CASP9 (caspase 9, apoptosis-related cysteine peptidase)

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Keyword

Gene: CASP9 (caspase 9, apoptosis-related cysteine peptidase) Homo sapiens

Symbol:

CASP9

Name:

caspase 9, apoptosis-related cysteine peptidase

Description:

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

APAF-3; APAF3; apoptotic protease activating factor 3; apoptotic protease MCH-6; apoptotic protease-activating factor 3; CASP-9; caspase 9; caspase 9, apoptosis-related cysteine protease; caspase-9; CASPASE-9c; ICE-LAP6; ICE-like apoptotic protease 6; MCH6; OTTHUMP00000002322; OTTHUMP00000002323; OTTHUMP00000002324; OTTHUMP00000242817; OTTHUMP00000242819; PPP1R56; protein phosphatase 1, regulatory subunit 56

Orthologs:

Mus musculus : Casp9 (caspase 9) MGI
Rattus norvegicus : Casp9 (caspase 9, apoptosis-related cysteine peptidase)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	1	15,715,945 - 15,748,943	-	NCBI
Human Genome Assembly HuRef	1	14,338,260 - 14,370,798	-	NCBI
Human Genome Assembly GRCh37	1	15,818,769 - 15,851,285	-	NCBI
Human Genome Assembly Build 36	1	15,691,378 - 15,723,377	-	NCBI
Human Cytogenetic Map	1	p36.21		NCBI
Human Genome Assembly	1	15,564,102 - 15,596,096		NCBI