STAT3 (signal transducer and activator of transcription 3 (acute-phase response factor))

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Keyword

Gene: STAT3 (signal transducer and activator of transcription 3 (acute-phase response factor)) Homo sapiens

Symbol:

STAT3

Name:

signal transducer and activator of transcription 3 (acute-phase response factor)

Description:

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

acute-phase response factor; APRF; DNA-binding protein APRF; FLJ20882; HIES; MGC16063; OTTHUMP00000198123; OTTHUMP00000198128; signal transducer and activator of transcription 3

Orthologs:

Mus musculus : Stat3 (signal transducer and activator of transcription 3) MGI
Rattus norvegicus : Stat3 (signal transducer and activator of transcription 3 (acute-phase response factor))

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	17	41,254,468 - 41,329,599	-	NCBI
Human Genome Assembly HuRef	17	36,230,024 - 36,304,785	-	NCBI
Human Genome Assembly GRCh37	17	40,465,343 - 40,540,513	-	NCBI
Human Genome Assembly Build 36	17	37,718,869 - 37,794,039	-	NCBI
Human Cytogenetic Map	17	q21.31		NCBI
Human Genome Assembly	17	37,718,868 - 37,794,039		NCBI