SGK2 (serum/glucocorticoid regulated kinase 2) - Rat Genome Database

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Gene: SGK2 (serum/glucocorticoid regulated kinase 2) Homo sapiens
Analyze
Symbol: SGK2
Name: serum/glucocorticoid regulated kinase 2
RGD ID: 1347154
HGNC Page HGNC:13900
Description: Enables potassium channel regulator activity. Predicted to be involved in intracellular signal transduction. Located in nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: dJ138B7.2; H-SGK2; serine/threonine-protein kinase Sgk2; serum/glucocorticoid-regulated kinase 2; SGK2, serine/threonine kinase 2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382043,559,027 - 43,585,627 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2043,558,968 - 43,588,237 (+)EnsemblGRCh38hg38GRCh38
GRCh372042,187,667 - 42,214,267 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362041,621,100 - 41,647,687 (+)NCBINCBI36Build 36hg18NCBI36
Build 342041,621,099 - 41,647,686NCBI
Celera2038,895,152 - 38,921,737 (+)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2038,923,264 - 38,950,126 (+)NCBIHuRef
CHM1_12042,091,437 - 42,118,025 (+)NCBICHM1_1
T2T-CHM13v2.02045,292,229 - 45,318,829 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrotoluene  (ISO)
2-amino-4,6-dinitrotoluene  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP)
ammonium chloride  (ISO)
ampicillin  (EXP)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
atorvastatin calcium  (EXP)
azoxystrobin  (EXP)
barium(0)  (EXP)
benzo[a]pyrene  (EXP,ISO)
Benzo[ghi]perylene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (ISO)
bromobenzene  (ISO)
buta-1,3-diene  (ISO)
captan  (ISO)
carbon nanotube  (ISO)
CGP 52608  (EXP)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP)
clofibrate  (ISO)
clothianidin  (EXP)
copper(II) sulfate  (EXP,ISO)
Cuprizon  (ISO)
cyclosporin A  (EXP)
D-glucose  (EXP)
dextran sulfate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dicrotophos  (EXP)
dioxygen  (EXP)
diquat  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP)
endosulfan  (ISO)
fenofibrate  (EXP)
fluvastatin  (EXP)
glucose  (EXP)
glutathione  (ISO)
GW 4064  (ISO)
hydrogen peroxide  (EXP)
isotretinoin  (EXP)
Licochalcone B  (EXP)
menadione  (EXP)
metformin  (ISO)
methylmercury chloride  (EXP)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
ouabain  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
phenobarbital  (EXP)
picoxystrobin  (EXP)
pirinixic acid  (ISO)
potassium atom  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
quinolin-8-ol  (EXP)
rifampicin  (EXP)
rotenone  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP)
simvastatin  (EXP)
sodium arsenite  (EXP)
streptozocin  (ISO)
tert-butyl hydroperoxide  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
troglitazone  (EXP,ISO)
urethane  (EXP)
valproic acid  (EXP)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (TAS)
nucleoplasm  (IDA)
nucleus  (IEA)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10548550   PMID:11707620   PMID:11780052   PMID:12397388   PMID:12477932   PMID:12632189   PMID:12634932   PMID:15134818   PMID:15203218   PMID:15489334   PMID:15578212   PMID:15790807  
PMID:16344560   PMID:16460280   PMID:19953087   PMID:20511718   PMID:20919962   PMID:21832049   PMID:21873635   PMID:21988832   PMID:22939624   PMID:24204015   PMID:25852190   PMID:26392083  
PMID:26740304   PMID:27553422   PMID:28611215   PMID:28639896   PMID:28846114   PMID:29513927   PMID:31002126   PMID:32296183   PMID:32565024   PMID:32707033   PMID:32848212   PMID:33660365  
PMID:33961781   PMID:34654719   PMID:34857952   PMID:36720852   PMID:36724073  


Genomics

Comparative Map Data
SGK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382043,559,027 - 43,585,627 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2043,558,968 - 43,588,237 (+)EnsemblGRCh38hg38GRCh38
GRCh372042,187,667 - 42,214,267 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362041,621,100 - 41,647,687 (+)NCBINCBI36Build 36hg18NCBI36
Build 342041,621,099 - 41,647,686NCBI
Celera2038,895,152 - 38,921,737 (+)NCBICelera
Cytogenetic Map20q13.12NCBI
HuRef2038,923,264 - 38,950,126 (+)NCBIHuRef
CHM1_12042,091,437 - 42,118,025 (+)NCBICHM1_1
T2T-CHM13v2.02045,292,229 - 45,318,829 (+)NCBIT2T-CHM13v2.0
Sgk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392162,829,249 - 162,856,059 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2162,829,250 - 162,856,047 (+)EnsemblGRCm39 Ensembl
GRCm382162,987,327 - 163,014,139 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2162,987,330 - 163,014,127 (+)EnsemblGRCm38mm10GRCm38
MGSCv372162,813,217 - 162,839,863 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362162,678,987 - 162,705,568 (+)NCBIMGSCv36mm8
Celera2168,934,488 - 168,961,119 (+)NCBICelera
Cytogenetic Map2H2NCBI
cM Map283.93NCBI
Sgk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83172,063,625 - 172,089,000 (+)NCBIGRCr8
mRatBN7.23151,644,102 - 151,669,480 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3151,644,102 - 151,669,480 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3155,452,311 - 155,477,655 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03163,951,255 - 163,976,603 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03161,694,860 - 161,720,202 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03159,361,313 - 159,385,843 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3159,368,273 - 159,384,775 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03165,557,662 - 165,581,916 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43153,849,825 - 153,890,111 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13153,778,278 - 153,794,932 (+)NCBI
Celera3150,301,782 - 150,326,821 (+)NCBICelera
Cytogenetic Map3q42NCBI
Sgk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544513,581,145 - 13,625,320 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544513,581,145 - 13,625,320 (-)NCBIChiLan1.0ChiLan1.0
SGK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22149,304,906 - 49,331,003 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12049,298,365 - 49,324,092 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02039,897,338 - 39,924,767 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12040,992,171 - 41,018,587 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2040,997,536 - 41,018,587 (+)Ensemblpanpan1.1panPan2
SGK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12431,272,395 - 31,294,409 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2431,272,493 - 31,294,195 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2430,916,070 - 30,938,174 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02431,986,104 - 32,001,288 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2431,980,261 - 32,001,114 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12431,243,810 - 31,265,914 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02431,355,174 - 31,377,248 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02431,895,633 - 31,917,764 (+)NCBIUU_Cfam_GSD_1.0
Sgk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640180,280,673 - 180,302,503 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365303,008,161 - 3,024,218 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365303,007,934 - 3,025,552 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SGK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1746,188,265 - 46,208,804 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11746,188,160 - 46,208,807 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21751,626,067 - 51,649,666 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SGK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1220,217,768 - 20,245,675 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl220,218,420 - 20,246,186 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605068,961,022 - 68,988,744 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sgk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479010,726,486 - 10,752,235 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479010,727,125 - 10,749,060 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in SGK2
19 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_170693.2(SGK2):c.209C>T (p.Ser70Phe) single nucleotide variant Malignant melanoma [RCV000072641] Chr20:43567980 [GRCh38]
Chr20:42196620 [GRCh37]
Chr20:41630034 [NCBI36]
Chr20:20q13.12
not provided
GRCh38/hg38 20p13-q13.33(chr20:99557-64277321)x3 copy number gain See cases [RCV000135859] Chr20:99557..64277321 [GRCh38]
Chr20:80198..62908674 [GRCh37]
Chr20:28198..62379118 [NCBI36]
Chr20:20p13-q13.33
pathogenic
GRCh38/hg38 20q11.22-13.12(chr20:35237946-47631818)x1 copy number loss See cases [RCV000140816] Chr20:35237946..47631818 [GRCh38]
Chr20:33825749..46260562 [GRCh37]
Chr20:33289165..45693969 [NCBI36]
Chr20:20q11.22-13.12
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555)x3 copy number gain See cases [RCV000510832] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33
pathogenic
NM_170693.3(SGK2):c.-23-150G>A single nucleotide variant not specified [RCV004324151] Chr20:43566323 [GRCh38]
Chr20:42194963 [GRCh37]
Chr20:20q13.12
uncertain significance
GRCh37/hg19 20p13-q13.33(chr20:61569-62915555) copy number gain See cases [RCV000512450] Chr20:61569..62915555 [GRCh37]
Chr20:20p13-q13.33
pathogenic
Single allele deletion Focal-onset seizure [RCV001004039] Chr20:34980430..46806549 [GRCh37]
Chr20:20q11.23-13.13
likely pathogenic
NM_170693.3(SGK2):c.380G>A (p.Arg127Gln) single nucleotide variant Colorectal cancer [RCV001543614] Chr20:43570636 [GRCh38]
Chr20:42199276 [GRCh37]
Chr20:20q13.12
likely pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62948788)x3 copy number gain not provided [RCV000741058] Chr20:63244..62948788 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62961294)x3 copy number gain not provided [RCV000741059] Chr20:63244..62961294 [GRCh37]
Chr20:20p13-q13.33
pathogenic
GRCh37/hg19 20p13-q13.33(chr20:63244-62912463)x3 copy number gain not provided [RCV000741057] Chr20:63244..62912463 [GRCh37]
Chr20:20p13-q13.33
pathogenic
NM_170693.3(SGK2):c.510+5GT[17] microsatellite not provided [RCV000948495] Chr20:43571065..43571068 [GRCh38]
Chr20:42199705..42199708 [GRCh37]
Chr20:20q13.12
benign
NM_170693.3(SGK2):c.228+8A>T single nucleotide variant not provided [RCV000885926] Chr20:43568007 [GRCh38]
Chr20:42196647 [GRCh37]
Chr20:20q13.12
benign
GRCh37/hg19 20q13.11-13.12(chr20:42087848-42275167)x1 copy number loss not provided [RCV000848260] Chr20:42087848..42275167 [GRCh37]
Chr20:20q13.11-13.12
uncertain significance
NM_170693.3(SGK2):c.943G>A (p.Gly315Arg) single nucleotide variant not specified [RCV004318694] Chr20:43584855 [GRCh38]
Chr20:42213495 [GRCh37]
Chr20:20q13.12
uncertain significance
NM_170693.3(SGK2):c.856A>G (p.Ile286Val) single nucleotide variant not specified [RCV004295228] Chr20:43579978 [GRCh38]
Chr20:42208618 [GRCh37]
Chr20:20q13.12
uncertain significance
NM_170693.3(SGK2):c.510+7_510+8insGGGGTGTG insertion not provided [RCV000954522] Chr20:43571064..43571065 [GRCh38]
Chr20:42199704..42199705 [GRCh37]
Chr20:20q13.12
likely benign
NM_170693.3(SGK2):c.510+5GT[16] microsatellite not provided [RCV002816484] Chr20:43571065..43571070 [GRCh38]
Chr20:42199705..42199710 [GRCh37]
Chr20:20q13.12
benign
NM_170693.3(SGK2):c.70C>A (p.Pro24Thr) single nucleotide variant not specified [RCV004190960] Chr20:43567101 [GRCh38]
Chr20:42195741 [GRCh37]
Chr20:20q13.12
uncertain significance
NM_170693.3(SGK2):c.616C>T (p.Leu206Phe) single nucleotide variant not specified [RCV004102910] Chr20:43574927 [GRCh38]
Chr20:42203567 [GRCh37]
Chr20:20q13.12
uncertain significance
NM_170693.3(SGK2):c.700T>C (p.Phe234Leu) single nucleotide variant not specified [RCV004148090] Chr20:43576230 [GRCh38]
Chr20:42204870 [GRCh37]
Chr20:20q13.12
uncertain significance
NM_170693.3(SGK2):c.83C>T (p.Pro28Leu) single nucleotide variant not specified [RCV004240399] Chr20:43567114 [GRCh38]
Chr20:42195754 [GRCh37]
Chr20:20q13.12
uncertain significance
NM_170693.3(SGK2):c.510+5GT[18] microsatellite not provided [RCV002862343] Chr20:43571065..43571066 [GRCh38]
Chr20:42199705..42199706 [GRCh37]
Chr20:20q13.12
benign
NM_170693.3(SGK2):c.647A>T (p.Asp216Val) single nucleotide variant not specified [RCV004206282] Chr20:43574958 [GRCh38]
Chr20:42203598 [GRCh37]
Chr20:20q13.12
uncertain significance
NM_170693.3(SGK2):c.749C>T (p.Pro250Leu) single nucleotide variant not specified [RCV004140398] Chr20:43576279 [GRCh38]
Chr20:42204919 [GRCh37]
Chr20:20q13.12
uncertain significance
NM_170693.3(SGK2):c.-23-139T>C single nucleotide variant not specified [RCV004110124] Chr20:43566334 [GRCh38]
Chr20:42194974 [GRCh37]
Chr20:20q13.12
uncertain significance
NM_170693.3(SGK2):c.739C>A (p.Leu247Met) single nucleotide variant not specified [RCV004245181] Chr20:43576269 [GRCh38]
Chr20:42204909 [GRCh37]
Chr20:20q13.12
uncertain significance
NM_170693.3(SGK2):c.527C>T (p.Thr176Met) single nucleotide variant not specified [RCV004230651] Chr20:43572067 [GRCh38]
Chr20:42200707 [GRCh37]
Chr20:20q13.12
uncertain significance
NM_170693.3(SGK2):c.-23-94G>C single nucleotide variant not specified [RCV004287166] Chr20:43566379 [GRCh38]
Chr20:42195019 [GRCh37]
Chr20:20q13.12
likely benign
NM_170693.3(SGK2):c.160C>T (p.Arg54Cys) single nucleotide variant not specified [RCV004447887] Chr20:43567931 [GRCh38]
Chr20:42196571 [GRCh37]
Chr20:20q13.12
uncertain significance
NM_170693.3(SGK2):c.251G>A (p.Arg84His) single nucleotide variant not specified [RCV004447888] Chr20:43569407 [GRCh38]
Chr20:42198047 [GRCh37]
Chr20:20q13.12
uncertain significance
NM_170693.3(SGK2):c.274C>T (p.Arg92Trp) single nucleotide variant not specified [RCV004447889] Chr20:43569430 [GRCh38]
Chr20:42198070 [GRCh37]
Chr20:20q13.12
uncertain significance
NM_170693.3(SGK2):c.319G>A (p.Glu107Lys) single nucleotide variant not specified [RCV004447890] Chr20:43569475 [GRCh38]
Chr20:42198115 [GRCh37]
Chr20:20q13.12
uncertain significance
NM_170693.3(SGK2):c.404G>A (p.Arg135Gln) single nucleotide variant not specified [RCV004447891] Chr20:43570660 [GRCh38]
Chr20:42199300 [GRCh37]
Chr20:20q13.12
uncertain significance
NM_170693.3(SGK2):c.-23-97G>C single nucleotide variant not specified [RCV004447892] Chr20:43566376 [GRCh38]
Chr20:42195016 [GRCh37]
Chr20:20q13.12
uncertain significance
NM_170693.3(SGK2):c.-23-73C>G single nucleotide variant not specified [RCV004447893] Chr20:43566400 [GRCh38]
Chr20:42195040 [GRCh37]
Chr20:20q13.12
uncertain significance
NM_170693.3(SGK2):c.909G>C (p.Lys303Asn) single nucleotide variant not specified [RCV004447885] Chr20:43580031 [GRCh38]
Chr20:42208671 [GRCh37]
Chr20:20q13.12
uncertain significance
NM_170693.3(SGK2):c.1007G>C (p.Gly336Ala) single nucleotide variant not specified [RCV004447886] Chr20:43584919 [GRCh38]
Chr20:42213559 [GRCh37]
Chr20:20q13.12
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2504
Count of miRNA genes:678
Interacting mature miRNAs:772
Transcripts:ENST00000341458, ENST00000373077, ENST00000373092, ENST00000373100, ENST00000412111, ENST00000423407, ENST00000426287, ENST00000485914, ENST00000496343
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D20S43  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372042,199,594 - 42,199,796UniSTSGRCh37
Build 362041,633,008 - 41,633,210RGDNCBI36
Celera2038,907,058 - 38,907,260RGD
Cytogenetic Map20q13.2UniSTS
HuRef2038,935,225 - 38,935,427UniSTS
Z94618  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372042,188,638 - 42,188,778UniSTSGRCh37
Build 362041,622,052 - 41,622,192RGDNCBI36
Celera2038,896,104 - 38,896,244RGD
Cytogenetic Map20q13.2UniSTS
HuRef2038,924,267 - 38,924,407UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 604 18 412 409 76 411 133 3 144 301 80 28 156 4
Low 1606 1506 1229 203 532 50 3213 804 3419 97 1277 1346 156 1044 1967 2
Below cutoff 225 1427 79 12 1190 4 970 1372 143 18 84 208 10 4 814 2 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001199264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_016276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_170693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF169034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF186470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK289596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308502 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY987010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC006523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC065511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG420383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT020098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD627734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471077 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA244897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DB183229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DC385330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF456917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z98752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000341458   ⟹   ENSP00000340608
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2043,565,798 - 43,585,627 (+)Ensembl
RefSeq Acc Id: ENST00000373077   ⟹   ENSP00000362168
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2043,559,027 - 43,585,300 (+)Ensembl
RefSeq Acc Id: ENST00000373100   ⟹   ENSP00000362192
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2043,559,027 - 43,585,627 (+)Ensembl
RefSeq Acc Id: ENST00000412111   ⟹   ENSP00000396222
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2043,565,237 - 43,572,072 (+)Ensembl
RefSeq Acc Id: ENST00000423407   ⟹   ENSP00000392795
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2043,565,115 - 43,585,632 (+)Ensembl
RefSeq Acc Id: ENST00000426287   ⟹   ENSP00000412214
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2043,566,316 - 43,585,016 (+)Ensembl
RefSeq Acc Id: ENST00000485914   ⟹   ENSP00000496823
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2043,559,076 - 43,570,998 (+)Ensembl
RefSeq Acc Id: ENST00000496343   ⟹   ENSP00000436841
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2043,559,066 - 43,588,237 (+)Ensembl
RefSeq Acc Id: ENST00000617268   ⟹   ENSP00000481432
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2043,564,786 - 43,566,525 (+)Ensembl
RefSeq Acc Id: ENST00000617358
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2043,565,185 - 43,569,643 (+)Ensembl
RefSeq Acc Id: ENST00000647716
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2043,574,377 - 43,580,671 (+)Ensembl
RefSeq Acc Id: ENST00000647834   ⟹   ENSP00000498203
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2043,558,968 - 43,566,531 (+)Ensembl
RefSeq Acc Id: ENST00000648083   ⟹   ENSP00000496987
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2043,559,033 - 43,570,998 (+)Ensembl
RefSeq Acc Id: ENST00000648530   ⟹   ENSP00000497528
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2043,559,042 - 43,576,378 (+)Ensembl
RefSeq Acc Id: NM_001199264   ⟹   NP_001186193
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382043,565,224 - 43,585,627 (+)NCBI
GRCh372042,187,566 - 42,214,317 (+)NCBI
HuRef2038,923,264 - 38,950,126 (+)ENTREZGENE
CHM1_12042,097,531 - 42,118,025 (+)NCBI
T2T-CHM13v2.02045,298,426 - 45,318,829 (+)NCBI
Sequence:
RefSeq Acc Id: NM_016276   ⟹   NP_057360
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382043,565,798 - 43,585,627 (+)NCBI
GRCh372042,187,566 - 42,214,317 (+)NCBI
Build 362041,628,151 - 41,647,687 (+)NCBI Archive
Celera2038,895,152 - 38,921,737 (+)RGD
HuRef2038,923,264 - 38,950,126 (+)ENTREZGENE
CHM1_12042,098,513 - 42,118,025 (+)NCBI
T2T-CHM13v2.02045,299,000 - 45,318,829 (+)NCBI
Sequence:
RefSeq Acc Id: NM_170693   ⟹   NP_733794
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382043,559,027 - 43,585,627 (+)NCBI
GRCh372042,187,566 - 42,214,317 (+)NCBI
Build 362041,621,100 - 41,647,687 (+)NCBI Archive
Celera2038,895,152 - 38,921,737 (+)RGD
HuRef2038,923,264 - 38,950,126 (+)ENTREZGENE
CHM1_12042,091,437 - 42,118,025 (+)NCBI
T2T-CHM13v2.02045,292,229 - 45,318,829 (+)NCBI
Sequence:
RefSeq Acc Id: NP_733794   ⟸   NM_170693
- UniProtKB: Q5TZR3 (UniProtKB/Swiss-Prot),   Q5H8Z1 (UniProtKB/Swiss-Prot),   Q5H8Y6 (UniProtKB/Swiss-Prot),   Q52PK5 (UniProtKB/Swiss-Prot),   Q9UKG6 (UniProtKB/Swiss-Prot),   Q9HBY8 (UniProtKB/Swiss-Prot),   A8K0N1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_057360   ⟸   NM_016276
- UniProtKB: Q9HBY8 (UniProtKB/Swiss-Prot),   Q5TZR3 (UniProtKB/Swiss-Prot),   Q5H8Z1 (UniProtKB/Swiss-Prot),   Q5H8Y6 (UniProtKB/Swiss-Prot),   Q52PK5 (UniProtKB/Swiss-Prot),   Q9UKG6 (UniProtKB/Swiss-Prot),   A8K0N1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001186193   ⟸   NM_001199264
- UniProtKB: Q5TZR3 (UniProtKB/Swiss-Prot),   Q5H8Z1 (UniProtKB/Swiss-Prot),   Q5H8Y6 (UniProtKB/Swiss-Prot),   Q52PK5 (UniProtKB/Swiss-Prot),   Q9UKG6 (UniProtKB/Swiss-Prot),   Q9HBY8 (UniProtKB/Swiss-Prot),   A8K0N1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000496987   ⟸   ENST00000648083
RefSeq Acc Id: ENSP00000497528   ⟸   ENST00000648530
RefSeq Acc Id: ENSP00000392795   ⟸   ENST00000423407
RefSeq Acc Id: ENSP00000412214   ⟸   ENST00000426287
RefSeq Acc Id: ENSP00000396222   ⟸   ENST00000412111
RefSeq Acc Id: ENSP00000362192   ⟸   ENST00000373100
RefSeq Acc Id: ENSP00000362168   ⟸   ENST00000373077
RefSeq Acc Id: ENSP00000436841   ⟸   ENST00000496343
RefSeq Acc Id: ENSP00000481432   ⟸   ENST00000617268
RefSeq Acc Id: ENSP00000496823   ⟸   ENST00000485914
RefSeq Acc Id: ENSP00000340608   ⟸   ENST00000341458
RefSeq Acc Id: ENSP00000498203   ⟸   ENST00000647834
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9HBY8-F1-model_v2 AlphaFold Q9HBY8 1-367 view protein structure

Promoters
RGD ID:6799061
Promoter ID:HG_KWN:39493
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:ENST00000373100,   OTTHUMT00000080382,   OTTHUMT00000080385,   UC002XKS.1,   UC002XKT.1,   UC010GGM.1
Position:
Human AssemblyChrPosition (strand)Source
Build 362041,620,551 - 41,621,051 (+)MPROMDB
RGD ID:13206963
Promoter ID:EPDNEW_H27061
Type:initiation region
Name:SGK2_2
Description:SGK2, serine/threonine kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H27062  EPDNEW_H27063  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382043,559,027 - 43,559,087EPDNEW
RGD ID:13206961
Promoter ID:EPDNEW_H27062
Type:initiation region
Name:SGK2_1
Description:SGK2, serine/threonine kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H27061  EPDNEW_H27063  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382043,565,224 - 43,565,284EPDNEW
RGD ID:13206965
Promoter ID:EPDNEW_H27063
Type:multiple initiation site
Name:SGK2_3
Description:SGK2, serine/threonine kinase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H27062  EPDNEW_H27061  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382043,568,003 - 43,568,063EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:13900 AgrOrtholog
COSMIC SGK2 COSMIC
Ensembl Genes ENSG00000101049 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000341458 ENTREZGENE
  ENST00000341458.10 UniProtKB/Swiss-Prot
  ENST00000373077.5 UniProtKB/TrEMBL
  ENST00000373100 ENTREZGENE
  ENST00000373100.7 UniProtKB/Swiss-Prot
  ENST00000412111.6 UniProtKB/TrEMBL
  ENST00000423407 ENTREZGENE
  ENST00000423407.7 UniProtKB/Swiss-Prot
  ENST00000426287.3 UniProtKB/Swiss-Prot
  ENST00000485914.2 UniProtKB/TrEMBL
  ENST00000496343.6 UniProtKB/TrEMBL
  ENST00000617268.1 UniProtKB/TrEMBL
  ENST00000647834.1 UniProtKB/TrEMBL
  ENST00000648083.1 UniProtKB/TrEMBL
  ENST00000648530.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000101049 GTEx
HGNC ID HGNC:13900 ENTREZGENE
Human Proteome Map SGK2 Human Proteome Map
InterPro AGC-kinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:10110 UniProtKB/Swiss-Prot
NCBI Gene 10110 ENTREZGENE
OMIM 607589 OMIM
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SERUM/GLUCOCORTICOID REGULATED KINASE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JNI2_HUMAN UniProtKB/TrEMBL
  A0A3B3IRL0_HUMAN UniProtKB/TrEMBL
  A0A3B3IRX6_HUMAN UniProtKB/TrEMBL
  A0A3B3IT40_HUMAN UniProtKB/TrEMBL
  A0A3B3IUG0_HUMAN UniProtKB/TrEMBL
  A8K0N1 ENTREZGENE, UniProtKB/TrEMBL
  F2Z3C8_HUMAN UniProtKB/TrEMBL
  Q52PK5 ENTREZGENE
  Q5H8Y5_HUMAN UniProtKB/TrEMBL
  Q5H8Y6 ENTREZGENE
  Q5H8Z1 ENTREZGENE
  Q5TZR3 ENTREZGENE
  Q9HBY8 ENTREZGENE
  Q9UKG6 ENTREZGENE
  SGK2_HUMAN UniProtKB/Swiss-Prot
  X6R8H3_HUMAN UniProtKB/TrEMBL
UniProt Secondary Q52PK5 UniProtKB/Swiss-Prot
  Q5H8Y6 UniProtKB/Swiss-Prot
  Q5H8Z1 UniProtKB/Swiss-Prot
  Q5TZR3 UniProtKB/Swiss-Prot
  Q9UKG6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-30 SGK2  serum/glucocorticoid regulated kinase 2    SGK2, serine/threonine kinase 2  Symbol and/or name change 5135510 APPROVED
2016-05-03 SGK2  SGK2, serine/threonine kinase 2    serum/glucocorticoid regulated kinase 2  Symbol and/or name change 5135510 APPROVED