ATF4 (activating transcription factor 4) - Rat Genome Database

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Gene: ATF4 (activating transcription factor 4) Homo sapiens
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Symbol: ATF4
Name: activating transcription factor 4
RGD ID: 733712
HGNC Page HGNC:786
Description: Enables several functions, including identical protein binding activity; leucine zipper domain binding activity; and promoter-specific chromatin binding activity. Contributes to transcription cis-regulatory region binding activity. Involved in several processes, including HRI-mediated signaling; cellular response to starvation; and positive regulation of macromolecule biosynthetic process. Located in several cellular components, including Lewy body core; centrosome; and nucleus. Part of ATF1-ATF4 transcription factor complex; ATF4-CREB1 transcription factor complex; and CHOP-ATF4 complex. Implicated in prostate carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: activating transcription factor atf-4; cAMP response element-binding protein 2; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; CREB-2; CREB2; cyclic AMP-dependent transcription factor ATF-4; cyclic AMP-responsive element-binding protein 2; DNA-binding protein TAXREB67; tax-responsive enhancer element B67; tax-responsive enhancer element-binding protein 67; TAXREB67; TXREB
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: ATF4P1   ATF4P2   ATF4P3   ATF4P4  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382239,520,559 - 39,522,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2239,519,695 - 39,522,683 (+)EnsemblGRCh38hg38GRCh38
GRCh372239,916,564 - 39,918,691 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,246,515 - 38,248,637 (+)NCBINCBI36Build 36hg18NCBI36
Build 342238,241,068 - 38,243,191NCBI
Celera2223,718,625 - 23,720,747 (+)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2222,881,158 - 22,883,280 (+)NCBIHuRef
CHM1_12239,875,308 - 39,877,431 (+)NCBICHM1_1
T2T-CHM13v2.02239,985,692 - 39,993,317 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-schisandrin B  (ISO)
(-)-citrinin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(R)-lipoic acid  (ISO)
(S)-amphetamine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-arachidonoylglycerol  (EXP)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4-Hydroxybenzophenone  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-phenylbutyric acid  (EXP,ISO)
4-tert-Octylphenol  (ISO)
5-fluorouracil  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (EXP)
acetylsalicylic acid  (EXP)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
actinomycin D  (EXP)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
Alisol B  (EXP)
all-trans-retinal  (EXP)
all-trans-retinoic acid  (ISO)
alpha-D-galactose  (EXP)
amino acid  (EXP,ISO)
amiodarone  (EXP,ISO)
amitrole  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (EXP)
antirheumatic drug  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
atazanavir sulfate  (EXP)
atrazine  (EXP,ISO)
avermectin  (EXP)
azoxystrobin  (EXP)
bathocuproine disulfonic acid  (EXP)
benzalkonium chloride  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bepridil  (EXP)
beta-D-glucosamine  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bongkrekic acid  (EXP)
boric acid  (EXP)
bortezomib  (EXP,ISO)
brefeldin A  (EXP)
busulfan  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP)
camptothecin  (EXP)
cannabidiol  (ISO)
cannabigerol  (ISO)
cantharidin  (EXP,ISO)
capsaicin  (EXP)
carbamazepine  (EXP)
carbon nanotube  (ISO)
carboxy-PTIO  (EXP)
cerium  (EXP)
CGP 52608  (EXP)
chenodeoxycholic acid  (EXP)
chloroacetaldehyde  (EXP)
chloroacetic acid  (ISO)
chlorogenic acid  (ISO)
chloropicrin  (EXP)
chloroquine  (ISO)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (ISO)
chromium(6+)  (EXP)
chrysene  (ISO)
cibenzoline  (EXP)
cidofovir anhydrous  (EXP)
cisplatin  (EXP,ISO)
clodronic acid  (EXP)
clofibrate  (ISO)
clofibric acid  (ISO)
cobalt dichloride  (EXP)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (EXP)
corilagin  (ISO)
crocidolite asbestos  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cylindrospermopsin  (EXP)
D-glucose  (EXP,ISO)
dantrolene  (ISO)
dapagliflozin  (ISO)
deguelin  (EXP)
deoxycholic acid  (EXP)
dexamethasone  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dihydrocapsaicin  (EXP)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (EXP,ISO)
dimethylarsinic acid  (EXP,ISO)
dimethylarsinous acid  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
diuron  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
endosulfan  (ISO)
epoxomicin  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ethylene glycol  (ISO)
etoposide  (ISO)
fangchinoline  (EXP)
fenofibrate  (EXP,ISO)
fenpyroximate  (EXP)
flavokawain B  (EXP)
fluoranthene  (ISO)
flutamide  (ISO)
FR900359  (EXP)
fructose  (ISO)
fulvestrant  (ISO)
fumonisin B1  (EXP)
furan  (ISO)
gadolinium trichloride  (ISO)
galactose  (EXP)
gentamycin  (ISO)
geraniol  (EXP)
glafenine  (ISO)
glucose  (EXP,ISO)
glutaraldehyde  (EXP)
glutathione  (EXP)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
glyphosate  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
graphene oxide  (EXP)
GSK2656157  (ISO)
helenalin  (EXP)
hexadecanoic acid  (ISO)
Honokiol  (EXP)
hydralazine  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
ibuprofen  (EXP)
ifosfamide  (EXP)
ionomycin  (EXP,ISO)
ivermectin  (EXP,ISO)
ketamine  (ISO)
KN-93  (ISO)
L-1,4-dithiothreitol  (EXP,ISO)
L-cysteine  (EXP)
L-methionine  (EXP)
L-serine  (EXP)
lead diacetate  (ISO)
lead(II) chloride  (EXP)
leflunomide  (EXP,ISO)
linsidomine  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (EXP)
LY294002  (EXP)
manganese(II) chloride  (ISO)
melatonin  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (ISO)
mitomycin C  (EXP,ISO)
MK-2206  (EXP)
morphine  (ISO)
N(4)-hydroxycytidine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-acylsphinganine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-hexadecanoylsphingosine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nelfinavir  (EXP)
niclosamide  (EXP)
nimesulide  (ISO)
Nodularin  (EXP)
Nonidet P-40  (EXP)
NORCANTHARIDIN  (EXP)
ochratoxin A  (EXP)
Octicizer  (ISO)
orlistat  (EXP)
oxidopamine  (ISO)
oxycodone  (EXP,ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
Pachymic acid  (EXP,ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
Pendulone  (EXP)
perfluorobutyric acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perhexiline  (EXP)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
picoxystrobin  (EXP)
pirinixic acid  (ISO)
piroxicam  (EXP)
pitavastatin  (EXP)
pitavastatin(1-)  (EXP)
potassium chromate  (EXP)
potassium dichromate  (EXP,ISO)
procymidone  (ISO)
progesterone  (EXP)
propiconazole  (ISO)
propylparaben  (ISO)
psoralen  (EXP)
pyrazinecarboxamide  (EXP,ISO)
pyrimidifen  (EXP)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP)
rac-lactic acid  (EXP)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
rimonabant  (EXP)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
salubrinal  (EXP,ISO)
SB 203580  (EXP)
SB-239063  (EXP)
SCH 23390  (ISO)
scopoletin  (ISO)
selenium atom  (EXP)
sertraline  (EXP)
sinapic acid  (ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
sodium fluoride  (ISO)
Soman  (ISO)
sorafenib  (EXP)
SR 144528  (EXP)
streptozocin  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (ISO)
sulindac  (EXP)
sunitinib  (EXP)
T-2 toxin  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP,ISO)
tebufenpyrad  (EXP)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
thifluzamide  (EXP)
thioacetamide  (ISO)
thymoquinone  (EXP)
Tiron  (EXP,ISO)
titanium dioxide  (ISO)
toosendanin  (EXP,ISO)
tributyl phosphate  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
triclocarban  (EXP)
triclosan  (EXP)
trimethylamine N-oxide  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (EXP,ISO)
umbelliferone  (ISO)
urethane  (EXP)
ursodeoxycholic acid  (EXP)
usnic acid  (EXP)
valproic acid  (ISO)
vildagliptin  (ISO)
withaferin A  (EXP)
XAV939  (EXP,ISO)
xylitol  (EXP)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc(0)  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
bone mineralization  (IEA,ISS)
cellular response to amino acid starvation  (IEA,ISS)
cellular response to glucose starvation  (IMP)
cellular response to hypoxia  (IEA,ISO)
cellular response to leucine starvation  (IDA,IEA)
cellular response to oxidative stress  (IEA,IMP,ISS)
cellular response to UV  (ISS)
circadian regulation of gene expression  (IEA,ISS)
circadian rhythm  (IEA)
embryonic hemopoiesis  (IEA,ISS)
endoplasmic reticulum unfolded protein response  (IEA,ISS)
gamma-aminobutyric acid signaling pathway  (IEA,ISO)
gluconeogenesis  (IEA,ISO,ISS)
HRI-mediated signaling  (IDA)
integrated stress response signaling  (IDA,IEA,NAS)
intracellular calcium ion homeostasis  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IEA,ISS)
L-asparagine metabolic process  (IDA)
lens fiber cell morphogenesis  (IEA,ISS)
mRNA transcription by RNA polymerase II  (IEA,ISS)
negative regulation of cold-induced thermogenesis  (IEA,ISS)
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  (IEA,IGI)
negative regulation of potassium ion transport  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISS)
negative regulation of translational initiation in response to stress  (ISS)
neuron differentiation  (IEA,ISO)
PERK-mediated unfolded protein response  (IEA,ISS,TAS)
positive regulation of apoptotic process  (TAS)
positive regulation of biomineral tissue development  (IEA,ISO)
positive regulation of DNA-templated transcription  (IDA,IEA,IMP,ISS,NAS)
positive regulation of gene expression  (IEA,IMP,ISO)
positive regulation of neuron apoptotic process  (IEA,ISS)
positive regulation of sodium-dependent phosphate transport  (IEA,ISO)
positive regulation of transcription by RNA polymerase I  (IMP)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,IMP,ISO,ISS,TAS)
positive regulation of vascular associated smooth muscle cell apoptotic process  (IEA,ISO)
positive regulation of vascular endothelial growth factor production  (IMP)
regulation of apoptotic process  (IEA)
regulation of DNA-templated transcription  (IEA,ISO,ISS)
regulation of osteoblast differentiation  (IDA,IEA)
regulation of synaptic plasticity  (IEA,ISS)
regulation of transcription by RNA polymerase II  (IBA,IEA,ISO,NAS)
response to endoplasmic reticulum stress  (IDA,IEA,IMP)
response to manganese-induced endoplasmic reticulum stress  (IEA)
response to nutrient levels  (IDA)
response to toxic substance  (IEA,ISO)
rhythmic process  (IEA)
transcription by RNA polymerase II  (IEA,ISO,ISS)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. STAMP2 increases oxidative stress and is critical for prostate cancer. Jin Y, etal., EMBO Mol Med. 2015 Mar;7(3):315-31. doi: 10.15252/emmm.201404181.
3. ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma. Linares JF, etal., Cell Metab. 2017 Dec 5;26(6):817-829.e6. doi: 10.1016/j.cmet.2017.09.001. Epub 2017 Oct 5.
4. Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease. Manaud G, etal., Am J Respir Cell Mol Biol. 2020 Jul;63(1):118-131. doi: 10.1165/rcmb.2019-0015OC.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. Tan Z, etal., J Neuroinflammation. 2018 Sep 21;15(1):275. doi: 10.1186/s12974-018-1311-5.
8. Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres. Tanaka T, etal., Genes Cells 1998 Dec;3(12):801-10.
9. The impact of the unfolded protein response on human disease. Wang S and Kaufman RJ, J Cell Biol. 2012 Jun 25;197(7):857-67. doi: 10.1083/jcb.201110131.
10. Endoplasmic reticulum stress and neurodegeneration in rats neonatally infected with borna disease virus. Williams BL and Lipkin WI, J Virol. 2006 Sep;80(17):8613-26. doi: 10.1128/JVI.00836-06.
11. miRNA-30a functions as a tumor suppressor by downregulating cyclin E2 expression in castration-resistant prostate cancer. Zhang L, etal., Mol Med Rep. 2016 Sep;14(3):2077-84. doi: 10.3892/mmr.2016.5469. Epub 2016 Jul 6.
Additional References at PubMed
PMID:1371974   PMID:1534408   PMID:1827203   PMID:1847461   PMID:2516827   PMID:8939898   PMID:9190894   PMID:9295363   PMID:9488481   PMID:10350644   PMID:10419887   PMID:10591208  
PMID:11018027   PMID:11025215   PMID:11087824   PMID:11238952   PMID:11274184   PMID:11478948   PMID:11564156   PMID:11960987   PMID:12471036   PMID:12477932   PMID:12689582   PMID:12743605  
PMID:12805554   PMID:12812986   PMID:12860379   PMID:12871976   PMID:14561767   PMID:14623284   PMID:14630807   PMID:14630918   PMID:14685163   PMID:14695168   PMID:14747470   PMID:15109498  
PMID:15277680   PMID:15314157   PMID:15385533   PMID:15461802   PMID:15475356   PMID:15489334   PMID:15677469   PMID:15775988   PMID:15788408   PMID:15911876   PMID:16169070   PMID:16189514  
PMID:16219772   PMID:16343488   PMID:16445384   PMID:16682973   PMID:16687408   PMID:16751776   PMID:17042743   PMID:17267404   PMID:17346882   PMID:17347301   PMID:17369260   PMID:17684156  
PMID:17707795   PMID:17726049   PMID:17822787   PMID:17872950   PMID:17938202   PMID:17996332   PMID:18052253   PMID:18163433   PMID:18171674   PMID:18189280   PMID:18195013   PMID:18255255  
PMID:18276110   PMID:18330356   PMID:18408768   PMID:18451308   PMID:18635891   PMID:18697751   PMID:18940792   PMID:19017641   PMID:19053519   PMID:19061639   PMID:19073601   PMID:19114033  
PMID:19164757   PMID:19193809   PMID:19251251   PMID:19274049   PMID:19417138   PMID:19447967   PMID:19453261   PMID:19509279   PMID:19855386   PMID:19946894   PMID:20022965   PMID:20102225  
PMID:20185790   PMID:20211142   PMID:20398657   PMID:20473272   PMID:20514020   PMID:20551969   PMID:20564243   PMID:20592469   PMID:20724472   PMID:20732869   PMID:20873783   PMID:20936779  
PMID:21044953   PMID:21087962   PMID:21113145   PMID:21203563   PMID:21244365   PMID:21408167   PMID:21516116   PMID:21683813   PMID:21706477   PMID:21801305   PMID:21832049   PMID:21866569  
PMID:21873635   PMID:21951999   PMID:21966512   PMID:21988832   PMID:22007000   PMID:22013210   PMID:22016052   PMID:22017875   PMID:22050711   PMID:22052162   PMID:22082360   PMID:22233381  
PMID:22246806   PMID:22338651   PMID:22363646   PMID:22422769   PMID:22435535   PMID:22485215   PMID:22609407   PMID:22658674   PMID:22691366   PMID:22813743   PMID:22848420   PMID:22898364  
PMID:22915762   PMID:22934019   PMID:22955275   PMID:22980225   PMID:23001845   PMID:23078367   PMID:23090478   PMID:23123191   PMID:23128233   PMID:23153536   PMID:23205607   PMID:23241898  
PMID:23242184   PMID:23294542   PMID:23339444   PMID:23392669   PMID:23471465   PMID:23661758   PMID:23665047   PMID:23792164   PMID:23891064   PMID:23908598   PMID:23916134   PMID:23975372  
PMID:24021586   PMID:24100623   PMID:24136195   PMID:24308964   PMID:24330582   PMID:24418603   PMID:24681956   PMID:24715035   PMID:24853302   PMID:24874742   PMID:24905361   PMID:24939851  
PMID:24952347   PMID:25002527   PMID:25052841   PMID:25078779   PMID:25130172   PMID:25142020   PMID:25171414   PMID:25236743   PMID:25241761   PMID:25332235   PMID:25375376   PMID:25416956  
PMID:25449779   PMID:25464930   PMID:25515538   PMID:25567807   PMID:25621764   PMID:25633195   PMID:25681212   PMID:25727012   PMID:25795775   PMID:25910212   PMID:25931127   PMID:26011642  
PMID:26030745   PMID:26091241   PMID:26111340   PMID:26125799   PMID:26172539   PMID:26239904   PMID:26504039   PMID:26648175   PMID:26700459   PMID:26771712   PMID:26791102   PMID:26797758  
PMID:26871637   PMID:26884600   PMID:26967115   PMID:27010621   PMID:27079961   PMID:27107014   PMID:27211800   PMID:27264869   PMID:27278863   PMID:27325740   PMID:27328454   PMID:27357269  
PMID:27567537   PMID:27651314   PMID:27796753   PMID:27935748   PMID:28186491   PMID:28380427   PMID:28438094   PMID:28460466   PMID:28473536   PMID:28514442   PMID:28553953   PMID:28566324  
PMID:28688763   PMID:28843961   PMID:28947141   PMID:28975618   PMID:29059168   PMID:29180619   PMID:29207036   PMID:29216929   PMID:29420561   PMID:29421327   PMID:29431743   PMID:29453334  
PMID:29601799   PMID:29716673   PMID:29892012   PMID:29921696   PMID:29991528   PMID:30003094   PMID:30012221   PMID:30012564   PMID:30021884   PMID:30044122   PMID:30100064   PMID:30209241  
PMID:30382797   PMID:30452882   PMID:30854784   PMID:30926605   PMID:31023583   PMID:31100053   PMID:31263264   PMID:31312022   PMID:31413325   PMID:31424999   PMID:31444471   PMID:31448831  
PMID:31504800   PMID:31515488   PMID:31534554   PMID:31551255   PMID:31642559   PMID:31691973   PMID:31862913   PMID:31930117   PMID:31960438   PMID:32052937   PMID:32132035   PMID:32132707  
PMID:32210535   PMID:32281291   PMID:32296183   PMID:32299090   PMID:32312748   PMID:32323565   PMID:32551949   PMID:32648994   PMID:32668192   PMID:32694731   PMID:32755585   PMID:32783256  
PMID:32814053   PMID:32888357   PMID:32911434   PMID:32938922   PMID:32945472   PMID:33108704   PMID:33111629   PMID:33154371   PMID:33229544   PMID:33384352   PMID:33414424   PMID:33420908  
PMID:33582407   PMID:33615565   PMID:33628101   PMID:33714955   PMID:33737080   PMID:33741715   PMID:33775689   PMID:33782384   PMID:33819187   PMID:33837631   PMID:33870911   PMID:33911065  
PMID:33946018   PMID:33950334   PMID:33961781   PMID:34015761   PMID:34156885   PMID:34239013   PMID:34298014   PMID:34403810   PMID:34664408   PMID:34709767   PMID:34808500   PMID:34914716  
PMID:35013120   PMID:35019856   PMID:35028855   PMID:35305370   PMID:35615577   PMID:35662627   PMID:35744931   PMID:35857794   PMID:35883579   PMID:35912788   PMID:35926799   PMID:35962830  
PMID:36051358   PMID:36245009   PMID:36377873   PMID:36416348   PMID:36555349   PMID:36587794   PMID:36996941   PMID:37028586   PMID:37273238   PMID:37410595   PMID:37591953   PMID:37837219  
PMID:37906604   PMID:37935302   PMID:37995805   PMID:38113413   PMID:38383612   PMID:38424194  


Genomics

Comparative Map Data
ATF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382239,520,559 - 39,522,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2239,519,695 - 39,522,683 (+)EnsemblGRCh38hg38GRCh38
GRCh372239,916,564 - 39,918,691 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,246,515 - 38,248,637 (+)NCBINCBI36Build 36hg18NCBI36
Build 342238,241,068 - 38,243,191NCBI
Celera2223,718,625 - 23,720,747 (+)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2222,881,158 - 22,883,280 (+)NCBIHuRef
CHM1_12239,875,308 - 39,877,431 (+)NCBICHM1_1
T2T-CHM13v2.02239,985,692 - 39,993,317 (+)NCBIT2T-CHM13v2.0
Atf4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391580,139,385 - 80,141,746 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1580,139,385 - 80,141,742 (+)EnsemblGRCm39 Ensembl
GRCm381580,255,184 - 80,257,545 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1580,255,184 - 80,257,541 (+)EnsemblGRCm38mm10GRCm38
MGSCv371580,085,614 - 80,087,971 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361580,082,756 - 80,084,759 (+)NCBIMGSCv36mm8
Celera1582,372,526 - 82,374,883 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.85NCBI
Atf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,684,681 - 113,686,739 (+)NCBIGRCr8
mRatBN7.27111,804,135 - 111,806,457 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,804,183 - 111,806,446 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7113,558,983 - 113,561,040 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,782,520 - 115,784,577 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,751,882 - 115,753,939 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,480,723 - 121,482,781 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,480,723 - 121,482,772 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,468,275 - 121,470,587 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,537,718 - 118,538,994NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17118,571,947 - 118,573,223NCBI
Cytogenetic Map7q34NCBI
Atf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541325,406,589 - 25,412,218 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541325,406,589 - 25,408,727 (+)NCBIChiLan1.0ChiLan1.0
ATF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22349,368,664 - 49,369,904 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12252,058,755 - 52,061,257 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02220,426,743 - 20,428,892 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12238,246,337 - 38,249,333 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2238,248,094 - 38,249,249 (+)Ensemblpanpan1.1panPan2
ATF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11025,528,880 - 25,531,018 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1025,528,874 - 25,530,993 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1025,464,741 - 25,466,879 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01026,280,612 - 26,282,756 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1026,280,619 - 26,282,738 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11025,995,219 - 25,997,329 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01026,314,765 - 26,316,875 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01026,490,223 - 26,492,367 (-)NCBIUU_Cfam_GSD_1.0
Atf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049459,104,066 - 9,105,487 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364922,110,634 - 2,115,996 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364922,114,478 - 2,115,969 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl58,742,967 - 8,745,368 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.158,742,964 - 8,745,752 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.256,042,584 - 6,044,651 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11922,092,046 - 22,094,184 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1922,091,667 - 22,095,230 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045103,557,595 - 103,561,018 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atf4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247528,822,740 - 8,825,032 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247528,822,955 - 8,825,019 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ATF4
33 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 22q12.3-13.33(chr22:37061769-50738932)x3 copy number gain See cases [RCV000051684] Chr22:37061769..50738932 [GRCh38]
Chr22:37457809..51177360 [GRCh37]
Chr22:35787755..49524226 [NCBI36]
Chr22:22q12.3-13.33
pathogenic
GRCh38/hg38 22q13.1-13.2(chr22:37721797-40860953)x3 copy number gain See cases [RCV000051685] Chr22:37721797..40860953 [GRCh38]
Chr22:38117804..41256957 [GRCh37]
Chr22:36447750..39586903 [NCBI36]
Chr22:22q13.1-13.2
pathogenic
GRCh38/hg38 22q12.3-13.33(chr22:33768441-50739977)x3 copy number gain See cases [RCV000051682] Chr22:33768441..50739977 [GRCh38]
Chr22:34164428..51178405 [GRCh37]
Chr22:32494428..49525271 [NCBI36]
Chr22:22q12.3-13.33
pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916608-50739836)x3 copy number gain See cases [RCV000133646] Chr22:16916608..50739836 [GRCh38]
Chr22:17397498..51178264 [GRCh37]
Chr22:15777498..49525130 [NCBI36]
Chr22:22q11.1-13.33
pathogenic
GRCh38/hg38 22q11.1-13.33(chr22:16916743-50739785)x3 copy number gain See cases [RCV000134730] Chr22:16916743..50739785 [GRCh38]
Chr22:17397633..51178213 [GRCh37]
Chr22:15777633..49525079 [NCBI36]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237518)x3 copy number gain See cases [RCV000240091] Chr22:16054691..51237518 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q12.3-13.33(chr22:35728929-51220961)x3 copy number gain See cases [RCV000240469] Chr22:35728929..51220961 [GRCh37]
Chr22:22q12.3-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51220902)x3 copy number gain See cases [RCV000446956] Chr22:16054691..51220902 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054691-51237463)x3 copy number gain See cases [RCV000448847] Chr22:16054691..51237463 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838) copy number gain See cases [RCV000510873] Chr22:16888900..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
NM_182810.3(ATF4):c.743C>T (p.Ser248Phe) single nucleotide variant Inborn genetic diseases [RCV003276398] Chr22:39522289 [GRCh38]
Chr22:39918294 [GRCh37]
Chr22:22q13.1
uncertain significance
NM_182810.3(ATF4):c.89G>A (p.Ser30Asn) single nucleotide variant Inborn genetic diseases [RCV003282325] Chr22:39521534 [GRCh38]
Chr22:39917539 [GRCh37]
Chr22:22q13.1
uncertain significance
GRCh37/hg19 22q11.1-13.33(chr22:16888900-51197838)x3 copy number gain See cases [RCV000512333] Chr22:16888900..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16054667-51243435)x3 copy number gain not provided [RCV000741689] Chr22:16054667..51243435 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51195728)x3 copy number gain not provided [RCV000741691] Chr22:16114244..51195728 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
GRCh37/hg19 22q11.1-13.33(chr22:16114244-51211392)x3 copy number gain not provided [RCV000741692] Chr22:16114244..51211392 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
NM_182810.3(ATF4):c.393T>C (p.Asn131=) single nucleotide variant not provided [RCV000880693] Chr22:39521939 [GRCh38]
Chr22:39917944 [GRCh37]
Chr22:22q13.1
benign
NM_182810.3(ATF4):c.966G>C (p.Glu322Asp) single nucleotide variant not provided [RCV000965503] Chr22:39522512 [GRCh38]
Chr22:39918517 [GRCh37]
Chr22:22q13.1
benign
GRCh37/hg19 22q12.2-13.33(chr22:30654764-51197838)x3 copy number gain not provided [RCV001007181] Chr22:30654764..51197838 [GRCh37]
Chr22:22q12.2-13.33
pathogenic
NM_182810.3(ATF4):c.772C>G (p.Pro258Ala) single nucleotide variant not provided [RCV000961759] Chr22:39522318 [GRCh38]
Chr22:39918323 [GRCh37]
Chr22:22q13.1
benign
NM_182810.3(ATF4):c.498C>T (p.Ser166=) single nucleotide variant not provided [RCV000900780] Chr22:39522044 [GRCh38]
Chr22:39918049 [GRCh37]
Chr22:22q13.1
benign
NM_182810.3(ATF4):c.240C>T (p.Ser80=) single nucleotide variant not provided [RCV000974157] Chr22:39521786 [GRCh38]
Chr22:39917791 [GRCh37]
Chr22:22q13.1
benign
NM_182810.3(ATF4):c.409A>T (p.Thr137Ser) single nucleotide variant not provided [RCV000966684] Chr22:39521955 [GRCh38]
Chr22:39917960 [GRCh37]
Chr22:22q13.1
likely benign
GRCh37/hg19 22q11.1-13.33(chr22:16888899-51197838)x3 copy number gain not provided [RCV000846344] Chr22:16888899..51197838 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
NM_182810.3(ATF4):c.487C>T (p.Leu163Phe) single nucleotide variant Inborn genetic diseases [RCV003271171] Chr22:39522033 [GRCh38]
Chr22:39918038 [GRCh37]
Chr22:22q13.1
uncertain significance
NM_182810.3(ATF4):c.404C>T (p.Pro135Leu) single nucleotide variant not provided [RCV000965501] Chr22:39521950 [GRCh38]
Chr22:39917955 [GRCh37]
Chr22:22q13.1
benign
NM_182810.3(ATF4):c.600C>T (p.Tyr200=) single nucleotide variant not provided [RCV000965502] Chr22:39522146 [GRCh38]
Chr22:39918151 [GRCh37]
Chr22:22q13.1
benign
NM_182810.3(ATF4):c.624A>G (p.Ile208Met) single nucleotide variant not provided [RCV000972140] Chr22:39522170 [GRCh38]
Chr22:39918175 [GRCh37]
Chr22:22q13.1
likely benign
NM_182810.3(ATF4):c.601G>A (p.Val201Ile) single nucleotide variant not provided [RCV000974333] Chr22:39522147 [GRCh38]
Chr22:39918152 [GRCh37]
Chr22:22q13.1
benign
NM_182810.3(ATF4):c.7G>A (p.Glu3Lys) single nucleotide variant not provided [RCV000899879] Chr22:39521452 [GRCh38]
Chr22:39917457 [GRCh37]
Chr22:22q13.1
benign
NM_182810.3(ATF4):c.971C>T (p.Ala324Val) single nucleotide variant not provided [RCV000955606] Chr22:39522517 [GRCh38]
Chr22:39918522 [GRCh37]
Chr22:22q13.1
benign
NM_182810.3(ATF4):c.912G>A (p.Glu304=) single nucleotide variant not provided [RCV000911711] Chr22:39522458 [GRCh38]
Chr22:39918463 [GRCh37]
Chr22:22q13.1
likely benign
NM_182810.3(ATF4):c.579G>A (p.Arg193=) single nucleotide variant not provided [RCV000890718] Chr22:39522125 [GRCh38]
Chr22:39918130 [GRCh37]
Chr22:22q13.1
likely benign
GRCh37/hg19 22q11.1-13.33(chr22:16197005-51224252)x3 copy number gain See cases [RCV001263056] Chr22:16197005..51224252 [GRCh37]
Chr22:22q11.1-13.33
pathogenic
NC_000022.10:g.(?_39621728)_(41077932_?)dup duplication Adenylosuccinate lyase deficiency [RCV001910122] Chr22:39621728..41077932 [GRCh37]
Chr22:22q13.1-13.2
uncertain significance
NC_000022.10:g.(?_35776672)_(42486826_?)dup duplication Adenylosuccinate lyase deficiency [RCV003119093] Chr22:35776672..42486826 [GRCh37]
Chr22:22q12.3-13.2
uncertain significance
NM_182810.3(ATF4):c.804G>A (p.Met268Ile) single nucleotide variant Inborn genetic diseases [RCV003258430] Chr22:39522350 [GRCh38]
Chr22:39918355 [GRCh37]
Chr22:22q13.1
uncertain significance
GRCh37/hg19 22q13.1-13.2(chr22:39768795-41946225)x3 copy number gain not provided [RCV002475709] Chr22:39768795..41946225 [GRCh37]
Chr22:22q13.1-13.2
uncertain significance
NM_182810.3(ATF4):c.353A>C (p.Asp118Ala) single nucleotide variant Inborn genetic diseases [RCV002767955] Chr22:39521899 [GRCh38]
Chr22:39917904 [GRCh37]
Chr22:22q13.1
uncertain significance
NM_182810.3(ATF4):c.920C>T (p.Thr307Ile) single nucleotide variant Inborn genetic diseases [RCV002984849] Chr22:39522466 [GRCh38]
Chr22:39918471 [GRCh37]
Chr22:22q13.1
uncertain significance
NM_182810.3(ATF4):c.1051C>T (p.Pro351Ser) single nucleotide variant Inborn genetic diseases [RCV002930956] Chr22:39522597 [GRCh38]
Chr22:39918602 [GRCh37]
Chr22:22q13.1
uncertain significance
NM_182810.3(ATF4):c.596C>T (p.Ala199Val) single nucleotide variant Inborn genetic diseases [RCV002891917] Chr22:39522142 [GRCh38]
Chr22:39918147 [GRCh37]
Chr22:22q13.1
uncertain significance
NM_182810.3(ATF4):c.248A>T (p.Asp83Val) single nucleotide variant Inborn genetic diseases [RCV002812783] Chr22:39521794 [GRCh38]
Chr22:39917799 [GRCh37]
Chr22:22q13.1
uncertain significance
NM_182810.3(ATF4):c.485C>T (p.Pro162Leu) single nucleotide variant Inborn genetic diseases [RCV002669442] Chr22:39522031 [GRCh38]
Chr22:39918036 [GRCh37]
Chr22:22q13.1
uncertain significance
NM_182810.3(ATF4):c.364C>T (p.Leu122Phe) single nucleotide variant Inborn genetic diseases [RCV002722837] Chr22:39521910 [GRCh38]
Chr22:39917915 [GRCh37]
Chr22:22q13.1
uncertain significance
NM_182810.3(ATF4):c.784G>T (p.Asp262Tyr) single nucleotide variant Inborn genetic diseases [RCV003217411] Chr22:39522330 [GRCh38]
Chr22:39918335 [GRCh37]
Chr22:22q13.1
uncertain significance
NM_182810.3(ATF4):c.685C>G (p.Leu229Val) single nucleotide variant Inborn genetic diseases [RCV003184720] Chr22:39522231 [GRCh38]
Chr22:39918236 [GRCh37]
Chr22:22q13.1
uncertain significance
NM_182810.3(ATF4):c.796G>C (p.Glu266Gln) single nucleotide variant Inborn genetic diseases [RCV003172815] Chr22:39522342 [GRCh38]
Chr22:39918347 [GRCh37]
Chr22:22q13.1
uncertain significance
NM_182810.3(ATF4):c.233C>T (p.Ala78Val) single nucleotide variant Inborn genetic diseases [RCV003356798] Chr22:39521779 [GRCh38]
Chr22:39917784 [GRCh37]
Chr22:22q13.1
uncertain significance
NM_182810.3(ATF4):c.313C>G (p.Leu105Val) single nucleotide variant Inborn genetic diseases [RCV003364223] Chr22:39521859 [GRCh38]
Chr22:39917864 [GRCh37]
Chr22:22q13.1
uncertain significance
NM_182810.3(ATF4):c.329A>G (p.Asp110Gly) single nucleotide variant Inborn genetic diseases [RCV003385403] Chr22:39521875 [GRCh38]
Chr22:39917880 [GRCh37]
Chr22:22q13.1
uncertain significance
NM_182810.3(ATF4):c.650A>G (p.Asn217Ser) single nucleotide variant Inborn genetic diseases [RCV003353879] Chr22:39522196 [GRCh38]
Chr22:39918201 [GRCh37]
Chr22:22q13.1
uncertain significance
GRCh37/hg19 22q13.1-13.31(chr22:39044105-45794212)x3 copy number gain not specified [RCV003986179] Chr22:39044105..45794212 [GRCh37]
Chr22:22q13.1-13.31
pathogenic
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR214hsa-miR-214-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23223004

Predicted Target Of
Summary Value
Count of predictions:222
Count of miRNA genes:78
Interacting mature miRNAs:78
Transcripts:ENST00000337304, ENST00000396680, ENST00000404241
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
RH71390  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372239,918,486 - 39,918,614UniSTSGRCh37
GRCh371774,221,825 - 74,221,953UniSTSGRCh37
Build 361771,733,420 - 71,733,548RGDNCBI36
Celera1770,815,752 - 70,815,880RGD
Celera2223,720,542 - 23,720,670UniSTS
Cytogenetic Map17q25.1UniSTS
Cytogenetic Map22q13.1UniSTS
HuRef2222,883,075 - 22,883,203UniSTS
HuRef1769,650,831 - 69,650,959UniSTS
GeneMap99-GB4 RH Map17497.67UniSTS
NCBI RH Map17797.2UniSTS
PMC166200P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372239,916,367 - 39,916,609UniSTSGRCh37
Build 362238,246,313 - 38,246,555RGDNCBI36
Celera2223,718,423 - 23,718,665RGD
Cytogenetic Map22q13.1UniSTS
HuRef2222,880,956 - 22,881,198UniSTS
RH48164  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372239,917,229 - 39,917,347UniSTSGRCh37
Build 362238,247,175 - 38,247,293RGDNCBI36
Celera2223,719,285 - 23,719,403RGD
Cytogenetic Map22q13.1UniSTS
HuRef2222,881,818 - 22,881,936UniSTS
GeneMap99-GB4 RH Map22135.33UniSTS
NCBI RH Map22157.4UniSTS
ATF4_4333  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372239,917,900 - 39,918,695UniSTSGRCh37
Build 362238,247,846 - 38,248,641RGDNCBI36
Celera2223,719,956 - 23,720,751RGD
HuRef2222,882,489 - 22,883,284UniSTS
RH79684  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map22q13.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 164 103 3 53 81 46 9 4 64 11 8 74
Medium 2268 2881 1720 622 1895 464 4274 2147 3699 414 1384 1597 171 1196 2714 4
Low 4 3 2 1 1 1 4 3 2 1 1 1
Below cutoff 2 1 1 1 1 8 1 8 2 3 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_182810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017028807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054325649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054325650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK057751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296028 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL022312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC008090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC011994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC016855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC022088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC044895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC073754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC073990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR450353 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D90209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M86842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000337304   ⟹   ENSP00000336790
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2239,520,564 - 39,522,683 (+)Ensembl
RefSeq Acc Id: ENST00000396680   ⟹   ENSP00000379912
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2239,520,576 - 39,522,668 (+)Ensembl
RefSeq Acc Id: ENST00000404241   ⟹   ENSP00000384587
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2239,519,695 - 39,522,683 (+)Ensembl
RefSeq Acc Id: ENST00000674568   ⟹   ENSP00000501783
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2239,520,579 - 39,522,602 (+)Ensembl
RefSeq Acc Id: ENST00000674835   ⟹   ENSP00000502610
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2239,520,604 - 39,522,602 (+)Ensembl
RefSeq Acc Id: ENST00000674920   ⟹   ENSP00000501863
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2239,520,562 - 39,522,683 (+)Ensembl
RefSeq Acc Id: ENST00000675582   ⟹   ENSP00000502056
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2239,520,564 - 39,522,602 (+)Ensembl
RefSeq Acc Id: ENST00000676346   ⟹   ENSP00000502400
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2239,520,576 - 39,522,602 (+)Ensembl
RefSeq Acc Id: ENST00000676430   ⟹   ENSP00000501638
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2239,520,747 - 39,521,528 (+)Ensembl
RefSeq Acc Id: ENST00000679776   ⟹   ENSP00000505360
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2239,520,563 - 39,522,602 (+)Ensembl
RefSeq Acc Id: ENST00000680446   ⟹   ENSP00000506657
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2239,520,578 - 39,522,602 (+)Ensembl
RefSeq Acc Id: ENST00000680748   ⟹   ENSP00000506141
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl2239,520,589 - 39,521,953 (+)Ensembl
RefSeq Acc Id: NM_001675   ⟹   NP_001666
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382239,520,559 - 39,522,686 (+)NCBI
GRCh372239,916,569 - 39,918,691 (+)NCBI
Build 362238,246,515 - 38,248,637 (+)NCBI Archive
HuRef2222,881,158 - 22,883,280 (+)ENTREZGENE
CHM1_12239,875,303 - 39,877,431 (+)NCBI
T2T-CHM13v2.02239,991,189 - 39,993,317 (+)NCBI
Sequence:
RefSeq Acc Id: NM_182810   ⟹   NP_877962
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382239,520,562 - 39,522,683 (+)NCBI
GRCh372239,916,569 - 39,918,691 (+)ENTREZGENE
Build 362238,246,515 - 38,248,637 (+)NCBI Archive
HuRef2222,881,158 - 22,883,280 (+)ENTREZGENE
CHM1_12239,875,308 - 39,877,431 (+)NCBI
T2T-CHM13v2.02239,991,192 - 39,993,314 (+)NCBI
Sequence:
RefSeq Acc Id: XM_054325649   ⟹   XP_054181624
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.02239,985,692 - 39,993,317 (+)NCBI
RefSeq Acc Id: XM_054325650   ⟹   XP_054181625
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.02239,985,692 - 39,993,317 (+)NCBI
RefSeq Acc Id: NP_001666   ⟸   NM_001675
- UniProtKB: Q96AQ3 (UniProtKB/Swiss-Prot),   Q9UH31 (UniProtKB/Swiss-Prot),   P18848 (UniProtKB/Swiss-Prot),   Q6ICP0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_877962   ⟸   NM_182810
- UniProtKB: Q96AQ3 (UniProtKB/Swiss-Prot),   Q9UH31 (UniProtKB/Swiss-Prot),   P18848 (UniProtKB/Swiss-Prot),   Q6ICP0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000336790   ⟸   ENST00000337304
RefSeq Acc Id: ENSP00000384587   ⟸   ENST00000404241
RefSeq Acc Id: ENSP00000379912   ⟸   ENST00000396680
RefSeq Acc Id: ENSP00000501863   ⟸   ENST00000674920
RefSeq Acc Id: ENSP00000502610   ⟸   ENST00000674835
RefSeq Acc Id: ENSP00000501783   ⟸   ENST00000674568
RefSeq Acc Id: ENSP00000502056   ⟸   ENST00000675582
RefSeq Acc Id: ENSP00000501638   ⟸   ENST00000676430
RefSeq Acc Id: ENSP00000502400   ⟸   ENST00000676346
RefSeq Acc Id: ENSP00000505360   ⟸   ENST00000679776
RefSeq Acc Id: ENSP00000506141   ⟸   ENST00000680748
RefSeq Acc Id: ENSP00000506657   ⟸   ENST00000680446
RefSeq Acc Id: XP_054181624   ⟸   XM_054325649
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054181625   ⟸   XM_054325650
- Peptide Label: isoform X1
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P18848-F1-model_v2 AlphaFold P18848 1-351 view protein structure

Promoters
RGD ID:6799896
Promoter ID:HG_KWN:42893
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour,   Jurkat,   Lymphoblastoid
Transcripts:ENST00000404241
Position:
Human AssemblyChrPosition (strand)Source
Build 362238,245,046 - 38,245,546 (+)MPROMDB
RGD ID:6799685
Promoter ID:HG_KWN:42894
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_001675,   NM_182810
Position:
Human AssemblyChrPosition (strand)Source
Build 362238,245,886 - 38,247,157 (+)MPROMDB
RGD ID:6851270
Promoter ID:EP73433
Type:single initiation site
Name:HS_ATF4
Description:Activating transcription factor 4 (tax-responsive enhancer elementB67).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 362238,246,514 - 38,246,574EPD
RGD ID:13604172
Promoter ID:EPDNEW_H28270
Type:initiation region
Name:ATF4_1
Description:activating transcription factor 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382239,520,563 - 39,520,623EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:786 AgrOrtholog
COSMIC ATF4 COSMIC
Ensembl Genes ENSG00000128272 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000337304 ENTREZGENE
  ENST00000337304.2 UniProtKB/Swiss-Prot
  ENST00000396680.3 UniProtKB/Swiss-Prot
  ENST00000404241.6 UniProtKB/Swiss-Prot
  ENST00000674568 UniProtKB/TrEMBL
  ENST00000674568.2 UniProtKB/Swiss-Prot
  ENST00000674835 UniProtKB/TrEMBL
  ENST00000674835.2 UniProtKB/Swiss-Prot
  ENST00000674920 ENTREZGENE
  ENST00000674920.3 UniProtKB/Swiss-Prot
  ENST00000675582.2 UniProtKB/TrEMBL
  ENST00000676346 UniProtKB/TrEMBL
  ENST00000676346.2 UniProtKB/Swiss-Prot
  ENST00000679776.1 UniProtKB/Swiss-Prot
  ENST00000680446.1 UniProtKB/TrEMBL
  ENST00000680748.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000128272 GTEx
HGNC ID HGNC:786 ENTREZGENE
Human Proteome Map ATF4 Human Proteome Map
InterPro bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:468 UniProtKB/Swiss-Prot
NCBI Gene 468 ENTREZGENE
OMIM 604064 OMIM
PANTHER ACTIVATING TRANSCRIPTION FACTOR ATF 4/5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA25086 PharmGKB
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A6Q8PFH6_HUMAN UniProtKB/TrEMBL
  A0A6Q8PG17_HUMAN UniProtKB/TrEMBL
  A0A6Q8PGY1_HUMAN UniProtKB/TrEMBL
  A0A6Q8PHB3_HUMAN UniProtKB/TrEMBL
  A0A7P0Z4J5_HUMAN UniProtKB/TrEMBL
  ATF4_HUMAN UniProtKB/Swiss-Prot
  B4DJD4_HUMAN UniProtKB/TrEMBL
  P18848 ENTREZGENE
  Q6ICP0 ENTREZGENE, UniProtKB/TrEMBL
  Q96AQ3 ENTREZGENE
  Q9UH31 ENTREZGENE
UniProt Secondary Q96AQ3 UniProtKB/Swiss-Prot
  Q9UH31 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-06-04 ATF4  activating transcription factor 4    activating transcription factor 4 (tax-responsive enhancer element B67)  Symbol and/or name change 5135510 APPROVED