CCND3 (cyclin D3) - Rat Genome Database

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Keyword

Gene: CCND3 (cyclin D3) Homo sapiens

Symbol:

CCND3

Name:

cyclin D3

Description:

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

D3-type cyclin; G1/S-specific cyclin D3; G1/S-specific cyclin-D3; OTTHUMP00000016390; OTTHUMP00000016391; OTTHUMP00000223406; OTTHUMP00000223407; OTTHUMP00000223408; OTTHUMP00000223409; OTTHUMP00000223413; OTTHUMP00000223414; OTTHUMP00000223415

Orthologs:

Mus musculus : Ccnd3 (cyclin D3) MGI

Related Pseudogenes:

CCND3P

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	6	41,813,223 - 41,927,013	-	NCBI
Human Genome Assembly HuRef	6	41,621,515 - 41,734,566	-	NCBI
Human Genome Assembly GRCh37	6	41,902,671 - 42,016,610	-	NCBI
Human Genome Assembly Build 36	6	42,010,649 - 42,017,530	-	NCBI
Human Cytogenetic Map	6	p21		NCBI
Human Genome Assembly	6	42,010,649 - 42,017,530		NCBI