Gene: CTLA4 (cytotoxic T-lymphocyte-associated protein 4)  Homo sapiens
Symbol: CTLA4
Name: cytotoxic T-lymphocyte-associated protein 4
Description: This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD; CD152; cd152 antigen; CD152 isoform; celiac disease 3; CELIAC3; CTLA-4; cytotoxic T lymphocyte associated antigen 4 short spliced form; cytotoxic T-lymphocyte antigen 4; cytotoxic T-lymphocyte protein 4; cytotoxic T-lymphocyte-associated antigen 4; cytotoxic T-lymphocyte-associated serine esterase-4; GRD4; GSE; ICOS; IDDM12; ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4; OTTHUMP00000163781; OTTHUMP00000216623; OTTHUMP00000216624
Orthologs: Mus musculus : Ctla4 (cytotoxic T-lymphocyte-associated protein 4)  MGI
Rattus norvegicus : Ctla4 (cytotoxic T-lymphocyte-associated protein 4)
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_12204,122,375 - 204,128,505+NCBI
Human Genome Assembly HuRef2196,579,809 - 196,585,939+NCBI
Human Genome Assembly GRCh372204,732,511 - 204,738,683+NCBI
Human Genome Assembly Build 362204,440,754 - 204,446,928+NCBI
Human Cytogenetic Map2q33 NCBI
Human Genome Assembly2204,558,016 - 204,564,189 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

Annotation    (Toggle Detail/Summary View)

Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Human Genome Assembly GRCh37)

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
  
More on CTLA4
Entrez Gene
Ensembl Gene
Genome Browser: (hg18) (hg19)
HGNC Report
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 737465
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2013-04-30
Status: ACTIVE



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