Gene: UGT1A3 (UDP glucuronosyltransferase 1 family, polypeptide A3)  Homo sapiens
Symbol: UGT1A3
Name: UDP glucuronosyltransferase 1 family, polypeptide A3
Description: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: OTTHUMP00000065193; OTTHUMP00000065199; UDP glucuronosyltransferase 1A3; udp glycosyltransferase 1 family, polypeptide a3; UDP glycosyltransferase 1 family, polypeptide A3; UDP-glucuronosyltransferase 1-3; UDP-glucuronosyltransferase 1-C; UDP-glucuronosyltransferase 1A3; UDPGT; UDPGT; UDPGT 1-3; UGT-1C; UGT-1C; UGT1*3; UGT1-03; UGT1-03; UGT1.3; UGT1.3; UGT1C
Orthologs: Mus musculus : Ugt1a2 (UDP glucuronosyltransferase 1 family, polypeptide A2)  MGI
Rattus norvegicus : Ugt1a2 (UDP glucuronosyltransferase 1 family, polypeptide A2)
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_12234,010,402 - 234,054,578+NCBI
Human Genome Assembly HuRef2226,437,616 - 226,481,779+NCBI
Human Genome Assembly GRCh372234,637,773 - 234,681,945+NCBI
Human Genome Assembly Build 362234,302,512 - 234,346,684+NCBI
Human Cytogenetic Map2q37 NCBI
Human Genome Assembly2234,419,772 - 234,463,945 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

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References - curated
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Genomics

Comparative Map Data
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QTLs in Region (Human Genome Assembly GRCh37)

Sequence

Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
  
More on UGT1A3
Entrez Gene
Ensembl Gene
Genome Browser: (hg18) (hg19)
HGNC Report
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 1352957
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2013-02-27
Status: ACTIVE



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