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Gene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | cell adhesion | | TAS | | 2290271 | PMID:18538446 | UniProtKB | PMID:18538446 | cytokine-mediated signaling pathway | | TAS | | 2290271 | PMID:18538446 | UniProtKB | PMID:18538446 | defense response to Gram-positive bacterium | | IEA | Ensembl:ENSMUSP00000003370 | 2290271 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | Fc-gamma receptor signaling pathway involved in phagocytosis | | TAS | | 2290271 | Reactome:REACT_160123 | Reactome | Reactome:REACT_160123 | inflammatory response | | IEA | UniProtKB-KW:KW-0395 | 2290271 | GO_REF:0000037 | UniProtKB | GO_REF:0000037 | innate immune response | | TAS | | 2290271 | Reactome:REACT_6802 | Reactome | Reactome:REACT_6802 | innate immune response-activating signal transduction | | TAS | | 2290271 | PMID:18538446 | UniProtKB | PMID:18538446 | integrin-mediated signaling pathway | | TAS | | 2290271 | PMID:18538446 | UniProtKB | PMID:18538446 | interferon-gamma-mediated signaling pathway | | TAS | | 2290271 | PMID:18538446 | UniProtKB | PMID:18538446 | leukocyte degranulation | | TAS | | 2290271 | PMID:18538446 | UniProtKB | PMID:18538446 | leukocyte migration involved in immune response | | TAS | | 2290271 | PMID:18538446 | UniProtKB | PMID:18538446 | lipopolysaccharide-mediated signaling pathway | | TAS | | 2290271 | PMID:18538446 | UniProtKB | PMID:18538446 | mesoderm development | | TAS | | 2290271 | PMID:3453117 | PINC | PMID:3453117 | negative regulation of apoptotic process | | IMP | | 2290271 | PMID:17535448 | UniProtKB | PMID:17535448 | peptidyl-tyrosine phosphorylation | | IMP | | 2290271 | PMID:10092522 | UniProtKB | PMID:10092522 | phagocytosis | | IEA | Ensembl:ENSMUSP00000003370 | 2290271 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | positive regulation of actin cytoskeleton reorganization | | IMP | | 2290271 | PMID:11904303 | UniProtKB | PMID:11904303 | positive regulation of actin cytoskeleton reorganization | | IDA | | 2290271 | PMID:15998323 | UniProtKB | PMID:15998323 | positive regulation of actin filament polymerization | | TAS | | 2290271 | PMID:18538446 | UniProtKB | PMID:18538446 | positive regulation of cell proliferation | | IMP | | 2290271 | PMID:10092522 | UniProtKB | PMID:10092522 | protein autophosphorylation | | IMP | | 2290271 | PMID:10092522 | UniProtKB | PMID:10092522 | protein phosphorylation | | TAS | | 2290271 | PMID:3496523 | PINC | PMID:3496523 | regulation of cell shape | | IMP | | 2290271 | PMID:10092522 | UniProtKB | PMID:10092522 | regulation of cell shape | | IMP | | 2290271 | PMID:11904303 | UniProtKB | PMID:11904303 | regulation of defense response to virus by virus | | TAS | | 2290271 | Reactome:REACT_11068 | Reactome | Reactome:REACT_11068 | regulation of inflammatory response | | TAS | | 2290271 | PMID:18538446 | UniProtKB | PMID:18538446 | regulation of phagocytosis | | IMP | | 2290271 | PMID:11904303 | UniProtKB | PMID:11904303 | regulation of podosome assembly | | IDA | | 2290271 | PMID:15998323 | UniProtKB | PMID:15998323 | regulation of sequence-specific DNA binding transcription factor activity | | IMP | | 2290271 | PMID:17535448 | UniProtKB | PMID:17535448 | respiratory burst after phagocytosis | | TAS | | 2290271 | PMID:18538446 | UniProtKB | PMID:18538446 | viral reproduction | | TAS | | 2290271 | Reactome:REACT_6185 | Reactome | Reactome:REACT_6185 | virus-host interaction | | IEA | UniProtKB-KW:KW-0945 | 2290271 | GO_REF:0000037 | UniProtKB | GO_REF:0000037 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Pathway Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Chemokine signaling pathway |
| Fc gamma R-mediated phagocytosis | |
| Pathway Interaction Database | Alpha-synuclein signaling (PID:200219) |
| amb2 Integrin signaling (PID:200127) | |
| Class I PI3K signaling events (PID:200116) | |
| CXCR4-mediated signaling events (PID:200099) | |
| EPHA forward signaling (PID:200142) | |
| Ephrin B reverse signaling (PID:200204) | |
| Glypican 1 network (PID:200026) | |
| IL6-mediated signaling events (PID:200146) | |
| IL8- and CXCR1-mediated signaling events (PID:200199) | |
| IL8- and CXCR2-mediated signaling events (PID:200167) | |
| PDGFR-beta signaling pathway (PID:200149) | |
| Regulation of p38-alpha and p38-beta (PID:200066) | |
| Signaling events mediated by PTP1B (PID:200042) | |
| Thromboxane A2 receptor signaling (PID:200082) | |
References - curated| 1. |
GOA_HUMAN data from the GO Consortium |
| 2. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 3. |
RGD automated import pipeline for gene-chemical interactions |
References - uncurated| PubMed | 10068673 |
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RGD Disease Portals| HCK has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| HCK (Homo sapiens) |
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| Hck (Mus musculus) |
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| Hck (Rattus norvegicus) |
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Position Markers| RH45427 |
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| RH92890 |
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| D20S512E |
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| SHGC-112528 |
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| AL031189 |
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| SGC34341 |
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| D20S727 |
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| G09843 |
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| HCK_3380 |
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| 336XG5 |
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QTLs in Region (Human Genome Assembly GRCh37)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NG_029471 | (Get FASTA) | Search GEO for Microarray Profiles |
| NM_001172129 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_001172130 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_001172131 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_001172132 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_001172133 | (Get FASTA) | Search GEO for Microarray Profiles | |
| NM_002110 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | ABBA01019283 | (Get FASTA) | Search GEO for Microarray Profiles |
| ABBA01019284 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK026432 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK225819 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK289896 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK290928 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK298726 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK314335 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AL049539 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AL353092 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AMYH01011834 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AMYH01011835 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AW139272 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC014435 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC073748 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC094847 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC108930 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC108931 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC113854 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC114463 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH471077 | (Get FASTA) | Search GEO for Microarray Profiles | |
| DA465978 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M16592 | (Get FASTA) | Search GEO for Microarray Profiles | |
| M73233 | (Get FASTA) | Search GEO for Microarray Profiles | |
| X58741 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001172132 | ||||||||||||||||||||
| RefSeq Status: | REVIEWED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001165603 | ||||||||||||||||||||
| Peptide Label: | isoform e | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001172133 | ||||||||||||||||||||
| RefSeq Status: | REVIEWED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001165604 | ||||||||||||||||||||
| Peptide Label: | isoform b | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_002110 | |||||||||||||||||||||||||
| RefSeq Status: | REVIEWED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_002101 | |||||||||||||||||||||||||
| Peptide Label: | isoform a | |||||||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001172129 | ||||||||||||||||||||
| RefSeq Status: | REVIEWED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001165600 | ||||||||||||||||||||
| Peptide Label: | isoform b | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001172130 | ||||||||||||||||||||
| RefSeq Status: | REVIEWED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001165601 | ||||||||||||||||||||
| Peptide Label: | isoform c | ||||||||||||||||||||
| Position: |
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| RefSeq Acc Id: | NM_001172131 | ||||||||||||||||||||
| RefSeq Status: | REVIEWED | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001165602 | ||||||||||||||||||||
| Peptide Label: | isoform d | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001165600 | (Get FASTA) |
| NP_001165601 | (Get FASTA) | |
| NP_001165602 | (Get FASTA) | |
| NP_001165603 | (Get FASTA) | |
| NP_001165604 | (Get FASTA) | |
| NP_002101 | (Get FASTA) | |
| GenBank Protein | AAA52644 | (Get FASTA) |
| AAH14435 | (Get FASTA) | |
| AAH73748 | (Get FASTA) | |
| AAH94847 | (Get FASTA) | |
| AAI08931 | (Get FASTA) | |
| AAI08932 | (Get FASTA) | |
| AAI13855 | (Get FASTA) | |
| AAI14464 | (Get FASTA) | |
| BAB15482 | (Get FASTA) | |
| BAF82585 | (Get FASTA) | |
| BAF83617 | (Get FASTA) | |
| BAG60878 | (Get FASTA) | |
| CAA41565 | (Get FASTA) | |
| EAW76392 | (Get FASTA) | |
| EAW76393 | (Get FASTA) | |
| EAW76394 | (Get FASTA) | |
| P08631 | (Get FASTA) |
Promoters| RGD ID: | 6798804 | ||||||||||
| Promoter ID: | HG_KWN:39014 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | Lymphoblastoid | ||||||||||
| Transcripts: | ENST00000375852, ENST00000375862, NM_001172133, OTTHUMT00000078605, UC002WXI.1, UC010GDY.1 | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| COSMIC | HCK | COSMIC |
| Ensembl Genes | ENSG00000101336 | ENTREZGENE |
| Ensembl Protein | ENSP00000365012 | ENTREZGENE |
| ENSP00000365022 | ENTREZGENE | |
| ENSP00000427757 | ENTREZGENE | |
| ENSP00000429848 | ENTREZGENE | |
| ENSP00000441169 | ENTREZGENE | |
| ENSP00000444986 | ENTREZGENE | |
| Ensembl Transcript | ENST00000375852 | ENTREZGENE |
| ENST00000375862 | ENTREZGENE | |
| ENST00000518730 | ENTREZGENE | |
| ENST00000520553 | ENTREZGENE | |
| ENST00000534862 | ENTREZGENE | |
| ENST00000538448 | ENTREZGENE | |
| Entrez Gene | 3055 | ENTREZGENE |
| Gene3D-CATH | SH2 | UniProtKB/Swiss-Prot |
| Germonline | ENSG00000101336 | |
| HGNC ID | 4840 | ENTREZGENE |
| HomoloGene Group ID | 20489 | ENTREZGENE |
| HPRD ID | 00796 | ENTREZGENE |
| InterPro | Kinase-like_dom | UniProtKB/Swiss-Prot |
| Prot_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| Protein_kinase_ATP_BS | UniProtKB/Swiss-Prot | |
| Ser-Thr/Tyr_kinase | UniProtKB/Swiss-Prot | |
| SH2 | UniProtKB/Swiss-Prot | |
| SH3_domain | UniProtKB/Swiss-Prot | |
| Tyr_kinase_AS | UniProtKB/Swiss-Prot | |
| Tyr_kinase_cat_dom | UniProtKB/Swiss-Prot | |
| KEGG Report | hsa:3055 | ENTREZGENE, UniProtKB/Swiss-Prot |
| OMIM | 142370 | OMIM |
| Pfam | Pkinase_Tyr | UniProtKB/Swiss-Prot |
| SH2 | UniProtKB/Swiss-Prot | |
| SH3_1 | UniProtKB/Swiss-Prot | |
| PharmGKB | PA29216 | PharmGKB |
| PRINTS | SH2DOMAIN | UniProtKB/Swiss-Prot |
| SH3DOMAIN | UniProtKB/Swiss-Prot | |
| TYRKINASE | UniProtKB/Swiss-Prot | |
| PROSITE | PROTEIN_KINASE_ATP | UniProtKB/Swiss-Prot |
| PROTEIN_KINASE_DOM | UniProtKB/Swiss-Prot | |
| PROTEIN_KINASE_TYR | UniProtKB/Swiss-Prot | |
| SH2 | UniProtKB/Swiss-Prot | |
| SH3 | UniProtKB/Swiss-Prot | |
| SMART | SH2 | UniProtKB/Swiss-Prot |
| SH3 | UniProtKB/Swiss-Prot | |
| TyrKc | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Kinase_like | UniProtKB/Swiss-Prot |
| SH3 | UniProtKB/Swiss-Prot | |
| UniGene | Hs.655210 | ENTREZGENE |
| UniProt | A8K4G3_HUMAN | UniProtKB/TrEMBL |
| H0Y3C5_HUMAN | UniProtKB/TrEMBL | |
| H7BXG4_HUMAN | UniProtKB/TrEMBL | |
| H7C5P9_HUMAN | UniProtKB/TrEMBL | |
| HCK_HUMAN | UniProtKB/Swiss-Prot | |
| J3KPD6_HUMAN | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2011-08-16 | HCK | hemopoietic cell kinase | HCK | hemopoietic cell kinase | Symbol and/or name change | 39860 | APPROVED |
| 2011-07-27 | HCK | hemopoietic cell kinase | HCK | hemopoietic cell kinase | Symbol and/or name change | 39860 | APPROVED |
| More on HCK | |||
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Entrez Gene | ||
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Ensembl Gene | ||
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HGNC Report | ||
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NCBI Map Viewer | ||
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Vista | ||
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Vista + UCSC | ||
| RGD Object Information | |
| RGD ID: | 732471 |
| Created: | 2004-01-12 |
| Species: | Homo sapiens |
| Last Modified: | 2013-06-11 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




