Annotation (Toggle Detail/Summary View) Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | EXP | | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of RGS2 mRNA | CTD | PMID:22079256 | (S)-nicotine | increases expression | ISO | RGD:732361 | 6480464 | Nicotine results in increased expression of RGS2 mRNA | CTD | PMID:17456735 | (S)-nicotine | multiple interactions | ISO | RGD:732361 | 6480464 | [Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of RGS2 mRNA; more ... | CTD | PMID:20230807 | 1,2,4-trimethylbenzene | increases expression | ISO | RGD:621665 | 6480464 | pseudocumene results in increased expression of RGS2 protein | CTD | PMID:17337753 | 1-chloro-2,4-dinitrobenzene | increases expression | EXP | | 6480464 | Dinitrochlorobenzene results in increased expression of RGS2 mRNA | CTD | PMID:20146380 | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | decreases expression | ISO | RGD:732361 | 6480464 | 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RGS2 mRNA | CTD | PMID:20230807 | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | multiple interactions | ISO | RGD:732361 | 6480464 | [Caffeine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of RGS2 mRNA; more ... | CTD | PMID:20230807 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:732361 | 6480464 | Ethinyl Estradiol results in increased expression of RGS2 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | decreases expression | ISO | RGD:621665 | 6480464 | Ethinyl Estradiol results in decreased expression of RGS2 mRNA | CTD | PMID:17351261 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:732361 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RGS2 mRNA | CTD | PMID:17942748 | 17beta-estradiol | increases expression | EXP | | 6480464 | Estradiol results in increased expression of RGS2 mRNA | CTD | PMID:20106945 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [Progesterone co-treated with Estradiol] results in increased expression of RGS2 mRNA | CTD | PMID:17404688 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:732361 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RGS2 mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:621665 | 6480464 | Tetrachlorodibenzodioxin affects the expression of RGS2 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of RGS2 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:621665 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of RGS2 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:732361 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of RGS2 mRNA | CTD | PMID:19770486 PMID:15652763 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:732361 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of RGS2 mRNA | CTD | PMID:15652763 PMID:19770486 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:732361 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of RGS2 mRNA | CTD | PMID:15652763 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of RGS2 mRNA | CTD | PMID:17101203 | 2-acetamidofluorene | increases expression | ISO | RGD:621665 | 6480464 | 2-Acetylaminofluorene results in increased expression of RGS2 mRNA | CTD | PMID:22584684 | 2-butoxyethanol | decreases expression | ISO | RGD:732361 | 6480464 | n-butoxyethanol results in decreased expression of RGS2 mRNA | CTD | PMID:19812364 | 3-iodobenzyl-5'-N-methylcarboxamidoadenosine | multiple interactions | ISO | RGD:621665 | 6480464 | N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA] | CTD | PMID:15452191 | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | RGD:732361 | 6480464 | [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of RGS2 mRNA | CTD | PMID:16054899 | 5-aza-2'-deoxycytidine | increases expression | EXP | | 6480464 | decitabine results in increased expression of RGS2 mRNA | CTD | PMID:16367923 | 5-aza-2'-deoxycytidine | multiple interactions | EXP | | 6480464 | [decitabine co-treated with vorinostat] affects the expression of RGS2 mRNA | CTD | PMID:17330099 | 5-fluorouracil | decreases expression | EXP | | 6480464 | Fluorouracil results in decreased expression of RGS2 mRNA | CTD | PMID:16510598 | aflatoxin B1 | affects expression | EXP | | 6480464 | Aflatoxin B1 affects the expression of RGS2 protein | CTD | PMID:20106945 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of RGS2 mRNA | CTD | PMID:22100608 | ammonium chloride | affects expression | ISO | RGD:621665 | 6480464 | Ammonium Chloride affects the expression of RGS2 mRNA | CTD | PMID:16483693 | amphetamine | increases expression | ISO | RGD:621665 | 6480464 | Amphetamine results in increased expression of RGS2 mRNA | CTD | PMID:10098858 | amphetamine | multiple interactions | ISO | RGD:621665 | 6480464 | Raclopride promotes the reaction [Amphetamine results in increased expression of RGS2 mRNA]; more ... | CTD | PMID:10098858 | benzene | decreases expression | ISO | RGD:732361 | 6480464 | Benzene results in decreased expression of RGS2 mRNA | CTD | PMID:15120971 PMID:15122651 | benzene | decreases expression | ISO | RGD:732361 | 6480464 | Benzene results in decreased expression of RGS2 mRNA | CTD | PMID:15122651 PMID:15120971 | benzo[a]pyrene | decreases expression | ISO | RGD:732361 | 6480464 | Benzo(a)pyrene results in decreased expression of RGS2 mRNA | CTD | PMID:21715664 PMID:19770486 | benzo[a]pyrene | increases expression | ISO | RGD:732361 | 6480464 | Benzo(a)pyrene results in increased expression of RGS2 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases expression | ISO | RGD:732361 | 6480464 | Benzo(a)pyrene results in decreased expression of RGS2 mRNA | CTD | PMID:21715664 more ... | benzo[a]pyrene | decreases expression | ISO | RGD:732361 | 6480464 | Benzo(a)pyrene results in decreased expression of RGS2 mRNA | CTD | PMID:21569818 more ... | benzo[a]pyrene | decreases expression | ISO | RGD:732361 | 6480464 | Benzo(a)pyrene results in decreased expression of RGS2 mRNA | CTD | PMID:19770486 more ... | benzo[a]pyrene | decreases expression | ISO | RGD:732361 | 6480464 | Benzo(a)pyrene results in decreased expression of RGS2 mRNA | CTD | PMID:19770486 PMID:21715664 | benzo[a]pyrene | multiple interactions | ISO | RGD:732361 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of RGS2 mRNA | CTD | PMID:21715664 | benzo[a]pyrene | decreases expression | ISO | RGD:732361 | 6480464 | Benzo(a)pyrene results in decreased expression of RGS2 mRNA | CTD | PMID:21715664 | cadmium sulfate | increases expression | EXP | | 6480464 | cadmium sulfate results in increased expression of RGS2 mRNA | CTD | PMID:21783983 | caffeine | multiple interactions | ISO | RGD:732361 | 6480464 | Caffeine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of RGS2 mRNA]; more ... | CTD | PMID:20230807 | CGS-21680 | multiple interactions | ISO | RGD:621665 | 6480464 | 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA] | CTD | PMID:15452191 | chloroprene | decreases expression | ISO | RGD:732361 | 6480464 | Chloroprene results in decreased expression of RGS2 mRNA | CTD | PMID:23125180 | chlorpyrifos | decreases expression | ISO | RGD:732361 | 6480464 | Chlorpyrifos results in decreased expression of RGS2 mRNA | CTD | PMID:20350560 | choline | multiple interactions | ISO | RGD:732361 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RGS2 mRNA | CTD | PMID:20938992 | cisplatin | increases expression | EXP | | 6480464 | Cisplatin results in increased expression of RGS2 mRNA | CTD | PMID:21603599 | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of RGS2 mRNA | CTD | PMID:19376846 PMID:19320972 | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of RGS2 mRNA | CTD | PMID:19320972 PMID:19376846 | cocaine | affects expression | ISO | RGD:621665 | 6480464 | Cocaine affects the expression of RGS2 mRNA | CTD | PMID:20187946 | cocaine | increases expression | ISO | RGD:621665 | 6480464 | Cocaine results in increased expression of RGS2 mRNA | CTD | PMID:10098858 | copper atom | multiple interactions | EXP | | 6480464 | [MT1 protein co-treated with MT2 protein] affects the reaction [Copper results in increased expression of RGS2 mRNA] | CTD | PMID:16629173 | copper(0) | multiple interactions | EXP | | 6480464 | [MT1 protein co-treated with MT2 protein] affects the reaction [Copper results in increased expression of RGS2 mRNA] | CTD | PMID:16629173 | copper(2+) sulfate | increases expression | EXP | | 6480464 | Copper Sulfate results in increased expression of RGS2 mRNA | CTD | PMID:19549813 | coumestrol | multiple interactions | EXP | | 6480464 | [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of RGS2 mRNA | CTD | PMID:19167446 | crocidolite asbestos | increases expression | EXP | | 6480464 | Asbestos, Crocidolite results in increased expression of RGS2 mRNA | CTD | PMID:18687144 | dexamethasone | multiple interactions | ISO | RGD:732361 | 6480464 | [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of RGS2 mRNA | CTD | PMID:16054899 | diarsenic trioxide | decreases expression | EXP | | 6480464 | arsenic trioxide results in decreased expression of RGS2 mRNA | CTD | PMID:21461292 more ... | diarsenic trioxide | decreases expression | EXP | | 6480464 | arsenic trioxide results in decreased expression of RGS2 mRNA | CTD | PMID:12852829 more ... | diarsenic trioxide | decreases expression | EXP | | 6480464 | arsenic trioxide results in decreased expression of RGS2 mRNA | CTD | PMID:12852829 more ... | diarsenic trioxide | decreases expression | EXP | | 6480464 | arsenic trioxide results in decreased expression of RGS2 mRNA | CTD | PMID:20458559 more ... | dibutyl phthalate | increases expression | ISO | RGD:621665 | 6480464 | Dibutyl Phthalate results in increased expression of RGS2 mRNA | CTD | PMID:21266533 | diuron | increases expression | ISO | RGD:621665 | 6480464 | Diuron results in increased expression of RGS2 mRNA | CTD | PMID:21551480 | folic acid | multiple interactions | ISO | RGD:732361 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RGS2 mRNA | CTD | PMID:20938992 | formaldehyde | increases expression | EXP | | 6480464 | Formaldehyde results in increased expression of RGS2 mRNA | CTD | PMID:20655997 | formaldehyde | increases expression | EXP | | 6480464 | Formaldehyde results in increased expression of RGS2 mRNA | CTD | PMID:20655997 PMID:23416264 | haloperidol | increases expression | ISO | RGD:621665 | 6480464 | Haloperidol results in increased expression of RGS2 mRNA | CTD | PMID:11516571 PMID:11409749 | haloperidol | increases expression | ISO | RGD:621665 | 6480464 | Haloperidol results in increased expression of RGS2 mRNA | CTD | PMID:11409749 PMID:11516571 | hydrogen peroxide | affects expression | EXP | | 6480464 | Hydrogen Peroxide affects the expression of RGS2 mRNA | CTD | PMID:20044591 | indole-3-methanol | affects expression | ISO | RGD:621665 | 6480464 | indole-3-carbinol affects the expression of RGS2 mRNA | CTD | PMID:21396975 | iron atom | increases expression | EXP | | 6480464 | Iron deficiency results in increased expression of RGS2 mRNA | CTD | PMID:20368581 | ketamine | decreases expression | ISO | RGD:621665 | 6480464 | Ketamine results in decreased expression of RGS2 mRNA | CTD | PMID:20080153 | L-methionine | multiple interactions | ISO | RGD:732361 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of RGS2 mRNA | CTD | PMID:20938992 | lithium atom | increases expression | EXP | | 6480464 | Lithium results in increased expression of RGS2 mRNA | CTD | PMID:21092101 | manganese atom | increases expression | EXP | | 6480464 | Manganese results in increased expression of RGS2 mRNA | CTD | PMID:17175027 | manganese(0) | increases expression | EXP | | 6480464 | Manganese results in increased expression of RGS2 mRNA | CTD | PMID:17175027 | manganese(II) chloride | increases expression | EXP | | 6480464 | manganese chloride results in increased expression of RGS2 mRNA | CTD | PMID:17175027 | melphalan | increases expression | EXP | | 6480464 | Melphalan results in increased expression of RGS2 mRNA | CTD | PMID:22363485 | methamphetamine | increases expression | ISO | RGD:621665 | 6480464 | Methamphetamine results in increased expression of RGS2 mRNA | CTD | PMID:10098858 | methotrexate | decreases expression | EXP | | 6480464 | Methotrexate results in decreased expression of RGS2 mRNA | CTD | PMID:17400583 | mitoxantrone | affects response to substance | EXP | | 6480464 | RGS2 protein affects the susceptibility to Mitoxantrone | CTD | PMID:16217747 | N-ethyl-N-nitrosourea | increases mutagenesis | ISO | RGD:732361 | 6480464 | Ethylnitrosourea results in increased mutagenesis of RGS2 gene | CTD | PMID:16724327 | N-nitrosodiethylamine | increases expression | ISO | RGD:621665 | 6480464 | Diethylnitrosamine results in increased expression of RGS2 mRNA | CTD | PMID:19638242 | ochratoxin A | increases expression | ISO | RGD:621665 | 6480464 | ochratoxin A results in increased expression of RGS2 mRNA | CTD | PMID:23358140 | paracetamol | affects expression | ISO | RGD:732361 | 6480464 | Acetaminophen affects the expression of RGS2 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of RGS2 mRNA | CTD | PMID:21420995 | perfluorooctane-1-sulfonic acid | decreases expression | ISO | RGD:621665 | 6480464 | perfluorooctane sulfonic acid results in decreased expression of RGS2 mRNA | CTD | PMID:18692542 | phenylephrine | multiple interactions | ISO | RGD:621665 | 6480464 | 2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Phenylephrine results in increased expression of RGS2 mRNA]; more ... | CTD | PMID:15452191 | phenylephrine | increases expression | ISO | RGD:621665 | 6480464 | Phenylephrine results in increased expression of RGS2 mRNA | CTD | PMID:15452191 more ... | phenylephrine | increases expression | ISO | RGD:621665 | 6480464 | Phenylephrine results in increased expression of RGS2 mRNA | CTD | PMID:15452191 more ... | phenylephrine | increases expression | ISO | RGD:621665 | 6480464 | Phenylephrine results in increased expression of RGS2 mRNA | CTD | PMID:18158353 more ... | phenylephrine | increases expression | ISO | RGD:621665 | 6480464 | Phenylephrine results in increased expression of RGS2 mRNA | CTD | PMID:16517124 more ... | phenylephrine | multiple interactions | ISO | RGD:621665 | 6480464 | RGS2 protein inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA]; more ... | CTD | PMID:16517124 | phenylephrine | affects response to substance | ISO | RGD:732361 | 6480464 | RGS2 protein affects the susceptibility to Phenylephrine | CTD | PMID:17644703 | profenofos | increases expression | ISO | RGD:621665 | 6480464 | profenofos results in increased expression of RGS2 mRNA | CTD | PMID:17569032 | progesterone | multiple interactions | EXP | | 6480464 | [Progesterone co-treated with Estradiol] results in increased expression of RGS2 mRNA | CTD | PMID:17404688 | progesterone | increases expression | EXP | | 6480464 | Progesterone results in increased expression of RGS2 mRNA | CTD | PMID:18070364 PMID:17404688 | progesterone | affects expression | ISO | RGD:732361 | 6480464 | Progesterone affects the expression of RGS2 mRNA | CTD | PMID:17251523 | progesterone | increases expression | EXP | | 6480464 | Progesterone results in increased expression of RGS2 mRNA | CTD | PMID:17404688 PMID:18070364 | quercetin | increases expression | EXP | | 6480464 | Quercetin results in increased expression of RGS2 mRNA | CTD | PMID:21632981 | quinolinic acid | decreases expression | ISO | RGD:621665 | 6480464 | Quinolinic Acid results in decreased expression of RGS2 mRNA; more ... | CTD | PMID:12207953 | ranitidine | multiple interactions | ISO | RGD:621665 | 6480464 | Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of RGS2 mRNA] | CTD | PMID:16415329 | reserpine | decreases expression | ISO | RGD:621665 | 6480464 | Reserpine results in decreased expression of RGS2 mRNA | CTD | PMID:14505795 | risperidone | increases expression | ISO | RGD:621665 | 6480464 | Risperidone results in increased expression of RGS2 mRNA | CTD | PMID:11516571 | rosiglitazone | multiple interactions | ISO | RGD:732361 | 6480464 | [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of RGS2 mRNA | CTD | PMID:16054899 | rosiglitazone | decreases expression | ISO | RGD:621665 | 6480464 | rosiglitazone results in decreased expression of RGS2 mRNA | CTD | PMID:21515302 | silicon dioxide | increases expression | ISO | RGD:732361 | 6480464 | Silicon Dioxide results in increased expression of RGS2 mRNA | CTD | PMID:19073995 | simvastatin | increases expression | EXP | | 6480464 | Simvastatin results in increased expression of RGS2 mRNA | CTD | PMID:17428261 | tamoxifen | affects expression | ISO | RGD:732361 | 6480464 | Tamoxifen affects the expression of RGS2 mRNA | CTD | PMID:20937368 | tert-butyl hydroperoxide | increases expression | EXP | | 6480464 | tert-Butylhydroperoxide results in increased expression of RGS2 mRNA | CTD | PMID:15336504 | troglitazone | decreases expression | ISO | RGD:732361 | 6480464 | troglitazone results in decreased expression of RGS2 mRNA | CTD | PMID:12732648 | troglitazone | decreases expression | ISO | RGD:621665 | 6480464 | troglitazone results in decreased expression of RGS2 mRNA | CTD | PMID:21515302 | undecane | increases expression | ISO | RGD:621665 | 6480464 | undecane results in increased expression of RGS2 protein | CTD | PMID:17337753 | vanadyl sulfate | increases expression | EXP | | 6480464 | vanadyl sulfate results in increased expression of RGS2 mRNA | CTD | PMID:16330358 | zinc atom | multiple interactions | EXP | | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of RGS2 mRNA | CTD | PMID:18593933 | zinc(0) | multiple interactions | EXP | | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of RGS2 mRNA | CTD | PMID:18593933 | | 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Gene Ontology AnnotationsBiological Process











