Gene: CYP1A1 (cytochrome P450, family 1, subfamily A, polypeptide 1)  Homo sapiens
Symbol: CYP1A1
Name: cytochrome P450, family 1, subfamily A, polypeptide 1
Description: This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AHH; AHRR; aryl hydrocarbon hydroxylase; CP11; CYP1; CYPIA1; cytochrome P1-450, dioxin-inducible; cytochrome P450 1A1; cytochrome P450 form 6; cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1; cytochrome P450-C; cytochrome P450-P1; flavoprotein-linked monooxygenase; OTTHUMP00000183469; P1-450; P450-C; P450DX; xenobiotic monooxygenase
Orthologs: Mus musculus : Cyp1a1 (cytochrome P450, family 1, subfamily a, polypeptide 1)  MGI
Rattus norvegicus : Cyp1a1 (cytochrome P450, family 1, subfamily a, polypeptide 1)
Related Pseudogenes: CYP1D1P  
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_11555,062,819 - 55,068,813-NCBI
Human Genome Assembly HuRef1551,809,772 - 51,815,766-NCBI
Human Genome Assembly GRCh371575,011,883 - 75,017,877-NCBI
Human Genome Assembly Build 361572,798,943 - 72,804,930-NCBI
Human Cytogenetic Map15q24.1 NCBI
Human Genome Assembly1572,798,942 - 72,804,930 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

Annotation    (Toggle Detail/Summary View)