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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | affects expression | ISO | RGD:10624 | 6480464 | Ethinyl Estradiol affects the expression of GC mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | multiple interactions | ISO | RGD:10624 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GC mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | increases expression | ISO | RGD:10624 | 6480464 | Ethinyl Estradiol results in increased expression of GC mRNA | CTD | PMID:17942748 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | RGD:10624 | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GC mRNA | CTD | PMID:17942748 | 2,6-dinitrotoluene | affects expression | ISO | RGD:2667 | 6480464 | 2,6-dinitrotoluene affects the expression of GC mRNA | CTD | PMID:21346803 | aflatoxin B1 | affects expression | EXP | | 6480464 | Aflatoxin B1 affects the expression of GC protein | CTD | PMID:20106945 | aflatoxin B1 | multiple interactions | ISO | RGD:2667 | 6480464 | [Aflatoxin B1 co-treated with Buthionine Sulfoximine] results in increased expression of GC mRNA | CTD | PMID:23288050 | aflatoxin B1 | increases expression | ISO | RGD:2667 | 6480464 | Aflatoxin B1 results in increased expression of GC mRNA | CTD | PMID:23288050 | ammonium chloride | affects expression | ISO | RGD:2667 | 6480464 | Ammonium Chloride affects the expression of GC mRNA | CTD | PMID:16483693 | arsenite(3-) | increases expression | ISO | RGD:10624 | 6480464 | arsenite results in increased expression of GC mRNA | CTD | PMID:18929588 | arsenite(3-) | multiple interactions | ISO | RGD:10624 | 6480464 | TRP53 protein affects the reaction [arsenite results in increased expression of GC mRNA] | CTD | PMID:18929588 | benzo[a]pyrene | multiple interactions | ISO | RGD:10624 | 6480464 | [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of GC mRNA | CTD | PMID:21715664 | bromobenzene | increases expression | ISO | RGD:2667 | 6480464 | bromobenzene results in increased expression of GC mRNA | CTD | PMID:15056800 | bromobenzene | increases expression | ISO | RGD:2667 | 6480464 | bromobenzene results in increased expression of GC mRNA | CTD | PMID:15056800 PMID:23288050 | calcitriol | affects abundance | EXP | | 6480464 | GC protein affects the abundance of Calcitriol | CTD | PMID:6894152 | calcitriol | affects binding | ISO | RGD:2667 | 6480464 | Calcitriol binds to GC protein | CTD | PMID:17444814 | calcitriol | affects binding | EXP | | 6480464 | GC protein polymorphism binds to Calcitriol | CTD | PMID:8370586 | calcitriol | affects transport | EXP | | 6480464 | GC protein affects the transport of Calcitriol | CTD | PMID:15820770 | calcium atom | affects expression | ISO | RGD:2667 | 6480464 | Calcium affects the expression of GC mRNA | CTD | PMID:15913539 | calcium(0) | affects expression | ISO | RGD:2667 | 6480464 | Calcium affects the expression of GC mRNA | CTD | PMID:15913539 | carbon atom | affects response to substance | EXP | | 6480464 | GC gene SNP affects the susceptibility to Carbon | CTD | PMID:21138591 | clofibrate | decreases expression | ISO | RGD:2667 | 6480464 | Clofibrate results in decreased expression of GC mRNA | CTD | PMID:12851107 | clofibric acid | multiple interactions | ISO | RGD:2667 | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GC mRNA | CTD | PMID:17602206 | cyclosporin A | decreases expression | EXP | | 6480464 | Cyclosporine results in decreased expression of GC mRNA | CTD | PMID:20106945 | cyclosporin A | increases expression | ISO | RGD:2667 | 6480464 | Cyclosporine results in increased expression of GC mRNA | CTD | PMID:21865292 | cyclosporin A | decreases expression | ISO | RGD:2667 | 6480464 | Cyclosporine results in decreased expression of GC mRNA | CTD | PMID:21865292 | doxorubicin | increases expression | ISO | RGD:10624 | 6480464 | Doxorubicin results in increased expression of GC mRNA | CTD | PMID:15033991 | elemental carbon | affects response to substance | EXP | | 6480464 | GC gene SNP affects the susceptibility to Carbon | CTD | PMID:21138591 | furan | affects binding | ISO | RGD:2667 | 6480464 | furan binds to GC protein | CTD | PMID:22240984 | furan | increases methylation | ISO | RGD:2667 | 6480464 | furan results in increased methylation of GC gene | CTD | PMID:22079235 | lead diacetate | increases expression | ISO | RGD:2667 | 6480464 | lead acetate results in increased expression of GC mRNA | CTD | PMID:22641619 | methylmercury(1+) | decreases expression | ISO | RGD:2667 | 6480464 | methylmercury II results in decreased expression of GC mRNA | CTD | PMID:17905399 | N-nitrosodiethylamine | multiple interactions | ISO | RGD:2667 | 6480464 | [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of GC mRNA | CTD | PMID:20360939 | N-nitrosodiethylamine | multiple interactions | ISO | RGD:2667 | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GC mRNA | CTD | PMID:17602206 | ochratoxin A | decreases expression | ISO | RGD:2667 | 6480464 | ochratoxin A results in decreased expression of GC mRNA | CTD | PMID:18417182 | ouabain | affects expression | EXP | | 6480464 | Ouabain affects the expression of GC protein | CTD | PMID:17268060 | paracetamol | affects expression | ISO | RGD:10624 | 6480464 | Acetaminophen affects the expression of GC mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | RGD:2667 | 6480464 | Acetaminophen results in increased expression of GC mRNA | CTD | PMID:23288050 | paracetamol | increases expression | ISO | RGD:2667 | 6480464 | Acetaminophen results in increased expression of GC protein | CTD | PMID:16687475 | paracetamol | affects expression | ISO | RGD:2667 | 6480464 | Acetaminophen affects the expression of GC protein | CTD | PMID:16099942 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of GC protein | CTD | PMID:11510020 | pirinixic acid | multiple interactions | ISO | RGD:10624 | 6480464 | [pirinixic acid co-treated with PPARA] results in decreased expression of GC mRNA | CTD | PMID:20813756 | pirinixic acid | decreases expression | ISO | RGD:10624 | 6480464 | pirinixic acid results in decreased expression of GC mRNA | CTD | PMID:20813756 | S-butyl-DL-homocysteine (S,R)-sulfoximine | multiple interactions | ISO | RGD:2667 | 6480464 | [Aflatoxin B1 co-treated with Buthionine Sulfoximine] results in increased expression of GC mRNA | CTD | PMID:23288050 | tacrolimus hydrate | decreases expression | ISO | RGD:2667 | 6480464 | Tacrolimus results in decreased expression of GC mRNA | CTD | PMID:21865292 | tetrachloromethane | affects expression | ISO | RGD:10624 | 6480464 | Carbon Tetrachloride affects the expression of GC mRNA | CTD | PMID:17484886 | thioacetamide | increases expression | ISO | RGD:2667 | 6480464 | Thioacetamide results in increased expression of GC mRNA | CTD | PMID:23288050 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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References - curated
References - uncurated
RGD Disease Portals| GC has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| GC (Homo sapiens) |
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| Gc (Mus musculus) |
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| Gc (Rattus norvegicus) |
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Position Markers| D4S2389 |
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| SHGC-59541 |
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| SHGC-67593 |
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| GDB:196472 |
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| PMC310762P2 |
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| PMC310762P4 |
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| PMC310762P5 |
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| RH68432 |
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| SHGC-50400 |
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| SHGC-33816 |
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| SHGC4-18 |
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| SHGC-24721 |
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QTLs in Region (Human Genome Assembly GRCh37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| RefSeq Acc Id: | NM_001204306 | ||||||||||||||||||||
| RefSeq Status: | REVIEWED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001191235 | ||||||||||||||||||||
| Peptide Label: | isoform 1 precursor | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001204307 | ||||||||||||||||||||
| RefSeq Status: | REVIEWED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001191236 | ||||||||||||||||||||
| Peptide Label: | isoform 3 precursor | ||||||||||||||||||||
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| RefSeq Acc Id: | NM_000583 | |||||||||||||||||||||||||
| RefSeq Status: | REVIEWED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_000574 | |||||||||||||||||||||||||
| Peptide Label: | isoform 1 precursor | |||||||||||||||||||||||||
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Protein Sequences
External Database Links| Database | Acc Id | Source(s) |
| COSMIC | GC | COSMIC |
| Ensembl Genes | ENSG00000145321 | ENTREZGENE |
| Ensembl Protein | ENSP00000273951 | ENTREZGENE |
| ENSP00000421725 | ENTREZGENE | |
| ENSP00000426683 | ENTREZGENE | |
| Ensembl Transcript | ENST00000273951 | ENTREZGENE |
| ENST00000504199 | ENTREZGENE | |
| ENST00000513476 | ENTREZGENE | |
| Entrez Gene | 2638 | ENTREZGENE |
| Germonline | ENSG00000145321 | |
| HGNC ID | 4187 | ENTREZGENE |
| HomoloGene Group ID | 486 | ENTREZGENE |
| HPRD ID | 00749 | ENTREZGENE |
| InterPro | Serum_albumin | UniProtKB/Swiss-Prot |
| Serum_albumin-like | UniProtKB/Swiss-Prot | |
| Serum_albumin_CS | UniProtKB/Swiss-Prot | |
| Serum_albumin_N | UniProtKB/Swiss-Prot | |
| VitD-bd | UniProtKB/Swiss-Prot | |
| VitD-bind_III | UniProtKB/Swiss-Prot | |
| IPI | IPI00555812 | UniProtKB/Swiss-Prot |
| IPI00965085 | UniProtKB/TrEMBL | |
| IPI00965382 | UniProtKB/TrEMBL | |
| IPI00968027 | UniProtKB/Swiss-Prot | |
| IPI00968182 | UniProtKB/TrEMBL | |
| KEGG Report | hsa:2638 | ENTREZGENE, UniProtKB/Swiss-Prot |
| OMIM | 139200 | OMIM |
| Pfam | Serum_albumin | UniProtKB/Swiss-Prot |
| VitD-bind_III | UniProtKB/Swiss-Prot | |
| PharmGKB | PA28601 | PharmGKB |
| PRINTS | SERUMALBUMIN | UniProtKB/Swiss-Prot |
| VITAMNDBNDNG | UniProtKB/Swiss-Prot | |
| PROSITE | ALBUMIN_1 | UniProtKB/Swiss-Prot |
| ALBUMIN_2 | UniProtKB/Swiss-Prot | |
| SMART | ALBUMIN | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | Serum_albumin | UniProtKB/Swiss-Prot |
| UniGene | Hs.418497 | ENTREZGENE |
| UniProt | D6RBJ7_HUMAN | UniProtKB/TrEMBL |
| D6RF20_HUMAN | UniProtKB/TrEMBL | |
| D6RF35_HUMAN | UniProtKB/TrEMBL | |
| VTDB_HUMAN | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2011-08-16 | GC | group-specific component (vitamin D binding protein) | GC | group-specific component (vitamin D binding protein) | Symbol and/or name change | 39860 | APPROVED |
| 2011-07-27 | GC | group-specific component (vitamin D binding protein) | GC | group-specific component (vitamin D binding protein) | Symbol and/or name change | 39860 | APPROVED |
| More on GC | |||
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Entrez Gene | ||
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Ensembl Gene | ||
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HGNC Report | ||
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NCBI Map Viewer | ||
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Vista | ||
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Vista + UCSC | ||
| RGD Object Information | |
| RGD ID: | 736902 |
| Created: | 2004-02-06 |
| Species: | Homo sapiens |
| Last Modified: | 2013-05-14 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




