ISO RGD:10510 6480464 Triiodothyronine inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; more ... CTD PMID:16150908 3,4-dihydrocoumarin increases expression ISO RGD:10510 6480464 3,4-dihydrocoumarin results in increased expression of EGF mRNA CTD PMID:22016648 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:10510 6480464 AG 1879 inhibits the reaction [EGF protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG protein]]]; more ... CTD PMID:16971554 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:2542 6480464 1-Methyl-3-isobutylxanthine promotes the reaction [FSHB protein inhibits the reaction [EGF results in increased phosphorylation of MAPK3 protein]]; more ... CTD PMID:21177760 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:10510 6480464 EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CALML4 mRNA]; more ... CTD PMID:16054899 4,4'-diaminodiphenylmethane decreases expression ISO RGD:10510 6480464 4,4'-diaminodiphenylmethane results in decreased expression of EGF mRNA CTD PMID:18648102 4,4'-diaminodiphenylmethane decreases expression ISO RGD:2542 6480464 4,4'-diaminodiphenylmethane results in decreased expression of EGF mRNA CTD PMID:18289764 4,5-dianilinophthalimide multiple interactions ISO RGD:2542 6480464 4,5-dianilinophthalimide inhibits the reaction [EGF protein results in increased susceptibility to Desoxycorticosterone] CTD PMID:11751714 acetaldehyde multiple interactions EXP   6480464 chelerythrine inhibits the reaction [EGF protein inhibits the reaction [Acetaldehyde affects the localization of TJP1 protein]]; more ... CTD PMID:17991733 acetaldehyde decreases response to substance EXP   6480464 EGF protein results in decreased susceptibility to Acetaldehyde CTD PMID:17991733 actinomycin D multiple interactions ISO RGD:2542 6480464 Dactinomycin inhibits the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA] CTD PMID:12632255 afimoxifene multiple interactions EXP   6480464 [4-hydroxytamoxifen co-treated with EGF protein] results in increased expression of CDH1 mRNA; more ... CTD PMID:19593637 aflatoxin B1 affects expression EXP   6480464 Aflatoxin B1 affects the expression of EGF protein CTD PMID:20106945 aflatoxin B1 increases expression ISO RGD:10510 6480464 Aflatoxin B1 results in increased expression of EGF mRNA CTD PMID:19770486 all-trans-retinoic acid decreases activity EXP   6480464 EGF protein results in decreased activity of Tretinoin CTD PMID:11171635 all-trans-retinoic acid multiple interactions ISO RGD:10510 6480464 Tretinoin promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of EGF protein] CTD PMID:2260090 all-trans-retinoic acid multiple interactions ISO RGD:2542 6480464 EGF protein inhibits the reaction [Tretinoin results in increased activity of ALPL protein] CTD PMID:11171635 all-trans-retinoic acid multiple interactions EXP   6480464 [Tretinoin co-treated with EGF protein co-treated with NOG protein] results in increased expression of SOX10 mRNA; more ... CTD PMID:17196394 alpha-hexachlorocyclohexane multiple interactions ISO RGD:2542 6480464 [EGF protein co-treated with alpha-hexachlorocyclohexane] results in increased expression of MYC mRNA CTD PMID:12632255 ammonium chloride affects expression ISO RGD:2542 6480464 Ammonium Chloride affects the expression of EGF mRNA CTD PMID:16483693 ammonium chloride multiple interactions ISO RGD:2542 6480464 [EGF protein co-treated with Ammonium Chloride] results in increased expression of MYC mRNA CTD PMID:12632255 amsacrine multiple interactions EXP   6480464 [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Amsacrine CTD PMID:16969495 arsenite(3-) multiple interactions ISO RGD:2542 6480464 SB 203580 results in decreased activity of [arsenite co-treated with EGF protein] CTD PMID:9733710 bacitracin decreases expression ISO RGD:2542 6480464 Bacitracin results in decreased expression of EGF mRNA CTD PMID:18289764 benzo[a]pyrene decreases expression ISO RGD:10510 6480464 Benzo(a)pyrene results in decreased expression of EGF mRNA CTD PMID:22228805 benzo[a]pyrene multiple interactions ISO RGD:10510 6480464 Benzo(a)pyrene inhibits the reaction [EGF protein binds to EGFR protein]; more ... CTD PMID:6309801 bicalutamide multiple interactions EXP   6480464 bicalutamide inhibits the reaction [FOS protein results in increased expression of EGF mRNA] CTD PMID:15466214 bis(2-chloroethyl) sulfide increases expression EXP   6480464 Mustard Gas results in increased expression of EGF protein CTD PMID:17266442 bisphenol A increases expression ISO RGD:10510 6480464 bisphenol A results in increased expression of EGF mRNA CTD PMID:11011959 butan-1-ol multiple interactions ISO RGD:2542 6480464 1-Butanol inhibits the reaction [EGF protein binds to and results in increased localization of EGFR protein]; more ... CTD PMID:11134345 calcitriol increases expression EXP   6480464 Calcitriol results in increased expression of EGF mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:2542 6480464 [Calcium co-treated with Calcitriol] affects the expression of EGF mRNA CTD PMID:15913539 calcitriol multiple interactions EXP   6480464 [Testosterone co-treated with Calcitriol] results in increased expression of EGF mRNA CTD PMID:21592394 calcium atom increases abundance EXP   6480464 EGF protein results in increased abundance of Calcium CTD PMID:11527950 calcium atom multiple interactions ISO RGD:2542 6480464 [Calcium co-treated with Calcitriol] affects the expression of EGF mRNA CTD PMID:15913539 calcium atom affects expression ISO RGD:2542 6480464 Calcium affects the expression of EGF mRNA CTD PMID:15913539 calcium atom multiple interactions ISO RGD:10510 6480464 [IGF2 protein co-treated with EGF protein] results in increased import of Calcium CTD PMID:2442157 calcium atom multiple interactions EXP   6480464 tyrphostin AG 1478 inhibits the reaction [EGF protein results in increased abundance of Calcium] CTD PMID:11527950 calcium(0) increases abundance EXP   6480464 EGF protein results in increased abundance of Calcium CTD PMID:11527950 calcium(0) multiple interactions ISO RGD:2542 6480464 [Calcium co-treated with Calcitriol] affects the expression of EGF mRNA CTD PMID:15913539 calcium(0) affects expression ISO RGD:2542 6480464 Calcium affects the expression of EGF mRNA CTD PMID:15913539 calcium(0) multiple interactions ISO RGD:10510 6480464 [IGF2 protein co-treated with EGF protein] results in increased import of Calcium CTD PMID:2442157 calcium(0) multiple interactions EXP   6480464 tyrphostin AG 1478 inhibits the reaction [EGF protein results in increased abundance of Calcium] CTD PMID:11527950 capsaicin multiple interactions EXP   6480464 Capsaicin inhibits the reaction [EGF results in increased activity of MMP9 protein]; more ... CTD PMID:21462327 capsaicin decreases expression ISO RGD:2542 6480464 Capsaicin results in decreased expression of EGF protein CTD PMID:14521749 capsaicin decreases activity ISO RGD:2542 6480464 Capsaicin results in decreased activity of EGF protein CTD PMID:9324159 chlorogenic acid decreases expression EXP   6480464 Chlorogenic Acid results in decreased expression of EGF mRNA CTD PMID:20706672 chloroquine multiple interactions EXP   6480464 Chloroquine inhibits the reaction [EGF protein results in decreased expression of EGFR protein] CTD PMID:20332299 ciguatoxin CTX1B affects expression ISO RGD:10510 6480464 Ciguatoxins affects the expression of EGF mRNA CTD PMID:18353800 cisplatin multiple interactions EXP   6480464 anthra(1,9-cd)pyrazol-6(2H)-one inhibits the reaction [EGF promotes the reaction [TGFB1 results in decreased susceptibility to Cisplatin]]; more ... CTD PMID:21613822 cisplatin decreases expression ISO RGD:2542 6480464 Cisplatin results in decreased expression of EGF protein CTD PMID:15033597 cisplatin decreases expression ISO RGD:2542 6480464 Cisplatin results in decreased expression of EGF mRNA CTD PMID:18289764 copper atom multiple interactions EXP   6480464 [NSC 689534 binds to Copper] which results in increased expression of EGF mRNA CTD PMID:20971185 copper atom decreases expression ISO RGD:2542 6480464 Copper results in decreased expression of EGF mRNA CTD PMID:22465980 copper(0) multiple interactions EXP   6480464 [NSC 689534 binds to Copper] which results in increased expression of EGF mRNA CTD PMID:20971185 copper(0) decreases expression ISO RGD:2542 6480464 Copper results in decreased expression of EGF mRNA CTD PMID:22465980 cortisol multiple interactions EXP   6480464 gefitinib promotes the reaction [Hydrocortisone inhibits the reaction [EGF protein results in increased abundance of Dinoprostone]]; more ... CTD PMID:17805209 crocidolite asbestos affects expression EXP   6480464 Asbestos, Crocidolite affects the expression of EGF mRNA CTD PMID:17331233 curcumin multiple interactions EXP   6480464 Curcumin inhibits the reaction [EGF protein results in increased expression of AQP3 protein]; more ... CTD PMID:18214481 curcumin multiple interactions EXP   6480464 Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:10851300 more ... curcumin multiple interactions EXP   6480464 Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:18214481 more ... curcumin multiple interactions EXP   6480464 Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:15129424 more ... curcumin multiple interactions ISO RGD:2542 6480464 Curcumin inhibits the reaction [EGF protein results in decreased expression of PPARG protein]; more ... CTD PMID:17372590 curcumin decreases activity EXP   6480464 Curcumin results in decreased activity of EGF protein CTD PMID:15486348 curcumin multiple interactions EXP   6480464 Curcumin inhibits the reaction [EGF protein results in increased secretion of PTHLH protein] CTD PMID:15129424 curcumin multiple interactions EXP   6480464 Curcumin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:15129424 more ... cycloheximide multiple interactions ISO RGD:2542 6480464 Cycloheximide promotes the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA] CTD PMID:12632255 cyclosporin A increases expression EXP   6480464 Cyclosporine results in increased expression of EGF mRNA CTD PMID:20106945 cyclosporin A decreases expression ISO RGD:2542 6480464 Cyclosporine results in decreased expression of EGF mRNA CTD PMID:21865292 cyproterone acetate multiple interactions ISO RGD:2542 6480464 [EGF protein co-treated with Cyproterone Acetate] results in increased expression of MYC mRNA CTD PMID:12632255 cytochalasin D multiple interactions ISO RGD:10510 6480464 EGF protein inhibits the reaction [Cytochalasin D results in increased phosphorylation of ABL1 protein] CTD PMID:21900236 D-glucose multiple interactions EXP   6480464 EGF protein inhibits the reaction [Glucose results in decreased expression of CAV1 mRNA] CTD PMID:19816600 D-glucose multiple interactions EXP   6480464 EGF protein promotes the reaction [Glucose results in increased expression of TGFA mRNA]; more ... CTD PMID:8638660 dasatinib (anhydrous) multiple interactions EXP   6480464 dasatinib inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:20664932 daunorubicin multiple interactions EXP   6480464 Daunorubicin inhibits the reaction [EGF protein results in increased abundance of Diglycerides] CTD PMID:11082532 DDT multiple interactions ISO RGD:2542 6480464 [EGF protein co-treated with DDT] results in increased expression of MYC mRNA CTD PMID:12632255 dexamethasone multiple interactions ISO RGD:2542 6480464 Dexamethasone inhibits the reaction [EGF protein results in increased expression of FOS mRNA]; more ... CTD PMID:7705776 dexamethasone multiple interactions ISO RGD:2542 6480464 Dexamethasone promotes the reaction [[EGF protein co-treated with Estradiol] results in increased expression of FOS mRNA] CTD PMID:12632255 dexamethasone multiple interactions ISO RGD:10510 6480464 EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of ARHGAP5 mRNA]; more ... CTD PMID:16054899 dexamethasone multiple interactions EXP   6480464 Dexamethasone inhibits the reaction [EGF protein results in increased expression of MAPK1 protein modified form]; more ... CTD PMID:17077316 dexamethasone multiple interactions EXP   6480464 Dexamethasone inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to ARAF protein]]; more ... CTD PMID:10807665 dexamethasone multiple interactions ISO RGD:10510 6480464 AG 1879 inhibits the reaction [EGF protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in increased expression of PPARG protein]]]; more ... CTD PMID:16971554 diarsenic trioxide increases expression ISO RGD:10510 6480464 arsenic trioxide results in increased expression of EGF mRNA CTD PMID:15073043 diethylstilbestrol increases expression ISO RGD:10510 6480464 Diethylstilbestrol results in increased expression of EGF mRNA CTD PMID:15336711 diethylstilbestrol increases expression ISO RGD:10510 6480464 Diethylstilbestrol results in increased expression of EGF mRNA CTD PMID:11011959 PMID:15336711 diethylstilbestrol multiple interactions ISO RGD:2542 6480464 [EGF protein co-treated with Diethylstilbestrol] results in increased expression of MYC mRNA CTD PMID:12632255 diethylstilbestrol increases expression ISO RGD:2542 6480464 Diethylstilbestrol results in increased expression of EGF mRNA CTD PMID:17011747 disodium selenite multiple interactions ISO RGD:10510 6480464 Sodium Selenite inhibits the reaction [Hydrogen Peroxide results in decreased expression of EGF mRNA] CTD PMID:17997286 doxorubicin multiple interactions EXP   6480464 [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Doxorubicin CTD PMID:16969495 doxorubicin increases expression ISO RGD:10510 6480464 Doxorubicin results in increased expression of EGF mRNA CTD PMID:22016648 elemental selenium multiple interactions ISO RGD:2542 6480464 Selenium inhibits the reaction [EGF protein results in increased abundance of Peroxides]; more ... CTD PMID:11158190 ethanolamine increases activity EXP   6480464 Ethanolamine results in increased activity of EGF protein CTD PMID:15802876 etoposide multiple interactions EXP   6480464 [EGF protein results in decreased expression of TOP2A protein] which results in decreased susceptibility to Etoposide CTD PMID:16969495 flurbiprofen increases expression ISO RGD:10510 6480464 Flurbiprofen results in increased expression of EGF mRNA CTD PMID:16949054 fructose increases uptake ISO RGD:2542 6480464 EGF protein results in increased uptake of Fructose CTD PMID:15691865 fructose multiple interactions ISO RGD:2542 6480464 wortmannin inhibits the reaction [EGF protein results in increased uptake of Fructose] CTD PMID:15691865 fulvestrant affects activity EXP   6480464 fulvestrant affects the activity of EGF protein CTD PMID:19395996 fulvestrant multiple interactions EXP   6480464 fulvestrant inhibits the reaction [EGF protein results in increased expression of TFF1 mRNA] CTD PMID:20206645 fulvestrant multiple interactions EXP   6480464 fulvestrant inhibits the reaction [EGF protein results in increased expression of PLAUR protein] CTD PMID:19395996 fulvestrant multiple interactions EXP   6480464 fulvestrant inhibits the reaction [[4-hydroxytamoxifen co-treated with EGF protein] results in increased expression of CDH1 protein] CTD PMID:19593637 gefitinib multiple interactions EXP   6480464 gefitinib inhibits the reaction [EGF affects the localization of MAPK1]; more ... CTD PMID:20088784 gefitinib multiple interactions EXP   6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:19318490 more ... gefitinib multiple interactions EXP   6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:19318490 more ... gefitinib multiple interactions EXP   6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; more ... CTD PMID:18927496 more ... gefitinib multiple interactions EXP   6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein] CTD PMID:19233551 more ... gefitinib multiple interactions EXP   6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:16243822 more ... gefitinib multiple interactions ISO RGD:10510 6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:15841081 gefitinib multiple interactions EXP   6480464 gefitinib promotes the reaction [Hydrocortisone inhibits the reaction [EGF protein results in increased abundance of Dinoprostone]] CTD PMID:17805209 gefitinib multiple interactions EXP   6480464 gefitinib inhibits the reaction [EGF results in increased activity of MAPK1 protein]; more ... CTD PMID:21787763 gefitinib multiple interactions EXP   6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]; more ... CTD PMID:19318490 gefitinib multiple interactions EXP   6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein] CTD PMID:19318490 more ... gefitinib multiple interactions EXP   6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein] CTD PMID:16243822 more ... gefitinib multiple interactions EXP   6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; more ... CTD PMID:18927496 more ... gefitinib multiple interactions EXP   6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of EGFR protein]; more ... CTD PMID:17898861 gefitinib multiple interactions EXP   6480464 gefitinib inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:19233551 geldanamycin multiple interactions ISO RGD:10510 6480464 geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]] CTD PMID:9664232 geldanamycin multiple interactions ISO RGD:2542 6480464 geldanamycin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [EGF protein binds to EGFR protein]] CTD PMID:9605431 genistein multiple interactions EXP   6480464 Genistein inhibits the reaction [EGF protein results in increased activity of AKT1 protein] CTD PMID:18431742 genistein decreases expression EXP   6480464 Genistein results in decreased expression of EGF mRNA CTD PMID:20706672 genistein multiple interactions ISO RGD:2542 6480464 [Genistein co-treated with vinclozolin] results in decreased expression of EGF mRNA CTD PMID:22317923 glucose multiple interactions EXP   6480464 EGF protein inhibits the reaction [Glucose results in decreased expression of CAV1 mRNA] CTD PMID:19816600 glucose multiple interactions EXP   6480464 EGF protein promotes the reaction [Glucose results in increased expression of TGFA mRNA]; more ... CTD PMID:8638660 glutathione affects abundance ISO RGD:2542 6480464 EGF protein affects the abundance of Glutathione CTD PMID:10544272 Goe 6976 multiple interactions ISO RGD:2542 6480464 Go 6976 inhibits the reaction [EGF protein binds to and results in increased localization of EGFR protein] CTD PMID:11134345 heparin decreases activity EXP   6480464 Heparin results in decreased activity of EGF protein CTD PMID:12714831 hydrogen peroxide decreases expression ISO RGD:10510 6480464 Hydrogen Peroxide results in decreased expression of EGF mRNA CTD PMID:17997286 hydrogen peroxide multiple interactions ISO RGD:10510 6480464 Sodium Selenite inhibits the reaction [Hydrogen Peroxide results in decreased expression of EGF mRNA] CTD PMID:17997286 ibuprofen multiple interactions EXP   6480464 Ibuprofen inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]; more ... CTD PMID:16340751 indomethacin multiple interactions ISO RGD:10510 6480464 allylpyrocatechol promotes the reaction [Indomethacin results in increased expression of EGF protein]; more ... CTD PMID:18431645 indomethacin increases expression ISO RGD:10510 6480464 Indomethacin results in increased expression of EGF protein CTD PMID:18431645 PMID:18237397 indomethacin multiple interactions ISO RGD:10510 6480464 Plant Extracts promotes the reaction [Indomethacin results in increased expression of EGF protein] CTD PMID:18237397 indomethacin increases expression ISO RGD:10510 6480464 Indomethacin results in increased expression of EGF protein CTD PMID:18237397 PMID:18431645 indomethacin multiple interactions EXP   6480464 Indomethacin promotes the reaction [Hydrocortisone inhibits the reaction [EGF protein results in increased abundance of Dinoprostone]] CTD PMID:17805209 indomethacin multiple interactions EXP   6480464 Indomethacin inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein]; more ... CTD PMID:12037131 inulin multiple interactions EXP   6480464 EGF protein inhibits the reaction [Acetaldehyde results in increased transport of Inulin]; more ... CTD PMID:17991733 ionomycin multiple interactions EXP   6480464 [Ionomycin co-treated with EGF protein] results in increased phosphorylation of MAPK1 protein; more ... CTD PMID:22317921 lovastatin multiple interactions EXP   6480464 Lovastatin inhibits the reaction [EGF protein promotes the reaction [EGFR protein results in increased phosphorylation of EGFR protein]] CTD PMID:12942316 lovastatin multiple interactions EXP   6480464 Lovastatin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; more ... CTD PMID:19760159 luteolin multiple interactions EXP   6480464 EGF protein inhibits the reaction [Luteolin results in decreased phosphorylation of PTK2 protein]; more ... CTD PMID:15135307 luteolin multiple interactions EXP   6480464 Luteolin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; more ... CTD PMID:22926442 LY294002 multiple interactions EXP   6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:16343977 more ... LY294002 multiple interactions EXP   6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:16343977 more ... LY294002 multiple interactions EXP   6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:16472761 more ... LY294002 multiple interactions EXP   6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased expression of AQP3 protein] CTD PMID:16848764 PMID:18214481 LY294002 multiple interactions EXP   6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in decreased expression of and results in decreased secretion of KLK3 protein]; more ... CTD PMID:16472761 LY294002 multiple interactions EXP   6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased expression of VEGFA mRNA] CTD PMID:15040022 mestranol multiple interactions ISO RGD:2542 6480464 [EGF protein co-treated with Mestranol] results in increased expression of MYC mRNA CTD PMID:12632255 midostaurin multiple interactions EXP   6480464 4'-N-benzoylstaurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of and results in increased localization of TP53 protein]] CTD PMID:15542774 mifepristone multiple interactions EXP   6480464 Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to GRB2 protein]]]; more ... CTD PMID:10807665 mifepristone multiple interactions EXP   6480464 Mifepristone inhibits the reaction [Progesterone promotes the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]]; more ... CTD PMID:16175315 mitomycin C multiple interactions EXP   6480464 Mitomycin inhibits the reaction [EGF protein results in increased uptake of Zinc] CTD PMID:1502195 monensin A multiple interactions ISO RGD:2542 6480464 [EGF protein co-treated with Monensin] results in increased expression of MYC mRNA CTD PMID:12632255 mono(2-ethylhexyl) phthalate decreases expression ISO RGD:10510 6480464 mono-(2-ethylhexyl)phthalate results in decreased expression of EGF mRNA CTD PMID:22401849 myricetin multiple interactions ISO RGD:10510 6480464 myricetin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; more ... CTD PMID:17693661 N-acetyl-L-cysteine multiple interactions ISO RGD:2542 6480464 Acetylcysteine inhibits the reaction [EGF protein results in increased abundance of 8-hydroxyguanosine]; more ... CTD PMID:11158190 N-methyl-N'-nitro-N-nitrosoguanidine affects activity EXP   6480464 Methylnitronitrosoguanidine affects the activity of EGF protein CTD PMID:15708576 N-methyl-N'-nitro-N-nitrosoguanidine multiple interactions EXP   6480464 Methylnitronitrosoguanidine inhibits the reaction [EGF protein results in increased activity of HRAS protein]; more ... CTD PMID:15708576 N-nitrosodiethylamine decreases expression ISO RGD:2542 6480464 Diethylnitrosamine results in decreased expression of EGF mRNA CTD PMID:19638242 N-nitrosodimethylamine increases expression ISO RGD:2542 6480464 Dimethylnitrosamine results in increased expression of EGF mRNA CTD PMID:17203207 nevirapine decreases expression EXP   6480464 Nevirapine results in decreased expression of EGF mRNA CTD PMID:19152342 nickel dichloride multiple interactions EXP   6480464 [nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of EGF protein CTD PMID:18437699 nocodazole multiple interactions EXP   6480464 Nocodazole inhibits the reaction [EGF protein results in increased expression of PSA mRNA] CTD PMID:20807808 omeprazole multiple interactions ISO RGD:10510 6480464 Omeprazole promotes the reaction [Indomethacin results in increased expression of EGF protein] CTD PMID:18431645 paclitaxel decreases expression EXP   6480464 Paclitaxel results in decreased expression of EGF mRNA CTD PMID:18058816 paclitaxel multiple interactions EXP   6480464 Paclitaxel inhibits the reaction [EGF protein results in increased expression of PSA mRNA] CTD PMID:20807808 paracetamol multiple interactions ISO RGD:2542 6480464 [EGF protein co-treated with HGF protein] promotes the reaction [Acetaminophen results in decreased expression of CYP1A2 mRNA] CTD PMID:12969438 perfluorooctanoic acid affects expression ISO RGD:10510 6480464 perfluorooctanoic acid affects the expression of EGF mRNA CTD PMID:17132714 perfluorooctanoic acid decreases expression ISO RGD:2542 6480464 perfluorooctanoic acid results in decreased expression of EGF mRNA CTD PMID:19162173 permethrin multiple interactions ISO RGD:2542 6480464 EGF protein inhibits the reaction [Permethrin results in increased expression of CYP2B1 mRNA] CTD PMID:14722249 PMID:11377398 permethrin multiple interactions ISO RGD:2542 6480464 EGF protein inhibits the reaction [Permethrin results in increased expression of CYP2B1 mRNA] CTD PMID:11377398 PMID:14722249 permethrin multiple interactions ISO RGD:2542 6480464 EGF protein inhibits the reaction [Permethrin results in increased expression of CYP3A1 mRNA] CTD PMID:11377398 phencyclidine increases expression ISO RGD:10510 6480464 Phencyclidine results in increased expression of EGF mRNA CTD PMID:12105081 phenobarbital multiple interactions ISO RGD:2542 6480464 Phenobarbital inhibits the reaction [EGF protein binds to EGFR protein] CTD PMID:10828207 phenobarbital multiple interactions ISO RGD:10510 6480464 Phenobarbital inhibits the reaction [EGF protein binds to EGFR protein] CTD PMID:6309801 phenobarbital multiple interactions ISO RGD:2542 6480464 EGF protein inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA] CTD PMID:14722249 PMID:11377398 phenobarbital multiple interactions ISO RGD:2542 6480464 EGF protein inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA] CTD PMID:11377398 PMID:14722249 phenylephrine multiple interactions ISO RGD:2542 6480464 ADAM17 protein affects the reaction [Phenylephrine results in increased cleavage of and results in increased secretion of EGF protein]; more ... CTD PMID:16760267 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:10510 6480464 Tetradecanoylphorbol Acetate inhibits the reaction [EGF protein binds to EGFR protein] CTD PMID:6309801 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:2542 6480464 bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of EGF protein]; more ... CTD PMID:12947092 phorbol 13-acetate 12-myristate increases expression EXP   6480464 Tetradecanoylphorbol Acetate results in increased expression of EGF protein CTD PMID:19447859 phorbol 13-acetate 12-myristate multiple interactions EXP   6480464 pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGF protein] CTD PMID:19447859 piperonyl butoxide decreases expression ISO RGD:2542 6480464 Piperonyl Butoxide results in decreased expression of EGF mRNA CTD PMID:22484513 pirinixic acid multiple interactions ISO RGD:10510 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of EGF mRNA CTD PMID:19710929 pirinixic acid decreases expression ISO RGD:2542 6480464 pirinixic acid results in decreased expression of EGF mRNA CTD PMID:19162173 progesterone multiple interactions EXP   6480464 Mifepristone inhibits the reaction [Progesterone promotes the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]]; more ... CTD PMID:16175315 prostaglandin D2 multiple interactions ISO RGD:2542 6480464 [EGF protein co-treated with Prostaglandin D2] results in increased expression of MYC mRNA CTD PMID:12632255 prostaglandin E2 multiple interactions EXP   6480464 gefitinib promotes the reaction [Hydrocortisone inhibits the reaction [EGF protein results in increased abundance of Dinoprostone]]; more ... CTD PMID:17805209 prostaglandin E2 increases abundance EXP   6480464 EGF protein results in increased abundance of Dinoprostone CTD PMID:17805209 pterostilbene multiple interactions EXP   6480464 pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGF protein] CTD PMID:19447859 quercetin multiple interactions EXP   6480464 EGF protein inhibits the reaction [Quercetin results in decreased phosphorylation of PTK2 protein]; more ... CTD PMID:15135307 quercetin decreases expression EXP   6480464 Quercetin results in decreased expression of EGF protein CTD PMID:12469199 quercetin multiple interactions EXP   6480464 Quercetin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:16619521 resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; more ... CTD PMID:14739659 resveratrol multiple interactions ISO RGD:2542 6480464 resveratrol inhibits the reaction [EGF protein results in increased expression of MUC5AC protein]; more ... CTD PMID:22213337 resveratrol multiple interactions EXP   6480464 EGF protein inhibits the reaction [resveratrol results in decreased phosphorylation of EGFR protein]; more ... CTD PMID:20729295 resveratrol multiple interactions ISO RGD:2542 6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:15849355 PMID:16626303 resveratrol decreases activity EXP   6480464 resveratrol results in decreased activity of EGF protein CTD PMID:16343977 resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; more ... CTD PMID:16343977 resveratrol multiple interactions EXP   6480464 EGF protein inhibits the reaction [resveratrol results in increased expression of FOS mRNA]; more ... CTD PMID:15542774 resveratrol multiple interactions ISO RGD:2542 6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:16626303 PMID:15849355 resveratrol multiple interactions ISO RGD:2542 6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased localization of GAB1 protein] CTD PMID:15849355 resveratrol multiple interactions ISO RGD:10510 6480464 PTPN11 protein affects the reaction [resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]] CTD PMID:15849355 resveratrol multiple interactions ISO RGD:2542 6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; more ... CTD PMID:16626303 Ro 31-8220 multiple interactions ISO RGD:2542 6480464 Ro 31-8220 inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; more ... CTD PMID:16877402 Ro 31-8220 multiple interactions ISO RGD:2542 6480464 Ro 31-8220 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of EGF protein] CTD PMID:12947092 rosiglitazone multiple interactions ISO RGD:10510 6480464 EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of CALML4 mRNA]; more ... CTD PMID:16054899 selenium atom multiple interactions ISO RGD:2542 6480464 Selenium inhibits the reaction [EGF protein results in increased abundance of Peroxides]; more ... CTD PMID:11158190 sirolimus multiple interactions EXP   6480464 Sirolimus inhibits the reaction [EGF protein results in increased phosphorylation of MTOR protein] CTD PMID:21187475 sirolimus decreases activity ISO RGD:10510 6480464 Sirolimus analog results in decreased activity of EGF protein CTD PMID:12406821 staurosporine multiple interactions EXP   6480464 Staurosporine inhibits the reaction [EGF protein inhibits the reaction [resveratrol inhibits the reaction [TP53 protein binds to MDM2 protein]]]; more ... CTD PMID:15542774 staurosporine multiple interactions ISO RGD:2542 6480464 EGF protein inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]; more ... CTD PMID:19406941 sulfasalazine increases expression ISO RGD:10510 6480464 Sulfasalazine results in increased expression of EGF mRNA CTD PMID:22016648 sulindac multiple interactions EXP   6480464 Sulindac inhibits the reaction [EGF protein results in increased phosphorylation of BAD protein]; more ... CTD PMID:12566304 tamoxifen affects activity EXP   6480464 Tamoxifen affects the activity of EGF protein CTD PMID:19395996 testosterone multiple interactions EXP   6480464 [Testosterone co-treated with Calcitriol] results in increased expression of EGF mRNA CTD PMID:21592394 testosterone decreases secretion ISO RGD:2542 6480464 EGF protein results in decreased secretion of Testosterone CTD PMID:19059320 testosterone multiple interactions ISO RGD:2542 6480464 EGF protein inhibits the reaction [AG 1879 inhibits the reaction [Testosterone results in increased phosphorylation of CREB1 protein]]; more ... CTD PMID:17272394 testosterone increases expression EXP   6480464 Testosterone results in increased expression of EGF mRNA CTD PMID:21592394 tetrachloromethane increases expression ISO RGD:2542 6480464 Carbon Tetrachloride results in increased expression of EGF mRNA CTD PMID:17631135 PMID:16097045 tetrachloromethane increases expression ISO RGD:2542 6480464 Carbon Tetrachloride results in increased expression of EGF mRNA CTD PMID:16097045 PMID:17631135 tetrachloromethane multiple interactions ISO RGD:2542 6480464 IL10 protein affects the reaction [Carbon Tetrachloride results in increased expression of EGF mRNA]; more ... CTD PMID:16097045 tetraphene multiple interactions ISO RGD:10510 6480464 benz(a)anthracene inhibits the reaction [EGF protein binds to EGFR protein]; more ... CTD PMID:6309801 tetrathiomolybdate(2-) multiple interactions EXP   6480464 tetrathiomolybdate inhibits the reaction [EGF protein results in increased oxidation of PTPN1 protein]; more ... CTD PMID:18480265 thapsigargin multiple interactions EXP   6480464 Thapsigargin inhibits the reaction [EGF protein affects the localization of PRKCB protein] CTD PMID:17991733 trans-resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; more ... CTD PMID:14739659 trans-resveratrol multiple interactions ISO RGD:2542 6480464 resveratrol inhibits the reaction [EGF protein results in increased expression of MUC5AC protein]; more ... CTD PMID:22213337 trans-resveratrol multiple interactions EXP   6480464 EGF protein inhibits the reaction [resveratrol results in decreased phosphorylation of EGFR protein]; more ... CTD PMID:20729295 trans-resveratrol multiple interactions ISO RGD:2542 6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:15849355 PMID:16626303 trans-resveratrol decreases activity EXP   6480464 resveratrol results in decreased activity of EGF protein CTD PMID:16343977 trans-resveratrol multiple interactions EXP   6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; more ... CTD PMID:16343977 trans-resveratrol multiple interactions EXP   6480464 EGF protein inhibits the reaction [resveratrol results in increased expression of FOS mRNA]; more ... CTD PMID:15542774 trans-resveratrol multiple interactions ISO RGD:2542 6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:16626303 PMID:15849355 trans-resveratrol multiple interactions ISO RGD:2542 6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased localization of GAB1 protein] CTD PMID:15849355 trans-resveratrol multiple interactions ISO RGD:10510 6480464 PTPN11 protein affects the reaction [resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]] CTD PMID:15849355 trans-resveratrol multiple interactions ISO RGD:2542 6480464 resveratrol inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; more ... CTD PMID:16626303 urethane multiple interactions ISO RGD:10510 6480464 [Urethane co-treated with Freund's Adjuvant] results in increased expression of EGF mRNA CTD PMID:12400877 urethane increases expression ISO RGD:10510 6480464 Urethane results in increased expression of EGF mRNA CTD PMID:12400877 valproic acid multiple interactions EXP   6480464 U 0126 inhibits the reaction [Valproic Acid promotes the reaction [EGF protein results in increased activity of ELK1 protein]] CTD PMID:15103026 vancomycin increases expression ISO RGD:10510 6480464 Vancomycin results in increased expression of EGF mRNA CTD PMID:18930951 vancomycin decreases expression ISO RGD:2542 6480464 Vancomycin results in decreased expression of EGF mRNA CTD PMID:18289764 wortmannin multiple interactions ISO RGD:2542 6480464 wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein] CTD PMID:15849355 wortmannin multiple interactions ISO RGD:2542 6480464 wortmannin inhibits the reaction [EGF protein results in increased uptake of Fructose] CTD PMID:15691865 zinc atom increases import ISO RGD:10510 6480464 EGF protein results in increased import of Zinc CTD PMID:16443356 zinc atom multiple interactions EXP   6480464 Mitomycin inhibits the reaction [EGF protein results in increased uptake of Zinc] CTD PMID:1502195 zinc atom increases uptake EXP   6480464 EGF protein results in increased uptake of Zinc CTD PMID:1502195 zinc atom multiple interactions ISO RGD:2542 6480464 Zinc inhibits the reaction [Phenanthrolines inhibits the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of and results in increased secretion of EGF protein]] CTD PMID:12947092 zinc atom increases expression ISO RGD:2542 6480464 Zinc deficiency results in increased expression of EGF mRNA CTD PMID:19111725 zinc sulfate multiple interactions ISO RGD:2542 6480464 [Zinc Sulfate co-treated with EGF protein] results in increased expression of MT1A mRNA CTD PMID:7705776 zinc(0) increases import ISO RGD:10510 6480464 EGF protein results in increased import of Zinc CTD PMID:16443356 zinc(0) increases uptake EXP   6480464 EGF protein results in increased uptake of Zinc CTD PMID:1502195 zinc(0) increases expression ISO RGD:2542 6480464 Zinc deficiency results in increased expression of EGF mRNA CTD PMID:19111725 zinc(0) multiple interactions ISO RGD:2542 6480464 Zinc inhibits the reaction [Phenanthrolines inhibits the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of and results in increased secretion of EGF protein]] CTD PMID:12947092 zinc(0) multiple interactions EXP   6480464 Mitomycin inhibits the reaction [EGF protein results in increased uptake of Zinc] CTD PMID:1502195 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) activation of MAPKK activity   IEA Ensembl:ENSMUSP00000029653 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 activation of transmembrane receptor protein tyrosine kinase activity   TAS   2290271 PMID:9712850 GOC PMID:9712850 angiogenesis   IDA   2290271 PMID:15611079 HGNC PMID:15611079 blood coagulation   TAS   2290271 Reactome:REACT_604 Reactome Reactome:REACT_604 branching morphogenesis of an epithelial tube   IEA Ensembl:ENSMUSP00000029653 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 DNA replication   TAS   2290271 PMID:9482941 PINC PMID:9482941 epidermal growth factor receptor signaling pathway   TAS   2290271 Reactome:REACT_9417 Reactome Reactome:REACT_9417 ERK1 and ERK2 cascade   IDA   2290271 PMID:16314496 UniProtKB PMID:16314496 fibroblast growth factor receptor signaling pathway   TAS   2290271 Reactome:REACT_9470 Reactome Reactome:REACT_9470 innate immune response   TAS   2290271 Reactome:REACT_6802 Reactome Reactome:REACT_6802 mammary gland alveolus development   IEA Ensembl:ENSMUSP00000029653 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of cholesterol efflux   IEA Ensembl:ENSMUSP00000029653 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 negative regulation of epidermal growth factor receptor signaling pathway   TAS   2290271 Reactome:REACT_12484 Reactome Reactome:REACT_12484 negative regulation of secretion   IDA   2290271 PMID:10559227 BHF-UCL PMID:10559227 neurotrophin TRK receptor signaling pathway   TAS   2290271 Reactome:REACT_11061 Reactome Reactome:REACT_11061 peptidyl-tyrosine phosphorylation   IEA Ensembl:ENSMUSP00000029653 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 phosphatidylinositol-mediated signaling   TAS   2290271 Reactome:REACT_12464 Reactome Reactome:REACT_12464 platelet activation   TAS   2290271 Reactome:REACT_798 Reactome Reactome:REACT_798 platelet degranulation   TAS   2290271 Reactome:REACT_318 Reactome Reactome:REACT_318 positive regulation of catenin import into nucleus   IDA   2290271 PMID:20302655 BHF-UCL PMID:20302655 positive regulation of cell proliferation   IDA   2290271 PMID:15611079 HGNC PMID:15611079 positive regulation of cell proliferation   IDA   2290271 PMID:7736574 MGI PMID:7736574 positive regulation of cell proliferation   IDA   2290271 PMID:20388803 BHF-UCL PMID:20388803 positive regulation of cerebellar granule cell precursor proliferation   IEA Ensembl:ENSMUSP00000029653 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of DNA binding   ISS UniProtKB:P01132 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 positive regulation of epidermal growth factor-activated receptor activity   IDA   2290271 PMID:15611079 HGNC PMID:15611079 positive regulation of epidermal growth factor-activated receptor activity   TAS   2290271 PMID:9712850 UniProtKB PMID:9712850 positive regulation of hyaluronan biosynthetic process   IDA   2290271 PMID:17324121 UniProtKB PMID:17324121 positive regulation of MAP kinase activity   IDA   2290271 PMID:15611079 HGNC PMID:15611079 positive regulation of mitosis   IDA   2290271 PMID:15611079 HGNC PMID:15611079 positive regulation of peptidyl-threonine phosphorylation   IDA   2290271 PMID:16314496 UniProtKB PMID:16314496 positive regulation of phosphorylation   IDA   2290271 PMID:15611079 HGNC PMID:15611079 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process   IEA Ensembl:ENSMUSP00000029653 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of transcription, DNA-dependent   IDA   2290271 PMID:16314496 UniProtKB PMID:16314496 regulation of calcium ion import   IDA   2290271 PMID:19996314 BHF-UCL PMID:19996314 regulation of protein localization to cell surface   IDA   2290271 PMID:19996314 BHF-UCL PMID:19996314 signal transduction   TAS   2290271 Reactome:REACT_12478 Reactome Reactome:REACT_12478 STAT protein import into nucleus   ISS UniProtKB:P01132 2290271 GO_REF:0000024 UniProtKB GO_REF:0000024 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) extracellular region   IC GO:0005154 2290271 PMID:9712850 UniProtKB PMID:9712850 extracellular region   TAS   2290271 Reactome:REACT_147854 Reactome Reactome:REACT_147854 extracellular region   TAS   2290271 Reactome:REACT_147781 Reactome Reactome:REACT_147781 extracellular region   TAS   2290271 Reactome:REACT_116141 Reactome Reactome:REACT_116141 extracellular region   TAS   2290271 Reactome:REACT_116154 Reactome Reactome:REACT_116154 extracellular region   TAS   2290271 Reactome:REACT_116063 Reactome Reactome:REACT_116063 extracellular region   TAS   2290271 Reactome:REACT_116004 Reactome Reactome:REACT_116004 extracellular region   TAS   2290271 Reactome:REACT_115884 Reactome Reactome:REACT_115884 extracellular region   TAS   2290271 Reactome:REACT_115903 Reactome Reactome:REACT_115903 extracellular region   TAS   2290271 Reactome:REACT_115841 Reactome Reactome:REACT_115841 extracellular region   TAS   2290271 Reactome:REACT_115809 Reactome Reactome:REACT_115809 extracellular region   TAS   2290271 Reactome:REACT_115796 Reactome Reactome:REACT_115796 extracellular region   TAS   2290271 Reactome:REACT_115745 Reactome Reactome:REACT_115745 extracellular region   TAS   2290271 Reactome:REACT_115627 Reactome Reactome:REACT_115627 extracellular region   TAS   2290271 Reactome:REACT_115604 Reactome Reactome:REACT_115604 extracellular region   TAS   2290271 Reactome:REACT_115562 Reactome Reactome:REACT_115562 extracellular region   TAS   2290271 Reactome:REACT_12592 Reactome Reactome:REACT_12592 extracellular region   TAS   2290271 Reactome:REACT_9481 Reactome Reactome:REACT_9481 extracellular region   TAS   2290271 Reactome:REACT_9401 Reactome Reactome:REACT_9401 extracellular region   TAS   2290271 Reactome:REACT_9397 Reactome Reactome:REACT_9397 extracellular region   TAS   2290271 Reactome:REACT_9388 Reactome Reactome:REACT_9388 extracellular region   TAS   2290271 Reactome:REACT_21351 Reactome Reactome:REACT_21351 extracellular region   TAS   2290271 Reactome:REACT_12636 Reactome Reactome:REACT_12636 extracellular region   TAS   2290271 Reactome:REACT_12632 Reactome Reactome:REACT_12632 extracellular region   TAS   2290271 Reactome:REACT_12629 Reactome Reactome:REACT_12629 extracellular region   TAS   2290271 Reactome:REACT_12626 Reactome Reactome:REACT_12626 extracellular region   TAS   2290271 Reactome:REACT_12605 Reactome Reactome:REACT_12605 extracellular region   TAS   2290271 Reactome:REACT_12601 Reactome Reactome:REACT_12601 extracellular region   TAS   2290271 Reactome:REACT_12580 Reactome Reactome:REACT_12580 extracellular region   TAS   2290271 Reactome:REACT_12569 Reactome Reactome:REACT_12569 extracellular region   TAS   2290271 Reactome:REACT_12562 Reactome Reactome:REACT_12562 extracellular region   TAS   2290271 Reactome:REACT_12527 Reactome Reactome:REACT_12527 extracellular region   TAS   2290271 Reactome:REACT_12521 Reactome Reactome:REACT_12521 extracellular region   TAS   2290271 Reactome:REACT_12520 Reactome Reactome:REACT_12520 extracellular region   TAS   2290271 Reactome:REACT_12515 Reactome Reactome:REACT_12515 extracellular region   TAS   2290271 Reactome:REACT_12514 Reactome Reactome:REACT_12514 extracellular region   TAS   2290271 Reactome:REACT_12501 Reactome Reactome:REACT_12501 extracellular region   TAS   2290271 Reactome:REACT_12495 Reactome Reactome:REACT_12495 extracellular region   TAS   2290271 Reactome:REACT_12491 Reactome Reactome:REACT_12491 extracellular region   TAS   2290271 Reactome:REACT_12490 Reactome Reactome:REACT_12490 extracellular region   TAS   2290271 Reactome:REACT_12466 Reactome Reactome:REACT_12466 extracellular region   TAS   2290271 Reactome:REACT_12451 Reactome Reactome:REACT_12451 extracellular region   TAS   2290271 Reactome:REACT_12432 Reactome Reactome:REACT_12432 extracellular region   TAS   2290271 Reactome:REACT_12425 Reactome Reactome:REACT_12425 extracellular region   TAS   2290271 Reactome:REACT_12424 Reactome Reactome:REACT_12424 extracellular region   TAS   2290271 Reactome:REACT_12423 Reactome Reactome:REACT_12423 extracellular region   TAS   2290271 Reactome:REACT_12412 Reactome Reactome:REACT_12412 extracellular region   TAS   2290271 Reactome:REACT_12407 Reactome Reactome:REACT_12407 extracellular region   TAS   2290271 Reactome:REACT_12402 Reactome Reactome:REACT_12402 extracellular region   TAS   2290271 Reactome:REACT_12401 Reactome Reactome:REACT_12401 extracellular region   TAS   2290271 Reactome:REACT_12392 Reactome Reactome:REACT_12392 extracellular region   TAS   2290271 Reactome:REACT_12390 Reactome Reactome:REACT_12390 extracellular region   TAS   2290271 Reactome:REACT_12387 Reactome Reactome:REACT_12387 extracellular region   TAS   2290271 Reactome:REACT_12386 Reactome Reactome:REACT_12386 extracellular region   TAS   2290271 Reactome:REACT_12381 Reactome Reactome:REACT_12381 extracellular region   TAS   2290271 Reactome:REACT_116135 Reactome Reactome:REACT_116135 extracellular region   TAS   2290271 Reactome:REACT_116096 Reactome Reactome:REACT_116096 extracellular region   TAS   2290271 Reactome:REACT_116087 Reactome Reactome:REACT_116087 extracellular region   TAS   2290271 Reactome:REACT_116044 Reactome Reactome:REACT_116044 extracellular region   TAS   2290271 Reactome:REACT_115990 Reactome Reactome:REACT_115990 extracellular region   TAS   2290271 Reactome:REACT_115850 Reactome Reactome:REACT_115850 extracellular region   TAS   2290271 Reactome:REACT_115811 Reactome Reactome:REACT_115811 extracellular region   TAS   2290271 Reactome:REACT_115797 Reactome Reactome:REACT_115797 extracellular region   TAS   2290271 Reactome:REACT_115779 Reactome Reactome:REACT_115779 extracellular region   TAS   2290271 Reactome:REACT_115772 Reactome Reactome:REACT_115772 extracellular region   TAS   2290271 Reactome:REACT_115761 Reactome Reactome:REACT_115761 extracellular region   TAS   2290271 Reactome:REACT_115744 Reactome Reactome:REACT_115744 extracellular region   TAS   2290271 Reactome:REACT_115734 Reactome Reactome:REACT_115734 extracellular region   TAS   2290271 Reactome:REACT_115732 Reactome Reactome:REACT_115732 extracellular region   TAS   2290271 Reactome:REACT_115673 Reactome Reactome:REACT_115673 extracellular region   TAS   2290271 Reactome:REACT_115659 Reactome Reactome:REACT_115659 extracellular region   TAS   2290271 Reactome:REACT_115623 Reactome Reactome:REACT_115623 extracellular region   TAS   2290271 Reactome:REACT_115614 Reactome Reactome:REACT_115614 extracellular region   TAS   2290271 Reactome:REACT_115609 Reactome Reactome:REACT_115609 extracellular region   TAS   2290271 Reactome:REACT_115602 Reactome Reactome:REACT_115602 extracellular region   TAS   2290271 Reactome:REACT_115568 Reactome Reactome:REACT_115568 extracellular region   TAS   2290271 Reactome:REACT_115532 Reactome Reactome:REACT_115532 extracellular space   IEA Ensembl:ENSMUSP00000029653 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 integral to membrane   IEA UniProtKB-KW:KW-0812 2290271 GO_REF:0000038 UniProtKB GO_REF:0000038 integral to membrane   IEA UniProtKB-KW:KW-0812 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 plasma membrane   IEA Ensembl:ENSMUSP00000029653 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 platelet alpha granule lumen   TAS   2290271 Reactome:REACT_21351 Reactome Reactome:REACT_21351 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) calcium ion binding   IEA InterPro:IPR001881|InterPro:IPR018097 2290271 GO_REF:0000002 InterPro GO_REF:0000002 epidermal growth factor receptor binding   TAS   2290271 PMID:15611079 HGNC PMID:15611079 epidermal growth factor receptor binding   TAS   2290271 PMID:9712850 UniProtKB PMID:9712850 growth factor activity   IDA   2290271 PMID:15611079 HGNC PMID:15611079 growth factor activity   IDA   2290271 PMID:7736574 MGI PMID:7736574 protein binding   IPI UniProtKB:P00533 2290271 PMID:12297050 IntAct PMID:12297050 protein binding   IPI UniProtKB:P00533 2290271 PMID:2790960 IntAct PMID:2790960 protein binding   IPI UniProtKB:P00533 2290271 PMID:12620237 IntAct PMID:12620237 transmembrane receptor protein tyrosine kinase activator activity   TAS   2290271 PMID:9712850 UniProtKB PMID:9712850 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) altered epidermal growth factor/neuregulin signaling pathway   TAS   5490965   RGD   bladder cancer pathway   IEA RGD:736832 6907045   KEGG hsa:05219 ceramide signaling pathway   EXP   6484113   PID PID:200119 ceramide signaling pathway   IEA RGD:736832 6907045   KEGG hsa:05212 E-cadherin signaling pathway   EXP   6484113   PID PID:200182 eicosanoid signaling pathway   EXP   6484113   PID PID:200082 endocytosis pathway   IEA RGD:736832 6907045   KEGG hsa:04144 endometrial cancer pathway   IEA RGD:736832 6907045   KEGG hsa:05213 epidermal growth factor/neuregulin signaling pathway   ISS RGD:2542 1626483   RGD   epidermal growth factor/neuregulin signaling pathway   IEA RGD:736832 6907045   KEGG hsa:04012 epidermal growth factor/neuregulin signaling pathway   EXP   6484113   PID PID:200159 epidermal growth factor/neuregulin signaling pathway   EXP   6484113   PID PID:200101 epidermal growth factor/neuregulin signaling pathway   TAS   2317963   RGD   glioma pathway   IEA RGD:736832 6907045   KEGG hsa:05214 hepatitis C virus infection pathway   IEA RGD:736832 6907045   KEGG hsa:05160 melanoma pathway   IEA RGD:736832 6907045   KEGG hsa:05218 mitogen activated protein kinase signaling pathway   IEA RGD:736832 6907045   KEGG hsa:04010 non-small cell lung cancer pathway   IEA RGD:736832 6907045   KEGG hsa:05223 pancreatic cancer pathway   TAS   5490965   RGD   pancreatic cancer pathway   IEA RGD:736832 6907045   KEGG hsa:05212 prostate cancer pathway   IEA RGD:736832 6907045   KEGG hsa:05215 External Database Links KEGG Pathway Bladder cancer Cytokine-cytokine receptor interaction Endocytosis Endometrial cancer ErbB signaling pathway Focal adhesion Gap junction Glioma Hepatitis C HIF-1 signaling pathway MAPK signaling pathway Melanoma Non-small cell lung cancer Pancreatic cancer Pathways in cancer PI3K-Akt signaling pathway Prostate cancer Regulation of actin cytoskeleton Pathway Interaction Database a6b1 and a6b4 Integrin signaling (PID:200190) Arf6 signaling events (PID:200073) Ceramide signaling pathway (PID:200119) EGF receptor (ErbB1) signaling pathway (PID:200101) EGFR-dependent Endothelin signaling events (PID:200112) ErbB receptor signaling network (PID:200159) ErbB1 downstream signaling (PID:200133) Internalization of ErbB1 (PID:200171) Posttranslational regulation of adherens junction stability and dissassembly (PID:200117) Regulation of Telomerase (PID:200086) SHP2 signaling (PID:200083) Signaling events mediated by PTP1B (PID:200042) Signaling events mediated by TCPTP (PID:200078) Stabilization and expansion of the E-cadherin adherens junction (PID:200182) Thromboxane A2 receptor signaling (PID:200082) Disease Annotations Acute Kidney Injury  (IEP) AIDS-Associated Nephropathy  (IEP) Carcinoma, Pancreatic Ductal  (IEP) Diabetic Nephropathies  (IEP) Enterocolitis, Necrotizing  (ISS) Gallbladder Neoplasms  (IAGP,IEP) Hypomagnesemia 4, Renal  (IEA) Hypomagnesemia primary  (IAGP) Lupus Nephritis  (IEP) Pancreatic Neoplasms  (IEP,TAS) Pancreatitis  (IEP) Pneumonia  (ISS) Reperfusion Injury  (IED) Wounds and Injuries  (ISS) Zollinger-Ellison Syndrome  (IED) Gene-Chemical Interaction Annotations (+)-taxifolin  (EXP) (-)-epigallocatechin 3-gallate  (EXP) (R)-noradrenaline  (ISO) 1-chloro-2,4-dinitrobenzene  (EXP) 11-deoxycorticosterone  (ISO) 17alpha-ethynylestradiol  (ISO) 17beta-estradiol  (EXP,ISO) 2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO) 2,4-dinitrotoluene  (ISO) 2,6-dinitrotoluene  (ISO) 2-acetamidofluorene  (ISO) 3,3',4,4',5-pentachlorobiphenyl  (ISO) 3,3',5-triiodo-L-thyronine  (ISO) 3,4-dihydrocoumarin  (ISO) 3-isobutyl-1-methyl-7H-xanthine  (ISO) 4,4'-diaminodiphenylmethane  (ISO) 4,5-dianilinophthalimide  (ISO) acetaldehyde  (EXP) actinomycin D  (ISO) afimoxifene  (EXP) aflatoxin B1  (EXP,ISO) all-trans-retinoic acid  (EXP,ISO) alpha-hexachlorocyclohexane  (ISO) ammonium chloride  (ISO) amsacrine  (EXP) arsenite(3-)  (ISO) bacitracin  (ISO) benzo[a]pyrene  (ISO) bicalutamide  (EXP) bis(2-chloroethyl) sulfide  (EXP) bisphenol A  (ISO) butan-1-ol  (ISO) calcitriol  (EXP,ISO) calcium atom  (EXP,ISO) calcium(0)  (EXP,ISO) capsaicin  (EXP,ISO) chlorogenic acid  (EXP) chloroquine  (EXP) ciguatoxin CTX1B  (ISO) cisplatin  (EXP,ISO) copper atom  (EXP,ISO) copper(0)  (EXP,ISO) cortisol  (EXP) crocidolite asbestos  (EXP) curcumin  (EXP,ISO) cycloheximide  (ISO) cyclosporin A  (EXP,ISO) cyproterone acetate  (ISO) cytochalasin D  (ISO) D-glucose  (EXP) dasatinib (anhydrous)  (EXP) daunorubicin  (EXP) DDT  (ISO) dexamethasone  (EXP,ISO) diarsenic trioxide  (ISO) diethylstilbestrol  (ISO) disodium selenite  (ISO) doxorubicin  (EXP,ISO) elemental selenium  (ISO) ethanolamine  (EXP) etoposide  (EXP) flurbiprofen  (ISO) fructose  (ISO) fulvestrant  (EXP) gefitinib  (EXP,ISO) geldanamycin  (ISO) genistein  (EXP,ISO) glucose  (EXP) glutathione  (ISO) Goe 6976  (ISO) heparin  (EXP) hydrogen peroxide  (ISO) ibuprofen  (EXP) indomethacin  (EXP,ISO) inulin  (EXP) ionomycin  (EXP) lovastatin  (EXP) luteolin  (EXP) LY294002  (EXP) mestranol  (ISO) midostaurin  (EXP) mifepristone  (EXP) mitomycin C  (EXP) monensin A  (ISO) mono(2-ethylhexyl) phthalate  (ISO) myricetin  (ISO) N-acetyl-L-cysteine  (ISO) N-methyl-N'-nitro-N-nitrosoguanidine  (EXP) N-nitrosodiethylamine  (ISO) N-nitrosodimethylamine  (ISO) nevirapine  (EXP) nickel dichloride  (EXP) nocodazole  (EXP) omeprazole  (ISO) paclitaxel  (EXP) paracetamol  (ISO) perfluorooctanoic acid  (ISO) permethrin  (ISO) phencyclidine  (ISO) phenobarbital  (ISO) phenylephrine  (ISO) phorbol 13-acetate 12-myristate  (EXP,ISO) piperonyl butoxide  (ISO) pirinixic acid  (ISO) progesterone  (EXP) prostaglandin D2  (ISO) prostaglandin E2  (EXP) pterostilbene  (EXP) quercetin  (EXP) resveratrol  (EXP,ISO) Ro 31-8220  (ISO) rosiglitazone  (ISO) selenium atom  (ISO) sirolimus  (EXP,ISO) staurosporine  (EXP,ISO) sulfasalazine  (ISO) sulindac  (EXP) tamoxifen  (EXP) testosterone  (EXP,ISO) tetrachloromethane  (ISO) tetraphene  (ISO) tetrathiomolybdate(2-)  (EXP) thapsigargin  (EXP) trans-resveratrol  (EXP,ISO) urethane  (ISO) valproic acid  (EXP) vancomycin  (ISO) wortmannin  (ISO) zinc atom  (EXP,ISO) zinc sulfate  (ISO) zinc(0)  (EXP,ISO) Gene Ontology Annotations Biological Process activation of MAPKK activity  (IEA) activation of transmembrane receptor protein tyrosine kinase activity  (TAS) angiogenesis  (IDA) blood coagulation  (TAS) branching morphogenesis of an epithelial tube  (IEA) DNA replication  (TAS) epidermal growth factor receptor signaling pathway  (TAS) ERK1 and ERK2 cascade  (IDA) fibroblast growth factor receptor signaling pathway  (TAS) innate immune response  (TAS) mammary gland alveolus development  (IEA) negative regulation of cholesterol efflux  (IEA) negative regulation of epidermal growth factor receptor signaling pathway  (TAS) negative regulation of secretion  (IDA) neurotrophin TRK receptor signaling pathway  (TAS) peptidyl-tyrosine phosphorylation  (IEA) phosphatidylinositol-mediated signaling  (TAS) platelet activation  (TAS) platelet degranulation  (TAS) positive regulation of catenin import into nucleus  (IDA) positive regulation of cell proliferation  (IDA) positive regulation of cerebellar granule cell precursor proliferation  (IEA) positive regulation of DNA binding  (ISS) positive regulation of epidermal growth factor-activated receptor activity  (IDA,TAS) positive regulation of hyaluronan biosynthetic process  (IDA) positive regulation of MAP kinase activity  (IDA) positive regulation of mitosis  (IDA) positive regulation of peptidyl-threonine phosphorylation  (IDA) positive regulation of phosphorylation  (IDA) positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process  (IEA) positive regulation of transcription, DNA-dependent  (IDA) regulation of calcium ion import  (IDA) regulation of protein localization to cell surface  (IDA) signal transduction  (TAS) STAT protein import into nucleus  (ISS) Cellular Component extracellular region  (IC,TAS) extracellular space  (IEA) integral to membrane  (IEA) plasma membrane  (IEA) platelet alpha granule lumen  (TAS) Molecular Function calcium ion binding  (IEA) epidermal growth factor receptor binding  (TAS) growth factor activity  (IDA) protein binding  (IPI) transmembrane receptor protein tyrosine kinase activator activity  (TAS) Molecular Pathway Annotations altered epidermal growth factor/neuregulin signaling pathway  (TAS) bladder cancer pathway  (IEA) ceramide signaling pathway  (EXP,IEA) E-cadherin signaling pathway  (EXP) eicosanoid signaling pathway  (EXP) endocytosis pathway  (IEA) endometrial cancer pathway  (IEA) epidermal growth factor/neuregulin signaling pathway  (EXP,IEA,ISS,TAS) glioma pathway  (IEA) hepatitis C virus infection pathway  (IEA) melanoma pathway  (IEA) mitogen activated protein kinase signaling pathway  (IEA) non-small cell lung cancer pathway  (IEA) pancreatic cancer pathway  (IEA,TAS) prostate cancer pathway  (IEA) External Database Links KEGG Pathway Bladder cancer Cytokine-cytokine receptor interaction Endocytosis Endometrial cancer ErbB signaling pathway Focal adhesion Gap junction Glioma Hepatitis C HIF-1 signaling pathway MAPK signaling pathway Melanoma Non-small cell lung cancer Pancreatic cancer Pathways in cancer PI3K-Akt signaling pathway Prostate cancer Regulation of actin cytoskeleton Pathway Interaction Database a6b1 and a6b4 Integrin signaling (PID:200190) Arf6 signaling events (PID:200073) Ceramide signaling pathway (PID:200119) EGF receptor (ErbB1) signaling pathway (PID:200101) EGFR-dependent Endothelin signaling events (PID:200112) ErbB receptor signaling network (PID:200159) ErbB1 downstream signaling (PID:200133) Internalization of ErbB1 (PID:200171) Posttranslational regulation of adherens junction stability and dissassembly (PID:200117) Regulation of Telomerase (PID:200086) SHP2 signaling (PID:200083) Signaling events mediated by PTP1B (PID:200042) Signaling events mediated by TCPTP (PID:200078) Stabilization and expansion of the E-cadherin adherens junction (PID:200182) Thromboxane A2 receptor signaling (PID:200082) References - curated 1. Cao YQ, etal., Zhong Xi Yi Jie He Xue Bao. 2005 May;3(3):220-4. 2. Cibrian D, etal., Clin Sci (Lond). 2006 May;110(5):563-73. 3. Dominguez JA, etal., Shock. 2011 Oct;36(4):381-9. 4. GOA_HUMAN data from the GO Consortium 5. Groenestege WM, etal., J Clin Invest. 2007 Aug;117(8):2260-7. 6. Khailova L, etal., Pediatr Res. 2009 Aug;66(2):140-4. 7. Liangos O, etal., Biomarkers. 2010 Aug;15(5):436-45. 8. Lindenmeyer MT, etal., J Am Soc Nephrol. 2007 Jun;18(6):1765-76. Epub 2007 May 2. 9. Papachristou GI, etal., Dig Dis Sci. 2010 Feb 3. 10. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 11. Pipeline to import Pathway Interaction Database annotations from NCI into RGD 12. Pryczynicz A, etal., Anticancer Res. 2008 Mar-Apr;28(2B):1399-404. 13. Reich HN, etal., J Mol Diagn. 2011 Mar;13(2):143-51. 14. RGD automated import pipeline for gene-chemical interactions 15. RGD Automated Pipelines 16. Sarosiek J, etal., Am J Gastroenterol. 2000 May;95(5):1158-65. 17. Schaudies RP, etal., Am J Physiol. 1990 Dec;259(6 Pt 1):G1056-61. 18. Singh AB and Harris RC, Cell Signal. 2005 Oct;17(10):1183-93. 19. Soler-Garcia AA, etal., Kidney Int. 2009 Jul;76(2):207-14. Epub 2009 Apr 8. 20. Vishnoi M, etal., Hum Immunol. 2008 Jun;69(6):360-7. Epub 2008 May 6. 21. Wong HH and Lemoine NR, Nat Rev Gastroenterol Hepatol. 2009 Jul;6(7):412-22. Epub 2009 Jun 9. 22. Yamanaka Y Nippon Ika Daigaku Zasshi. 1992 Feb;59(1):51-61. 23. Yukawa M, etal., Hum Pathol. 1993 Jan;24(1):37-40. 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17673689   17762162   17851837   17852426   17898861   17912028   17940864   17943082   17950068   17962208   17968796   17986122   17991726   17991733   18006148   18036246   18080773   18088275   18094008   18096367   18156174   18167406   18212060   18271526   18271972   18276761   18292095   18325497   18349392   18365874   18382118   18398039   18434322   18441095   18463167   18467441   18483390   18485152   18487214   18490463   18511414   18519765   18543351   18583979   18632979   18676680   18722874   18757521   18773861   18813355   18831963   18844210   18990689   19010984   19011936   19014905   19020743   19032382   19064572   19073827   19074885   19081071   19086053   19087984   19110611   19124506   19127217   19141999   19144868   19167371   19170196   19172394   19179548   19203995   19236842   19319135   19336395   19380191   19388850   19403524   19415484   19453261   19460345   19470771   19484147   19488063   19491269   19492417   19520791   19531499   19544388   19549686   19549816   19592671   19604397   19608641   19619867   19624835   19625176   19634110   19670348   19692168   19708171   19727227   19749156   19817957   19823871   19834535   19840254   19840943   19853299   19880507   19887603   19895983   19896111   19900104   19913121   19920151   19921131   19951549   19953086   19996314   20033794   20036812   20092031   20101173   20108217   20126978   20157331   20158379   20164030   20169434   20197289   20201065   20201926   20203692   20207214   20303009   20332099   20351270   20362419   20364107   20375273   20379614   20398806   20412119   20418097   20423485   20424473   20429940   20430735   20444693   20453000   20466569   20472833   20487573   20498653   20514023   20564212   20587610   20598233   20606012   20621058   20628086   20628624   20631636   20634891   20644561   20674545   20690902   20714325   20727496   20727996   20800603   20818748   20819124   20830310   20832399   20851879   20854793   20889718   20963824   20969541   21029725   21048224   21062739   21087604   21099256   21123997   21186997   21187523   21209099   21212517   21224998   21236296   21247755   21273531   21274378   21309478   21358296   21376205   21436680   21439278   21533003   21567271   21678081   21752154   21868386   21872446   21971700   21982438   22022452   22033246   22070650   22087246   22106858   22122913   22129558   22236006   22279551   22293333   22308022   22401280   22403631   22404757   22413835   22416276   22433566   22457050   22479527   22479638   22481252   22493503   22503865   22504456   22505024   22532606   22534548   22574813   22621366   22668508   22677173   22701712   22721997   22727668   22745586   22782629   22829589   22829952   22852842   22914212   22925500   22951723   22990108   23007402   23201894   2789514   2790960   300079   3486749   3491360   6290982   6382023   6603475   7540053   7558411   7615511   7640657   7730382   7736574   8077234   8123596   8413296   8419140   8639530   8796265   8845374   9188692   9356464   9482941   9544989   9661876   9687510   9712850   9925763 RGD Disease Portals EGF has been annotated in the following RGD Disease Portals. Biological Process Cancer Diseases Cancer Pathways Biological Process Cardiovascular Diseases Cardiovascular Pathways Biological Process Diabetes Diseases Diabetes Pathways Biological Process Immune and Inflammatory Diseases Immune and Inflammatory Pathways Biological Process Neurological Pathways Biological Process Obesity Diseases Obesity Pathways Biological Process Respiratory Diseases Respiratory Pathways Genomics Comparative Map Data EGF   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 4 110,628,399 - 110,728,472 + NCBI Human Genome Assembly HuRef 4 106,566,131 - 106,666,223 + NCBI Human Genome Assembly GRCh37 4 110,834,040 - 110,934,118 + NCBI Human Genome Assembly Build 36 4 111,053,499 - 111,152,868 + NCBI Human Cytogenetic Map 4 q25   NCBI Human Genome Assembly 4 111,191,653 - 111,291,023   NCBI Egf   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 3 129,677,575 - 129,755,322 - NCBI Mouse cM Map 3 58.5   NCBI Mouse Celera Assembly 3 136,187,440 - 136,268,006 - NCBI Mouse Genome Assembly Build 37 3 129,380,493 - 129,458,240 - NCBI Mouse Genome Assembly Build 36.1 3 129,380,496 - 129,458,234 - NCBI Mouse Cytogenetic Map 3 G3   NCBI Egf   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 2 q42-q43   NCBI RGSC Genome Assembly v5.0 2 253,481,574 - 253,482,579 - NCBI RGSC Genome Assembly v5.0 2 74,746,757 - 74,782,858 + NCBI RGSC Genome Assembly v5.0 2 88,549,762 - 88,621,573 + NCBI RGSC Genome Assembly v3.4 2 227,103,900 - 227,195,062 - NCBI Rat Celera Assembly 2 210,511,076 - 210,588,041 - NCBI Genome Assembly 3.1 2 227,090,579 - 227,181,742 - NCBI RH 3.4 2 1556.7   RGD Position Markers D4S2623   Map Chr Position Strand Source Human Whitehead-YAC Contig Map 4     UniSTS Human Whitehead-RH Map 4 566.7   UniSTS Human deCODE Assembly Map 4 113.7   UniSTS Human TNG Radiation Hybrid Map 4 67970.0   UniSTS Human Genome Assembly HuRef 4 106,621,811 - 106,622,091   UniSTS Human Genome Assembly HuRef 4 106,621,890 - 106,622,091   UniSTS Human Genome Assembly GRCh37 4 110,889,706 - 110,889,990   UniSTS Human Genome Assembly GRCh37 4 110,889,785 - 110,889,990   UniSTS Human Celera Assembly 4 108,183,432 - 108,183,712   RGD Human Celera Assembly 4 108,183,511 - 108,183,712   UniSTS Human Genome Assembly Build 36 4 111,109,155 - 111,109,439   RGD Human Cytogenetic Map 4 q22   UniSTS Human Cytogenetic Map 4 q   UniSTS Human Cytogenetic Map 4 q25   UniSTS Marshfield Human Genetic Map 4 114.04   UniSTS Marshfield Human Genetic Map 4 114.04   RGD SHGC4-992   Map Chr Position Strand Source Human GeneMap99-G3 RH Map 4 6272.0   UniSTS Human TNG Radiation Hybrid Map 4 68025.0   UniSTS Human Genome Assembly HuRef 4 106,565,160 - 106,565,356   UniSTS Human Genome Assembly GRCh37 4 110,833,069 - 110,833,265   UniSTS Human Celera Assembly 4 108,126,800 - 108,126,996   RGD Human Genome Assembly Build 36 4 111,052,518 - 111,052,714   RGD Human Cytogenetic Map 4 q25   UniSTS EGF_435   Map Chr Position Strand Source Human Genome Assembly HuRef 4 106,664,822 - 106,665,550   UniSTS Human Genome Assembly GRCh37 4 110,932,717 - 110,933,445   UniSTS Human Celera Assembly 4 108,226,441 - 108,227,169   RGD Human Genome Assembly Build 36 4 111,152,166 - 111,152,894   RGD D4S2350   Map Chr Position Strand Source Human Whitehead-YAC Contig Map 4     UniSTS Human Whitehead-RH Map 4 568.4   UniSTS Human Genome Assembly HuRef 4 106,580,899 - 106,581,153   UniSTS Human Genome Assembly GRCh37 4 110,848,789 - 110,849,043   UniSTS Human Celera Assembly 4 108,142,520 - 108,142,774   RGD Human Genome Assembly Build 36 4 111,068,238 - 111,068,492   RGD Human Cytogenetic Map 4 q25   UniSTS D4S3145   Map Chr Position Strand Source Human GeneMap99-G3 RH Map 4 6279.0   UniSTS Human TNG Radiation Hybrid Map 4 67984.0   UniSTS Human Genome Assembly HuRef 4 106,664,826 - 106,664,934   UniSTS Human Genome Assembly GRCh37 4 110,932,721 - 110,932,829   UniSTS Human Celera Assembly 4 108,226,445 - 108,226,553   RGD Human Genome Assembly Build 36 4 111,152,170 - 111,152,278   RGD Human Cytogenetic Map 4 q25   UniSTS QTLs in Region (Human Genome Assembly GRCh37) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 1331636 COPD13_H Chronic obstructive pulmonary disease QTL 13 (human) 1.56 Chronic airflow obstruction post-BD FEV1 minus pre-BD FEV1 4 57681817 183160300 Human 1298424 OSTEAR21_H Osteoarthritis QTL 21 (human) 3.9 Joint/bone inflammation hip osteoarthritis 4 62246959 139220795 Human 1298442 RA7_H Rheumatoid arthritis QTL 7 (human) .0001 Joint/bone inflammation rheumatoid arthritis 4 86435044 112435044 Human 1643539 GLUCO18_H Glucose level QTL 18 (human) .79 .028 Glucose level non-insulin-dependent 4 86435044 112435044 Human 2315895 GLUCO188_H Glucose level QTL 188 (human) 1.43 Glucose level 4 86435044 112435044 Human 1300001 BP26_H Blood pressure QTL 26 (human) 3.2 Blood pressure systolic 4 90770130 116770130 Human 2293460 PRSTS302_H Prostate tumor susceptibility QTL 302 (human) .002 Prostate tumor susceptibility 4 97889848 123889848 Human 2289626 BW484_H Body weight QTL 484 (human) 2.39 Body fat amount percent fat 4 99434973 110889990 Human 2289563 BW441_H Body weight QTL 441 (human) 2.66 .0005 Body weight BMI 4 99434973 185151317 Human 1643256 BW127_H Body Weight QTL 127 (human) 1.31 .007 Body weight body mass index 4 107240860 133240860 Human 1559222 SAPOA2_H Serum apolipoprotein A level QTL 2 (human) 2.35 Apolipoprotein level apolipoprotein A-II level 4 108376545 190440336 Human 2300243 PRSTS352_H Prostate tumor susceptibility QTL 352 (human) 1.6 Prostate tumor susceptibility 4 110607736 136607736 Human 2316670 GLUCO243_H Glucose level QTL 243 (human) 1.37 Glucose level 4 110889706 130298080 Human 1357365 HRTRT1_H Heart rate QTL 1 (human) 3.9 .00435 Heart rate resting heart rate 4 110889706 141751658 Human Sequence Nucleotide Sequences Nucleotide RefSeqs NG_011441 (Get FASTA) Search GEO for Microarray Profiles   NM_001178130 (Get FASTA) Search GEO for Microarray Profiles   NM_001178131 (Get FASTA) Search GEO for Microarray Profiles   NM_001963 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide ABBA01063785 (Get FASTA) Search GEO for Microarray Profiles   ABBA01063786 (Get FASTA) Search GEO for Microarray Profiles   AC004050 (Get FASTA) Search GEO for Microarray Profiles   AC005509 (Get FASTA) Search GEO for Microarray Profiles   AF023155 (Get FASTA) Search GEO for Microarray Profiles   AI628974 (Get FASTA) Search GEO for Microarray Profiles   AK299306 (Get FASTA) Search GEO for Microarray Profiles   AK307734 (Get FASTA) Search GEO for Microarray Profiles   AMYH01014458 (Get FASTA) Search GEO for Microarray Profiles   AY548762 (Get FASTA) Search GEO for Microarray Profiles   BC093731 (Get FASTA) Search GEO for Microarray Profiles   BC113461 (Get FASTA) Search GEO for Microarray Profiles   BC143357 (Get FASTA) Search GEO for Microarray Profiles   CA437074 (Get FASTA) Search GEO for Microarray Profiles   CH471057 (Get FASTA) Search GEO for Microarray Profiles   CU446298 (Get FASTA) Search GEO for Microarray Profiles   DB227969 (Get FASTA) Search GEO for Microarray Profiles   DB349864 (Get FASTA) Search GEO for Microarray Profiles   JQ346088 (Get FASTA) Search GEO for Microarray Profiles   X04571 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_001963 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_001954 Peptide Label: isoform 1 preproprotein Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 4 110,628,399 - 110,728,472 + NCBI Human Genome Assembly HuRef 4 106,566,131 - 106,666,223 + ENTREZGENE Human Genome Assembly GRCh37 4 110,834,040 - 110,934,118 + ENTREZGENE Human Genome Assembly Build 36 4 111,053,499 - 111,152,868 + NCBI Archive RefSeq Acc Id: NM_001178130 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_001171601 Peptide Label: isoform 2 preproprotein Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 4 110,628,399 - 110,728,472 + NCBI Human Genome Assembly HuRef 4 106,566,131 - 106,666,223 + ENTREZGENE Human Genome Assembly GRCh37 4 110,834,040 - 110,934,118 + ENTREZGENE RefSeq Acc Id: NM_001178131 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_001171602 Peptide Label: isoform 3 preproprotein Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 4 110,628,399 - 110,728,472 + NCBI Human Genome Assembly HuRef 4 106,566,131 - 106,666,223 + ENTREZGENE Human Genome Assembly GRCh37 4 110,834,040 - 110,934,118 + ENTREZGENE Protein Sequences Protein RefSeqs NP_001171601 (Get FASTA)   NP_001171602 (Get FASTA)   NP_001954 (Get FASTA) GenBank Protein AAA72173 (Get FASTA)   AAH93731 (Get FASTA)   AAI13462 (Get FASTA)   AAS83395 (Get FASTA)   AFA26280 (Get FASTA)   BAG61319 (Get FASTA)   CAA28240 (Get FASTA)   EAX06257 (Get FASTA)   P01133 (Get FASTA) Promoters RGD ID: 6802178 Promoter ID: HG_KWN:48911 Type: Non-CpG SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: K562 Transcripts: NM_001178130,   NM_001178131,   NM_001963 Position: Map Chr Position Strand Source Human Genome Assembly Build 36 4 111,053,366 - 111,053,866 + MPROMDB RGD ID: 6858704 Promoter ID: EPDNEW_H2517 Type: initiation region Name: CNIH4_1 Description: cornichon homolog 4 SO ACC ID: SO:0000170 Source: EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) Position: Map Chr Position Strand Source Human Genome Assembly Build 36 1 224,544,587 - 224,544,647   EPDNEW Additional Information External Database Links Database Acc Id Source(s) COSMIC EGF COSMIC Ensembl Genes ENSG00000138798 ENTREZGENE Ensembl Protein ENSP00000265171 ENTREZGENE   ENSP00000424316 ENTREZGENE Ensembl Transcript ENST00000265171 ENTREZGENE   ENST00000509793 ENTREZGENE Entrez Gene 1950 ENTREZGENE Gene3D-CATH 55.10 UniProtKB/Swiss-Prot   6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot HGNC ID 3229 ENTREZGENE HomoloGene Group ID 1483 ENTREZGENE HPRD ID 00578 ENTREZGENE InterPro 6-blade_b-propeller_TolB-like UniProtKB/Swiss-Prot   EGF-like_Ca-bd UniProtKB/Swiss-Prot   EGF-like_reg_CS UniProtKB/Swiss-Prot   EGF-type_Asp/Asn_hydroxyl_site UniProtKB/Swiss-Prot   EGF_3 UniProtKB/Swiss-Prot   EGF_Ca-bd_CS UniProtKB/Swiss-Prot   GFP_like UniProtKB/Swiss-Prot   LDLR_classB_rpt UniProtKB/Swiss-Prot   Pro-epidermal_GF UniProtKB/Swiss-Prot IPI IPI00000073 UniProtKB/Swiss-Prot   IPI00966866 UniProtKB/Swiss-Prot   IPI00967121 UniProtKB/TrEMBL KEGG Report hsa:1950 ENTREZGENE, UniProtKB/Swiss-Prot OMIM 131530 OMIM   611718 OMIM Pfam EGF UniProtKB/Swiss-Prot   EGF_CA UniProtKB/Swiss-Prot   Ldl_recept_b UniProtKB/Swiss-Prot PharmGKB EGF RGD, PharmGKB PIRSF Pro-epidermal_growth_factor UniProtKB/Swiss-Prot PROSITE ASX_HYDROXYL UniProtKB/Swiss-Prot   EGF_1 UniProtKB/Swiss-Prot   EGF_2 UniProtKB/Swiss-Prot   EGF_3 UniProtKB/Swiss-Prot   EGF_CA UniProtKB/Swiss-Prot   LDLRB UniProtKB/Swiss-Prot SMART EGF UniProtKB/Swiss-Prot   EGF_CA UniProtKB/Swiss-Prot   SM00135 UniProtKB/Swiss-Prot UniGene Hs.419815 ENTREZGENE UniProt E7EVD2_HUMAN UniProtKB/TrEMBL   EGF_HUMAN UniProtKB/Swiss-Prot Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2011-08-16 EGF  epidermal growth factor  EGF  epidermal growth factor  Symbol and/or name change 39860 APPROVED 2011-07-27 EGF  epidermal growth factor  EGF  epidermal growth factor (beta-urogastrone)  Symbol and/or name change 39860 APPROVED

More on EGF Entrez Gene Ensembl Gene Genome Browser: (hg18) (hg19) HGNC Report NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 736832 Created: 2004-02-06 Species: Homo sapiens Last Modified: 2013-04-09 Status: ACTIVE