MAP3K1 (mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase)

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Keyword

Gene: MAP3K1 (mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase) Homo sapiens

Symbol:

MAP3K1

Name:

mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase

Description:

The protein encoded by this gene is a serine/threonine kinase and is part of some signal transduction cascades, including the ERK and JNK kinase pathways as well as the NF-kappa-B pathway. The encoded protein is activated by autophosphorylation and requires magnesium as a cofactor in phosphorylating other proteins. This protein has E3 ligase activity conferred by a plant homeodomain (PHD) in its N-terminus and phospho-kinase activity conferred by a kinase domain in its C-terminus. [provided by RefSeq, Mar 2012]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

MAP/ERK kinase kinase 1; MAPK/ERK kinase kinase 1; MAPKKK1; MEK kinase 1; MEKK; MEKK 1; MEKK 1; MEKK1; mitogen-activated protein kinase kinase kinase 1; OTTHUMP00000065818; SRXY6

Orthologs:

Mus musculus : Map3k1 (mitogen-activated protein kinase kinase kinase 1) MGI
Rattus norvegicus : Map3k1 (mitogen activated protein kinase kinase kinase 1)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	5	56,047,939 - 56,128,999	+	NCBI
Human Genome Assembly HuRef	5	53,082,897 - 53,163,892	+	NCBI
Human Genome Assembly GRCh37	5	56,110,900 - 56,191,979	+	NCBI
Human Genome Assembly Build 36	5	56,146,657 - 56,227,736	+	NCBI
Human Cytogenetic Map	5	q11.2		NCBI