JUN (Jun proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: JUN (Jun proto-oncogene, AP-1 transcription factor subunit) Homo sapiens
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Symbol: JUN
Name: Jun proto-oncogene, AP-1 transcription factor subunit
RGD ID: 734356
HGNC Page HGNC:6204
Description: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; GTPase activator activity; and R-SMAD binding activity. Involved in several processes, including positive regulation of vascular associated smooth muscle cell proliferation; regulation of DNA-templated transcription; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in RNA polymerase II transcription regulator complex and nucleoplasm. Part of euchromatin and transcription factor AP-1 complex. Implicated in pulmonary tuberculosis. Biomarker of Hodgkin's lymphoma; breast cancer; carcinoma (multiple); colorectal adenoma; and glaucoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: activator protein 1; AP-1; AP1; c-Jun; cJUN; enhancer-binding protein AP1; Jun activation domain binding protein; jun oncogene; jun proto-oncogene; p39; proto-oncogene c-Jun; proto-oncogene cJun; transcription factor AP-1; transcription factor AP-1 subunit Jun; transcription factor Jun; v-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38158,780,791 - 58,784,047 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl158,776,845 - 58,784,048 (-)EnsemblGRCh38hg38GRCh38
GRCh37159,246,463 - 59,249,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36159,019,051 - 59,022,373 (-)NCBINCBI36Build 36hg18NCBI36
Build 34158,958,483 - 58,961,806NCBI
Celera157,530,296 - 57,533,618 (-)NCBICelera
Cytogenetic Map1p32.1NCBI
HuRef157,356,787 - 57,360,109 (-)NCBIHuRef
CHM1_1159,361,828 - 59,365,150 (-)NCBICHM1_1
T2T-CHM13v2.0158,659,236 - 58,662,492 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(+)-pilocarpine  (ISO)
(+)-Pimaric acid  (EXP)
(+)-taxifolin  (EXP)
(+)-Tetrandrine  (EXP)
(-)-alpha-phellandrene  (EXP)
(-)-anisomycin  (EXP,ISO)
(-)-citrinin  (EXP)
(-)-demecolcine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(-)-selegiline  (EXP)
(20R)-protopanaxadiol  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (EXP,ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dichlorobenzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dichlorobenzene  (ISO)
1,4-dithiothreitol  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP,ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
2-methylcholine  (EXP)
2-palmitoylglycerol  (EXP)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-Methylenedioxyamphetamine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-aminobenzamide  (EXP)
3-Methoxynobiletin  (EXP)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nitroquinoline N-oxide  (ISO)
4-tert-Octylphenol  (EXP)
4-vinylcyclohexene dioxide  (ISO)
5,6,7-trimethoxyflavone  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-bromo-2'-deoxyuridine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (EXP)
5-fluorouracil  (EXP)
5-Nitro-2-(3-phenylpropylamino)benzoic acid  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
7H-xanthine  (ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (EXP)
9-Methoxycamptothecin  (EXP)
9H-xanthine  (ISO)
acetaldehyde  (EXP,ISO)
acetamide  (ISO)
acetylleucyl-leucyl-norleucinal  (ISO)
acetylsalicylic acid  (EXP)
acrolein  (EXP,ISO)
acrylamide  (ISO)
acrylonitrile  (EXP)
actinomycin D  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (EXP,ISO)
AH23848  (EXP)
alcohol  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Chaconine  (ISO)
alpha-D-galactose  (ISO)
alpha-naphthoflavone  (EXP,ISO)
alpha-phellandrene  (EXP)
alpha-pinene  (EXP)
aluminium atom  (ISO)
aluminium oxide  (EXP)
aluminium(0)  (ISO)
alvocidib  (EXP)
amiodarone  (EXP,ISO)
ammonium chloride  (ISO)
amphetamine  (EXP,ISO)
andrographolide  (EXP)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (EXP)
antirheumatic drug  (EXP)
antroquinonol  (EXP)
AP20187  (EXP)
Apicularen A  (ISO)
apigenin  (EXP)
apocynin  (EXP)
apomorphine  (EXP)
arachidonic acid  (EXP,ISO)
aristolochic acid A  (EXP)
Aroclor 1254  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
atazanavir sulfate  (EXP)
atorvastatin calcium  (EXP)
ATP  (EXP)
atrazine  (EXP,ISO)
atropine  (ISO)
auraptene  (EXP)
Azaspiracid  (EXP)
azathioprine  (EXP)
bacitracin  (ISO)
baicalein  (EXP)
bathocuproine disulfonic acid  (EXP)
Bay-K-8644  (ISO)
benzene  (EXP,ISO)
benzene-1,2,4-triol  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
Benzo[k]fluoranthene  (EXP)
benzofurans  (EXP)
benzophenanthridine  (EXP)
Benzoyl peroxide  (EXP,ISO)
benzyl isothiocyanate  (EXP)
benzylpenicillin  (ISO)
berberine  (ISO)
beryllium sulfate  (ISO)
beta-carotene  (ISO)
beta-cyclodextrin  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP)
bezafibrate  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (EXP)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bortezomib  (EXP,ISO)
bromodichloromethane  (ISO)
bucladesine  (EXP,ISO)
budesonide  (ISO)
bufalin  (EXP)
buspirone  (ISO)
butanal  (EXP)
butylated hydroxyanisole  (EXP,ISO)
butyric acid  (EXP)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP,ISO)
caffeine  (ISO)
Calcimycin  (ISO)
calcitriol  (EXP)
Calphostin C  (ISO)
camostat  (ISO)
camptothecin  (EXP,ISO)
cannabidiol  (EXP,ISO)
Cannabinol  (ISO)
cantharidin  (EXP)
capsaicin  (EXP,ISO)
captan  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carboplatin  (ISO)
Carnosol  (ISO)
cefaloridine  (ISO)
celastrol  (ISO)
celecoxib  (EXP,ISO)
cerium trichloride  (ISO)
ceruletide  (ISO)
CGP 52608  (EXP)
chenodeoxycholic acid  (EXP)
chloramphenicol  (EXP)
chlorogenic acid  (ISO)
chloropicrin  (EXP)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chromium atom  (EXP,ISO)
chromium trioxide  (EXP)
chromium(6+)  (EXP,ISO)
chrysene  (EXP)
chrysin  (EXP)
ciglitazone  (ISO)
Cinobufagin  (EXP)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clofibric acid  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cocaine  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (EXP)
cordycepin  (EXP)
corn oil  (ISO)
corosolic acid  (ISO)
corticosterone  (ISO)
coumestrol  (EXP)
crocidolite asbestos  (EXP,ISO)
CU-O LINKAGE  (EXP)
cudratricusxanthone A  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (EXP)
cypermethrin  (ISO)
cytarabine  (EXP)
D-glucitol  (EXP)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
daidzein  (EXP)
DDE  (ISO)
DDT  (EXP)
deguelin  (EXP)
dehydroepiandrosterone  (EXP)
delphinidin  (EXP)
delta-tocotrienol  (EXP)
deoxycholic acid  (EXP)
Deoxycorticosterone acetate  (ISO)
deoxynivalenol  (EXP,ISO)
desferrioxamine B  (EXP)
Destruxin B  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dextromethorphan  (ISO)
diallyl disulfide  (EXP)
Diallyl sulfide  (ISO)
diallyl trisulfide  (EXP,ISO)
Diallyltetrasulfane  (ISO)
diamminedichloroplatinum  (EXP)
diarsenic trioxide  (EXP,ISO)
diazepam  (ISO)
diazinon  (ISO)
dibenziodolium  (ISO)
dibenzofuran  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (EXP,ISO)
dicoumarol  (EXP)
Dictamnine  (EXP)
dieckol  (EXP)
dieldrin  (EXP,ISO)
diethyl maleate  (EXP,ISO)
diethylstilbestrol  (ISO)
dihydroartemisinin  (EXP)
dihydrolipoic acid  (ISO)
diiodine  (ISO)
Dimaprit  (EXP)
dimemorfan  (ISO)
dimethyl sulfoxide  (EXP,ISO)
dimethylarsinic acid  (EXP)
dinophysistoxin 1  (EXP)
dioxygen  (EXP)
diquat  (EXP)
disodium selenite  (EXP,ISO)
disulfiram  (EXP)
divanadium pentaoxide  (EXP)
dizocilpine maleate  (ISO)
dobutamine  (ISO)
donepezil hydrochloride  (ISO)
dopamine  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
efavirenz  (EXP)
elemental selenium  (ISO)
ellagic acid  (EXP)
endosulfan  (EXP,ISO)
enilconazole  (EXP)
Enterolactone  (EXP)
enzyme inhibitor  (EXP)
epoxiconazole  (ISO)
Erionite  (ISO)
erythrosin B  (ISO)
estra-1,3,5(10)-triene-3,16beta-diol  (ISO)
estriol  (ISO)
etacrynic acid  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
etoposide  (EXP)
etoxazole  (ISO)
fenofibrate  (EXP,ISO)
fenthion  (EXP)
fentin chloride  (ISO)
ferric oxide  (ISO)
ferrosoferric oxide  (EXP)
ferulic acid  (ISO)
fisetin  (EXP)
Flavokawain A  (ISO)
flavonol  (EXP)
flufenoxuron  (ISO)
flumequine  (ISO)
fluoranthene  (ISO)
fluoxetine  (EXP,ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (EXP)
formononetin  (ISO)
fotemustine  (EXP)
fructose  (ISO)
fulvestrant  (EXP)
furan  (ISO)
galactose  (ISO)
gallic acid  (EXP)
gamma-aminobutyric acid  (ISO)
gamma-hexachlorocyclohexane  (EXP,ISO)
gamma-tocopherol  (ISO)
gemcitabine  (EXP)
Geniposide pentaacetate  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
geraniol  (EXP)
gingerol  (ISO)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glycidol  (ISO)
glycine betaine  (ISO)
glycitein  (EXP)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
glyphosate  (EXP)
Goe 6976  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
gossypin  (EXP)
haloperidol  (ISO)
hemin  (EXP,ISO)
heparin  (EXP,ISO)
heptachlor  (EXP)
herbimycin  (ISO)
hexachlorobenzene  (ISO)
hexadecanoic acid  (EXP)
hyaluronic acid  (EXP)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (EXP)
hydroquinone O-beta-D-glucopyranoside  (EXP)
hydroxychloroquine  (EXP)
hydroxytyrosol  (EXP,ISO)
hyperforin  (EXP)
icariin  (ISO)
Indeno[1,2,3-cd]pyrene  (EXP)
indole-3-methanol  (EXP,ISO)
indometacin  (EXP,ISO)
inulin  (ISO)
ionomycin  (EXP)
irinotecan  (EXP,ISO)
iron atom  (EXP)
iron dichloride  (EXP,ISO)
iron trichloride  (ISO)
iron(0)  (EXP)
iron(2+) sulfate (anhydrous)  (EXP)
iron(III) nitrilotriacetate  (ISO)
isoflavones  (EXP)
isoflurane  (ISO)
isoprenaline  (ISO)
Isorhapontigenin  (ISO)
kaempferol  (EXP)
kainic acid  (ISO)
kanamycin A  (ISO)
ketamine  (ISO)
kojic acid  (ISO)
KT 5720  (EXP)
L-1,4-dithiothreitol  (ISO)
L-methionine  (ISO)
lanthanum atom  (ISO)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
leflunomide  (EXP)
Licochalcone B  (EXP,ISO)
limonene  (ISO)
linalool  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
lithium atom  (ISO)
lithium chloride  (ISO)
lithium hydride  (ISO)
lithocholic acid  (ISO)
losartan  (ISO)
lovastatin  (ISO)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
lycopene  (EXP)
Maduramicin  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (ISO)
maslinic acid  (ISO)
masoprocol  (EXP,ISO)
Mecamylamine  (ISO)
mechlorethamine  (EXP,ISO)
MeIQx  (ISO)
melatonin  (ISO)
melittin  (EXP,ISO)
menadione  (EXP)
mercury atom  (ISO)
mercury dibromide  (EXP)
mercury dichloride  (ISO)
mercury(0)  (ISO)
mesalamine  (ISO)
metacetamol  (ISO)
metformin  (EXP)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methohexital  (EXP)
methotrexate  (EXP,ISO)
methyl methanesulfonate  (EXP)
methylarsonic acid  (EXP)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (EXP)
methyltestosterone  (EXP)
metoprolol  (ISO)
metyrapone  (ISO)
mevinphos  (ISO)
Mezerein  (ISO)
mibolerone  (EXP)
microcystin-LR  (EXP,ISO)
minocycline  (EXP)
miquelianin  (EXP)
mitoxantrone  (EXP)
ML-7  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
monocrotophos  (EXP,ISO)
morin  (ISO)
morphine  (EXP)
morusin  (ISO)
Muconic dialdehyde  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N-(6-acetamidohexyl)acetamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-feruloyltyramine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-nitrosomorpholine  (ISO)
N-Nitrosopyrrolidine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naphthalene  (EXP)
naringin  (ISO)
nefazodone  (EXP,ISO)
neocuproine  (ISO)
neomycin  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (EXP,ISO)
niclosamide  (EXP,ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nilotinib  (EXP)
nimodipine  (ISO)
nimustine  (EXP)
nitric oxide  (ISO)
nitrofurantoin  (ISO)
nitrofurazone  (ISO)
nitrogen dioxide  (ISO)
nitroprusside  (ISO)
nocodazole  (EXP)
Nodularin  (EXP)
Nonylphenol  (ISO)
Nor-9-carboxy-delta9-THC  (EXP)
NSC 23766  (EXP)
obeticholic acid  (EXP)
ochratoxin A  (EXP,ISO)
okadaic acid  (EXP,ISO)
olmesartan  (ISO)
oltipraz  (EXP)
omipalisib  (EXP)
organoselenium compound  (EXP)
orphenadrine  (ISO)
ouabain  (EXP)
oxaliplatin  (EXP,ISO)
oxidopamine  (EXP,ISO)
oxybutynin  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (EXP)
p-cresol  (EXP)
p-menthan-3-ol  (EXP)
p-tert-Amylphenol  (EXP)
paclitaxel  (EXP,ISO)
palytoxin  (ISO)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
paraquat  (EXP,ISO)
patulin  (ISO)
PD 0325901  (ISO)
pent-4-enoic acid  (ISO)
pentobarbital  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perindopril  (ISO)
permethrin  (ISO)
pevonedistat  (ISO)
phenethyl caffeate  (EXP)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
phenytoin  (ISO)
PhIP  (ISO)
phorbol 12,13-dibutanoate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (ISO)
phosphane  (ISO)
phylloquinone  (EXP)
physostigmine  (ISO)
pifithrin-?  (ISO)
piperine  (EXP,ISO)
piperonyl butoxide  (ISO)
pipoxolan  (ISO)
pirfenidone  (EXP)
pirinixic acid  (EXP,ISO)
potassium atom  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (EXP)
prazosin  (ISO)
prednisolone  (ISO)
prednisone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prodigiosin  (EXP)
progesterone  (ISO)
propan-2-ol  (EXP)
propofol  (ISO)
prostaglandin J2  (EXP)
protein kinase inhibitor  (ISO)
pterostilbene  (ISO)
pyridine  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quartz  (ISO)
quercetin  (EXP,ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (EXP)
raloxifene  (EXP)
ranitidine  (ISO)
razoxane  (EXP)
reactive oxygen species  (EXP)
Rebamipide  (ISO)
reserpine  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP)
Riluzole  (ISO)
ritonavir  (EXP)
Ro 31-8220  (ISO)
ropinirole  (EXP)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP)
rutin  (EXP)
ruxolitinib  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
saccharin  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (EXP)
SCH772984  (ISO)
sclareol  (EXP)
scoparone  (ISO)
scopolamine  (ISO)
scutellarin  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
secobarbital  (EXP)
selenium atom  (ISO)
serpentine asbestos  (ISO)
sertraline  (EXP)
Shikonin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
sodium hydroxide  (ISO)
Sodium salicylate  (ISO)
Soman  (ISO)
sorafenib  (EXP)
staurosporine  (ISO)
stavudine  (ISO)
streptozocin  (ISO)
styrene  (EXP)
sulfadimethoxine  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sulindac  (ISO)
sulindac sulfide  (EXP)
Sunset Yellow FCF  (EXP)
superoxide  (ISO)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
tartrazine  (EXP)
taurine  (ISO)
taurolithocholic acid  (EXP)
tauroursodeoxycholic acid  (EXP)
tebufenpyrad  (EXP)
terbufos  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloroethene  (EXP)
tetrachloromethane  (ISO)
tetramethylpyrazine  (EXP,ISO)
tetraphene  (EXP)
tetrodotoxin  (ISO)
thalidomide  (EXP)
thapsigargin  (EXP,ISO)
Theaflavin 3,3'-digallate  (ISO)
thiamylal  (EXP)
thimerosal  (EXP)
thioacetamide  (ISO)
thiopental  (EXP)
thiourea  (ISO)
Tiron  (EXP)
titanium dioxide  (EXP)
tocopherol  (ISO)
tofacitinib  (EXP)
topotecan  (EXP,ISO)
torcetrapib  (EXP)
trametinib  (EXP)
transplatin  (EXP)
triacsin C  (EXP)
tributylstannane  (EXP)
Tributyltin oxide  (ISO)
trichloroacetic acid  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
trimethyltin  (ISO)
trioxsalen  (ISO)
Triptolide  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tungsten  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (EXP,ISO)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (ISO)
undecane  (ISO)
urethane  (EXP,ISO)
Urolithin A  (EXP)
ursolic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vanadyl sulfate  (EXP)
vancomycin  (ISO)
Vernodalin  (EXP)
vincaleukoblastine  (EXP)
vinclozolin  (ISO)
vincristine  (EXP)
vitamin D  (EXP,ISO)
vitamin E  (EXP,ISO)
vorinostat  (EXP)
wedelolactone  (ISO)
wogonin  (EXP,ISO)
xanthones  (ISO)
zearalenone  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP,ISO)
zinc oxide  (EXP,ISO)
zinc protoporphyrin  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
apoptotic process  (ISO)
axon regeneration  (ISO)
cell population proliferation  (ISO)
cellular response to anisomycin  (ISO)
cellular response to cadmium ion  (IMP)
cellular response to calcium ion  (ISO)
cellular response to hypoxia  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to potassium ion starvation  (ISO)
cellular response to prolactin  (ISO)
cellular response to reactive oxygen species  (IMP)
cellular response to zinc ion starvation  (ISO)
circadian rhythm  (ISO)
DNA-templated transcription  (ISO)
eyelid development in camera-type eye  (ISO)
immune response  (ISO)
integrated stress response signaling  (NAS)
leading edge cell differentiation  (ISO)
learning  (ISO)
liver development  (ISO)
membrane depolarization  (ISO)
microglial cell activation  (ISO)
monocyte differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of DNA-templated transcription  (IDA)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of protein autophosphorylation  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA,IMP)
outflow tract morphogenesis  (ISO)
positive regulation of apoptotic process  (IMP,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of DNA-templated transcription  (IDA,IMP)
positive regulation of DNA-templated transcription initiation  (IDA)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of epithelial cell migration  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of miRNA transcription  (IMP,ISS)
positive regulation of monocyte differentiation  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,ISO,NAS)
positive regulation of vascular associated smooth muscle cell proliferation  (IMP)
regulation of cell cycle  (IBA,IEA,ISO)
regulation of cell population proliferation  (IBA,IEA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,NAS)
release from viral latency  (IDA)
release of cytochrome c from mitochondria  (ISO)
response to cAMP  (ISO)
response to cytokine  (ISO)
response to endoplasmic reticulum stress  (IMP)
response to ethanol  (ISO)
response to hydrogen peroxide  (ISO)
response to insulin  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to muscle stretch  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to steroid hormone  (ISO)
response to xenobiotic stimulus  (ISO)
SMAD protein signal transduction  (IDA)
transcription by RNA polymerase II  (ISO)
transforming growth factor beta receptor signaling pathway  (IDA)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Bcl-xL expression and regulation in the progression, recurrence, and cisplatin resistance of oral cancer. Alam M and Mishra R, Life Sci. 2021 Sep 1;280:119705. doi: 10.1016/j.lfs.2021.119705. Epub 2021 Jun 8.
2. Specific transcription factors prognostic for prostate cancer progression. Aoyagi K, etal., Clin Cancer Res. 1998 Sep;4(9):2153-60.
3. Immunohistochemical analysis of c-myc, c-jun and estrogen receptor in normal, hyperplastic and neoplastic endometrium. Bircan S, etal., Pathol Oncol Res. 2005;11(1):32-9. Epub 2005 Mar 31.
4. c-Jun has multiple enhancing activities in the novel cross talk between the androgen receptor and Ets variant gene 1 in prostate cancer. Cai C, etal., Mol Cancer Res. 2007 Jul;5(7):725-35.
5. Impaired activation of Stat1 and c-Jun as a possible defect in macrophages of patients with active tuberculosis. Esquivel-Solis H, etal., Clin Exp Immunol. 2009 Oct;158(1):45-54.
6. Activation of cardiac c-Jun NH(2)-terminal kinases and p38-mitogen-activated protein kinases with abrupt changes in hemodynamic load. Fischer TA, etal., Hypertension. 2001 May;37(5):1222-8.
7. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
8. Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer. Gupta S, etal., Sci Rep. 2015 Nov 19;5:16811. doi: 10.1038/srep16811.
9. Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. Ikeda F, etal., J Clin Invest 2004 Aug;114(4):475-84.
10. Temporal expression of immediate early gene mRNA during the supravital reaction in mouse brain and lung after mechanical asphyxiation. Ikematsu K, etal., Forensic Sci Int. 2008 Aug 6;179(2-3):152-6. Epub 2008 Jul 14.
11. Co-expression of c-Jun and ATF-2 characterizes the surviving retinal ganglion cells which maintain axonal connections after partial optic nerve injury. Kreutz MR, etal., Brain Res Mol Brain Res. 1999 Jun 8;69(2):232-41.
12. Oral steroids enhance epithelial repair in nasal polyposis via upregulation of the AP-1 gene network. Li CW, etal., Thorax. 2009 Apr;64(4):306-12. Epub 2009 Jan 21.
13. microRNA-149-5p mediates the PM2.5-induced inflammatory response by targeting TAB2 via MAPK and NF-κB signaling pathways in vivo and in vitro. Li Q, etal., Cell Biol Toxicol. 2021 Jul 31. pii: 10.1007/s10565-021-09638-5. doi: 10.1007/s10565-021-09638-5.
14. Immunohistochemical detection of RAS, JUN, FOS, and p53 oncoprotein expression in human colorectal adenomas and carcinomas. Magrisso IJ, etal., Lab Invest. 1993 Dec;69(6):674-81.
15. Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B. Mathas S, etal., EMBO J 2002 Aug 1;21(15):4104-13.
16. Expression of fos and jun proto-oncogenes in benign versus malignant human uterine tissue. Nephew KP, etal., Gynecol Oncol. 2000 Mar;76(3):388-96.
17. C-jun activation in acquired cystic kidney disease and renal cell carcinoma. Oya M, etal., J Urol 2005 Aug;174(2):726.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
20. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Expression of c-jun oncogene in hyperplastic and carcinomatous human prostate. Tiniakos DG, etal., Urology. 2006 Jan;67(1):204-8.
23. Overexpression of members of the AP-1 transcriptional factor family from an early stage of renal carcinogenesis and inhibition of cell growth by AP-1 gene antisense oligonucleotides in the Tsc2 gene mutant (Eker) rat model. Urakami S, etal., Biochem Biophys Res Commun. 1997 Dec 8;241(1):24-30.
24. Distinct Expression of c-Jun and HSP27 in Axotomized and Spared Bulbospinal Neurons After Cervical Spinal Cord Injury. Vinit S, etal., J Mol Neurosci. 2010 Dec 4.
25. c-Jun activation is associated with proliferation and angiogenesis in invasive breast cancer. Vleugel MM, etal., Hum Pathol. 2006 Jun;37(6):668-74.
26. Integrated microarray analysis provided novel insights to the pathogenesis of glaucoma. Wang J, etal., Mol Med Rep. 2017 Dec;16(6):8735-8746. doi: 10.3892/mmr.2017.7711. Epub 2017 Oct 4.
27. Chronic alcohol intake reduces retinoic acid concentration and enhances AP-1 (c-Jun and c-Fos) expression in rat liver. Wang XD, etal., Hepatology. 1998 Sep;28(3):744-50. doi: 10.1002/hep.510280321.
28. Immune cell profiling of COVID-19 patients in the recovery stage by single-cell sequencing. Wen W, etal., Cell Discov. 2020 May 4;6:31. doi: 10.1038/s41421-020-0168-9. eCollection 2020.
29. Prolonged c-Jun expression in the basolateral amygdala following bulbectomy: possible implications for antidepressant activity and time of onset. Wrynn AS, etal., Brain Res Mol Brain Res. 2000 Mar 10;76(1):7-17.
Additional References at PubMed
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PMID:11432833   PMID:11448159   PMID:11477071   PMID:11479302   PMID:11532856   PMID:11551904   PMID:11641401   PMID:11689449   PMID:11704680   PMID:11708771   PMID:11738026   PMID:11739718  
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PMID:18570890   PMID:18572021   PMID:18597608   PMID:18600430   PMID:18617512   PMID:18619508   PMID:18621151   PMID:18644981   PMID:18646516   PMID:18650425   PMID:18653452   PMID:18653705  
PMID:18664273   PMID:18671972   PMID:18692129   PMID:18708361   PMID:18725194   PMID:18757369   PMID:18775869   PMID:18805449   PMID:18823944   PMID:18838675   PMID:18844221   PMID:18845538  
PMID:18848838   PMID:18922473   PMID:18923650   PMID:18931081   PMID:18936204   PMID:18940179   PMID:18940813   PMID:18950845   PMID:18952102   PMID:18957410   PMID:18957422   PMID:18985028  
PMID:18992165   PMID:19015316   PMID:19018257   PMID:19020743   PMID:19022561   PMID:19028685   PMID:19035162   PMID:19064921   PMID:19074269   PMID:19080373   PMID:19105933   PMID:19123467  
PMID:19131506   PMID:19156129   PMID:19164581   PMID:19165171   PMID:19166930   PMID:19176525   PMID:19193763   PMID:19203995   PMID:19206162   PMID:19215067   PMID:19219074   PMID:19231233  
PMID:19238531   PMID:19249008   PMID:19258923   PMID:19270716   PMID:19274049   PMID:19281909   PMID:19306295   PMID:19334540   PMID:19357699   PMID:19358752   PMID:19384981   PMID:19433309  
PMID:19435822   PMID:19495976   PMID:19499154   PMID:19513521   PMID:19527717   PMID:19528235   PMID:19531482   PMID:19578717   PMID:19591174   PMID:19595408   PMID:19616043   PMID:19628677  
PMID:19653276   PMID:19654329   PMID:19656241   PMID:19701800   PMID:19714312   PMID:19723051   PMID:19734233   PMID:19734545   PMID:19738058   PMID:19758340   PMID:19758438   PMID:19782465  
PMID:19787273   PMID:19794957   PMID:19795388   PMID:19806201   PMID:19811296   PMID:19818398   PMID:19837979   PMID:19841138   PMID:19859790   PMID:19860880   PMID:19861239   PMID:19874574  
PMID:19878434   PMID:19885545   PMID:19898747   PMID:19910471   PMID:19910486   PMID:19913121   PMID:19919900   PMID:19921846   PMID:19937141   PMID:19937979   PMID:19939924   PMID:19944700  
PMID:19959471   PMID:19965873   PMID:20012528   PMID:20042607   PMID:20044606   PMID:20051654   PMID:20053993   PMID:20074357   PMID:20093361   PMID:20093369   PMID:20102225   PMID:20102411  
PMID:20133937   PMID:20137127   PMID:20170659   PMID:20185758   PMID:20193273   PMID:20194533   PMID:20195357   PMID:20198339   PMID:20203690   PMID:20222112   PMID:20225236   PMID:20227498  
PMID:20232342   PMID:20304822   PMID:20306472   PMID:20331627   PMID:20331972   PMID:20331980   PMID:20333648   PMID:20353950   PMID:20353996   PMID:20371606   PMID:20395206   PMID:20410304  
PMID:20430872   PMID:20432452   PMID:20448330   PMID:20459032   PMID:20479762   PMID:20482821   PMID:20483790   PMID:20498278   PMID:20503287   PMID:20505831   PMID:20507572   PMID:20508969  
PMID:20510020   PMID:20511396   PMID:20514406   PMID:20519498   PMID:20531301   PMID:20543003   PMID:20554528   PMID:20557936   PMID:20590529   PMID:20607803   PMID:20619956   PMID:20628086  
PMID:20628624   PMID:20665665   PMID:20680410   PMID:20683948   PMID:20688351   PMID:20697347   PMID:20698984   PMID:20732415   PMID:20837772   PMID:20852630   PMID:20936779   PMID:20939893  
PMID:20942798   PMID:20943203   PMID:20952681   PMID:20955203   PMID:20976196   PMID:20977688   PMID:21030269   PMID:21034562   PMID:21081043   PMID:21081472   PMID:21106530   PMID:21106746  
PMID:21113145   PMID:21134350   PMID:21145111   PMID:21148792   PMID:21196933   PMID:21199371   PMID:21212516   PMID:21268080   PMID:21289643   PMID:21338584   PMID:21349840   PMID:21350237  
PMID:21357535   PMID:21360282   PMID:21364631   PMID:21381700   PMID:21393476   PMID:21397653   PMID:21410405   PMID:21417953   PMID:21439937   PMID:21451046   PMID:21454713   PMID:21496208  
PMID:21511059   PMID:21518489   PMID:21526160   PMID:21530485   PMID:21555589   PMID:21559334   PMID:21565167   PMID:21570970   PMID:21607373   PMID:21617575   PMID:21617851   PMID:21640141  
PMID:21647439   PMID:21675959   PMID:21685329   PMID:21697091   PMID:21699750   PMID:21703547   PMID:21732343   PMID:21739277   PMID:21743958   PMID:21745629   PMID:21799768   PMID:21801875  
PMID:21814482   PMID:21822357   PMID:21829441   PMID:21835421   PMID:21835891   PMID:21860413   PMID:21862593   PMID:21872498   PMID:21873635   PMID:21895606   PMID:21937452   PMID:21972703  
PMID:21988832   PMID:21989944   PMID:22001392   PMID:22002117   PMID:22051934   PMID:22077140   PMID:22083952   PMID:22092038   PMID:22095282   PMID:22110360   PMID:22119392   PMID:22132731  
PMID:22139817   PMID:22176144   PMID:22189957   PMID:22235337   PMID:22239235   PMID:22265050   PMID:22266871   PMID:22271085   PMID:22271878   PMID:22307329   PMID:22327296   PMID:22328508  
PMID:22331067   PMID:22354960   PMID:22384197   PMID:22384232   PMID:22394497   PMID:22399296   PMID:22417306   PMID:22429882   PMID:22438909   PMID:22450687   PMID:22484283   PMID:22508041  
PMID:22512945   PMID:22570239   PMID:22597534   PMID:22675553   PMID:22681889   PMID:22685373   PMID:22688014   PMID:22719067   PMID:22749179   PMID:22771387   PMID:22791811   PMID:22797068  
PMID:22801218   PMID:22843696   PMID:22853846   PMID:22860098   PMID:22869147   PMID:22879913   PMID:22904686   PMID:22911824   PMID:22926518   PMID:22933572   PMID:22966201   PMID:22974165  
PMID:22981541   PMID:22988241   PMID:23027619   PMID:23027969   PMID:23028371   PMID:23041974   PMID:23047699   PMID:23135283   PMID:23153494   PMID:23163821   PMID:23182717   PMID:23223231  
PMID:23226410   PMID:23236059   PMID:23269699   PMID:23300800   PMID:23331079   PMID:23339184   PMID:23362975   PMID:23382074   PMID:23396363   PMID:23404426   PMID:23404530   PMID:23454483  
PMID:23455325   PMID:23467542   PMID:23523566   PMID:23546882   PMID:23562910   PMID:23578467   PMID:23580428   PMID:23583295   PMID:23602568   PMID:23602572   PMID:23608488   PMID:23614275  
PMID:23615400   PMID:23624934   PMID:23625009   PMID:23625206   PMID:23661758   PMID:23665382   PMID:23665993   PMID:23669365   PMID:23671702   PMID:23678002   PMID:23682787   PMID:23686163  
PMID:23690655   PMID:23720779   PMID:23747343   PMID:23749999   PMID:23750012   PMID:23752183   PMID:23762317   PMID:23762330   PMID:23770289   PMID:23814048   PMID:23816567   PMID:23818969  
PMID:23832539   PMID:23835612   PMID:23844083   PMID:23858473   PMID:23906792   PMID:23922701   PMID:23929433   PMID:23942796   PMID:24004834   PMID:24027432   PMID:24029232   PMID:24038215  
PMID:24038602   PMID:24073601   PMID:24091941   PMID:24100343   PMID:24113186   PMID:24162774   PMID:24187576   PMID:24190040   PMID:24225433   PMID:24244375   PMID:24263171   PMID:24265756  
PMID:24291398   PMID:24335313   PMID:24366538   PMID:24366551   PMID:24369359   PMID:24375836   PMID:24439903   PMID:24447950   PMID:24481121   PMID:24500404   PMID:24526449   PMID:24551192  
PMID:24559171   PMID:24566851   PMID:24574500   PMID:24587316   PMID:24606718   PMID:24623306   PMID:24631457   PMID:24636898   PMID:24641824   PMID:24658403   PMID:24679696   PMID:24707477  
PMID:24743307   PMID:24753227   PMID:24768539   PMID:24780373   PMID:24796531   PMID:24819052   PMID:24830720   PMID:24852265   PMID:24884571   PMID:24912525   PMID:24913175   PMID:24914133  
PMID:24931237   PMID:24952347   PMID:24981860   PMID:24999758   PMID:25016017   PMID:25019989   PMID:25031700   PMID:25047843   PMID:25064159   PMID:25070240   PMID:25077945   PMID:25098452  
PMID:25117710   PMID:25199502   PMID:25200491   PMID:25201048   PMID:25204501   PMID:25205054   PMID:25205654   PMID:25230788   PMID:25239830   PMID:25241761   PMID:25271301   PMID:25281386  
PMID:25318890   PMID:25338512   PMID:25422452   PMID:25428452   PMID:25435485   PMID:25463304   PMID:25476526   PMID:25477266   PMID:25483191   PMID:25499265   PMID:25526895   PMID:25533033  
PMID:25536346   PMID:25544773   PMID:25545366   PMID:25571870   PMID:25600770   PMID:25609649   PMID:25625784   PMID:25647783   PMID:25656613   PMID:25665578   PMID:25670814   PMID:25684043  
PMID:25710583   PMID:25771902   PMID:25796446   PMID:25813203   PMID:25865119   PMID:25879517   PMID:25895972   PMID:25945750   PMID:26018080   PMID:26031809   PMID:26035356   PMID:26075907  
PMID:26136365   PMID:26186194   PMID:26237449   PMID:26242913   PMID:26258633   PMID:26260845   PMID:26270987   PMID:26280733   PMID:26287601   PMID:26336885   PMID:26387545   PMID:26389662  
PMID:26394174   PMID:26397987   PMID:26418950   PMID:26426522   PMID:26459591   PMID:26476743   PMID:26485645   PMID:26493679   PMID:26496610   PMID:26497679   PMID:26514923   PMID:26530832  
PMID:26540629   PMID:26562662   PMID:26631725   PMID:26707143   PMID:26718209   PMID:26719067   PMID:26747248   PMID:26792858   PMID:26799482   PMID:26832411   PMID:26858249   PMID:26862581  
PMID:26941330   PMID:26964667   PMID:26965145   PMID:26972000   PMID:26988982   PMID:26992854   PMID:27022066   PMID:27060496   PMID:27067395   PMID:27072265   PMID:27076368   PMID:27078844  
PMID:27089238   PMID:27102414   PMID:27147707   PMID:27173017   PMID:27173435   PMID:27181591   PMID:27185392   PMID:27210483   PMID:27215316   PMID:27220321   PMID:27243212   PMID:27261462  
PMID:27278863   PMID:27338330   PMID:27341307   PMID:27424491   PMID:27458189   PMID:27495086   PMID:27516213   PMID:27533465   PMID:27534417   PMID:27556506   PMID:27558649   PMID:27565346  
PMID:27590109   PMID:27609421   PMID:27617961   PMID:27634452   PMID:27637333   PMID:27646874   PMID:27735944   PMID:27758885   PMID:27840425   PMID:27864692   PMID:27882939   PMID:27894081  
PMID:27941886   PMID:27956703   PMID:28013342   PMID:28036276   PMID:28036297   PMID:28158710   PMID:28178378   PMID:28185919   PMID:28269757   PMID:28327155   PMID:28358415   PMID:28366453  
PMID:28394299   PMID:28447716   PMID:28473536   PMID:28488757   PMID:28514442   PMID:28515304   PMID:28566324   PMID:28566434   PMID:28586006   PMID:28591827   PMID:28618937   PMID:28694294  
PMID:28701355   PMID:28753655   PMID:28790303   PMID:28794006   PMID:28794385   PMID:28859074   PMID:28887744   PMID:28893904   PMID:28931675   PMID:28939042   PMID:28981843   PMID:29020630  
PMID:29061731   PMID:29225075   PMID:29305491   PMID:29305742   PMID:29331040   PMID:29346117   PMID:29351796   PMID:29440459   PMID:29507755   PMID:29600594   PMID:29693707   PMID:29735545  
PMID:29738531   PMID:29748389   PMID:29789579   PMID:29844126   PMID:30001480   PMID:30021895   PMID:30044990   PMID:30077625   PMID:30106127   PMID:30119690   PMID:30125263   PMID:30293548  
PMID:30315111   PMID:30365109   PMID:30395942   PMID:30419930   PMID:30431076   PMID:30458989   PMID:30488826   PMID:30585729   PMID:30586711   PMID:30617160   PMID:30804502   PMID:30877256  
PMID:30909560   PMID:30948508   PMID:31155351   PMID:31182485   PMID:31207072   PMID:31239290   PMID:31341047   PMID:31394193   PMID:31444232   PMID:31515488   PMID:31556968   PMID:31615122  
PMID:31634687   PMID:31665637   PMID:31789394   PMID:31831627   PMID:31843895   PMID:31915283   PMID:31945349   PMID:31953146   PMID:31964911   PMID:32054096   PMID:32203420   PMID:32281291  
PMID:32296036   PMID:32296183   PMID:32319607   PMID:32350443   PMID:32369499   PMID:32493933   PMID:32513696   PMID:32572902   PMID:32596961   PMID:32723872   PMID:32807449   PMID:32814053  
PMID:32841759   PMID:32886291   PMID:32911434   PMID:32950569   PMID:32977498   PMID:33033234   PMID:33046662   PMID:33080218   PMID:33086033   PMID:33306668   PMID:33308098   PMID:33361772  
PMID:33367717   PMID:33421101   PMID:33495806   PMID:33511552   PMID:33572115   PMID:33640491   PMID:33844457   PMID:33849838   PMID:33918729   PMID:33939321   PMID:33961781   PMID:33966634  
PMID:34079125   PMID:34163012   PMID:34278468   PMID:34359927   PMID:34499807   PMID:34512147   PMID:34534615   PMID:34597346   PMID:34671206   PMID:34709727   PMID:34712224   PMID:34714590  
PMID:34741373   PMID:34780483   PMID:34942351   PMID:34959221   PMID:34972106   PMID:35032548   PMID:35123547   PMID:35140242   PMID:35199941   PMID:35271311   PMID:35445627   PMID:35748872  
PMID:35831314   PMID:35851726   PMID:35988817   PMID:35996525   PMID:36059491   PMID:36163022   PMID:36183833   PMID:36224531   PMID:36251994   PMID:36373674   PMID:36461607   PMID:36476606  
PMID:36477312   PMID:36581088   PMID:36629882   PMID:36746125   PMID:36754276   PMID:36899005   PMID:36907253   PMID:36941472   PMID:37175814   PMID:37219487   PMID:37310025   PMID:37310848  
PMID:37434557   PMID:37543013   PMID:37604584   PMID:37689310   PMID:37827155   PMID:37894811   PMID:38012744   PMID:38206773   PMID:38278470   PMID:38310103   PMID:38360978   PMID:38517374  


Genomics

Comparative Map Data
JUN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38158,780,791 - 58,784,047 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl158,776,845 - 58,784,048 (-)EnsemblGRCh38hg38GRCh38
GRCh37159,246,463 - 59,249,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36159,019,051 - 59,022,373 (-)NCBINCBI36Build 36hg18NCBI36
Build 34158,958,483 - 58,961,806NCBI
Celera157,530,296 - 57,533,618 (-)NCBICelera
Cytogenetic Map1p32.1NCBI
HuRef157,356,787 - 57,360,109 (-)NCBIHuRef
CHM1_1159,361,828 - 59,365,150 (-)NCBICHM1_1
T2T-CHM13v2.0158,659,236 - 58,662,492 (-)NCBIT2T-CHM13v2.0
Jun
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39494,937,273 - 94,940,459 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl494,937,271 - 94,940,459 (-)EnsemblGRCm39 Ensembl
GRCm38495,049,036 - 95,052,222 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl495,049,034 - 95,052,222 (-)EnsemblGRCm38mm10GRCm38
MGSCv37494,715,727 - 94,718,913 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36494,541,073 - 94,544,205 (-)NCBIMGSCv36mm8
Celera493,436,543 - 93,439,728 (-)NCBICelera
Cytogenetic Map4C5NCBI
cM Map443.34NCBI
Jun
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85115,009,900 - 115,012,993 (-)NCBIGRCr8
mRatBN7.25109,894,175 - 109,897,268 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5109,893,145 - 109,897,656 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5112,464,752 - 112,467,841 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05114,190,270 - 114,193,359 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05114,252,804 - 114,255,893 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05114,011,184 - 114,014,277 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5114,011,189 - 114,014,277 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05117,957,730 - 117,960,823 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45115,358,166 - 115,361,259 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15115,363,396 - 115,365,980 (-)NCBI
Celera5108,510,040 - 108,513,133 (-)NCBICelera
Cytogenetic Map5q33NCBI
Jun
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554641,107,598 - 1,110,326 (+)NCBIChiLan1.0ChiLan1.0
JUN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21168,063,962 - 168,067,574 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11167,218,036 - 167,219,853 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0158,042,794 - 58,045,536 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1159,747,129 - 59,750,446 (-)NCBIpanpan1.1PanPan1.1panPan2
JUN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1550,966,698 - 50,968,939 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha551,033,459 - 51,034,786 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0551,147,773 - 51,149,113 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl551,148,001 - 51,149,014 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1551,098,106 - 51,099,438 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0551,043,349 - 51,044,688 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0551,326,980 - 51,328,311 (+)NCBIUU_Cfam_GSD_1.0
Jun
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505872,379,192 - 72,381,903 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365223,035,346 - 3,036,350 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365223,034,364 - 3,037,632 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JUN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6153,685,682 - 153,687,636 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16153,686,425 - 153,687,635 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26141,231,122 - 141,232,332 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JUN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12074,204,481 - 74,207,835 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2074,205,542 - 74,206,546 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603343,155,224 - 43,158,790 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Jun
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248621,538,455 - 1,539,426 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248621,537,886 - 1,540,633 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in JUN
5 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_002228.4(JUN):c.658C>G (p.Pro220Ala) single nucleotide variant Inborn genetic diseases [RCV002514250]|not provided [RCV000049575] Chr1:58782413 [GRCh38]
Chr1:59248085 [GRCh37]
Chr1:1p32.1
uncertain significance|not provided
GRCh38/hg38 1p32.3-31.3(chr1:50222546-61618373)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051819]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051819]|See cases [RCV000051819] Chr1:50222546..61618373 [GRCh38]
Chr1:50688218..62084045 [GRCh37]
Chr1:50460805..61856633 [NCBI36]
Chr1:1p32.3-31.3
pathogenic
GRCh38/hg38 1p32.3-31.1(chr1:52595352-76767765)x3 copy number gain See cases [RCV000051822] Chr1:52595352..76767765 [GRCh38]
Chr1:53061024..77233450 [GRCh37]
Chr1:52833612..77006038 [NCBI36]
Chr1:1p32.3-31.1
pathogenic
GRCh38/hg38 1p32.2-31.1(chr1:57350574-71325924)x1 copy number loss See cases [RCV000053841] Chr1:57350574..71325924 [GRCh38]
Chr1:57816246..71791607 [GRCh37]
Chr1:57588834..71564195 [NCBI36]
Chr1:1p32.2-31.1
pathogenic
GRCh38/hg38 1p32.3-31.3(chr1:53738212-61439648)x1 copy number loss See cases [RCV000053839] Chr1:53738212..61439648 [GRCh38]
Chr1:54203885..61905320 [GRCh37]
Chr1:53976473..61677908 [NCBI36]
Chr1:1p32.3-31.3
pathogenic
GRCh38/hg38 1p32.3-31.3(chr1:53627272-64248854)x1 copy number loss See cases [RCV000139470] Chr1:53627272..64248854 [GRCh38]
Chr1:54092945..64714537 [GRCh37]
Chr1:53865533..64487125 [NCBI36]
Chr1:1p32.3-31.3
pathogenic
GRCh38/hg38 1p32.3-31.3(chr1:52787503-67339873)x3 copy number gain See cases [RCV000141758] Chr1:52787503..67339873 [GRCh38]
Chr1:53253175..67805556 [GRCh37]
Chr1:53025763..67578144 [NCBI36]
Chr1:1p32.3-31.3
likely pathogenic
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12
likely benign
GRCh37/hg19 1p32.3-31.3(chr1:55791287-63405767)x1 copy number loss See cases [RCV000447265] Chr1:55791287..63405767 [GRCh37]
Chr1:1p32.3-31.3
pathogenic
GRCh37/hg19 1p32.3-31.3(chr1:55831175-62285511)x3 copy number gain See cases [RCV000447469] Chr1:55831175..62285511 [GRCh37]
Chr1:1p32.3-31.3
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NM_002228.4(JUN):c.559G>T (p.Ala187Ser) single nucleotide variant Inborn genetic diseases [RCV003280847] Chr1:58782512 [GRCh38]
Chr1:59248184 [GRCh37]
Chr1:1p32.1
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p32.1(chr1:59246581-59250312)x1 copy number loss not provided [RCV000749005] Chr1:59246581..59250312 [GRCh37]
Chr1:1p32.1
benign
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1
uncertain significance
NM_002228.4(JUN):c.219G>T (p.Ser73=) single nucleotide variant not provided [RCV000893541] Chr1:58782852 [GRCh38]
Chr1:59248524 [GRCh37]
Chr1:1p32.1
benign
NM_002228.4(JUN):c.465C>T (p.Gly155=) single nucleotide variant not provided [RCV000912985] Chr1:58782606 [GRCh38]
Chr1:59248278 [GRCh37]
Chr1:1p32.1
likely benign
GRCh37/hg19 1p32.2-32.1(chr1:58346207-59924256)x3 copy number gain See cases [RCV001194535] Chr1:58346207..59924256 [GRCh37]
Chr1:1p32.2-32.1
uncertain significance
GRCh37/hg19 1p32.3-31.3(chr1:53675707-66644963)x1 copy number loss Chromosome 1p32-p31 deletion syndrome [RCV001263218] Chr1:53675707..66644963 [GRCh37]
Chr1:1p32.3-31.3
pathogenic
NM_002228.4(JUN):c.659del (p.Pro220fs) deletion Breast neoplasm [RCV002285232] Chr1:58782412 [GRCh38]
Chr1:59248084 [GRCh37]
Chr1:1p32.1
pathogenic
NM_002228.4(JUN):c.40C>T (p.Leu14Phe) single nucleotide variant Inborn genetic diseases [RCV002984080] Chr1:58783031 [GRCh38]
Chr1:59248703 [GRCh37]
Chr1:1p32.1
uncertain significance
Single allele inversion Bilateral polymicrogyria [RCV003459046] Chr1:33246132..61045156 [GRCh38]
Chr1:1p35.1-31.3
likely pathogenic
GRCh37/hg19 1p32.1-31.3(chr1:59121165-62057570)x1 copy number loss not specified [RCV003987139] Chr1:59121165..62057570 [GRCh37]
Chr1:1p32.1-31.3
pathogenic
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR125B1hsa-miR-125b-5pOncomiRDBexternal_infoNANA22797068
MIR125B2hsa-miR-125b-5pOncomiRDBexternal_infoNANA22797068
MIR155hsa-miR-155-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22508041

Predicted Target Of
Summary Value
Count of predictions:688
Count of miRNA genes:404
Interacting mature miRNAs:433
Transcripts:ENST00000371222
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
PMC129043P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37159,249,750 - 59,250,039UniSTSGRCh37
Build 36159,022,338 - 59,022,627RGDNCBI36
Celera157,533,583 - 57,533,872RGD
HuRef157,360,074 - 57,360,363UniSTS
PMC133732P5  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37159,249,735 - 59,249,862UniSTSGRCh37
Build 36159,022,323 - 59,022,450RGDNCBI36
Celera157,533,568 - 57,533,695RGD
Cytogenetic Map1p32.1UniSTS
Cytogenetic Map1p32-p31UniSTS
HuRef157,360,059 - 57,360,186UniSTS
PMC151710P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37159,249,357 - 59,249,566UniSTSGRCh37
Build 36159,021,945 - 59,022,154RGDNCBI36
Celera157,533,190 - 57,533,399RGD
Cytogenetic Map1p32.1UniSTS
Cytogenetic Map1p32-p31UniSTS
HuRef157,359,681 - 57,359,890UniSTS
PMC153970P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37159,247,747 - 59,247,902UniSTSGRCh37
Build 36159,020,335 - 59,020,490RGDNCBI36
Celera157,531,580 - 57,531,735RGD
Cytogenetic Map1p32-p31UniSTS
HuRef157,358,071 - 57,358,226UniSTS
PMC55707P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37159,247,747 - 59,248,742UniSTSGRCh37
Build 36159,020,335 - 59,021,330RGDNCBI36
Celera157,531,580 - 57,532,575RGD
Cytogenetic Map1p32-p31UniSTS
HuRef157,358,071 - 57,359,066UniSTS
JUN_454  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37159,246,347 - 59,247,209UniSTSGRCh37
Build 36159,018,935 - 59,019,797RGDNCBI36
Celera157,530,180 - 57,531,042RGD
HuRef157,356,671 - 57,357,533UniSTS
RH68404  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37159,246,511 - 59,246,682UniSTSGRCh37
Build 36159,019,099 - 59,019,270RGDNCBI36
Celera157,530,344 - 57,530,515RGD
Cytogenetic Map1p32-p31UniSTS
HuRef157,356,835 - 57,357,006UniSTS
GeneMap99-GB4 RH Map1165.46UniSTS
NCBI RH Map1385.9UniSTS
RH68524  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37159,248,705 - 59,248,856UniSTSGRCh37
Build 36159,021,293 - 59,021,444RGDNCBI36
Celera157,532,538 - 57,532,689RGD
Cytogenetic Map1p32-p31UniSTS
HuRef157,359,029 - 57,359,180UniSTS
GeneMap99-GB4 RH Map1166.58UniSTS
D1S3319  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37159,246,959 - 59,247,291UniSTSGRCh37
Build 36159,019,547 - 59,019,879RGDNCBI36
Celera157,530,792 - 57,531,124RGD
Cytogenetic Map1p32-p31UniSTS
HuRef157,357,283 - 57,357,615UniSTS
Whitehead-YAC Contig Map1 UniSTS
G15909  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37159,247,117 - 59,247,347UniSTSGRCh37
Build 36159,019,705 - 59,019,935RGDNCBI36
Celera157,530,950 - 57,531,180RGD
Cytogenetic Map1p32-p31UniSTS
HuRef157,357,441 - 57,357,671UniSTS
D5Lev15  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37159,247,133 - 59,247,435UniSTSGRCh37
Celera157,530,966 - 57,531,268UniSTS
HuRef157,357,457 - 57,357,759UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 62 67 55 8 263 17 45 3 49 97 176 81
Medium 2366 2557 1663 616 1499 459 4072 2165 3637 413 1397 1511 172 1 1028 2707 2
Low 9 364 7 8 441 6 21 15 51 3 14 5 3 4 2
Below cutoff 1 3 1 3 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_047027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002228 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK307137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL136985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY217548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC002646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC068522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG831943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI793062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU782554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD370800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS542415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LC461705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M23544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U60581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000371222   ⟹   ENSP00000360266
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl158,780,791 - 58,784,047 (-)Ensembl
RefSeq Acc Id: ENST00000678696   ⟹   ENSP00000503132
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl158,776,845 - 58,784,048 (-)Ensembl
RefSeq Acc Id: ENST00000710273   ⟹   ENSP00000518166
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl158,780,791 - 58,784,047 (-)Ensembl
RefSeq Acc Id: NM_002228   ⟹   NP_002219
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38158,780,791 - 58,784,047 (-)NCBI
GRCh37159,246,463 - 59,249,785 (-)ENTREZGENE
Build 36159,019,051 - 59,022,373 (-)NCBI Archive
HuRef157,356,787 - 57,360,109 (-)ENTREZGENE
CHM1_1159,361,828 - 59,365,150 (-)NCBI
T2T-CHM13v2.0158,659,236 - 58,662,492 (-)NCBI
Sequence:
RefSeq Acc Id: NP_002219   ⟸   NM_002228
- UniProtKB: Q6FHM7 (UniProtKB/Swiss-Prot),   Q96G93 (UniProtKB/Swiss-Prot),   P05412 (UniProtKB/Swiss-Prot),   Q6FHK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000360266   ⟸   ENST00000371222
RefSeq Acc Id: ENSP00000503132   ⟸   ENST00000678696
RefSeq Acc Id: ENSP00000518166   ⟸   ENST00000710273
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P05412-F1-model_v2 AlphaFold P05412 1-331 view protein structure

Promoters
RGD ID:6855690
Promoter ID:EPDNEW_H1010
Type:initiation region
Name:JUN_1
Description:Jun proto-oncogene, AP-1 transcription factor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38158,784,016 - 58,784,076EPDNEW
RGD ID:6853392
Promoter ID:EP74521
Type:initiation region
Name:HS_JUN
Description:V-jun sarcoma virus 17 oncogene homolog (avian).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 36159,022,276 - 59,022,336EPD

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6204 AgrOrtholog
COSMIC JUN COSMIC
Ensembl Genes ENSG00000177606 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000371222 ENTREZGENE
  ENST00000371222.4 UniProtKB/Swiss-Prot
  ENST00000678696.1 UniProtKB/Swiss-Prot
  ENST00000710273.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000177606 GTEx
HGNC ID HGNC:6204 ENTREZGENE
Human Proteome Map JUN Human Proteome Map
InterPro bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  JNK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leuzip_Jun UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3725 UniProtKB/Swiss-Prot
NCBI Gene 3725 ENTREZGENE
OMIM 165160 OMIM
PANTHER JUN TRANSCRIPTION FACTOR-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11462:SF8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Jun UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB JUN RGD, PharmGKB
PRINTS LEUZIPPRJUN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47454 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0AA34QVR9_HUMAN UniProtKB/TrEMBL
  JUN_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q6FHK0 ENTREZGENE, UniProtKB/TrEMBL
  Q6FHM7 ENTREZGENE
  Q96G93 ENTREZGENE
UniProt Secondary Q6FHM7 UniProtKB/Swiss-Prot
  Q96G93 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-10 JUN  Jun proto-oncogene, AP-1 transcription factor subunit  JUN  jun proto-oncogene  Symbol and/or name change 5135510 APPROVED
2011-07-27 JUN  jun proto-oncogene  JUN  jun oncogene  Symbol and/or name change 5135510 APPROVED