Gene: LEPR (leptin receptor)  Homo sapiens Symbol: LEPR Name: leptin receptor Description: The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010] Type: protein-coding RefSeq Status: REVIEWED Also known as: CD295; DKFZp686B1731; huB219; LEP-R; LEP-R; LEPRD; leptin receptor; OB receptor; OB-R; OB-R; OBR; OTTHUMP00000010692; OTTHUMP00000010693; OTTHUMP00000010694; OTTHUMP00000010695 Orthologs: Mus musculus : Lepr (leptin receptor)  MGI Rattus norvegicus : Lepr (leptin receptor) Is Marker For: QTLs:   LDLPS20_H   LDLPS19_H   LDLPS21_H   Latest Assembly: Human Genome Assembly GRCh37 Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 1 65,960,272 - 66,176,877 + NCBI Human Genome Assembly HuRef 1 63,995,123 - 64,212,195 + NCBI Human Genome Assembly GRCh37 1 65,886,335 - 66,103,176 + NCBI Human Genome Assembly Build 36 1 65,658,906 - 65,875,410 + NCBI Human Cytogenetic Map 1 p31   NCBI Human Genome Assembly 1 65,598,338 - 65,814,843   NCBI Model Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Arteriosclerosis Spontaneous IED   1581846   RGD   Cardiomyopathy, Dilated Susceptibility IAGP   2311129 DNA:polymorphism: :p.Q223R (human) RGD   Diabetes Mellitus, Type 2   IAGP   2311141 DNA:polymorphisms (human) RGD   Diabetes Mellitus, Type 2 Susceptibility IAGP   2311144 DNA:insertion:3' utr (human) RGD   Heart Failure   ISS RGD:10865 5128823 protein:increased phosphorylation:heart RGD   Hypertension   IAGP   5129161 DNA:polymorphisms:exons RGD   Hypertrophy, Left Ventricular   ISS RGD:3001 5129122   RGD   Hypogonadism   IEA   7240710   OMIM   Insulin Resistance   IAGP   2311142 associated with Obesity;DNA:polymorphism: :p.K656N (human) RGD   Insulin Resistance   IAGP   2311138 associated with Diabetes Mellitus, Non-Insulin-Dependent;DNA:polymorphism: :p.K656N (human) RGD   Myocardial Ischemia Susceptibility IAGP   2311129 DNA:polymorphism: :p.Q223R (human) RGD   Myocardial Reperfusion Injury   ISS RGD:3001 5129123 mRNA:decreased expression:heart RGD   Nasal Polyps   IEP   5129163 mRNA:increased expression:nose RGD   Obesity   IEA   1331525   RGD   Obesity   ISS RGD:3001 1600612   RGD   Obesity   IAGP   1600611   RGD   Obesity   ISS RGD:3001 729297 DNA:missense mutation: :p.Q269P (rat) RGD   Obesity Susceptibility IAGP   5128855 DNA:polymorphism:exon:p.Q223R (human) RGD   Obesity   ISS RGD:10865 5129154 mRNA:decreased expression:lung RGD   Obesity, Morbid   IEA   7240710   OMIM   Pneumonia, Pneumococcal   ISS RGD:10865 5128846   RGD   Pre-Eclampsia   ISS RGD:3001 5128718 protein:increased expression:placenta RGD   Pulmonary Disease, Chronic Obstructive   IEP   5128813 protein:decreased expression:lung RGD   Pulmonary Disease, Chronic Obstructive Disease_progression IAGP   5128813 DNA:SNPs: : RGD   Sleep Apnea Syndromes   IEP   5128873   RGD   Sleep Apnea, Obstructive Susceptibility IAGP   5128855 DNA:polymorphism:exon:p.Q223R (human) RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (R)-carnitine affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of Carnitine CTD PMID:20567778 (R)-pantothenic acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of Pantothenic Acid CTD PMID:20567778 (S)-nicotine increases expression ISO RGD:3001 6480464 Nicotine results in increased expression of LEPR mRNA CTD PMID:22265867 1-methylnicotinamide affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of N(1)-methylnicotinamide CTD PMID:20567778 17alpha-ethynylestradiol multiple interactions ISO RGD:10865 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LEPR mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression ISO RGD:10865 6480464 Ethinyl Estradiol results in increased expression of LEPR mRNA CTD PMID:17942748 17alpha-ethynylestradiol decreases expression ISO RGD:3001 6480464 Ethinyl Estradiol results in decreased expression of LEPR mRNA CTD PMID:17351261 17beta-estradiol affects abundance ISO RGD:3001 6480464 LEPR protein affects the abundance of Estradiol CTD PMID:15093691 17beta-estradiol decreases expression EXP   6480464 Estradiol results in decreased expression of LEPR mRNA CTD PMID:19167446 17beta-estradiol decreases expression ISO RGD:10865 6480464 Estradiol results in decreased expression of LEPR mRNA CTD PMID:14664709 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP   6480464 Tetrachlorodibenzodioxin results in increased expression of LEPR mRNA CTD PMID:20106945 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:3001 6480464 Tetrachlorodibenzodioxin results in decreased expression of LEPR mRNA CTD PMID:20959002 PMID:21724226 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:3001 6480464 Tetrachlorodibenzodioxin results in decreased expression of LEPR mRNA CTD PMID:21724226 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP   6480464 Tetrachlorodibenzodioxin affects the expression of LEPR mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:3001 6480464 Tetrachlorodibenzodioxin affects the expression of LEPR mRNA CTD PMID:15977195 PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:3001 6480464 Tetrachlorodibenzodioxin affects the expression of LEPR mRNA CTD PMID:15977195 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:10865 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LEPR mRNA CTD PMID:17942748 2,4-dinitrotoluene affects expression ISO RGD:3001 6480464 2,4-dinitrotoluene affects the expression of LEPR mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression ISO RGD:3001 6480464 2,6-dinitrotoluene affects the expression of LEPR mRNA CTD PMID:21346803 2-amino-2-deoxy-D-galactopyranose increases response to substance ISO RGD:10865 6480464 LEPR gene mutant form results in increased susceptibility to Galactosamine CTD PMID:19913045 2-amino-2-deoxy-D-galactopyranose multiple interactions ISO RGD:10865 6480464 [LEPR gene mutant form results in increased susceptibility to Galactosamine] which results in increased expression of IL12B mRNA; more ... CTD PMID:19913045 2-hydroxy-4-methylvaleric acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of alpha-hydroxyisocaproic acid CTD PMID:20567778 2-hydroxyisobutyric acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of 2-hydroxyisobutyric acid CTD PMID:20567778 2-oxoadipic acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of alpha-ketoadipic acid CTD PMID:20567778 2-oxoglutaric acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of alpha-ketoglutaric acid CTD PMID:20567778 3-methyl-2-oxobutanoic acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of alpha-ketoisovalerate CTD PMID:20567778 3-methyl-2-oxovaleric acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of alpha-keto-beta-methylvaleric acid CTD PMID:20567778 4,4'-diaminodiphenylmethane affects expression ISO RGD:10865 6480464 4,4'-diaminodiphenylmethane affects the expression of LEPR mRNA CTD PMID:18648102 acetohydrazide decreases expression ISO RGD:10865 6480464 acetylhydrazine results in decreased expression of LEPR mRNA CTD PMID:15282401 acetylcholine multiple interactions ISO RGD:10865 6480464 acetovanillone inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]; more ... CTD PMID:19478208 acetylcholine decreases response to substance ISO RGD:10865 6480464 LEPR gene mutant form results in decreased susceptibility to Acetylcholine CTD PMID:19478208 allantoin affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of Allantoin CTD PMID:20567778 ammonium chloride affects expression ISO RGD:3001 6480464 Ammonium Chloride affects the expression of LEPR mRNA CTD PMID:16483693 apocynin multiple interactions ISO RGD:10865 6480464 acetovanillone inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]; more ... CTD PMID:19478208 arsenic atom decreases expression ISO RGD:10865 6480464 Arsenic results in decreased expression of LEPR mRNA CTD PMID:19654921 astaxanthin multiple interactions ISO RGD:10865 6480464 astaxanthine inhibits the reaction [LEPR gene mutant form results in increased expression of AIFM1 mRNA]; more ... CTD PMID:16964424 benzo[a]pyrene decreases expression ISO RGD:10865 6480464 Benzo(a)pyrene results in decreased expression of LEPR mRNA CTD PMID:19770486 benzo[a]pyrene decreases expression EXP   6480464 Benzo(a)pyrene results in decreased expression of LEPR mRNA CTD PMID:22316170 benzo[a]pyrene decreases expression ISO RGD:3001 6480464 Benzo(a)pyrene results in decreased expression of LEPR mRNA CTD PMID:21839799 bisphenol A increases expression EXP   6480464 bisphenol A results in increased expression of LEPR mRNA; more ... CTD PMID:22343039 butyric acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of Butyric Acid CTD PMID:20567778 caffeine increases expression ISO RGD:3001 6480464 Caffeine results in increased expression of LEPR mRNA CTD PMID:22583948 calcium atom affects expression ISO RGD:3001 6480464 Calcium affects the expression of LEPR mRNA CTD PMID:15913539 calcium(0) affects expression ISO RGD:3001 6480464 Calcium affects the expression of LEPR mRNA CTD PMID:15913539 caproic acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of hexanoic acid CTD PMID:20567778 choline affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of Choline CTD PMID:20567778 choline multiple interactions ISO RGD:10865 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LEPR mRNA CTD PMID:20938992 chromium atom multiple interactions ISO RGD:10865 6480464 LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of BTC mRNA]; more ... CTD PMID:16940432 ciguatoxin CTX1B affects expression ISO RGD:10865 6480464 Ciguatoxins affects the expression of LEPR mRNA CTD PMID:18353800 citric acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of Citric Acid CTD PMID:20567778 clofibrate increases expression ISO RGD:3001 6480464 Clofibrate results in increased expression of LEPR mRNA CTD PMID:22008536 clofibric acid multiple interactions ISO RGD:3001 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of LEPR mRNA CTD PMID:17602206 coumestrol decreases expression EXP   6480464 Coumestrol results in decreased expression of LEPR mRNA CTD PMID:19167446 coumestrol multiple interactions EXP   6480464 [Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of LEPR mRNA CTD PMID:19167446 creatinine affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of Creatinine CTD PMID:20567778 cytarabine decreases expression EXP   6480464 Cytarabine results in decreased expression of LEPR mRNA CTD PMID:21198554 D-glucose decreases response to substance ISO RGD:10865 6480464 LEPR results in decreased susceptibility to Glucose CTD PMID:20567778 D-glucose affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of Glucose CTD PMID:20567778 diazoxide increases expression ISO RGD:3001 6480464 Isoproterenol results in increased expression of LEPR mRNA; more ... CTD PMID:20307649 diazoxide multiple interactions ISO RGD:3001 6480464 CPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEPR mRNA]; more ... CTD PMID:20307649 dibutyl phthalate increases expression ISO RGD:3001 6480464 Dibutyl Phthalate results in increased expression of LEPR mRNA CTD PMID:21266533 diethyl maleate decreases expression ISO RGD:3001 6480464 diethyl maleate results in decreased expression of LEPR mRNA CTD PMID:21161181 dobutamine affects response to substance ISO RGD:10865 6480464 LEPR protein affects the susceptibility to Dobutamine CTD PMID:20175764 estrone multiple interactions ISO RGD:10865 6480464 Estrone inhibits the reaction [LEPR gene mutant form inhibits the reaction [EGFR protein results in increased phosphorylation of EGFR protein]]; more ... CTD PMID:1753381 ethanol multiple interactions ISO RGD:3001 6480464 LEPR gene mutant form inhibits the reaction [Ethanol results in increased expression of MT1A mRNA]; more ... CTD PMID:15475485 ethanol decreases expression ISO RGD:3001 6480464 Ethanol results in decreased expression of LEPR mRNA CTD PMID:16098508 ethanol multiple interactions ISO RGD:3001 6480464 Drugs, Chinese Herbal inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEPR protein] CTD PMID:18227024 ethanol increases response to substance ISO RGD:3001 6480464 LEPR gene mutant form results in increased susceptibility to Ethanol CTD PMID:15475485 ethylmalonic acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of Methylmalonic Acid CTD PMID:20567778 folic acid multiple interactions ISO RGD:10865 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LEPR mRNA CTD PMID:20938992 formic acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of formic acid CTD PMID:20567778 fumaric acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of fumaric acid CTD PMID:20567778 furan increases methylation ISO RGD:3001 6480464 furan results in increased methylation of LEPR gene CTD PMID:22079235 galactaric acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of galactaric acid CTD PMID:20567778 gefitinib decreases expression EXP   6480464 gefitinib results in decreased expression of LEPR mRNA CTD PMID:16685379 glucose decreases response to substance ISO RGD:10865 6480464 LEPR results in decreased susceptibility to Glucose CTD PMID:20567778 glucose affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of Glucose CTD PMID:20567778 glutaric acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of glutaric acid CTD PMID:20567778 hydrazine increases expression ISO RGD:3001 6480464 hydrazine results in increased expression of LEPR mRNA CTD PMID:15370871 indoxyl sulfate affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of Indican CTD PMID:20567778 isobutyric acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of isobutyric acid CTD PMID:20567778 isoprenaline increases expression ISO RGD:3001 6480464 Isoproterenol results in increased expression of LEPR mRNA; more ... CTD PMID:20307649 isoprenaline multiple interactions ISO RGD:3001 6480464 CPU0213 inhibits the reaction [Isoproterenol results in increased expression of LEPR mRNA]; more ... CTD PMID:20307649 isovaleric acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of isovaleric acid CTD PMID:20567778 L-methionine affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of Methionine CTD PMID:20567778 L-methionine multiple interactions ISO RGD:10865 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of LEPR mRNA CTD PMID:20938992 lactic acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of Lactic Acid CTD PMID:20567778 malonic acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of malonic acid CTD PMID:20567778 mercury atom decreases expression EXP   6480464 Mercury results in decreased expression of LEPR mRNA CTD PMID:16823088 mercury(0) decreases expression EXP   6480464 Mercury results in decreased expression of LEPR mRNA CTD PMID:16823088 methylmalonic acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of Methylmalonic Acid CTD PMID:20567778 morphine increases expression ISO RGD:10865 6480464 Morphine results in increased expression of LEPR mRNA CTD PMID:20144693 N-ethyl-N-nitrosourea increases mutagenesis ISO RGD:10865 6480464 Ethylnitrosourea results in increased mutagenesis of LEPR gene CTD PMID:16724327 N-methyl-6-pyridone-3-carboxamide affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of N'-methyl-2-pyridone-5-carboxamide CTD PMID:20567778 N-methylnicotinate affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of trigonelline CTD PMID:20567778 N-nitrosodiethylamine multiple interactions ISO RGD:3001 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of LEPR mRNA CTD PMID:18164116 N-nitrosodiethylamine multiple interactions ISO RGD:3001 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of LEPR mRNA CTD PMID:17602206 nicotinic acid multiple interactions ISO RGD:10865 6480464 LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in decreased expression of BTC mRNA]; more ... CTD PMID:16940432 orotic acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of Orotic Acid CTD PMID:20567778 ozone multiple interactions ISO RGD:10865 6480464 LEPR gene mutant form promotes the reaction [Ozone results in increased expression of CCL11 protein]; more ... CTD PMID:16373670 ozone increases response to substance ISO RGD:10865 6480464 LEPR gene mutant form results in increased susceptibility to Ozone CTD PMID:16373670 perfluorooctanoic acid increases expression ISO RGD:10865 6480464 perfluorooctanoic acid results in increased expression of LEPR mRNA CTD PMID:17681415 phenobarbital increases expression ISO RGD:3001 6480464 Phenobarbital results in increased expression of LEPR mRNA CTD PMID:22008536 phenobarbital affects expression ISO RGD:10865 6480464 Phenobarbital affects the expression of LEPR mRNA CTD PMID:23091169 pirinixic acid multiple interactions EXP   6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of LEPR mRNA CTD PMID:19710929 pirinixic acid increases expression ISO RGD:10865 6480464 pirinixic acid results in increased expression of LEPR mRNA CTD PMID:18301758 more ... pirinixic acid increases expression ISO RGD:10865 6480464 pirinixic acid results in increased expression of LEPR mRNA CTD PMID:20813756 more ... pirinixic acid increases expression ISO RGD:10865 6480464 pirinixic acid results in increased expression of LEPR mRNA CTD PMID:18445702 more ... pregnenolone 16alpha-carbonitrile decreases expression ISO RGD:3001 6480464 Pregnenolone Carbonitrile results in decreased expression of LEPR mRNA CTD PMID:19162173 razoxane decreases expression ISO RGD:3001 6480464 Razoxane results in decreased expression of LEPR mRNA CTD PMID:19915844 resveratrol multiple interactions ISO RGD:10865 6480464 resveratrol inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]; more ... CTD PMID:19478208 riddelliine increases expression ISO RGD:3001 6480464 riddelliine results in increased expression of LEPR mRNA CTD PMID:18047727 simvastatin affects response to substance EXP   6480464 LEPR polymorphism affects the susceptibility to Simvastatin CTD PMID:18854995 PMID:14625131 simvastatin affects response to substance EXP   6480464 LEPR polymorphism affects the susceptibility to Simvastatin CTD PMID:14625131 PMID:18854995 succinic acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of Succinic Acid CTD PMID:20567778 sucrose affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of Sucrose CTD PMID:20567778 superoxide multiple interactions ISO RGD:10865 6480464 resveratrol inhibits the reaction [LEPR gene mutant form results in increased abundance of Superoxides]; more ... CTD PMID:19478208 superoxide increases abundance ISO RGD:10865 6480464 LEPR gene mutant form results in increased abundance of Superoxides CTD PMID:19478208 tacrine increases expression ISO RGD:3001 6480464 Tacrine results in increased expression of LEPR mRNA CTD PMID:12832660 taurine affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of Taurine CTD PMID:20567778 testosterone affects abundance ISO RGD:3001 6480464 LEPR protein affects the abundance of Testosterone CTD PMID:15093691 tetrachloromethane multiple interactions ISO RGD:3001 6480464 Drugs, Chinese Herbal inhibits the reaction [[Carbon Tetrachloride co-treated with Ethanol] results in increased expression of LEPR protein] CTD PMID:18227024 thioacetamide decreases expression ISO RGD:3001 6480464 Thioacetamide results in decreased expression of LEPR mRNA; more ... CTD PMID:17621560 thioacetamide multiple interactions ISO RGD:3001 6480464 Lipopolysaccharides inhibits the reaction [Thioacetamide results in decreased expression of LEPR mRNA] CTD PMID:17621560 thioacetamide multiple interactions ISO RGD:3001 6480464 LEPR gene mutant form inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]; more ... CTD PMID:11984526 topotecan affects response to substance EXP   6480464 LEPR protein affects the susceptibility to Topotecan CTD PMID:16217747 trans-resveratrol multiple interactions ISO RGD:10865 6480464 resveratrol inhibits the reaction [LEPR gene mutant form results in decreased susceptibility to Acetylcholine]; more ... CTD PMID:19478208 trimellitic anhydride decreases expression ISO RGD:10865 6480464 trimellitic anhydride results in decreased expression of LEPR mRNA CTD PMID:19042947 valeric acid affects abundance ISO RGD:10865 6480464 LEPR affects the abundance of n-pentanoic acid CTD PMID:20567778 zinc atom multiple interactions ISO RGD:3001 6480464 [LEPR gene mutant form results in increased susceptibility to Ethanol] which results in decreased abundance of Zinc CTD PMID:15475485 zinc(0) multiple interactions ISO RGD:3001 6480464 [LEPR gene mutant form results in increased susceptibility to Ethanol] which results in decreased abundance of Zinc CTD PMID:15475485 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) cell surface receptor signaling pathway   TAS   2290271 PMID:9537324 PINC PMID:9537324 cholesterol metabolic process   IEA Ensembl:ENSMUSP00000037385 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 energy reserve metabolic process   TAS   2290271 PMID:9537324 PINC PMID:9537324 multicellular organismal development   TAS   2290271 PMID:9537324 PINC PMID:9537324 negative regulation of hydrolase activity   IEA Ensembl:ENSMUSP00000037385 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) extracellular region   IEA UniProtKB-SubCell:SL-0243 2290271 GO_REF:0000039 UniProtKB GO_REF:0000039 integral to membrane   IEA UniProtKB-KW:KW-0812 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 plasma membrane   IEA UniProtKB-SubCell:SL-0039 2290271 GO_REF:0000039 UniProtKB GO_REF:0000039 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) cytokine receptor activity   IEA InterPro:IPR003529|InterPro:IPR003531 2290271 GO_REF:0000002 InterPro GO_REF:0000002 protein binding   IPI UniProtKB:Q9UNH7 2290271 PMID:11279102 HGNC PMID:11279102 protein binding   IPI UniProtKB:P62993 2290271 PMID:17474147 IntAct PMID:17474147 transmembrane signaling receptor activity   TAS   2290271 PMID:9537324 PINC PMID:9537324 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) altered energy homeostasis pathway   TAS   1357910   RGD   altered leptin system pathway   TAS   1357910   RGD   altered leptin system pathway   IMP   1600611   RGD   energy homeostasis pathway   TAS   1357909   RGD   Jak-Stat signaling pathway   IEA RGD:735832 6907045   KEGG hsa:04630 leptin system pathway   TAS   1357909   RGD   leptin system pathway   IDA   1600611   RGD   leptin system pathway   ISS RGD:10865 1625125   RGD   obesity disease pathway   IMP   1600611   RGD   External Database Links KEGG Pathway Adipocytokine signaling pathway Cytokine-cytokine receptor interaction Jak-STAT signaling pathway Neuroactive ligand-receptor interaction Pathway Interaction Database Signaling events mediated by PTP1B (PID:200042) Phenotype Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) abnormal immune system physiology   IAGP   1600611   RGD   increased body mass index   IAGP   2311139 DNA:polymorphisms: :multiple RGD   increased circulating cholesterol level   IAGP   2311139 DNA:polymorphism: :4950G>A RGD   increased circulating triglyceride level   IAGP   2311139 DNA:polymorphism: :4950G>A RGD   increased systemic arterial systolic blood pressure   IAGP   2311139 DNA:polymorphism: :4950G>A RGD   obese   IAGP   1600611   RGD   polyphagia   IAGP   1600611   RGD   small gonad   IAGP   1600611   RGD   Disease Annotations Arteriosclerosis  (IED) Cardiomyopathy, Dilated  (IAGP) Diabetes Mellitus, Type 2  (IAGP) Heart Failure  (ISS) Hypertension  (IAGP) Hypertrophy, Left Ventricular  (ISS) Hypogonadism  (IEA) Insulin Resistance  (IAGP) Myocardial Ischemia  (IAGP) Myocardial Reperfusion Injury  (ISS) Nasal Polyps  (IEP) Obesity  (IAGP,IEA,ISS) Obesity, Morbid  (IEA) Pneumonia, Pneumococcal  (ISS) Pre-Eclampsia  (ISS) Pulmonary Disease, Chronic Obstructive  (IAGP,IEP) Sleep Apnea Syndromes  (IEP) Sleep Apnea, Obstructive  (IAGP) Gene-Chemical Interaction Annotations (R)-carnitine  (ISO) (R)-pantothenic acid  (ISO) (S)-nicotine  (ISO) 1-methylnicotinamide  (ISO) 17alpha-ethynylestradiol  (ISO) 17beta-estradiol  (EXP,ISO) 2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO) 2,4-dinitrotoluene  (ISO) 2,6-dinitrotoluene  (ISO) 2-amino-2-deoxy-D-galactopyranose  (ISO) 2-hydroxy-4-methylvaleric acid  (ISO) 2-hydroxyisobutyric acid  (ISO) 2-oxoadipic acid  (ISO) 2-oxoglutaric acid  (ISO) 3-methyl-2-oxobutanoic acid  (ISO) 3-methyl-2-oxovaleric acid  (ISO) 4,4'-diaminodiphenylmethane  (ISO) acetohydrazide  (ISO) acetylcholine  (ISO) allantoin  (ISO) ammonium chloride  (ISO) apocynin  (ISO) arsenic atom  (ISO) astaxanthin  (ISO) benzo[a]pyrene  (EXP,ISO) bisphenol A  (EXP) butyric acid  (ISO) caffeine  (ISO) calcium atom  (ISO) calcium(0)  (ISO) caproic acid  (ISO) choline  (ISO) chromium atom  (ISO) ciguatoxin CTX1B  (ISO) citric acid  (ISO) clofibrate  (ISO) clofibric acid  (ISO) coumestrol  (EXP) creatinine  (ISO) cytarabine  (EXP) D-glucose  (ISO) diazoxide  (ISO) dibutyl phthalate  (ISO) diethyl maleate  (ISO) dobutamine  (ISO) estrone  (ISO) ethanol  (ISO) ethylmalonic acid  (ISO) folic acid  (ISO) formic acid  (ISO) fumaric acid  (ISO) furan  (ISO) galactaric acid  (ISO) gefitinib  (EXP) glucose  (ISO) glutaric acid  (ISO) hydrazine  (ISO) indoxyl sulfate  (ISO) isobutyric acid  (ISO) isoprenaline  (ISO) isovaleric acid  (ISO) L-methionine  (ISO) lactic acid  (ISO) malonic acid  (ISO) mercury atom  (EXP) mercury(0)  (EXP) methylmalonic acid  (ISO) morphine  (ISO) N-ethyl-N-nitrosourea  (ISO) N-methyl-6-pyridone-3-carboxamide  (ISO) N-methylnicotinate  (ISO) N-nitrosodiethylamine  (ISO) nicotinic acid  (ISO) orotic acid  (ISO) ozone  (ISO) perfluorooctanoic acid  (ISO) phenobarbital  (ISO) pirinixic acid  (EXP,ISO) pregnenolone 16alpha-carbonitrile  (ISO) razoxane  (ISO) resveratrol  (ISO) riddelliine  (ISO) simvastatin  (EXP) succinic acid  (ISO) sucrose  (ISO) superoxide  (ISO) tacrine  (ISO) taurine  (ISO) testosterone  (ISO) tetrachloromethane  (ISO) thioacetamide  (ISO) topotecan  (EXP) trans-resveratrol  (ISO) trimellitic anhydride  (ISO) valeric acid  (ISO) zinc atom  (ISO) zinc(0)  (ISO) Gene Ontology Annotations Biological Process cell surface receptor signaling pathway  (TAS) cholesterol metabolic process  (IEA) energy reserve metabolic process  (TAS) multicellular organismal development  (TAS) negative regulation of hydrolase activity  (IEA) Cellular Component extracellular region  (IEA) integral to membrane  (IEA) plasma membrane  (IEA) Molecular Function cytokine receptor activity  (IEA) protein binding  (IPI) transmembrane signaling receptor activity  (TAS) Molecular Pathway Annotations altered energy homeostasis pathway  (TAS) altered leptin system pathway  (IMP,TAS) energy homeostasis pathway  (TAS) Jak-Stat signaling pathway  (IEA) leptin system pathway  (IDA,ISS,TAS) obesity disease pathway  (IMP) External Database Links KEGG Pathway Adipocytokine signaling pathway Cytokine-cytokine receptor interaction Jak-STAT signaling pathway Neuroactive ligand-receptor interaction Pathway Interaction Database Signaling events mediated by PTP1B (PID:200042) Phenotype Annotations abnormal immune system physiology  (IAGP) increased body mass index  (IAGP) increased circulating cholesterol level  (IAGP) increased circulating triglyceride level  (IAGP) increased systemic arterial systolic blood pressure  (IAGP) obese  (IAGP) polyphagia  (IAGP) small gonad  (IAGP) References - curated 1. Anderson CM, etal., Am J Obstet Gynecol. 2005 Jul;193(1):267-72. 2. Becker KG, etal., Nat Genet 2004 May;36(5):431-2. 3. Bell CG, etal., Nat Rev Genet 2005 Mar;6(3):221-34. 4. Bienertova-Vasku JA, etal., Heart Vessels. 2009 Mar;24(2):131-7. Epub 2009 Apr 1. 5. de Luis DA, etal., Diabetes Res Clin Pract. 2008 Sep;81(3):e9-e11. Epub 2008 Jul 15. 6. de Luis DA, etal., J Diabetes Complications. 2008 May-Jun;22(3):199-204. Epub 2008 Apr 16. 7. Farooqi IS, etal., N Engl J Med. 2007 Jan 18;356(3):237-47. 8. GOA_HUMAN data from the GO Consortium 9. Han HR, etal., Clin Genet. 2008 Aug;74(2):105-15. Epub 2008 Jun 28. 10. Hansel NN, etal., Eur Respir J. 2009 Jul;34(1):103-10. Epub 2009 Feb 5. 11. Howard JK and Flier JS, Trends Endocrinol Metab. 2006 Nov;17(9):365-71. Epub 2006 Sep 28. 12. Iida M, etal., Biochem Biophys Res Commun 1996 Jul 16;224(2):597-604. 13. Jequier E Ann N Y Acad Sci 2002 Jun;967:379-88. 14. Karlsson EA, etal., J Nutr. 2010 Sep;140(9):1691-7. Epub 2010 Jun 30. 15. Mancuso P, etal., J Immunol. 2011 Jan 15;186(2):1081-90. Epub 2010 Dec 10. 16. Manzella D, etal., Int J Obes Relat Metab Disord. 2002 Mar;26(3):370-5. 17. McGaffin KR, etal., Cardiovasc Res. 2008 Jan;77(1):54-63. Epub 2007 Sep 20. 18. Nannipieri M, etal., Diabetes Care. 2006 Nov;29(11):2509-11. 19. Park HY, etal., Exp Mol Med. 2001 Jun 30;33(2):95-102. 20. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 21. Popko K, etal., J Physiol Pharmacol. 2007 Nov;58 Suppl 5(Pt 2):551-61. 22. Purdham DM, etal., Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2877-84. Epub 2004 Jul 29. 23. Purdham DM, etal., Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H441-6. Epub 2008 May 9. 24. Qu Y, etal., Diabetes Res Clin Pract. 2008 Jul;81(1):33-7. Epub 2008 Apr 24. 25. RGD automated import pipeline for gene-chemical interactions 26. RGD Automated Pipelines 27. Rosmond R, etal., J Clin Endocrinol Metab. 2000 Sep;85(9):3126-31. 28. Song SY, etal., Laryngoscope. 2010 May;120(5):1046-50. 29. Takaya K, etal., Nat Genet. 1996 Oct;14(2):130-1. 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Cancer Pathways Cardiovascular Diseases Cardiovascular Pathways Cardiovascular Phenotypes Diabetes Diseases Diabetes Pathways Diabetes Phenotypes Immune and Inflammatory Diseases Immune and Inflammatory Pathways Immune and Inflammatory Phenotypes Neurological Diseases Neurological Pathways Neurological Phenotypes Biological Process Obesity Diseases Obesity Pathways Obesity Phenotypes Respiratory Diseases Respiratory Pathways Genomics Candidate Gene Status LEPR is a candidate Gene for BW413_H LEPR is a candidate Gene for GLUCO303_H Comparative Map Data LEPR   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 1 65,960,272 - 66,176,877 + NCBI Human Genome Assembly HuRef 1 63,995,123 - 64,212,195 + NCBI Human Genome Assembly GRCh37 1 65,886,335 - 66,103,176 + NCBI Human Genome Assembly Build 36 1 65,658,906 - 65,875,410 + NCBI Human Cytogenetic Map 1 p31   NCBI Human Genome Assembly 1 65,598,338 - 65,814,843   NCBI Lepr   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 4 101,717,407 - 101,815,354 + NCBI Mouse cM Map 4 46.96   NCBI Mouse Celera Assembly 4 100,061,452 - 100,155,523 + NCBI Mouse Genome Assembly Build 37 4 101,390,012 - 101,487,959 + NCBI Mouse Genome Assembly Build 36.1 4 101,390,044 - 101,487,910 + NCBI Mouse Cytogenetic Map 4 C6   NCBI Lepr   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 5 q33   NCBI RGSC Genome Assembly v5.0 5 124,380,327 - 124,525,200 + NCBI RGSC Genome Assembly v5.0 5 124,555,678 - 124,556,585 + NCBI RGSC Genome Assembly v3.4 5 122,320,075 - 122,503,449 + NCBI Rat Celera Assembly 5 114,817,255 - 114,982,861 + NCBI Genome Assembly 3.1 5 122,325,300 - 122,508,673   NCBI RH 3.4 5 803.7   RGD Position Markers SHGC-74954   Map Chr Position Strand Source Human NCBI RH Map 1 434.7   UniSTS Human GeneMap99-GB4 RH Map 1 174.74   UniSTS Human TNG Radiation Hybrid Map 1 90960.0   UniSTS Human Genome Assembly HuRef 1 64,008,058 - 64,008,159   UniSTS Human Genome Assembly GRCh37 1 65,899,258 - 65,899,359   UniSTS Human Celera Assembly 1 64,189,842 - 64,189,943   RGD Human Genome Assembly Build 36 1 65,671,846 - 65,671,947   RGD Human Cytogenetic Map 1 p31   UniSTS Human Cytogenetic Map 1 p31.3   UniSTS SHGC-74936   Map Chr Position Strand Source Human GeneMap99-GB4 RH Map 1 173.9   UniSTS Human TNG Radiation Hybrid Map 1 90964.0   UniSTS Human Genome Assembly HuRef 1 64,003,963 - 64,004,092   UniSTS Human Genome Assembly GRCh37 1 65,895,163 - 65,895,292   UniSTS Human Celera Assembly 1 64,185,747 - 64,185,876   RGD Human Genome Assembly Build 36 1 65,667,751 - 65,667,880   RGD Human Cytogenetic Map 1 p31   UniSTS Human Cytogenetic Map 1 p31.3   UniSTS RH80929   Map Chr Position Strand Source Human GeneMap99-GB4 RH Map 1 174.59   UniSTS Human Genome Assembly HuRef 1 64,007,463 - 64,007,702   UniSTS Human Genome Assembly GRCh37 1 65,898,663 - 65,898,902   UniSTS Human Celera Assembly 1 64,189,247 - 64,189,486   RGD Human Genome Assembly Build 36 1 65,671,251 - 65,671,490   RGD Human Cytogenetic Map 1 p31   UniSTS Human Cytogenetic Map 1 p31.3   UniSTS AL034254   Map Chr Position Strand Source Human Genome Assembly HuRef 1 64,056,620 - 64,056,830   UniSTS Human Genome Assembly GRCh37 1 65,947,820 - 65,948,030   UniSTS Human Celera Assembly 1 64,238,454 - 64,238,664   RGD Human Genome Assembly Build 36 1 65,720,408 - 65,720,618   RGD Human Cytogenetic Map 1 p31   UniSTS RH102615   Map Chr Position Strand Source Human GeneMap99-GB4 RH Map 1 173.9   UniSTS Human Genome Assembly HuRef 1 64,010,162 - 64,010,334   UniSTS Human Genome Assembly GRCh37 1 65,901,362 - 65,901,534   UniSTS Human Celera Assembly 1 64,191,946 - 64,192,118   RGD Human Genome Assembly Build 36 1 65,673,950 - 65,674,122   RGD Human Cytogenetic Map 1 p31   UniSTS Human Cytogenetic Map 1 p31.3   UniSTS G62073   Map Chr Position Strand Source Human Genome Assembly HuRef 1 64,007,618 - 64,007,747   UniSTS Human Genome Assembly GRCh37 1 65,898,818 - 65,898,947   UniSTS Human Celera Assembly 1 64,189,402 - 64,189,531   RGD Human Genome Assembly Build 36 1 65,671,406 - 65,671,535   RGD Human Cytogenetic Map 1 p31   UniSTS Human Cytogenetic Map 1 p31.3   UniSTS SHGC-112228   Map Chr Position Strand Source Human TNG Radiation Hybrid Map 1 37233.0   UniSTS Human Genome Assembly HuRef 1 64,141,690 - 64,141,978   UniSTS Human Genome Assembly GRCh37 1 66,032,980 - 66,033,268   UniSTS Human Celera Assembly 1 64,323,597 - 64,323,885   RGD Human Genome Assembly Build 36 1 65,805,568 - 65,805,856   RGD Human Cytogenetic Map 1 p31   UniSTS RH68452   Map Chr Position Strand Source Human GeneMap99-GB4 RH Map 1 173.9   UniSTS Human Genome Assembly HuRef 1 64,006,937 - 64,007,088   UniSTS Human Genome Assembly GRCh37 1 65,898,137 - 65,898,288   UniSTS Human Celera Assembly 1 64,188,721 - 64,188,872   RGD Human Genome Assembly Build 36 1 65,670,725 - 65,670,876   RGD Human Cytogenetic Map 1 p31   UniSTS Human Cytogenetic Map 1 p31.3   UniSTS LEPR-2   Map Chr Position Strand Source Human Genome Assembly HuRef 1 64,210,999 - 64,211,501   UniSTS Human Genome Assembly GRCh37 1 66,101,980 - 66,102,482   UniSTS Human Celera Assembly 1 64,392,591 - 64,393,093   RGD Human Genome Assembly Build 36 1 65,874,568 - 65,875,070   RGD Human Cytogenetic Map 1 p31   UniSTS PMC209419P1   Map Chr Position Strand Source Human Genome Assembly HuRef 1 64,211,024 - 64,211,261   UniSTS Human Genome Assembly GRCh37 1 66,102,005 - 66,102,242   UniSTS Human Celera Assembly 1 64,392,616 - 64,392,853   RGD Human Genome Assembly Build 36 1 65,874,593 - 65,874,830   RGD Human Cytogenetic Map 1 p31   UniSTS PMC310709P1   Map Chr Position Strand Source Human Genome Assembly HuRef 1 64,211,292 - 64,211,656   UniSTS Human Genome Assembly GRCh37 1 66,102,273 - 66,102,637   UniSTS Human Celera Assembly 1 64,392,884 - 64,393,248   RGD Human Genome Assembly Build 36 1 65,874,861 - 65,875,225   RGD Human Cytogenetic Map 1 p31   UniSTS OBRGRP_2328   Map Chr Position Strand Source Human Genome Assembly HuRef 1 64,006,417 - 64,007,116   UniSTS Human Genome Assembly GRCh37 1 65,897,617 - 65,898,316   UniSTS Human Celera Assembly 1 64,188,201 - 64,188,900   RGD Human Genome Assembly Build 36 1 65,670,205 - 65,670,904   RGD G20438   Map Chr Position Strand Source Human Genome Assembly HuRef 1 64,006,803 - 64,006,977   UniSTS Human Genome Assembly GRCh37 1 65,898,003 - 65,898,177   UniSTS Human Celera Assembly 1 64,188,587 - 64,188,761   RGD Human Genome Assembly Build 36 1 65,670,591 - 65,670,765   RGD Human Cytogenetic Map 1 p31   UniSTS Human Cytogenetic Map 1 p31.3   UniSTS A005R18   Map Chr Position Strand Source Human NCBI RH Map 1 434.7   UniSTS Human GeneMap99-GB4 RH Map 1 173.9   UniSTS Human TNG Radiation Hybrid Map 1 91020.0   UniSTS Human Genome Assembly HuRef 1 64,006,803 - 64,006,977   UniSTS Human Genome Assembly GRCh37 1 65,898,003 - 65,898,177   UniSTS Human Celera Assembly 1 64,188,587 - 64,188,761   RGD Human Genome Assembly Build 36 1 65,670,591 - 65,670,765   RGD Human Cytogenetic Map 1 p31   UniSTS Human Cytogenetic Map 1 p31.3   UniSTS MARC_46109-46110:1108421773:4   Map Chr Position Strand Source Human Genome Assembly HuRef 1 64,184,699 - 64,184,940   UniSTS Human Genome Assembly GRCh37 1 66,075,682 - 66,075,923   UniSTS Human Celera Assembly 1 64,366,293 - 64,366,534   RGD Human Genome Assembly Build 36 1 65,848,270 - 65,848,511   RGD D1S3711   Map Chr Position Strand Source Human Genome Assembly HuRef 1 64,211,360 - 64,211,798   UniSTS Human Genome Assembly GRCh37 1 66,102,341 - 66,102,779   UniSTS Human Celera Assembly 1 64,392,952 - 64,393,390   RGD Human Genome Assembly Build 36 1 65,874,929 - 65,875,367   RGD Human Cytogenetic Map 1 p31   UniSTS SHGC-74948   Map Chr Position Strand Source Human GeneMap99-GB4 RH Map 1 174.38   UniSTS Human TNG Radiation Hybrid Map 1 37217.0   UniSTS Human Genome Assembly HuRef 1 64,209,970 - 64,210,097   UniSTS Human Genome Assembly GRCh37 1 66,100,951 - 66,101,078   UniSTS Human Celera Assembly 1 64,391,562 - 64,391,689   RGD Human Genome Assembly Build 36 1 65,873,539 - 65,873,666   RGD Human Cytogenetic Map 1 p31   UniSTS SHGC-32733   Map Chr Position Strand Source Human GeneMap99-G3 RH Map 1 3282.0   UniSTS Human Whitehead-RH Map 1 202.3   UniSTS Human GeneMap99-GB4 RH Map 1 175.7   UniSTS Human Stanford-G3 RH Map 1 3276.0   UniSTS Human TNG Radiation Hybrid Map 1 90974.0   UniSTS Human Genome Assembly HuRef 1 64,006,127 - 64,006,252   UniSTS Human Genome Assembly GRCh37 1 65,897,327 - 65,897,452   UniSTS Human Celera Assembly 1 64,187,911 - 64,188,036   RGD Human Genome Assembly Build 36 1 65,669,915 - 65,670,040   RGD Human Cytogenetic Map 1 p31   UniSTS Human Cytogenetic Map 1 p31.3   UniSTS RH79027   Map Chr Position Strand Source Human GeneMap99-GB4 RH Map 1 173.9   UniSTS Human Genome Assembly HuRef 1 64,006,725 - 64,006,862   UniSTS Human Genome Assembly GRCh37 1 65,897,925 - 65,898,062   UniSTS Human Celera Assembly 1 64,188,509 - 64,188,646   RGD Human Genome Assembly Build 36 1 65,670,513 - 65,670,650   RGD Human Cytogenetic Map 1 p31   UniSTS Human Cytogenetic Map 1 p31.3   UniSTS AL009879   Map Chr Position Strand Source Human Genome Assembly HuRef 1 64,066,556 - 64,066,681   UniSTS Human Genome Assembly GRCh37 1 65,957,768 - 65,957,893   UniSTS Human Celera Assembly 1 64,248,390 - 64,248,515   RGD Human Genome Assembly Build 36 1 65,730,356 - 65,730,481   RGD Human Cytogenetic Map 1 p31   UniSTS SHGC-56809   Map Chr Position Strand Source Human TNG Radiation Hybrid Map 1 37217.0   UniSTS Human Genome Assembly HuRef 1 64,209,815 - 64,210,058   UniSTS Human Genome Assembly GRCh37 1 66,100,796 - 66,101,039   UniSTS Human Celera Assembly 1 64,391,407 - 64,391,650   RGD Human Genome Assembly Build 36 1 65,873,384 - 65,873,627   RGD Human Cytogenetic Map 1 p31   UniSTS LEPR_4006   Map Chr Position Strand Source Human Genome Assembly HuRef 1 64,211,096 - 64,211,940   UniSTS Human Genome Assembly GRCh37 1 66,102,077 - 66,102,921   UniSTS Human Celera Assembly 1 64,392,688 - 64,393,532   RGD Human Genome Assembly Build 36 1 65,874,665 - 65,875,509   RGD D1S3710   Map Chr Position Strand Source Human Cytogenetic Map 1 p31   UniSTS QTLs in Region (Human Genome Assembly GRCh37) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 1581540 BP60_H Blood pressure QTL 60 (human) Blood pressure hypertension susceptibility 1 19957148 198620398 Human 1300019 BP25_H Blood pressure QTL 25 (human) 3.5 Blood pressure systolic 1 44873494 70873494 Human 2314561 GLUCO47_H Glucose level QTL 47 (human) 1.1 Glucose level 1 45239052 71239052 Human 1357319 AASTH8_H Allergic/atopic asthma related QTL 8 (human) 1.29 Reversible airflow obstruction ETS positive 1 45792083 93210281 Human 1559226 SLEP4_H Serum leptin concentration QTL 4 (human) 3.4 Hormone level leptin 1 48281268 100177738 Human 2314743 GLUCO70_H Glucose level QTL 70 (human) 1.5 .015 Glucose level non-insulin dependent 1 48599959 74599959 Human 2293365 PRSTS245_H Prostate tumor susceptibility QTL 245 (human) Prostate tumor susceptibility 1 50816757 76816757 Human 2293421 PRSTS244_H Prostate tumor susceptibility QTL 244 (human) Prostate tumor susceptibility 1 50816757 76816757 Human 1578594 LDLPS19_H Low density lipoprotein particle size QTL 19 (human) 2.56 .00009 LDL particle size 1 52994755 78994755 Human 1578602 LDLPS21_H Low density lipoprotein particle size QTL 21 (human) 2.05 .00037 LDL particle size 1 52994755 78994755 Human 1578620 LDLPS20_H Low density lipoprotein particle size QTL 21 (human) 2.04 .00046 LDL particle size 1 52994755 78994755 Human 1298477 OSTEAR1_H Osteoarthritis QTL 1 (human) 2.96 Joint/bone inflammation hand osteoarthritis 1 61229503 87229503 Human 2315786 GLUCO163_H Glucose level QTL 163 (human) 1.44 .0115 Glucose level 1 61972222 77655589 Human Sequence Nucleotide Sequences Nucleotide RefSeqs NG_015831 (Get FASTA) Search GEO for Microarray Profiles   NM_001003679 (Get FASTA) Search GEO for Microarray Profiles   NM_001003680 (Get FASTA) Search GEO for Microarray Profiles   NM_001198687 (Get FASTA) Search GEO for Microarray Profiles   NM_001198688 (Get FASTA) Search GEO for Microarray Profiles   NM_001198689 (Get FASTA) Search GEO for Microarray Profiles   NM_002303 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AA813024 (Get FASTA) Search GEO for Microarray Profiles   ABBA01074542 (Get FASTA) Search GEO for Microarray Profiles   ABBA01074543 (Get FASTA) Search GEO for Microarray Profiles   AC097063 (Get FASTA) Search GEO for Microarray Profiles   AC119800 (Get FASTA) Search GEO for Microarray Profiles   AI436180 (Get FASTA) Search GEO for Microarray Profiles   AK001042 (Get FASTA) Search GEO for Microarray Profiles   AK290208 (Get FASTA) Search GEO for Microarray Profiles   AMYH01000686 (Get FASTA) Search GEO for Microarray Profiles   AMYH01000687 (Get FASTA) Search GEO for Microarray Profiles   AW302522 (Get FASTA) Search GEO for Microarray Profiles   BC031086 (Get FASTA) Search GEO for Microarray Profiles   BC035120 (Get FASTA) Search GEO for Microarray Profiles   BC131779 (Get FASTA) Search GEO for Microarray Profiles   BX475249 (Get FASTA) Search GEO for Microarray Profiles   CQ860097 (Get FASTA) Search GEO for Microarray Profiles   U43168 (Get FASTA) Search GEO for Microarray Profiles   U50748 (Get FASTA) Search GEO for Microarray Profiles   U52912 (Get FASTA) Search GEO for Microarray Profiles   U52913 (Get FASTA) Search GEO for Microarray Profiles   U52914 (Get FASTA) Search GEO for Microarray Profiles   U59263 (Get FASTA) Search GEO for Microarray Profiles   U66495 (Get FASTA) Search GEO for Microarray Profiles   U66496 (Get FASTA) Search GEO for Microarray Profiles   U66497 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_002303 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_002294 Peptide Label: isoform 1 precursor Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 1 65,960,272 - 66,176,877 + NCBI Human Genome Assembly HuRef 1 63,995,123 - 64,212,195 + ENTREZGENE Human Genome Assembly GRCh37 1 65,886,335 - 66,103,176 + ENTREZGENE Human Genome Assembly Build 36 1 65,658,906 - 65,875,410 + NCBI Archive RefSeq Acc Id: NM_001003679 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_001003679 Peptide Label: isoform 3 precursor Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 1 65,960,272 - 66,176,877 + NCBI Human Genome Assembly HuRef 1 63,995,123 - 64,212,195 + ENTREZGENE Human Genome Assembly GRCh37 1 65,886,335 - 66,103,176 + ENTREZGENE Human Genome Assembly Build 36 1 65,658,906 - 65,873,699 + NCBI Archive RefSeq Acc Id: NM_001003680 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_001003680 Peptide Label: isoform 2 precursor Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 1 65,960,272 - 66,176,877 + NCBI Human Genome Assembly HuRef 1 63,995,123 - 64,212,195 + ENTREZGENE Human Genome Assembly GRCh37 1 65,886,335 - 66,103,176 + ENTREZGENE Human Genome Assembly Build 36 1 65,658,906 - 65,868,693 + NCBI Archive RefSeq Acc Id: NM_001198689 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_001185618 Peptide Label: isoform 3 precursor Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 1 65,960,272 - 66,176,877 + NCBI Human Genome Assembly HuRef 1 63,995,123 - 64,212,195 + ENTREZGENE Human Genome Assembly GRCh37 1 65,886,335 - 66,103,176 + ENTREZGENE RefSeq Acc Id: NM_001198687 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_001185616 Peptide Label: isoform 2 precursor Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 1 65,960,272 - 66,176,877 + NCBI Human Genome Assembly HuRef 1 63,995,123 - 64,212,195 + ENTREZGENE Human Genome Assembly GRCh37 1 65,886,335 - 66,103,176 + ENTREZGENE RefSeq Acc Id: NM_001198688 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_001185617 Peptide Label: isoform 4 precursor Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 1 65,960,272 - 66,176,877 + NCBI Human Genome Assembly HuRef 1 63,995,123 - 64,212,195 + ENTREZGENE Human Genome Assembly GRCh37 1 65,886,335 - 66,103,176 + ENTREZGENE Protein Sequences Protein RefSeqs NP_001003679 (Get FASTA)   NP_001003680 (Get FASTA)   NP_001185616 (Get FASTA)   NP_001185617 (Get FASTA)   NP_001185618 (Get FASTA)   NP_002294 (Get FASTA) GenBank Protein AAA93015 (Get FASTA)   AAB07495 (Get FASTA)   AAB07496 (Get FASTA)   AAB07497 (Get FASTA)   AAB09673 (Get FASTA)   AAC23650 (Get FASTA)   AAC50509 (Get FASTA)   AAC50510 (Get FASTA)   AAC50511 (Get FASTA)   AAH31086 (Get FASTA)   AAI31780 (Get FASTA)   AAI60009 (Get FASTA)   BAF82897 (Get FASTA)   CAH25983 (Get FASTA)   P48357 (Get FASTA) Promoters RGD ID: 6785930 Promoter ID: HG_KWN:3114 Type: CpG-Island SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4 Transcripts: ENST00000344610,   ENST00000406510,   OTTHUMT00000025132,   OTTHUMT00000025133,   OTTHUMT00000025263,   OTTHUMT00000025265,   OTTHUMT00000025275,   OTTHUMT00000025276,   OTTHUMT00000025277,   UC009WAO.1,   UC009WAP.1,   UC009WAQ.1 Position: Map Chr Position Strand Source Human Genome Assembly Build 36 1 65,658,231 - 65,659,132 + MPROMDB RGD ID: 6785924 Promoter ID: HG_KWN:3116 Type: CpG-Island SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: K562 Transcripts: OTTHUMT00000025278,   UC001DCJ.1,   UC001DCK.1 Position: Map Chr Position Strand Source Human Genome Assembly Build 36 1 65,763,556 - 65,764,056 + MPROMDB Additional Information External Database Links Database Acc Id Source(s) COSMIC LEPR COSMIC Ensembl Genes ENSG00000116678 ENTREZGENE Ensembl Protein ENSP00000360097 ENTREZGENE   ENSP00000360098 ENTREZGENE   ENSP00000360099 ENTREZGENE Ensembl Transcript ENST00000371058 ENTREZGENE   ENST00000371059 ENTREZGENE   ENST00000371060 ENTREZGENE Entrez Gene 3953 ENTREZGENE Gene3D-CATH Ig-like_fold UniProtKB/Swiss-Prot Germonline ENSG00000116678 HGNC ID 6554 ENTREZGENE HomoloGene Group ID 1731 ENTREZGENE HPRD ID 03001 ENTREZGENE InterPro Fibronectin_type3 UniProtKB/Swiss-Prot   Hematopoietin_rcpt_Gp130_CS UniProtKB/Swiss-Prot   Hempt_rcpt_S_F1_CS UniProtKB/Swiss-Prot   Ig-like UniProtKB/Swiss-Prot   Ig-like_fold UniProtKB/Swiss-Prot   IgC2-like_lig-bd UniProtKB/Swiss-Prot   Lep_receptor UniProtKB/Swiss-Prot IPI IPI00009243 UniProtKB/Swiss-Prot   IPI00219708 UniProtKB/Swiss-Prot   IPI00219709 UniProtKB/Swiss-Prot   IPI00219710 UniProtKB/Swiss-Prot   IPI00219711 UniProtKB/Swiss-Prot   IPI01014481 UniProtKB/TrEMBL KEGG Report hsa:3953 ENTREZGENE, UniProtKB/Swiss-Prot OMIM 601007 OMIM   614963 OMIM PANTHER Lep_receptor UniProtKB/Swiss-Prot Pfam fn3 UniProtKB/TrEMBL   Lep_receptor_Ig UniProtKB/Swiss-Prot PharmGKB LEPR RGD, PharmGKB PROSITE FN3 UniProtKB/Swiss-Prot   HEMATOPO_REC_L_F2 UniProtKB/Swiss-Prot   HEMATOPO_REC_S_F1 UniProtKB/TrEMBL   IG_LIKE UniProtKB/Swiss-Prot SMART FN3 UniProtKB/Swiss-Prot Superfamily-SCOP FN_III-like UniProtKB/Swiss-Prot UniGene Hs.23581 ENTREZGENE   Hs.723178 ENTREZGENE UniProt A2RRQ4_HUMAN UniProtKB/TrEMBL   LEPR_HUMAN UniProtKB/Swiss-Prot   Q4G138_HUMAN UniProtKB/TrEMBL Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2011-08-16 LEPR  leptin receptor  LEPR  leptin receptor  Symbol and/or name change 39860 APPROVED 2011-07-27 LEPR  leptin receptor  LEPR  leptin receptor  Symbol and/or name change 39860 APPROVED

More on LEPR Entrez Gene Ensembl Gene Genome Browser: (hg18) (hg19) HGNC Report NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 735832 Created: 2004-02-06 Species: Homo sapiens Last Modified: 2013-04-30 Status: ACTIVE