Gene: DDT (D-dopachrome tautomerase)
Homo sapiens
Symbol:
DDT
Name:
D-dopachrome tautomerase
Description:
D-dopachrome tautomerase converts D-dopachrome into 5,6-dihydroxyindole. The DDT gene is related to the migration inhibitory factor (MIF) in terms of sequence, enzyme activity, and gene structure. DDT and MIF are closely linked on chromosome 22. [provided by RefSeq, Jul 2008]
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
D-dopachrome decarboxylase; DDCT; FLJ78842; OTTHUMP00000198527; OTTHUMP00000198528; OTTHUMP00000198529; phenylpyruvate tautomerase II
Orthologs:
Mus musculus : Ddt
(D-dopachrome tautomerase)
MGI
Ddt
(D-dopachrome tautomerase)
Latest Assembly:
Human Genome Assembly GRCh37
Position:
Map Chr Position Strand Source Human Alternate Assembly CHM1_1 22 8,268,180 - 8,276,649 - NCBI Human Genome Assembly HuRef 22 7,261,709 - 7,270,163 - NCBI Human Genome Assembly GRCh37 22 24,313,554 - 24,322,019 - NCBI Human Celera Assembly 22 8,114,132 - 8,122,585 - NCBI Human Genome Assembly Build 36 22 22,643,554 - 22,652,019 - NCBI Human Cytogenetic Map 22 q11.23 NCBI Human Genome Assembly 22 22,638,114 - 22,646,573 NCBI
Model
Gene-Chemical Interaction Annotations
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane multiple interactions ISO RGD:61923 6480464 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of DDT mRNA]; more ... CTD PMID:19414516 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of DDT mRNA CTD PMID:23019147 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:62216 6480464 Tetrachlorodibenzodioxin affects the expression of DDT mRNA CTD PMID:21570461 3',5'-cyclic AMP multiple interactions ISO RGD:61923 6480464 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of DDT mRNA] CTD PMID:19414516 3H-1,2-dithiole-3-thione increases expression ISO RGD:61923 6480464 1,2-dithiol-3-thione results in increased expression of DDT mRNA CTD PMID:19162173 aflatoxin B1 affects expression EXP 6480464 Aflatoxin B1 affects the expression of DDT protein CTD PMID:20106945 aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of DDT mRNA CTD PMID:22100608 aflatoxin B1 decreases expression ISO RGD:62216 6480464 Aflatoxin B1 results in decreased expression of DDT mRNA CTD PMID:19770486 all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of DDT mRNA CTD PMID:21934132 ammonium chloride affects expression ISO RGD:61923 6480464 Ammonium Chloride affects the expression of DDT mRNA CTD PMID:16483693 benzo[a]pyrene decreases expression EXP 6480464 Benzo(a)pyrene results in decreased expression of DDT mRNA CTD PMID:20106945 benzo[a]pyrene increases expression ISO RGD:62216 6480464 Benzo(a)pyrene results in increased expression of DDT mRNA CTD PMID:22228805 bromobenzene affects binding ISO RGD:61923 6480464 bromobenzene metabolite binds to DDT protein CTD PMID:17305373 cadmium dichloride decreases methylation ISO RGD:61923 6480464 Cadmium Chloride results in decreased methylation of DDT promoter CTD PMID:22457795 cadmium dichloride decreases expression ISO RGD:61923 6480464 Cadmium Chloride results in decreased expression of DDT protein CTD PMID:22081424 clofibrate multiple interactions ISO RGD:62216 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of DDT mRNA; more ... CTD PMID:17585979 copper atom affects binding EXP 6480464 DDT protein binds to Copper CTD PMID:14534351 copper(0) affects binding EXP 6480464 DDT protein binds to Copper CTD PMID:14534351 corticosterone increases expression ISO RGD:61923 6480464 Corticosterone results in increased expression of DDT mRNA CTD PMID:15755911 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of DDT mRNA CTD PMID:20106945 dibutyl phthalate decreases expression ISO RGD:61923 6480464 Dibutyl Phthalate results in decreased expression of DDT mRNA CTD PMID:21266533 dibutyl phthalate decreases expression ISO RGD:61923 6480464 Dibutyl Phthalate results in decreased expression of DDT mRNA CTD PMID:17379624 PMID:21266533 fumonisin B1 decreases expression ISO RGD:62216 6480464 fumonisin B1 results in decreased expression of DDT mRNA CTD PMID:16221962 hydralazine multiple interactions EXP 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of DDT mRNA CTD PMID:17183730 hydrazine decreases expression ISO RGD:61923 6480464 hydrazine results in decreased expression of DDT protein CTD PMID:15370871 isotretinoin decreases expression EXP 6480464 Isotretinoin results in decreased expression of DDT mRNA CTD PMID:20436886 lovastatin decreases expression ISO RGD:62216 6480464 Lovastatin results in decreased expression of DDT mRNA CTD PMID:20493250 methamphetamine affects expression ISO RGD:61923 6480464 Methamphetamine affects the expression of DDT protein CTD PMID:17904249 ochratoxin A decreases expression ISO RGD:61923 6480464 ochratoxin A results in decreased expression of DDT mRNA CTD PMID:12700408 paracetamol multiple interactions ISO RGD:62216 6480464 PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of DDT mRNA] CTD PMID:17585979 pirinixic acid increases expression ISO RGD:62216 6480464 pirinixic acid results in increased expression of DDT mRNA CTD PMID:18301758 more ... pirinixic acid increases expression ISO RGD:62216 6480464 pirinixic acid results in increased expression of DDT mRNA CTD PMID:16221962 more ... pirinixic acid increases expression ISO RGD:62216 6480464 pirinixic acid results in increased expression of DDT mRNA CTD PMID:16221962 more ... pirinixic acid increases expression ISO RGD:62216 6480464 pirinixic acid results in increased expression of DDT mRNA CTD PMID:18301758 more ... pirinixic acid increases expression ISO RGD:62216 6480464 pirinixic acid results in increased expression of DDT mRNA CTD PMID:20813756 more ... tetrachloromethane increases expression ISO RGD:61923 6480464 Carbon Tetrachloride results in increased expression of DDT protein CTD PMID:18930782 valproic acid multiple interactions EXP 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of DDT mRNA CTD PMID:17183730 vancomycin increases expression ISO RGD:62216 6480464 Vancomycin results in increased expression of DDT mRNA CTD PMID:18930951
Gene Ontology Annotations
Biological Process melanin biosynthetic process IEA UniProtKB-KW:KW-0470 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037
1576339 LVC3_H Left ventricular contractility QTL 3 (human) 2.83 Left ventricular contractility 22 4859557 30859557 Human 1643575 GLUCO35_H Glucose level QTL 35 (human) .002 Glucose level non-insulin-dependent 22 4859557 30859557 Human 2315817 GLUCO186_H Glucose level QTL 186 (human) 2.51 Glucose level 22 4859557 30859557 Human 2302775 MAMTS36_H Mammary tumor susceptibility QTL 36 (human) .055 Mammary tumor susceptibility 22 11023431 37023431 Human 1581529 BP71_H Blood pressure QTL 71 (human) 2 .001 Blood pressure pulse pressure 22 11491180 37491180 Human 2289428 BW313_H Body weight QTL 313 (human) 2.09 .0015 Body weight BMI 22 11740249 37740249 Human 2314579 GLUCO58_H Glucose level QTL 58 (human) 1.1 Glucose level 22 12952272 38952272 Human 1559353 SCL95_H Serum cholesterol level QTL 95 (human) 1.55 .004 Lipid level HDL cholesterol 22 13015963 39015963 Human 2315442 GLUCO141_H Glucose level QTL 141 (human) 3.2 .0016 Glucose level 22 14031815 40031815 Human 1358845 MULTSCL13_H Multiple sclerosis susceptibility QTL 13 (human) Multiple sclerosis susceptibility 22 15856571 41856571 Human 2314778 GLUCO97_H Glucose level QTL 97 (human) 3.4 .001 Glucose level non-insulin dependent 22 15856571 41856571 Human 1300033 BP38_H Blood pressure QTL 38 (human) 2.07 Blood pressure hypertension susceptibility 22 21595686 47595686 Human 2292884 PRSTS36_H Prostate tumor susceptibility QTL 36 (human) Prostate tumor susceptibility early onsset 22 21595686 47595686 Human 2301166 PRSTS398_H Prostate tumor susceptibility QTL 398 (human) 2.21 Prostate tumor susceptibility 22 21595686 47595686 Human 2302769 MAMTS33_H Mammary tumor susceptibility QTL 33 (human) .046 Mammary tumor susceptibility 22 23274073 49274073 Human 1331647 COPD4_H Chronic obstructive pulmonary disease QTL 4 (human) 1.37 Chronic airflow obstruction FEV1 <80% predicted and FEV/FVC<90% predicted 22 23406771 49406771 Human 2292840 PRSTS91_H Prostate tumor susceptibility QTL 91 (human) Prostate tumor susceptibility 22 23750965 49750965 Human 2292844 PRSTS85_H Prostate tumor susceptibility QTL 85 (human) Prostate tumor susceptibility 22 23750965 49750965 Human 2302754 MAMTS30_H Mammary tumor susceptibility QTL 30 (human) .013 Mammary tumor susceptibility 22 24023322 50023322 Human
Gene Ontology Annotations
