ORM1 (orosomucoid 1) - Rat Genome Database

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Gene: ORM1 (orosomucoid 1) Homo sapiens
Analyze
Symbol: ORM1
Name: orosomucoid 1
RGD ID: 1351569
HGNC Page HGNC:8498
Description: Involved in regulation of cytokine production. Located in extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: A1AG1; AGP 1; AGP-A; AGP1; alpha-1-acid glycoprotein 1; epididymis secretory sperm binding protein Li 153w; HEL-S-153w; OMD 1; ORM; orosomucoid-1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389114,323,098 - 114,326,479 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9114,323,098 - 114,326,479 (+)EnsemblGRCh38hg38GRCh38
GRCh379117,085,378 - 117,088,759 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369116,125,157 - 116,128,578 (+)NCBINCBI36Build 36hg18NCBI36
Build 349114,164,889 - 114,168,311NCBI
Celera987,732,978 - 87,736,434 (+)NCBICelera
Cytogenetic Map9q32NCBI
HuRef986,691,053 - 86,694,374 (+)NCBIHuRef
CHM1_19117,232,023 - 117,235,479 (+)NCBICHM1_1
T2T-CHM13v2.09126,522,292 - 126,525,673 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(2E,4E)-hexa-2,4-dienoic acid  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrotoluene  (ISO)
2-hydroxypropanoic acid  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (ISO)
7,12-dimethyltetraphene  (ISO)
8-anilinonaphthalene-1-sulfonic acid  (EXP)
acetamide  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
Benoxacor  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
biphenyl-2-ol  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (EXP)
carbon nanotube  (ISO)
carmustine  (ISO)
carnosic acid  (ISO)
CGP 52608  (EXP)
chlorpromazine  (EXP)
cholic acid  (ISO)
choline  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP)
cylindrospermopsin  (ISO)
DAUDA  (EXP)
DDE  (ISO)
dehydroepiandrosterone  (ISO)
dexamethasone  (EXP,ISO)
dibenzofurans  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dimethyl sulfoxide  (ISO)
dipyridamole  (EXP)
dorsomorphin  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (ISO)
epoxiconazole  (ISO)
erythrosin B  (ISO)
ethylparaben  (EXP)
flavonoids  (ISO)
furan  (ISO)
glafenine  (ISO)
graphite  (ISO)
hexachlorobenzene  (ISO)
indometacin  (EXP)
inulin  (ISO)
lead(0)  (EXP)
leflunomide  (EXP)
lidocaine  (EXP)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
mercaptopurine  (ISO)
methotrexate  (ISO)
methoxychlor  (ISO)
Mezerein  (ISO)
naphthalene  (ISO)
nimesulide  (ISO)
nitrofen  (ISO)
nitrofurantoin  (ISO)
O-methyleugenol  (EXP)
okadaic acid  (ISO)
oleanolic acid  (ISO)
oxycodone  (ISO)
ozone  (ISO)
palytoxin  (ISO)
panobinostat  (EXP)
paracetamol  (ISO)
paraoxon  (ISO)
parathion  (ISO)
PCB138  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylmercury acetate  (EXP)
PhIP  (ISO)
phorone  (ISO)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
propionic acid  (ISO)
propranolol  (ISO)
prostaglandin E2  (ISO)
purine-6-thiol  (ISO)
quartz  (ISO)
quercetin  (EXP)
rac-lactic acid  (EXP)
resveratrol  (ISO)
rosuvastatin calcium  (EXP)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
saccharin  (ISO)
SB 431542  (EXP)
selenium atom  (ISO)
senecionine  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (ISO)
streptozocin  (ISO)
styrene oxide  (ISO)
sulforaphane  (ISO)
testosterone  (EXP)
tetrachloromethane  (ISO)
tin(II) chloride (anhydrous)  (ISO)
tioguanine  (ISO)
titanium dioxide  (ISO)
tremolite asbestos  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (EXP)
vinclozolin  (ISO)
vitamin E  (ISO)
vitamin K  (ISO)
warfarin  (EXP)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Alpha-1-acid glycoprotein concentrations and protein binding of propranolol in Sprague-Dawley and Dark Agouti rat strains treated by phenobarbital. Chauvelot-Moachon L, etal., J Pharmacol Exp Ther. 1988 Mar;244(3):1103-8.
2. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
3. Hepatic pharmacokinetics of propranolol in rats with adjuvant-induced systemic inflammation. Hung DY, etal., Am J Physiol Gastrointest Liver Physiol. 2006 Feb;290(2):G343-51. Epub 2005 Sep 15.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1567356   PMID:2409529   PMID:2479939   PMID:2541064   PMID:2822385   PMID:2970990   PMID:3360326   PMID:3463531   PMID:3770479   PMID:3795040   PMID:4561179   PMID:4603214  
PMID:4711474   PMID:6809283   PMID:7795416   PMID:8076819   PMID:8432561   PMID:8774350   PMID:9050929   PMID:9380773   PMID:9455924   PMID:11027547   PMID:11336643   PMID:11418606  
PMID:11814462   PMID:11911961   PMID:11925509   PMID:12477932   PMID:12480518   PMID:12576428   PMID:12754519   PMID:14718574   PMID:14760718   PMID:15013397   PMID:15084671   PMID:15111541  
PMID:15253437   PMID:15489334   PMID:16261636   PMID:16272158   PMID:16290938   PMID:16335952   PMID:16502470   PMID:16740002   PMID:17048007   PMID:17321687   PMID:17675532   PMID:17944232  
PMID:17987628   PMID:18273814   PMID:18510947   PMID:18624398   PMID:18680736   PMID:18823996   PMID:18981009   PMID:19018521   PMID:19141860   PMID:19198000   PMID:19395425   PMID:19459043  
PMID:19616527   PMID:19794411   PMID:19958090   PMID:20237496   PMID:20371432   PMID:20442402   PMID:20617306   PMID:20959405   PMID:21300760   PMID:21349832   PMID:21621584   PMID:21638284  
PMID:21726491   PMID:21873635   PMID:21988832   PMID:22048274   PMID:22147846   PMID:22216449   PMID:22516433   PMID:22574522   PMID:22587817   PMID:22633841   PMID:22708402   PMID:22807450  
PMID:22889924   PMID:22908695   PMID:23192962   PMID:23376485   PMID:23381943   PMID:23526947   PMID:23533145   PMID:23936770   PMID:23940561   PMID:23973664   PMID:24357727   PMID:24359035  
PMID:24389491   PMID:24981860   PMID:25408356   PMID:25689617   PMID:26186194   PMID:26193215   PMID:26563422   PMID:26563517   PMID:27021626   PMID:27068509   PMID:27559042   PMID:27754964  
PMID:28514442   PMID:28554261   PMID:28927749   PMID:31399619   PMID:31482685   PMID:31601857   PMID:31736338   PMID:31930291   PMID:32707033   PMID:33070381   PMID:33459949   PMID:33580265  
PMID:33640788   PMID:33813392   PMID:33961781   PMID:34210751   PMID:34265865   PMID:34654351   PMID:34758357   PMID:34963738   PMID:35188865   PMID:35272364   PMID:35384245   PMID:35765957  
PMID:35864588   PMID:36462134   PMID:36696913   PMID:37640741  


Genomics

Comparative Map Data
ORM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389114,323,098 - 114,326,479 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9114,323,098 - 114,326,479 (+)EnsemblGRCh38hg38GRCh38
GRCh379117,085,378 - 117,088,759 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369116,125,157 - 116,128,578 (+)NCBINCBI36Build 36hg18NCBI36
Build 349114,164,889 - 114,168,311NCBI
Celera987,732,978 - 87,736,434 (+)NCBICelera
Cytogenetic Map9q32NCBI
HuRef986,691,053 - 86,694,374 (+)NCBIHuRef
CHM1_19117,232,023 - 117,235,479 (+)NCBICHM1_1
T2T-CHM13v2.09126,522,292 - 126,525,673 (+)NCBIT2T-CHM13v2.0
Orm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39463,262,793 - 63,266,400 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl463,262,797 - 63,266,400 (+)EnsemblGRCm39 Ensembl
GRCm38463,344,556 - 63,348,163 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl463,344,560 - 63,348,163 (+)EnsemblGRCm38mm10GRCm38
MGSCv37463,005,600 - 63,009,196 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36462,830,927 - 62,834,523 (+)NCBIMGSCv36mm8
Celera462,001,528 - 62,005,125 (+)NCBICelera
Cytogenetic Map4B3NCBI
cM Map433.96NCBI
Orm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8581,788,509 - 81,791,661 (+)NCBIGRCr8
mRatBN7.2576,766,637 - 76,776,149 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl576,772,941 - 76,776,154 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx579,172,063 - 79,175,233 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0580,989,208 - 80,992,378 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0580,964,702 - 80,967,872 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0579,179,668 - 79,182,820 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl579,179,417 - 79,182,820 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0583,293,902 - 83,297,054 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4580,325,042 - 80,328,194 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1580,330,154 - 80,333,307 (+)NCBI
Celera575,706,909 - 75,710,061 (+)NCBICelera
RH 3.4 Map5578.8RGD
Cytogenetic Map5q24NCBI
Orm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541913,262,119 - 13,264,986 (-)NCBIChiLan1.0ChiLan1.0
ORM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21125,050,683 - 25,055,905 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1925,053,044 - 25,058,777 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0985,421,254 - 85,424,659 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19113,793,293 - 113,796,639 (+)NCBIpanpan1.1PanPan1.1panPan2
ORM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11254,939,154 - 254,943,065 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21286,190,518 - 286,194,344 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1q210-q212NCBI
LOC103218970
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11225,257,002 - 25,261,255 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1225,256,969 - 25,260,446 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603517,564,284 - 17,568,317 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in ORM1
9 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
ORM1*F1 single nucleotide variant ORM1*F1 [RCV000017422]|OROSOMUCOID POLYMORPHISM [RCV000017421] Chr9:9q34.1-q34.3 pathogenic|benign
ORM1*F2 variation ORM1*F2 [RCV000017424]|OROSOMUCOID POLYMORPHISM [RCV000017423] Chr9:9q34.1-q34.3 pathogenic|benign
ORM1*S variation ORM1*S [RCV000017426]|OROSOMUCOID POLYMORPHISM [RCV000017425] Chr9:9q34.1-q34.3 pathogenic|benign
GRCh38/hg38 9q22.33-33.1(chr9:99138048-115011033)x1 copy number loss See cases [RCV000050315] Chr9:99138048..115011033 [GRCh38]
Chr9:101900330..117773312 [GRCh37]
Chr9:100940151..116813133 [NCBI36]
Chr9:9q22.33-33.1		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000050348] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q32(chr9:114246876-114637081)x3 copy number gain See cases [RCV000052236] Chr9:114246876..114637081 [GRCh38]
Chr9:117009156..117399361 [GRCh37]
Chr9:116048977..116439182 [NCBI36]
Chr9:9q32		 uncertain significance
GRCh38/hg38 9q32(chr9:114270395-114677524)x3 copy number gain See cases [RCV000052237] Chr9:114270395..114677524 [GRCh38]
Chr9:117032675..117439804 [GRCh37]
Chr9:116072496..116479625 [NCBI36]
Chr9:9q32		 uncertain significance
GRCh38/hg38 9q22.33-33.1(chr9:99349916-115767475)x1 copy number loss See cases [RCV000052921] Chr9:99349916..115767475 [GRCh38]
Chr9:102112198..118529754 [GRCh37]
Chr9:101152019..117569575 [NCBI36]
Chr9:9q22.33-33.1		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124532)x3 copy number gain See cases [RCV000053745] Chr9:193412..138124532 [GRCh38]
Chr9:204193..141018984 [GRCh37]
Chr9:194193..140138805 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053748]|See cases [RCV000053748] Chr9:193412..138179445 [GRCh38]
Chr9:266045..141073897 [GRCh37]
Chr9:256045..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138114463)x3 copy number gain See cases [RCV000053746] Chr9:193412..138114463 [GRCh38]
Chr9:214367..141008915 [GRCh37]
Chr9:204367..140128736 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
NM_000607.2(ORM1):c.114+115C>T single nucleotide variant Lung cancer [RCV000108055] Chr9:114323362 [GRCh38]
Chr9:117085642 [GRCh37]
Chr9:9q32		 uncertain significance
GRCh38/hg38 9p24.3-q34.3(chr9:204193-138179445) copy number gain See cases [RCV000133791] Chr9:204193..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138124524)x3 copy number gain See cases [RCV000138783] Chr9:193412..138124524 [GRCh38]
Chr9:204090..141018976 [GRCh37]
Chr9:194090..140138797 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q32(chr9:114246889-114637174)x3 copy number gain See cases [RCV000138841] Chr9:114246889..114637174 [GRCh38]
Chr9:117009169..117399454 [GRCh37]
Chr9:116048990..116439275 [NCBI36]
Chr9:9q32		 likely benign
GRCh38/hg38 9p11.2-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000139207] Chr9:193412..138159073 [GRCh38]
Chr9:68420641..141053525 [GRCh37]
Chr9:67910461..140173346 [NCBI36]
Chr9:9p11.2-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138159073)x3 copy number gain See cases [RCV000138962] Chr9:193412..138159073 [GRCh38]
Chr9:204104..141053525 [GRCh37]
Chr9:194104..140173346 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic|conflicting data from submitters
GRCh38/hg38 9q31.2-33.1(chr9:107530314-117965944)x1 copy number loss See cases [RCV000140794] Chr9:107530314..117965944 [GRCh38]
Chr9:110292595..120728222 [GRCh37]
Chr9:109332416..119768043 [NCBI36]
Chr9:9q31.2-33.1		 pathogenic
GRCh38/hg38 9q32(chr9:114193726-114677465)x3 copy number gain See cases [RCV000140795] Chr9:114193726..114677465 [GRCh38]
Chr9:116956006..117439745 [GRCh37]
Chr9:115995827..116479566 [NCBI36]
Chr9:9q32		 benign
GRCh38/hg38 9p24.3-q34.3(chr9:203861-138125937)x3 copy number gain See cases [RCV000141876] Chr9:203861..138125937 [GRCh38]
Chr9:203861..141020389 [GRCh37]
Chr9:193861..140140210 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:203862-138125937)x3 copy number gain See cases [RCV000143476] Chr9:203862..138125937 [GRCh38]
Chr9:203862..141020389 [GRCh37]
Chr9:193862..140140210 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh38/hg38 9q22.33-33.1(chr9:99138048-115011033)x1 copy number loss See cases [RCV000148264] Chr9:99138048..115011033 [GRCh38]
Chr9:101900330..117773312 [GRCh37]
Chr9:100940151..116813133 [NCBI36]
Chr9:9q22.33-33.1		 pathogenic
GRCh38/hg38 9p24.3-q34.3(chr9:193412-138179445)x3 copy number gain See cases [RCV000148113] Chr9:193412..138179445 [GRCh38]
Chr9:204193..141073897 [GRCh37]
Chr9:194193..140193718 [NCBI36]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:163131-141122114)x3 copy number gain See cases [RCV000240081] Chr9:163131..141122114 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q32(chr9:116978042-117187294)x1 copy number loss See cases [RCV000240427] Chr9:116978042..117187294 [GRCh37]
Chr9:9q32		 uncertain significance
GRCh37/hg19 9p24.3-q34.3(chr9:62525-141006407) copy number gain See cases [RCV000449375] Chr9:62525..141006407 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q31.3-33.1(chr9:111348809-118687200)x1 copy number loss See cases [RCV000449308] Chr9:111348809..118687200 [GRCh37]
Chr9:9q31.3-33.1		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020389)x3 copy number gain not specified [RCV003986800] Chr9:203861..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q31.1-33.3(chr9:104604851-126253089)x1 copy number loss See cases [RCV000447763] Chr9:104604851..126253089 [GRCh37]
Chr9:9q31.1-33.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203864-141020389)x3 copy number gain See cases [RCV000448978] Chr9:203864..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q31.3-33.2(chr9:114299780-123267736)x1 copy number loss See cases [RCV000511049] Chr9:114299780..123267736 [GRCh37]
Chr9:9q31.3-33.2		 pathogenic
GRCh37/hg19 9q21.11-34.3(chr9:71069743-140999928) copy number gain Global developmental delay [RCV000626548] Chr9:71069743..140999928 [GRCh37]
Chr9:9q21.11-34.3		 likely pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:203862-141020389) copy number gain See cases [RCV000512392] Chr9:203862..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q31.3-33.3(chr9:113083182-126779494)x1 copy number loss not provided [RCV000748606] Chr9:113083182..126779494 [GRCh37]
Chr9:9q31.3-33.3		 pathogenic
GRCh37/hg19 9q32(chr9:117054195-117502242)x3 copy number gain not provided [RCV000748633] Chr9:117054195..117502242 [GRCh37]
Chr9:9q32		 benign
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141122247)x3 copy number gain not provided [RCV000748055] Chr9:10590..141122247 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141107672)x3 copy number gain not provided [RCV000748053] Chr9:10590..141107672 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:46587-141066491)x3 copy number gain not provided [RCV000748063] Chr9:46587..141066491 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:10590-141114095)x2 copy number gain not provided [RCV000748054] Chr9:10590..141114095 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
NM_000607.4(ORM1):c.113G>A (p.Arg38Gln) single nucleotide variant not provided [RCV000947197] Chr9:114323246 [GRCh38]
Chr9:117085526 [GRCh37]
Chr9:9q32		 benign
GRCh37/hg19 9p24.3-q34.3(chr9:203861-141020388)x3 copy number gain not provided [RCV000845900] Chr9:203861..141020388 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q32(chr9:116936770-117450535)x3 copy number gain not provided [RCV000848120] Chr9:116936770..117450535 [GRCh37]
Chr9:9q32		 uncertain significance
GRCh37/hg19 9q21.11-34.3(chr9:71416475-141020389)x3 copy number gain not provided [RCV000847808] Chr9:71416475..141020389 [GRCh37]
Chr9:9q21.11-34.3		 pathogenic
GRCh37/hg19 9q31.3-32(chr9:113982711-117443628)x1 copy number loss not provided [RCV000847543] Chr9:113982711..117443628 [GRCh37]
Chr9:9q31.3-32		 uncertain significance
GRCh37/hg19 9q32(chr9:116642144-117613527)x1 copy number loss not provided [RCV001006255] Chr9:116642144..117613527 [GRCh37]
Chr9:9q32		 uncertain significance
NC_000009.11:g.(?_116956664)_(117267081_?)dup duplication not provided [RCV001339460] Chr9:116956664..117267081 [GRCh37]
Chr9:9q32		 uncertain significance
GRCh37/hg19 9q32-33.1(chr9:116506015-119942279) copy number loss not specified [RCV002052832] Chr9:116506015..119942279 [GRCh37]
Chr9:9q32-33.1		 uncertain significance
GRCh37/hg19 9q21.11-33.2(chr9:71349994-122603410) copy number gain not specified [RCV002053853] Chr9:71349994..122603410 [GRCh37]
Chr9:9q21.11-33.2		 likely pathogenic
GRCh37/hg19 9q31.1-33.3(chr9:104604851-126253089) copy number loss not specified [RCV002052825] Chr9:104604851..126253089 [GRCh37]
Chr9:9q31.1-33.3		 pathogenic
GRCh37/hg19 9q32-34.11(chr9:116422275-131713233) copy number gain not specified [RCV002052831] Chr9:116422275..131713233 [GRCh37]
Chr9:9q32-34.11		 pathogenic
GRCh37/hg19 9p24.3-q34.3(chr9:353349-141020389) copy number gain not specified [RCV002053823] Chr9:353349..141020389 [GRCh37]
Chr9:9p24.3-q34.3		 pathogenic
GRCh37/hg19 9q31.2-32(chr9:109265628-117650999) copy number loss not specified [RCV002052828] Chr9:109265628..117650999 [GRCh37]
Chr9:9q31.2-32		 likely pathogenic
GRCh37/hg19 9p24.3-q34.11(chr9:203861-131603223)x3 copy number gain See cases [RCV002292402] Chr9:203861..131603223 [GRCh37]
Chr9:9p24.3-q34.11		 pathogenic
GRCh37/hg19 9p22.1-q33.1(chr9:19356861-119513311) copy number loss Distal tetrasomy 15q [RCV002280776] Chr9:19356861..119513311 [GRCh37]
Chr9:9p22.1-q33.1		 uncertain significance
NM_000607.4(ORM1):c.452C>T (p.Thr151Met) single nucleotide variant not specified [RCV004148932] Chr9:114325064 [GRCh38]
Chr9:117087344 [GRCh37]
Chr9:9q32		 uncertain significance
NM_000607.4(ORM1):c.184A>G (p.Ile62Val) single nucleotide variant not specified [RCV004183192] Chr9:114323732 [GRCh38]
Chr9:117086012 [GRCh37]
Chr9:9q32		 uncertain significance
NM_000607.4(ORM1):c.316A>G (p.Ile106Val) single nucleotide variant not specified [RCV004332013] Chr9:114324076 [GRCh38]
Chr9:117086356 [GRCh37]
Chr9:9q32		 uncertain significance
GRCh37/hg19 9q32(chr9:117037819-117102046)x1 copy number loss not specified [RCV003986841] Chr9:117037819..117102046 [GRCh37]
Chr9:9q32		 uncertain significance
NM_000607.4(ORM1):c.286T>G (p.Tyr96Asp) single nucleotide variant not specified [RCV004502356] Chr9:114324046 [GRCh38]
Chr9:117086326 [GRCh37]
Chr9:9q32		 uncertain significance
NM_000607.4(ORM1):c.377A>G (p.Lys126Arg) single nucleotide variant not specified [RCV004502358] Chr9:114324838 [GRCh38]
Chr9:117087118 [GRCh37]
Chr9:9q32		 uncertain significance
NM_000607.4(ORM1):c.302G>A (p.Arg101Gln) single nucleotide variant not specified [RCV004502357] Chr9:114324062 [GRCh38]
Chr9:117086342 [GRCh37]
Chr9:9q32		 uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:815
Count of miRNA genes:543
Interacting mature miRNAs:623
Transcripts:ENST00000259396, ENST00000477456, ENST00000538816
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
G62008  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379117,092,210 - 117,092,750UniSTSGRCh37
GRCh379117,085,439 - 117,085,979UniSTSGRCh37
Build 369116,125,260 - 116,125,800RGDNCBI36
Celera987,739,887 - 87,740,427UniSTS
Celera987,733,114 - 87,733,654RGD
Cytogenetic Map9q32UniSTS
Cytogenetic Map9q31-q32UniSTS
HuRef986,691,054 - 86,691,594UniSTS
HuRef986,697,675 - 86,698,215UniSTS
STS-X05784  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379117,095,350 - 117,095,516UniSTSGRCh37
GRCh379117,088,573 - 117,088,739UniSTSGRCh37
Build 369116,128,394 - 116,128,560RGDNCBI36
Celera987,743,027 - 87,743,193UniSTS
Celera987,736,248 - 87,736,414RGD
Cytogenetic Map9q31-q32UniSTS
Cytogenetic Map9q32UniSTS
HuRef986,700,815 - 86,700,981UniSTS
HuRef986,694,188 - 86,694,354UniSTS
GeneMap99-GB4 RH Map9357.94UniSTS
RH11587  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh379117,094,190 - 117,095,504UniSTSGRCh37
GRCh379117,087,413 - 117,088,727UniSTSGRCh37
Celera987,735,088 - 87,736,402UniSTS
Celera987,741,867 - 87,743,181UniSTS
Cytogenetic Map9q32UniSTS
Cytogenetic Map9q31-q32UniSTS
HuRef986,699,655 - 86,700,969UniSTS
HuRef986,693,028 - 86,694,342UniSTS
GeneMap99-GB4 RH Map9363.14UniSTS
NCBI RH Map91018.7UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 4 394 394 6 394 2 2
Medium 100 729 111 48 791 48 74 25 20 3 113 283 87 27
Low 1092 942 821 97 411 13 1532 800 1108 81 802 842 86 771 894 1
Below cutoff 733 881 308 56 205 3 1621 905 1654 167 350 267 55 292 1140 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB014887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK316207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL356796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC026238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC104818 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC104820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC143314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BI908589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU794584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M13692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  N68733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000259396   ⟹   ENSP00000259396
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9114,323,098 - 114,326,479 (+)Ensembl
RefSeq Acc Id: ENST00000477456
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl9114,323,766 - 114,325,251 (+)Ensembl
RefSeq Acc Id: NM_000607   ⟹   NP_000598
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh389114,323,098 - 114,326,479 (+)NCBI
GRCh379117,085,303 - 117,088,759 (+)ENTREZGENE
Build 369116,125,157 - 116,128,578 (+)NCBI Archive
HuRef986,691,053 - 86,694,374 (+)ENTREZGENE
CHM1_19117,232,023 - 117,235,479 (+)NCBI
T2T-CHM13v2.09126,522,292 - 126,525,673 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_000598   ⟸   NM_000607
- Peptide Label: precursor
- UniProtKB: Q5U067 (UniProtKB/Swiss-Prot),   Q5T539 (UniProtKB/Swiss-Prot),   B7ZKQ5 (UniProtKB/Swiss-Prot),   Q8TC16 (UniProtKB/Swiss-Prot),   P02763 (UniProtKB/Swiss-Prot),   V9HWF6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000259396   ⟸   ENST00000259396
Protein Domains
Lipocalin/cytosolic fatty-acid binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P02763-F1-model_v2 AlphaFold P02763 1-201 view protein structure

Promoters
RGD ID:7215957
Promoter ID:EPDNEW_H13725
Type:multiple initiation site
Name:ORM1_1
Description:orosomucoid 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H13726  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh389114,315,386 - 114,315,446EPDNEW
RGD ID:7215961
Promoter ID:EPDNEW_H13726
Type:initiation region
Name:ORM1_2
Description:orosomucoid 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H13725  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh389114,323,062 - 114,323,122EPDNEW
RGD ID:6849620
Promoter ID:EP16070
Type:single initiation site
Name:HS_ORM1
Description:alpha 1-acid glycoprotein 1.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 153; Mammalian alpha 1-acid glycoprotein.
Experiment Methods:Nuclease protection; Primer extension; Nuclease protection; transfected or transformed cells; Primer extension; transgenic organisms
Regulation:liver; (induced by or strongly expressed in) acute phase
Position:No map positions available.

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:8498 AgrOrtholog
COSMIC ORM1 COSMIC
Ensembl Genes ENSG00000229314 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000259396 ENTREZGENE
  ENST00000259396.9 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000229314 GTEx
HGNC ID HGNC:8498 ENTREZGENE
Human Proteome Map ORM1 Human Proteome Map
InterPro A1A_glycop UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calycin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5004 UniProtKB/Swiss-Prot
NCBI Gene 5004 ENTREZGENE
OMIM 138600 OMIM
PANTHER ALPHA-1-ACID GLYCOPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALPHA-1-ACID GLYCOPROTEIN 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lipocalin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ORM1 RGD, PharmGKB
PIRSF AGP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS A1AGLPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Lipocalins UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A1AG1_HUMAN UniProtKB/Swiss-Prot
  B7ZKQ5 ENTREZGENE
  P02763 ENTREZGENE
  Q5T539 ENTREZGENE
  Q5U067 ENTREZGENE
  Q8TC16 ENTREZGENE
  V9HWF6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B7ZKQ5 UniProtKB/Swiss-Prot
  Q5T539 UniProtKB/Swiss-Prot
  Q5U067 UniProtKB/Swiss-Prot
  Q8TC16 UniProtKB/Swiss-Prot