HRAS (v-Ha-ras Harvey rat sarcoma viral oncogene homolog)

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Keyword

Gene: HRAS (v-Ha-ras Harvey rat sarcoma viral oncogene homolog) Homo sapiens

Symbol:

HRAS

Name:

v-Ha-ras Harvey rat sarcoma viral oncogene homolog

Description:

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

C-BAS/HAS; C-H-RAS; C-HA-RAS1; c-has/bas p21 protein; c-ras-Ki-2 activated oncogene; CTLO; GTP- and GDP-binding peptide B; GTPase HRas; H-Ras-1; H-RASIDX; ha-Ras; Ha-Ras1 proto-oncoprotein; HAMSV; HRAS1; K-RAS; N-RAS; OTTHUMP00000162769; OTTHUMP00000166053; OTTHUMP00000166055; OTTHUMP00000166056; p19 H-RasIDX protein; p21ras; Ras family small GTP binding protein H-Ras; RASH1; transformation gene: oncogene HAMSV; transforming protein p21

Orthologs:

Mus musculus : Hras1 (Harvey rat sarcoma virus oncogene 1) MGI
Rattus norvegicus : Hras (Harvey rat sarcoma virus oncogene)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	11	469,903 - 472,037	-	NCBI
Human Genome Assembly HuRef	11	346,981 - 349,115	-	NCBI
Human Genome Assembly GRCh37	11	532,242 - 535,550	-	NCBI
Human Genome Assembly Build 36	11	522,242 - 525,550	-	NCBI
Human Cytogenetic Map	11	p15.5		NCBI
Human Genome Assembly	11	522,242 - 525,550		NCBI