Gene: PSMD9 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 9)
Homo sapiens
Symbol:
PSMD9
Name:
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
Description:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
26S proteasome non-ATPase regulatory subunit 9; 26S proteasome regulatory subunit p27; homolog of rat Bridge 1; MGC8644; OTTHUMP00000239793; OTTHUMP00000239794; OTTHUMP00000239796; OTTHUMP00000239800; OTTHUMP00000239801; p27; proteasome 26S non-ATPase regulatory subunit 9; Rpn4
Orthologs:
Mus musculus : Psmd9
(proteasome (prosome, macropain) 26S subunit, non-ATPase, 9)
MGI
Psmd9
(proteasome (prosome, macropain) 26S subunit, non-ATPase, 9)
Latest Assembly:
Human Genome Assembly GRCh37
Position:
Map Chr Position Strand Source Human Alternate Assembly CHM1_1 12 122,123,809 - 122,152,950 + NCBI Human Genome Assembly HuRef 12 119,337,911 - 119,366,980 + NCBI Human Genome Assembly GRCh37 12 122,326,637 - 122,355,771 + NCBI Human Genome Assembly Build 36 12 120,811,029 - 120,840,154 + NCBI Human Cytogenetic Map 12 q24.31-q24.32 NCBI Human Genome Assembly 12 120,789,365 - 120,818,490 NCBI
Model
Gene Ontology Annotations
1331644 AASTH7_H Allergic/atopic asthma related QTL 7 (human) 2.29 Reversible airflow obstruction asthma score 12 74133886 133812422 Human 1559248 SAPOA1_H Serum apolipoprotein A level QTL 1 (human) 2.02 Apolipoprotein level apolipoprotein A-I 12 95712415 133789251 Human 1643452 BW104_H Body weight QTL 104 (human) 1.89 .005 Body fat amount abdominal visceral 12 102789645 128789645 Human 2292994 PRSTS146_H Prostate tumor susceptibility QTL 146 (human) 5.69 .000022 Prostate tumor susceptibility 12 103060538 129060538 Human 1331642 AASTH6_H Allergic/atopic asthma related QTL 6 (human) 2.46 .0004 Reversible airflow obstruction post-bronchodilator FEV1 12 103082760 129082760 Human 1357293 AASTH20_H Allergic/atopic asthma related QTL 20 (human) 1.13 Reversible airflow obstruction post-bronchodilator FEV1 12 103082760 129082760 Human 1643266 BW201_H Body weight QTL 201 (human) 3.79 .00001 Body fat amount percent body fat 12 103082760 129082760 Human 1643270 BW198_H Body weight QTL 198 (human) 3.57 .00003 Body weight BMI 12 103082760 129082760 Human 1643277 BW203_H Body weight QTL 203 (human) 3.05 .00009 Body morphometry waist circumference 12 103082760 129082760 Human 1643313 BW234_H Body weight QTL 234 (human) 1.08 Body weight body mass index 12 103082760 129082760 Human 2314720 INSUL18_H Insulin level QTL 18(human) 2 .106 Insulin level 12 103082760 129082760 Human 1298449 UAE2_H Urinary albumin excretion QTL 2 (human) 2 .005 Urinary albumin excretion urine albumin:creatinine ratio (ACR) 12 103232104 129232104 Human 2289480 SLEP16_H Serum leptin level QTL 16 (human) 2.06 Hormone level leptin 12 106170388 132170388 Human 2316666 GLUCO252_H Glucose level QTL 252 (human) 3.65 Glucose level 12 107147609 133147609 Human 1643308 BW235_H Body weight QTL 235 (human) 1.86 Body weight body mass index 12 107188584 133188584 Human 1643411 BW278_H Body Weight QTL 278 (human) 1.79 .002 Body weight 12 107188584 133188584 Human 2293466 PRSTS305_H Prostate tumor susceptibility QTL 305 (human) .024 Prostate tumor susceptibility 12 107188584 133188584 Human 1643468 SLIPL18_H Serum lipid level QTL 18 (human) 2.6 .02 Lipid level 12 114961269 133812422 Human 2314558 GLUCO46_H Glucose level QTL 46 (human) 1.1 Glucose level 12 114961269 133812422 Human 2289606 BW476_H Body weight QTL 476 (human) 2.9 Body fat amount abdominal 12 116060455 131962898 Human 2316044 GLUCO197_H Glucose level QTL 197 (human) .03 Glucose level 12 116082709 126625403 Human 1576338 MYI6_H Myocardial infarction susceptibility QTL 6 (human) 5.62 Myocardial infarction susceptibility early-onset 12 117397776 133812422 Human 1576332 MYI14_H Myocardial infarction susceptibility QTL 14 (human) 4.44 Myocardial infarction susceptibility early-onset 12 117397776 133812422 Human 2293368 PRSTS218_H Prostate tumor susceptibility QTL 218 (human) 1.05 Prostate tumor susceptibility 12 117397776 133812422 Human 2293401 PRSTS216_H Prostate tumor susceptibility QTL 216 (human) 1.76 Prostate tumor susceptibility 12 117397776 133812422 Human 2293420 PRSTS217_H Prostate tumor susceptibility QTL 217 (human) 1.89 Prostate tumor susceptibility 12 117397776 133812422 Human 2289471 BW218_H Body weight QTL 218 (human) 1.96 Body fat amount percent fat 12 119170322 126625403 Human 2289628 BW500_H Body weight QTL 500 (human) 3.8 Body fat amount percent fat 12 120188466 127961399 Human 2289630 BW501_H Body weight QTL 501 (human) 2.4 Body fat amount percent fat 12 120188466 127961399 Human 2289632 BW502_H Body weight QTL 502 (human) 1.5 Body fat amount percent fat 12 120188466 127961399 Human 2314793 GLUCO112_H Glucose level QTL 112 (human) 2.24 Glucose level 12 120188466 130397814 Human
Gene Ontology Annotations
