UGT1A6 (UDP glucuronosyltransferase 1 family, polypeptide A6)

Help | FTP Download | Citing RGD | Contact Us

Keyword

Gene: UGT1A6 (UDP glucuronosyltransferase 1 family, polypeptide A6) Homo sapiens

Symbol:

UGT1A6

Name:

UDP glucuronosyltransferase 1 family, polypeptide A6

Description:

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

GNT1; HLUGP; HLUGP1; MGC29860; OTTHUMP00000065198; OTTHUMP00000065199; OTTHUMP00000199449; OTTHUMP00000199450; phenol-metabolizing UDP-glucuronosyltransferase; UDP glycosyltransferase 1 family, polypeptide A6; UDP-glucuronosyltransferase 1 family polypeptide A6s; UDP-glucuronosyltransferase 1-6; UDP-glucuronosyltransferase 1-F; UDP-glucuronosyltransferase 1A6; UDPGT; UDPGT 1-6; UGT-1F; UGT1; UGT1*6; UGT1-06; UGT1.6; UGT1A6S; UGT1F

Orthologs:

Mus musculus : Ugt1a6a (UDP glucuronosyltransferase 1 family, polypeptide A6A) MGI
Rattus norvegicus : Ugt1a6 (UDP glucuronosyltransferase 1 family, polypeptide A6)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	2	233,972,932 - 234,054,584	+	NCBI
Human Genome Assembly HuRef	2	226,400,315 - 226,481,785	+	NCBI
Human Genome Assembly GRCh37	2	234,600,321 - 234,681,951	+	NCBI
Human Genome Assembly Build 36	2	234,265,060 - 234,346,690	+	NCBI
Human Cytogenetic Map	2	q37		NCBI
Human Genome Assembly	2	234,382,320 - 234,463,945		NCBI