PTGS2 (prostaglandin-endoperoxide synthase 2) - Rat Genome Database

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Gene: PTGS2 (prostaglandin-endoperoxide synthase 2) Homo sapiens
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Symbol: PTGS2
Name: prostaglandin-endoperoxide synthase 2
RGD ID: 731006
HGNC Page HGNC:9605
Description: Enables enzyme binding activity and prostaglandin-endoperoxide synthase activity. Involved in cellular response to hypoxia and cyclooxygenase pathway. Located in endoplasmic reticulum; neuron projection; and nuclear membrane. Implicated in several diseases, including artery disease (multiple); arthritis (multiple); avian influenza; liver disease (multiple); and lung disease (multiple). Biomarker of several diseases, including carcinoma (multiple); functioning pituitary adenoma (multiple); in situ carcinoma (multiple); lung disease (multiple); and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: COX-2; COX2; cyclooxygenase 2; cyclooxygenase 2b; cyclooxygenase-2; GRIPGHS; hCox-2; PGG/HS; PGH synthase 2; PGHS-2; PHS II; PHS-2; prostaglandin G/H synthase 2; prostaglandin G/H synthase and cyclooxygenase; prostaglandin H2 synthase 2; prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381186,671,791 - 186,680,423 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1186,671,791 - 186,680,922 (-)EnsemblGRCh38hg38GRCh38
GRCh371186,640,923 - 186,649,555 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361184,907,592 - 184,916,179 (-)NCBINCBI36Build 36hg18NCBI36
Build 341183,372,625 - 183,381,213NCBI
Celera1159,751,694 - 159,760,309 (-)NCBICelera
Cytogenetic Map1q31.1NCBI
HuRef1157,875,712 - 157,884,327 (-)NCBIHuRef
CHM1_11188,062,673 - 188,071,288 (-)NCBICHM1_1
T2T-CHM13v2.01186,026,616 - 186,035,248 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (EXP)
acute kidney failure  (ISO)
Acute Liver Failure  (IMP,ISO)
Acute Lung Injury  (ISO)
adenocarcinoma  (EXP,ISO)
Adrenal Gland Neoplasms  (EXP)
Albuminuria  (EXP)
Alcohol Withdrawal Delirium  (ISO)
allergic rhinitis  (EXP)
Alzheimer's disease  (IEP,ISO)
amyotrophic lateral sclerosis  (EXP,IEP)
Anaphylaxis  (ISO)
Anorexia  (ISO)
arteriosclerosis  (IAGP,ISO)
asphyxia neonatorum  (EXP)
aspirin-induced respiratory disease  (EXP,IEP)
asthma  (IAGP,IMP,ISO)
atherosclerosis  (EXP)
autistic disorder  (EXP)
avian influenza  (IMP)
B-Cell Chronic Lymphocytic Leukemia  (EXP)
B-cell lymphoma  (EXP)
Barrett's esophagus  (EXP,IEP,ISO)
bipolar disorder  (IEP)
bladder neck obstruction  (EXP)
Bone Fractures  (ISO)
Bone Neoplasms  (EXP)
Brain Injuries  (EXP,ISO)
brain ischemia  (EXP,ISO)
Breast Neoplasms  (EXP,IEP)
Burns  (EXP)
Cachexia  (EXP)
Calcification of Aortic Valve  (ISO)
carcinoma  (EXP)
Cardiac Arrhythmias  (EXP)
cardiomyopathy  (EXP)
cardiovascular system disease  (EXP,IMP)
Cerebral Hemorrhage  (ISO)
cervix uteri carcinoma in situ  (IEP)
Chemical and Drug Induced Liver Injury  (EXP,ISO)
cholangiocarcinoma  (EXP,IAGP,IEP)
chronic obstructive pulmonary disease  (IAGP,IEP)
cognitive disorder  (EXP)
colitis  (EXP,ISO)
Colonic Neoplasms  (EXP,ISO)
Colorectal Neoplasms  (EXP)
congestive heart failure  (EXP)
coronary artery disease  (EXP)
Cough  (IMP)
COVID-19  (HEP)
Creutzfeldt-Jakob disease  (IEP)
Crohn's disease  (ISO)
cryptorchidism  (ISO)
cystic fibrosis  (IAGP,IEP)
cystitis  (ISO)
demyelinating disease  (IEP,ISO)
depressive disorder  (EXP)
diabetes mellitus  (EXP,ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
disease of cellular proliferation  (EXP)
Drug-Related Side Effects and Adverse Reactions  (EXP)
ductal carcinoma in situ  (IEP)
duodenal ulcer  (EXP)
Edema  (EXP)
end stage renal disease  (EXP)
Endometrial Neoplasms  (IEP)
endometriosis  (EXP,ISO)
Endotoxemia  (ISO)
Esophageal Neoplasms  (EXP,IAGP,ISO)
esophagitis  (IAGP)
esophagus adenocarcinoma  (EXP,IEP)
esophagus squamous cell carcinoma  (EXP)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (EXP,ISO)
Experimental Liver Cirrhosis  (EXP)
Experimental Mammary Neoplasms  (ISO)
Experimental Radiation Injuries  (ISO)
familial adenomatous polyposis  (EXP)
Fetal Growth Retardation  (ISO)
Fever  (EXP,ISO)
Fibrosis  (EXP,ISO)
Gallbladder Neoplasms  (IAGP,IEP,ISO)
gastric ulcer  (EXP,ISO)
gastritis  (ISO)
gastroesophageal reflux disease  (EXP)
gastrointestinal stromal tumor  (IAGP)
glioblastoma  (IEP,ISO)
gliosarcoma  (ISO)
granulosa cell tumor  (IEP)
Graves ophthalmopathy  (EXP)
growth hormone secreting pituitary adenoma  (IEP)
head and neck squamous cell carcinoma  (EXP)
hepatocellular carcinoma  (EXP,IAGP,IEP,ISO)
high grade glioma  (EXP)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Huntington's disease  (ISO)
hydronephrosis  (EXP)
Hyperalgesia  (EXP,ISO)
Hyperemia  (EXP)
hyperglycemia  (EXP)
Hyperplasia  (EXP)
hypertension  (EXP,ISO)
Hypoxia  (ISO)
in situ carcinoma  (EXP,IEP,ISO)
Inflammation  (EXP,ISO)
inflammatory bowel disease  (EXP)
interstitial lung disease 2  (IAGP,IDA,IEP)
intestinal obstruction  (ISO)
Intestinal Polyps  (EXP)
invasive ductal carcinoma  (EXP)
kidney disease  (EXP)
Kidney Neoplasms  (EXP)
Laryngeal Neoplasms  (IEP)
Laryngeal Papillomatosis  (IMP)
Left Ventricular Hypertrophy  (ISO)
leiomyosarcoma  (EXP)
liver cirrhosis  (IMP)
lung cancer  (ISO)
lung disease  (EXP)
lung non-small cell carcinoma  (IAGP,IEP)
Lymphatic Metastasis  (IAGP,IEP)
melanoma  (EXP)
metabolic dysfunction-associated steatotic liver disease  (ISO)
Metabolic Syndrome  (ISO)
mouth disease  (EXP)
Mouth Neoplasms  (EXP,ISO)
myocardial infarction  (IAGP)
Myocardial Reperfusion Injury  (ISO)
myocarditis  (ISO)
Nasal Polyps  (IEP)
Neoplasm Metastasis  (EXP,IEP,IMP,ISO)
Neoplasm Recurrence, Local  (EXP)
nephroblastoma  (IEP)
nephrotic syndrome  (ISO)
nervous system disease  (EXP)
Neurogenic Inflammation  (EXP)
obesity  (EXP,ISO)
obstructive sleep apnea  (IEP)
occupational asthma  (EXP)
open-angle glaucoma  (EXP)
oral mucosa leukoplakia  (EXP)
oral submucous fibrosis  (EXP)
osteoarthritis  (EXP,IAGP)
Ovarian Neoplasms  (IEP)
Pain  (IAGP,ISO)
pancreatic cancer  (EXP,IAGP,IEP,IMP)
pancreatic ductal carcinoma  (ISO)
pancreatitis  (EXP,ISO)
papilloma  (EXP)
parathyroid carcinoma  (IAGP)
Parkinsonism  (ISO)
pericardial effusion  (EXP)
Peripheral Nerve Injuries  (IEP,ISO)
pleurisy  (ISO)
polycystic kidney disease  (ISO)
portal hypertension  (ISO)
pre-malignant neoplasm  (EXP)
Precocious Puberty  (EXP)
Premature Birth  (EXP)
prolactinoma  (IEP)
prostate cancer  (IAGP)
prostate carcinoma in situ  (IEP)
prostatic hypertrophy  (IEP)
Prostatic Neoplasms  (EXP,IDA,IEP)
prostatitis  (ISO)
proteinuria  (EXP)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (IAGP,ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (EXP,IEP,ISO)
Reperfusion Injury  (EXP,ISO)
retrograde amnesia  (ISO)
rheumatoid arthritis  (EXP,IMP)
sarcoidosis  (IAGP,IEP)
schizophrenia  (ISO)
secondary hyperparathyroidism  (IEP,ISO)
skin disease  (EXP)
Skin Neoplasms  (EXP)
Sleep Deprivation  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (EXP)
status epilepticus  (EXP,ISO)
steatotic liver disease  (ISO)
Stomach Neoplasms  (EXP)
Stroke  (EXP,IAGP)
Subarachnoid Hemorrhage  (ISO)
systemic lupus erythematosus  (EXP)
systemic scleroderma  (IEP)
thrombosis  (EXP)
Thyroid Neoplasms  (EXP)
Tongue Neoplasms  (EXP)
transitional cell carcinoma  (EXP,IEP)
traumatic brain injury  (EXP)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (EXP,IAGP,IEP,ISO)
Urologic Neoplasms  (IEP)
Uterine Cervical Neoplasms  (IEP)
Ventilator-Induced Lung Injury  (ISO)
visual epilepsy  (ISO)
Wernicke encephalopathy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-alpha-viniferin  (ISO)
(+)-catechin  (EXP,ISO)
(+)-isolariciresinol  (ISO)
(+)-pilocarpine  (ISO)
(+)-pinoresinol  (ISO)
(+)-syringaresinol  (ISO)
(+)-syringaresinol beta-D-glucoside  (ISO)
(+)-taxifolin  (ISO)
(-)-Arctigenin  (ISO)
(-)-citrinin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-matairesinol  (ISO)
(1->4)-beta-D-glucan  (ISO)
(1S)-bornane-2,3-dione  (EXP)
(20S)-ginsenoside Rh1  (ISO)
(24S)-24-hydroxycholesterol  (EXP)
(25R)-cholest-5-ene-3beta,26-diol  (EXP)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoic acid  (ISO)
(E)-thiamethoxam  (ISO)
(R)-adrenaline  (ISO)
(R)-amygdalin  (EXP)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1'-acetoxychavicol acetate  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-dioctanoyl-sn-glycero-3-phosphate  (EXP)
1,2-naphthoquinone  (EXP)
1,3,5-trinitrobenzene  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
1,4-dithiothreitol  (EXP)
1,4-phenylenediamine  (EXP)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP,ISO)
1-bromopropane  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-hydroxy-2-naphthoic acid  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-methylnicotinamide  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (EXP)
1-phenyl-1-cyclopentanecarboxylic acid 2-[2-(diethylamino)ethoxy]ethyl ester  (EXP)
1-Phenyl-6,7-dihydroxy-isochroman  (EXP)
11-deoxycorticosterone  (ISO)
11-deoxyprostaglandin E1  (EXP)
12(S)-HPETE  (ISO)
15-acetyldeoxynivalenol  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
16,16-dimethylprostaglandin E2  (EXP,ISO)
17-hydroxyjolkinolide B  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',4,4'-tetrachlorobiphenyl  (EXP)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-(4-hydroxyphenyl)ethanol  (ISO)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-[4-[3-[2-(trifluoromethyl)-9-thioxanthenylidene]propyl]-1-piperazinyl]ethanol  (EXP)
2-acetamidofluorene  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (EXP)
2-acetyloxy-4-(trifluoromethyl)benzoic acid  (EXP,ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-arachidonoylglycerol  (EXP,ISO)
2-butoxyethanol  (ISO)
2-hydroxy-17beta-estradiol  (EXP)
2-Hydroxy-4-trifluoromethyl benzoic acid  (EXP)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (EXP)
2-hydroxypropanoic acid  (EXP)
2-methoxy-17beta-estradiol  (EXP)
2-Methoxy-4-methylphenol  (ISO)
2-palmitoylglycerol  (EXP)
2-tert-butylhydroquinone  (ISO)
22-Hydroxycholesterol  (EXP)
26-hydroxycholesterol  (EXP)
3',5'-cyclic AMP  (ISO)
3',5'-di-O-methyltricetin  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,3'-diindolylmethane  (EXP,ISO)
3,4-dichloroaniline  (EXP)
3,4-dihydroxybenzoic acid  (ISO)
3,4-Methylenedioxyamphetamine  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-acetyldeoxynivalenol  (ISO)
3-hydroxyphenylacetic acid  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methyl-3H-imidazo[4,5-f]quinolin-2-amine  (EXP)
3-methyladenine  (EXP)
3-methylcholanthrene  (EXP,ISO)
3-nitropropanoic acid  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
3-phenylpropionic acid  (EXP)
4,4'-methylene-bis-(2-chloroaniline)  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-chlorobiphenyl  (EXP)
4-ethoxyaniline  (EXP)
4-hydroxy-17beta-estradiol  (EXP)
4-hydroxy-TEMPO  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nitroquinoline N-oxide  (EXP,ISO)
4-phenylbutyric acid  (EXP)
5,6,7-trimethoxyflavone  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP,ISO)
5-(N,N-hexamethylene)amiloride  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP)
6-oxoprostaglandin F1alpha  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (ISO)
7,8-diacetoxy-4-methylcoumarin  (EXP)
7-NITROINDAZOLE  (ISO)
7alpha-hydroxycholesterol  (EXP)
8-Br-cAMP  (EXP)
8-epi-prostaglandin F2alpha  (EXP)
8-hydroxy-2'-deoxyguanosine  (EXP)
8-OH-DPAT  (ISO)
9,10-anthraquinone  (EXP)
9-(tetrahydrofuryl)adenine  (EXP)
9-cis-retinoic acid  (EXP)
9-Methoxycamptothecin  (EXP)
[6]-Shogaol  (EXP,ISO)
AACOCF3  (EXP,ISO)
acadesine  (EXP)
acenaphthoquinone  (EXP)
acetaldehyde  (EXP)
acetic acid  (ISO)
acetylsalicylic acid  (EXP,ISO)
Aciculatin  (ISO)
acrolein  (EXP,ISO)
acrylamide  (ISO)
acteoside  (EXP)
actinomycin D  (EXP,ISO)
acyclovir  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin G1  (ISO)
AH23848  (EXP)
AICA ribonucleotide  (ISO)
albuterol  (EXP)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
alendronic acid  (ISO)
alfacalcidol  (ISO)
aliskiren  (ISO)
all-trans-4-oxoretinoic acid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
allantoin  (ISO)
allopurinol  (ISO)
allyl alcohol  (ISO)
Aloe emodin  (ISO)
alpha-Chaconine  (ISO)
alpha-D-galactose  (ISO)
alpha-linolenic acid  (EXP,ISO)
alpha-mangostin  (ISO)
alpha-methylhistamine  (ISO)
alpha-naphthoflavone  (EXP,ISO)
alpha-Zearalanol  (EXP)
Alternaramide  (ISO)
alternariol  (ISO)
aluminium atom  (ISO)
aluminium sulfate (anhydrous)  (EXP)
aluminium(0)  (ISO)
amarogentin  (ISO)
amentoflavone  (EXP)
amikacin  (EXP)
amiloride  (ISO)
aminoguanidine  (ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
ammonium hexachloroplatinate  (EXP)
Ammothamnine  (EXP,ISO)
amodiaquine  (EXP)
amphetamine  (ISO)
amphibole asbestos  (EXP,ISO)
ampicillin  (ISO)
anandamide  (EXP,ISO)
Anemoside B4  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
anthracene-1,8,9-triol  (ISO)
antimycin A  (EXP,ISO)
antirheumatic drug  (EXP)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
arachidonic acid  (EXP,ISO)
Archazolid B  (EXP)
Arctiin  (ISO)
arecoline  (EXP,ISO)
aripiprazole  (EXP)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
asarone  (ISO)
asbestos  (EXP)
asiatic acid  (ISO)
astaxanthin  (ISO)
astilbin  (EXP)
atenolol  (EXP)
atorvastatin calcium  (ISO)
ATP  (EXP)
atrazine  (ISO)
atropine  (ISO)
auranofin  (EXP,ISO)
auraptene  (EXP)
aureusidin  (ISO)
azathioprine  (EXP)
baicalein  (EXP,ISO)
baicalin  (ISO)
bellidifolin  (EXP)
benfotiamine  (ISO)
benzalkonium chloride  (EXP)
benzamide  (ISO)
benzatropine  (EXP)
benzene  (EXP,ISO)
benzidine  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP,ISO)
Benzo[a]pyrene-7,8-diol  (EXP)
benzo[b]fluoranthene  (EXP)
Benzo[k]fluoranthene  (EXP,ISO)
benzoic acid  (ISO)
Benzoyl peroxide  (EXP,ISO)
Benzoylpaeoniflorin  (EXP)
berberine  (ISO)
Bergenin  (ISO)
beryllium sulfate  (EXP)
Besigomsin  (ISO)
beta-amyrin  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (EXP)
beta-ionone  (EXP,ISO)
beta-naphthoflavone  (ISO)
beta-tocopherol  (ISO)
betulinic acid  (ISO)
bicalutamide  (EXP)
bifenthrin  (EXP,ISO)
biochanin A  (EXP)
biphenyl-2,2'-diol  (ISO)
biphenyl-2-ol  (ISO)
biphenyl-4,4'-diol  (ISO)
biphenyl-4-amine  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bisphenol A dimethacrylate  (EXP)
Bisphenol A glycidylmethacrylate  (EXP)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
bortezomib  (EXP)
Botulinum toxin type A  (ISO)
BQ 123  (EXP,ISO)
bromfenac  (EXP)
bromobenzene  (ISO)
brucine  (EXP)
bucladesine  (EXP,ISO)
budesonide  (ISO)
bufalin  (EXP)
bupivacaine  (EXP)
busulfan  (EXP,ISO)
butan-1-ol  (EXP,ISO)
butanal  (EXP)
butane-2,3-dione  (EXP)
Butralin  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (EXP)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (EXP,ISO)
Calcimycin  (EXP,ISO)
calciol  (ISO)
calcitriol  (EXP,ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
candesartan  (ISO)
cannabidiol  (EXP,ISO)
cannabidiolic acid  (EXP)
capecitabine  (EXP,ISO)
capillarisin  (EXP)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
captopril  (EXP,ISO)
carazolol  (EXP)
carbachol  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
carboplatin  (EXP)
carfilzomib  (ISO)
carnosic acid  (ISO)
carnosine  (ISO)
carrageenan  (ISO)
carvacrol  (ISO)
Cassiastearoptene  (ISO)
catalpol  (ISO)
CCCP  (EXP,ISO)
celastrol  (EXP)
celecoxib  (EXP,ISO)
cerium trichloride  (EXP)
ceruletide  (ISO)
cetylpyridinium  (EXP)
chaetoglobosin A  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chloramphenicol  (ISO)
chlordecone  (ISO)
chlorobenzene  (EXP)
chlorogenic acid  (ISO)
chloropicrin  (EXP)
chloroquine  (EXP)
chlorothalonil  (EXP)
chlorphenamine  (EXP)
chlorpropham  (ISO)
chlorpyrifos  (EXP,ISO)
choline  (ISO)
chondroitin sulfate  (EXP)
chromium(6+)  (EXP,ISO)
chrysin  (EXP,ISO)
chrysin 5,7-dimethyl ether  (ISO)
ciglitazone  (EXP,ISO)
cilostazol  (ISO)
cinaciguat  (ISO)
ciprofibrate  (ISO)
cirsilineol  (ISO)
Cirsimarin  (ISO)
cis-caffeic acid  (EXP,ISO)
cisplatin  (EXP,ISO)
citronellol  (EXP,ISO)
clofibrate  (ISO)
cobalt atom  (EXP)
cobalt dichloride  (EXP,ISO)
colforsin daropate hydrochloride  (EXP,ISO)
conjugated linoleic acid  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (EXP,ISO)
corilagin  (EXP,ISO)
corn oil  (ISO)
corosolic acid  (EXP,ISO)
corticosterone  (ISO)
cortisol  (EXP,ISO)
costunolide  (ISO)
crocidolite asbestos  (EXP)
crocin-1  (EXP)
cumene hydroperoxide  (EXP)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (EXP)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cyprodinil  (ISO)
cytarabine  (EXP,ISO)
D-glucose  (EXP,ISO)
daidzein  (EXP,ISO)
dapagliflozin  (ISO)
dapoxetine  (ISO)
DAPT  (EXP)
daunorubicin  (ISO)
DDD  (EXP)
DDE  (EXP,ISO)
DDT  (EXP)
Decursin  (ISO)
deguelin  (EXP)
dehydroascorbic acid  (ISO)
dehydrocostus lactone  (ISO)
Dehydrodiisoeugenol  (ISO)
delta-tocopherol  (ISO)
demethoxycurcumin  (ISO)
deoxycholic acid  (EXP,ISO)
deoxynivalenol  (EXP,ISO)
desferrioxamine B  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dextromethorphan  (ISO)
Diacetoxyscirpenol  (ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (EXP)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenziodolium  (EXP,ISO)
dibenzofuran  (ISO)
dibenzoylmethane  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dichloromethane  (EXP)
diclofenac  (EXP,ISO)
dieckol  (EXP,ISO)
dienogest  (EXP)
diethyl phthalate  (ISO)
Dihydrotanshinone I  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
diisopropyl fluorophosphate  (ISO)
dimethoate  (ISO)
dimethyl sulfoxide  (EXP,ISO)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (EXP)
dioscin  (ISO)
diosgenin  (EXP)
diosmin  (ISO)
dioxygen  (EXP,ISO)
diphenhydramine  (EXP)
dipyridamole  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dizocilpine maleate  (ISO)
dobutamine  (EXP)
donepezil hydrochloride  (EXP,ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
DuP 697  (EXP,ISO)
edelfosine  (EXP)
elemental selenium  (ISO)
embelin  (EXP)
emodin  (ISO)
enalapril  (ISO)
endosulfan  (ISO)
enilconazole  (ISO)
enniatin  (EXP)
entacapone  (EXP)
entinostat  (EXP)
equol  (EXP)
erastin  (EXP,ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (EXP,ISO)
eriodictyol  (ISO)
erlotinib hydrochloride  (EXP)
esmolol  (EXP)
ethanol  (EXP,ISO)
Ethyl pyruvate  (ISO)
ethylbenzene  (ISO)
ethylisopropylamiloride  (ISO)
etodolac  (EXP,ISO)
etoposide  (EXP)
etoricoxib  (EXP,ISO)
eugenol  (EXP,ISO)
eupatilin  (ISO)
everolimus  (ISO)
Evodiamine  (EXP)
famotidine  (ISO)
febuxostat  (ISO)
fenbendazole  (EXP)
fenhexamid  (ISO)
fenofibrate  (ISO)
ferric ammonium citrate  (EXP)
ferrosoferric oxide  (EXP)
ferrostatin-1  (EXP,ISO)
ferulic acid  (EXP,ISO)
Fexofenadine hydrochloride  (EXP)
finasteride  (ISO)
Flavokawain A  (ISO)
flavone  (ISO)
fludioxonil  (ISO)
fludrocortisone  (EXP)
flufenamic acid  (EXP)
fluoranthene  (ISO)
fluoxetine  (ISO)
flupenthixol  (EXP)
flurbiprofen  (EXP,ISO)
Fluridone  (EXP)
flutamide  (EXP)
fluvoxamine  (EXP,ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP,ISO)
formononetin  (ISO)
Forsythiaside  (ISO)
Fraxinellone  (ISO)
fructose  (ISO)
fucoidan  (ISO)
fucoxanthin  (ISO)
fulvestrant  (EXP,ISO)
Fulvic acid  (EXP)
furosemide  (ISO)
Fusarenone X  (ISO)
galactose  (ISO)
gallic acid  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-linolenic acid  (EXP)
gamma-tocopherol  (EXP,ISO)
Gastrodin  (EXP,ISO)
gefitinib  (EXP,ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (ISO)
genkwanin  (EXP)
gentamycin  (ISO)
geraniol  (EXP,ISO)
gingerol  (EXP,ISO)
ginsenoside C-K  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (ISO)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glyburide  (ISO)
glycidol  (ISO)
glycyrol  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
Goe 6976  (EXP,ISO)
gold atom  (EXP,ISO)
gold(0)  (EXP,ISO)
gossypin  (ISO)
guaiacol  (ISO)
guggulsterone  (EXP)
GW 1929  (EXP)
GW 501516  (EXP)
haloperidol  (ISO)
halothane  (ISO)
harmaline  (ISO)
helenalin  (EXP,ISO)
helioxanthin  (ISO)
heparin  (ISO)
herbimycin  (ISO)
hesperetin  (ISO)
hesperidin  (EXP,ISO)
hexachlorobenzene  (EXP,ISO)
hexane  (EXP)
hinokiflavone  (ISO)
histamine  (EXP,ISO)
homocysteine  (EXP)
homoeriodictyol  (ISO)
Honokiol  (EXP,ISO)
hydrochlorothiazide  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP)
hydroquinone  (EXP,ISO)
hydroxytyrosol  (EXP)
Ibudilast  (ISO)
ibuprofen  (EXP,ISO)
icariin  (ISO)
icariside II  (EXP)
icatibant  (ISO)
ICI 118551  (EXP)
icosanoid  (EXP)
ifosfamide  (ISO)
iloprost  (ISO)
imidazoles  (EXP)
immunological adjuvant  (ISO)
indirubin-3'-monoxime  (EXP)
indole-3-methanol  (EXP,ISO)
indometacin  (EXP,ISO)
indoprofen  (EXP)
irbesartan  (ISO)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron dextran  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) citrate  (EXP,ISO)
iron(III) nitrilotriacetate  (ISO)
isatin  (ISO)
isoflurane  (ISO)
isoliquiritigenin  (EXP,ISO)
isoniazide  (EXP)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP,ISO)
isothiocyanate  (ISO)
isotretinoin  (EXP)
ivermectin  (ISO)
JTE-013  (EXP)
juglone  (EXP)
kaempferol  (EXP,ISO)
kaempferol 3-O-beta-D-glucoside  (ISO)
kainic acid  (ISO)
kenpaullone  (ISO)
ketoconazole  (EXP)
ketoprofen  (EXP)
ketorolac  (EXP,ISO)
ketorolac tromethamine  (EXP)
KN-93  (ISO)
KT 5720  (ISO)
L-1,4-dithiothreitol  (EXP)
L-arginine  (ISO)
L-ascorbic acid  (EXP,ISO)
L-dehydroascorbic acid  (ISO)
L-gamma-glutamyl-L-cysteine  (ISO)
L-glutamic acid  (ISO)
L-methionine  (ISO)
L-proline betaine  (EXP)
lansoprazole  (ISO)
lapatinib  (EXP)
Lasiocarpine  (EXP)
lead diacetate  (ISO)
lead nitrate  (EXP)
lead(0)  (EXP,ISO)
Leonurine  (ISO)
levamisole  (EXP)
levofloxacin  (EXP)
Licarin A  (ISO)
lidocaine  (ISO)
linoleic acid  (EXP,ISO)
linuron  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (ISO)
lipoxin A4  (ISO)
liraglutide  (ISO)
lithium chloride  (EXP,ISO)
lithocholic acid  (EXP)
loganin  (ISO)
lonafarnib  (EXP)
lornoxicam  (EXP)
losartan  (EXP,ISO)
lovastatin  (EXP,ISO)
Lucidone  (EXP)
lumiracoxib  (EXP)
lupeol  (ISO)
lutein  (EXP)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
lycorine  (ISO)
lysophosphatidylcholine  (ISO)
Malabaricone C  (ISO)
malaoxon  (EXP)
malathion  (EXP)
maleimides  (EXP)
mancozeb  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP,ISO)
manoalide  (EXP)
maslinic acid  (ISO)
masoprocol  (EXP)
MC1568  (EXP)
mebendazole  (EXP)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (EXP)
MeIQx  (EXP)
melatonin  (EXP,ISO)
melittin  (EXP,ISO)
meloxicam  (EXP,ISO)
melphalan  (EXP)
mercury dichloride  (ISO)
mesalamine  (ISO)
metaproterenol  (EXP)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
Methanandamide  (EXP)
methanol  (EXP)
methiocarb  (ISO)
methotrexate  (EXP,ISO)
methoxamine  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP)
methyltestosterone  (EXP)
metoprolol  (EXP,ISO)
mevalonic acid  (EXP)
microcystin-LR  (EXP,ISO)
midostaurin  (ISO)
mifepristone  (ISO)
minocycline  (ISO)
miquelianin  (ISO)
misoprostol  (ISO)
mitomycin C  (EXP)
Mitotane  (EXP)
Mitragynine  (ISO)
MK-2206  (EXP)
Mofezolac (TN)  (ISO)
monascin  (EXP)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzyl phthalate  (EXP)
Monobutylphthalate  (EXP)
monotropein  (ISO)
montelukast  (ISO)
morin  (ISO)
morphine  (ISO)
Morroniside  (ISO)
morusin  (ISO)
myo-inositol hexakisphosphate  (ISO)
myricetin  (EXP,ISO)
myricitrin  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP,ISO)
N(omega)-methyl-L-arginine  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-feruloyltyramine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-phosphocreatine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
nabumetone  (ISO)
naphthalenes  (ISO)
naproxen  (EXP,ISO)
Narciclasine  (ISO)
naringin  (ISO)
nebivolol  (EXP)
Neferine  (ISO)
neoastilbin  (EXP)
neoechinulin A  (ISO)
neohesperidin dihydrochalcone  (ISO)
nerolidol  (ISO)
nickel atom  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (ISO)
nickel sulfate  (EXP,ISO)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nifedipine  (EXP,ISO)
Niflumic acid  (EXP,ISO)
nimesulide  (EXP,ISO)
nitric oxide  (ISO)
nitrofen  (ISO)
nitrogen dioxide  (EXP)
nitroprusside  (EXP,ISO)
nobiletin  (ISO)
nomifensine  (EXP)
Nonylphenol  (ISO)
Nookatone  (ISO)
notoginsenoside R1  (ISO)
NS-398  (EXP,ISO)
o-anisidine  (EXP)
o-cresol  (ISO)
O-methylsalicylic acid  (ISO)
Obacunone  (EXP)
ochratoxin A  (EXP,ISO)
ofloxacin  (ISO)
okadaic acid  (EXP,ISO)
oleanolic acid  (EXP,ISO)
oleic acid  (EXP)
oleoyl ethanolamide  (ISO)
oleuropein  (EXP,ISO)
omeprazole  (ISO)
omethoate  (ISO)
onapristone  (ISO)
orciprenaline  (EXP)
organoselenium compound  (EXP,ISO)
oridonin  (ISO)
orlistat  (EXP)
oroxylin A  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
oxidopamine  (EXP,ISO)
oxybenzone  (EXP)
oxytocin  (ISO)
ozone  (EXP,ISO)
p-tolualdehyde  (ISO)
Pachymic acid  (EXP,ISO)
paclitaxel  (EXP,ISO)
paeoniflorin  (EXP)
Paeonol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (EXP,ISO)
paroxetine  (EXP)
parthenolide  (EXP,ISO)
patchouli alcohol  (ISO)
PCB138  (EXP)
pelargonidin  (ISO)
penbutolol  (EXP)
pentane-2,3-dione  (EXP)
Pentoxifylline  (ISO)
peptidoglycan  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
PGI3  (EXP)
phenanthridone  (ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenobarbital  (ISO)
phenylarsine oxide  (EXP,ISO)
phenylbutazone  (EXP)
phenylephrine  (ISO)
phenylhydrazine  (ISO)
phenytoin  (ISO)
PhIP  (EXP,ISO)
phloretic acid  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (ISO)
phosphatidic acid  (EXP,ISO)
phosphorus atom  (EXP)
phosphorus(.)  (EXP)
pifithrin-?  (ISO)
pinostrobin  (ISO)
pioglitazone  (EXP,ISO)
piperine  (ISO)
pipoxolan  (ISO)
pirimiphos-methyl  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (EXP,ISO)
platinum  (EXP)
platinum(0)  (EXP)
platycodin D  (ISO)
pluronic P-123  (ISO)
Poloxamer  (ISO)
poly(I:C)  (ISO)
poly(vinylpyrrolidone)  (ISO)
polymyxin B2  (EXP,ISO)
ponasterone A  (ISO)
potassium bromate  (ISO)
potassium chloride  (ISO)
potassium iodide  (EXP)
Pranoprofen  (EXP)
pravastatin  (ISO)
prednisolone  (EXP)
PRIM-O-GLUCOSYLCIMIFUGIN  (ISO)
pristane  (ISO)
proanthocyanidin  (ISO)
procyclidine  (EXP)
prodigiosin  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
propranolol  (EXP,ISO)
prostaglandin A1  (ISO)
prostaglandin D2  (ISO)
prostaglandin D3  (EXP)
prostaglandin E2  (EXP,ISO)
prostaglandin E3  (EXP)
prostaglandin F1alpha  (EXP)
prostaglandin F2alpha  (EXP,ISO)
prostaglandin G2  (ISO)
prostaglandin I2  (ISO)
protein kinase inhibitor  (EXP)
protoporphyrin  (ISO)
protriptyline  (EXP)
prunetin  (ISO)
pterostilbene  (EXP,ISO)
puerarin  (ISO)
puromycin  (ISO)
pyrazines  (ISO)
pyrene  (EXP)
pyridoxamine  (ISO)
pyrimethanil  (ISO)
pyrogallol  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quercetin 3-sulfate  (EXP)
rac-lactic acid  (EXP)
radon atom  (ISO)
radon(0)  (ISO)
raloxifene  (EXP,ISO)
ramipril  (ISO)
ranitidine  (ISO)
reactive oxygen species  (EXP,ISO)
Rebamipide  (ISO)
rebaudioside A  (EXP)
reserpine  (ISO)
resolvin D1  (ISO)
resolvin D2  (ISO)
resorcinol  (EXP)
resveratrol  (EXP,ISO)
Rhein  (EXP)
rimonabant  (ISO)
rivastigmine  (EXP)
Ro 31-8220  (EXP,ISO)
rofecoxib  (EXP,ISO)
rotenone  (ISO)
rottlerin  (EXP,ISO)
rubimaillin  (EXP)
rutin  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
S-adenosyl-L-methioninate  (EXP)
S-adenosyl-L-methionine  (EXP)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
Salvianolic acid A  (ISO)
sarpogrelate  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (EXP)
SC-58125  (EXP,ISO)
scalaradial  (EXP)
scoparone  (ISO)
scopolamine  (ISO)
selenium atom  (ISO)
senecionine  (EXP)
Senkirkine  (EXP)
serotonin  (ISO)
serpentine asbestos  (EXP)
sertraline  (EXP)
Sesamol  (ISO)
sevoflurane  (ISO)
Shikonin  (ISO)
silibinin  (ISO)
silicon atom  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (ISO)
sirolimus  (ISO)
sirtinol  (EXP)
SKF-96365 hydrochloride  (EXP)
sodium arsenite  (EXP,ISO)
sodium atom  (ISO)
sodium aurothiomalate  (EXP)
sodium chloride  (ISO)
sodium chromate  (ISO)
sodium dodecyl sulfate  (EXP)
sodium fluoride  (EXP,ISO)
sodium hydrogensulfite  (ISO)
Sodium salicylate  (EXP,ISO)
sodium sulfite  (ISO)
Soman  (ISO)
Sophocarpine  (ISO)
Sophoricoside  (ISO)
sorbinil  (ISO)
soyasaponin I  (ISO)
sphinganine 1-phosphate  (EXP)
sphingosine 1-phosphate  (EXP)
staurosporine  (EXP)
stavudine  (ISO)
sterigmatocystin  (ISO)
steviol  (EXP)
stevioside  (EXP)
stigmasterol  (ISO)
streptozocin  (ISO)
styrene  (EXP)
succimer  (ISO)
succinic acid  (EXP)
sucrose  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulfur dioxide  (EXP,ISO)
sulindac  (EXP,ISO)
sulindac sulfide  (EXP)
sulindac sulfone  (EXP,ISO)
superoxide  (ISO)
suramin  (EXP)
Swertiamarin  (ISO)
syringic acid  (ISO)
T-2 toxin  (ISO)
tacrine  (ISO)
tacrolimus hydrate  (EXP,ISO)
taiwanin C  (ISO)
tamarixetin  (EXP)
tamoxifen  (EXP,ISO)
tangeretin  (ISO)
tannic acid  (ISO)
Tanshinone I  (EXP,ISO)
taurocholic acid  (EXP,ISO)
tebuconazole  (ISO)
telmisartan  (EXP,ISO)
temozolomide  (EXP)
TEMPO  (ISO)
tenofovir disoproxil fumarate  (ISO)
tephrosin  (EXP)
terameprocol  (ISO)
terephthalic acid  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (ISO)
tetrachloro-1,4-benzoquinone  (ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
tetradecane  (ISO)
tetrahydrocurcumin  (ISO)
tetrahydropalmatine  (ISO)
tetramethylpyrazine  (EXP,ISO)
tetraphene  (EXP)
tetrathiomolybdate(2-)  (EXP)
thalidomide  (EXP,ISO)
thapsigargin  (EXP,ISO)
theaflavin  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thiamethoxam  (ISO)
thiamine(1+) chloride  (ISO)
thioacetamide  (ISO)
thiocitrulline  (ISO)
thiophanate-methyl  (ISO)
thiourea  (ISO)
thiram  (EXP)
thromboxane A2  (EXP,ISO)
thromboxane B2  (EXP,ISO)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
thyroxine  (EXP,ISO)
tienilic acid  (EXP)
titanium dioxide  (EXP,ISO)
tolcapone  (EXP)
toluene  (EXP,ISO)
topotecan  (ISO)
trans-caffeic acid  (EXP,ISO)
trans-piceid  (EXP,ISO)
trazodone  (EXP,ISO)
tributylstannane  (EXP,ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
Trihexyphenidyl  (EXP)
Triptolide  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (ISO)
Tungsten carbide  (EXP)
tunicamycin  (ISO)
Tylophorine  (EXP)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (ISO)
undecane  (ISO)
uranium atom  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vanadyl sulfate  (EXP)
vanillin  (ISO)
vemurafenib  (EXP)
venom  (EXP)
vincristine  (ISO)
vinorelbine  (EXP)
vinyl carbamate  (ISO)
vitamin E  (EXP,ISO)
vorinostat  (EXP)
VX nerve agent  (ISO)
wedelolactone  (EXP)
withaferin A  (ISO)
wogonin  (ISO)
wortmannin  (EXP,ISO)
xanthohumol  (EXP,ISO)
yohimbine  (ISO)
zafirlukast  (EXP)
zearalenone  (EXP)
zerumbone  (EXP,ISO)
zidovudine  (ISO)
zileuton  (ISO)
zinc atom  (EXP,ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP,ISO)
zinc(0)  (EXP,ISO)
zingerone  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEA,ISO)
bone mineralization  (IEA,ISO)
brown fat cell differentiation  (IEA)
cellular oxidant detoxification  (IEA)
cellular response to ATP  (IEA,ISO)
cellular response to fluid shear stress  (IEA,ISO)
cellular response to heat  (IEA,ISO)
cellular response to homocysteine  (IEA,ISO)
cellular response to hypoxia  (IEP)
cellular response to lead ion  (IEA,ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (IEA,ISO)
cellular response to non-ionic osmotic stress  (IEA)
cellular response to organonitrogen compound  (IEA,ISO)
cyclooxygenase pathway  (IBA,IDA,IEA,ISO)
decidualization  (IEA,ISO)
embryo implantation  (IEA,ISO)
hair cycle  (IEA,ISO)
learning  (IEA,ISO)
maintenance of blood-brain barrier  (IEA,ISO)
memory  (IEA,ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of calcium ion transport  (IEA,ISO)
negative regulation of cell cycle  (IEA,ISO)
negative regulation of cell population proliferation  (IEA,ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress  (IEA)
negative regulation of smooth muscle contraction  (IEA,ISO)
negative regulation of synaptic transmission, dopaminergic  (IEA,ISO)
positive regulation of apoptotic process  (IEA,ISO)
positive regulation of brown fat cell differentiation  (IEA,ISS)
positive regulation of cell migration involved in sprouting angiogenesis  (IEA,ISO,ISS)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of fever generation  (IEA,ISS)
positive regulation of fibroblast growth factor production  (IEA,ISS)
positive regulation of nitric oxide biosynthetic process  (IEA,ISS)
positive regulation of peptidyl-serine phosphorylation  (IEA)
positive regulation of platelet-derived growth factor production  (IEA,ISS)
positive regulation of prostaglandin biosynthetic process  (IEA,NAS)
positive regulation of protein import into nucleus  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (IEA,ISO)
positive regulation of smooth muscle contraction  (IEA,ISO)
positive regulation of synaptic plasticity  (IEA,ISO)
positive regulation of synaptic transmission, glutamatergic  (IEA,ISO)
positive regulation of transforming growth factor beta production  (IEA,ISS)
positive regulation of vascular endothelial growth factor production  (IEA,ISS)
positive regulation of vasoconstriction  (IEA,ISO)
prostaglandin biosynthetic process  (IDA,IEA,ISO,ISS,NAS)
prostaglandin secretion  (IEA,ISO)
regulation of blood pressure  (IEA,ISO,ISS)
regulation of cell population proliferation  (IEA,ISO)
regulation of inflammatory response  (NAS)
regulation of neuroinflammatory response  (IEA,ISS)
response to angiotensin  (IEA,ISO)
response to cytokine  (IEA,ISO)
response to estradiol  (IEA,ISO)
response to fatty acid  (IEA,ISO)
response to fructose  (IEA,ISO)
response to glucocorticoid  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to manganese ion  (IEA,ISO)
response to nematode  (IEA,ISO)
response to organic cyclic compound  (IEA)
response to organonitrogen compound  (ISO)
response to oxidative stress  (IEA)
response to tumor necrosis factor  (IEA,ISO)
response to vitamin D  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acetylsalicylic acid pharmacodynamics pathway  (EXP)
antipyrine drug pathway  (EXP)
arachidonic acid metabolic pathway  (EXP,IEA)
celecoxib pharmacodynamics pathway  (EXP)
celecoxib pharmacokinetics pathway   (EXP)
cyclooxygenase mediated pathway of arachidonic acid metabolism  (TAS)
diclofenac pharmacodynamics pathway  (EXP)
diflunisal pharmacodynamics pathway  (EXP)
etodolac pharmacodynamics pathway  (EXP)
etoposide pharmacodynamics pathway  (EXP)
etoposide pharmacokinetics pathway  (EXP)
fenoprofen pharmacodynamics pathway  (EXP)
flurbiprofen pharmacodynamics pathway  (EXP)
ibuprofen pharmacodynamics pathway  (EXP)
ibuprofen pharmacokinetics pathway  (EXP)
indometacin pharmacodynamics pathway  (EXP)
indometacin pharmacodynamics pathway  (EXP)
ketoprofen pharmacodynamics pathway  (EXP)
ketorolac pharmacodynamics pathway  (EXP)
Leishmaniasis pathway  (IEA)
leukotriene C4 synthase deficiency pathway  (EXP)
lornoxicam pharmacodynamics pathway  (EXP)
magnesium salicylate pharmacodynamics pathway  (EXP)
mefenamic acid pharmacodynamics pathway  (EXP)
meloxicam pharmacodynamics pathway  (EXP)
nabumetone pharmacodynamics pathway  (EXP)
naproxen pharmacodynamics pathway   (EXP)
paracetamol drug pathway  (EXP,TAS)
piroxicam pharmacodynamics pathway  (EXP)
pro-inflammatory cytokine mediated pathway   (ISO)
prostanoid biosynthetic pathway  (TAS)
salicylic acid pharmacodynamics pathway  (EXP)
small cell lung carcinoma pathway  (IEA)
sodium salicylate pharmacodynamics pathway  (EXP)
sphingosine 1-phosphate signaling pathway  (EXP)
sulindac pharmacodynamics pathway  (EXP)
tenoxicam pharmacodynamics pathway  (EXP)
tiaprofenic acid pharmacodynamics pathway  (EXP)
tolmetin pharmacodynamics pathway  (EXP)
valdecoxib pharmacodynamics pathway   (EXP)
vascular endothelial growth factor signaling pathway  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
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2. Celecoxib as an in vivo probe of cyclooxygenase-2 mechanisms underlying retrograde amnesia in an animal model of ECT. Andrade C, etal., J Neural Transm. 2008 Jul;115(7):1063-70. Epub 2008 Jun 4.
3. The prognostic significance of COX-2 and survivin expression in ovarian cancer. Athanassiadou P, etal., Pathol Res Pract. 2008;204(4):241-9. Epub 2008 Jan 2.
4. The neuroprotective effects of cyclooxygenase-2 inhibition in a mouse model of aneurysmal subarachnoid hemorrhage. Ayer R, etal., Acta Neurochir Suppl. 2011;111:145-9.
5. Cyclooxygenase expression and prostaglandin levels in central nervous system tissues during the course of chronic relapsing experimental autoimmune encephalomyelitis (EAE). Ayoub SS, etal., Inflamm Res. 2011 Oct;60(10):919-28. Epub 2011 Jun 12.
6. Loss of 15-hydroxyprostaglandin dehydrogenase indicates a tumor suppressor role in pituitary adenomas. Bai JW, etal., Oncol Rep. 2012 Aug;28(2):714-20. doi: 10.3892/or.2012.1806. Epub 2012 May 9.
7. Overexpression of ELAV-like Protein HuR is Associated with Increased COX-2 Expression in Atrophy, High-grade Prostatic Intraepithelial Neoplasia, and Incidental Prostate Cancer in Cystoprostatectomies. Barbisan F, etal., Eur Urol. 2008 Apr 30.
8. Uteroplacental insufficiency alters nephrogenesis and downregulates cyclooxygenase-2 expression in a model of IUGR with adult-onset hypertension. Baserga M, etal., Am J Physiol Regul Integr Comp Physiol. 2007 May;292(5):R1943-55. Epub 2007 Feb 1.
9. Serum Concentrations of Cyclooxygenase-2 in Patients with Systemic Sclerosis: Association with Lower Frequency of Pulmonary Fibrosis. Bassyouni IH, etal., J Clin Immunol. 2011 Oct 7.
10. Perioperative use of beta-blockers and COX-2 inhibitors may improve immune competence and reduce the risk of tumor metastasis. Benish M, etal., Ann Surg Oncol. 2008 Jul;15(7):2042-52. Epub 2008 Apr 9.
11. COX-2-dependent and potentially cardioprotective effects of negative inotropic substances released after ischemia. Birkenmeier K, etal., Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2148-54. Epub 2007 Jul 27.
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13. Reduced expression of cyclooxygenase-2 in primary breast cancer. Boneberg EM, etal., J Natl Cancer Inst. 2008 Jul 16;100(14):1042-3. Epub 2008 Jul 8.
14. Genes that mediate breast cancer metastasis to the brain. Bos PD, etal., Nature. 2009 Jun 18;459(7249):1005-9. Epub 2009 May 6.
15. PGE2 induces apoptosis of hepatic stellate cells and attenuates liver fibrosis in mice by downregulating miR-23a-5p and miR-28a-5p. Brea R, etal., Biochim Biophys Acta Mol Basis Dis. 2018 Feb;1864(2):325-337. doi: 10.1016/j.bbadis.2017.11.001. Epub 2017 Nov 3.
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17. Contrasting effects of cyclooxygenase-1 (COX-1) and COX-2 deficiency on the host response to influenza A viral infection. Carey MA, etal., J Immunol. 2005 Nov 15;175(10):6878-84.
18. Anti-inflammatory effects of low molecular weight heparin derivative in a rat model of carrageenan-induced pleurisy. Ceccarelli M, etal., J Cell Mol Med. 2009 Aug;13(8B):2704-12.
19. Association of prostaglandin-endoperoxide synthase 2 gene polymorphisms with asthma and atopy in Chinese children. Chan IH, etal., Allergy. 2007 Jul;62(7):802-9.
20. Prostaglandin G/H synthase-2 (cyclooxygenase-2) mRNA expression is decreased in Alzheimer's disease. Chang JW, etal., Neurobiol Aging. 1996 Sep-Oct;17(5):801-8.
21. Cryptorchidism-induced CFTR down-regulation results in disruption of testicular tight junctions through up-regulation of NF-kappaB/COX-2/PGE2. Chen J, etal., Hum Reprod. 2012 Sep;27(9):2585-97. doi: 10.1093/humrep/des254. Epub 2012 Jul 9.
22. Celecoxib attenuates liver steatosis and inflammation in non-alcoholic steatohepatitis induced by high-fat diet in rats. Chen J, etal., Mol Med Report. 2011 Jun 2. doi: 10.3892/mmr.2011.501.
23. [Expressions of cyclooxygenase-2 and matrix metalloproteinase-2 and airflow obstruction in patients with chronic obstructive pulmonary disease]. Chen Y and Chen P, Zhonghua Jie He He Hu Xi Za Zhi. 2005 May;28(5):324-7.
24. Expression of c-erbB-2 and cyclooxygenase-2 in intrahepatic cholangiocarcinoma. Choi HJ, etal., Hepatogastroenterology. 2009 May-Jun;56(91-92):606-9.
25. FSH-regulated gene expression profiles in ovarian tumours and normal ovaries. Chu S, etal., Mol Hum Reprod. 2002 May;8(5):426-33.
26. Intraprostatic botulinum toxin a injection inhibits cyclooxygenase-2 expression and suppresses prostatic pain on capsaicin induced prostatitis model in rat. Chuang YC, etal., J Urol. 2008 Aug;180(2):742-8. Epub 2008 Jun 13.
27. Anti-inflammatory effect of low intensity ultrasound (LIUS) on complete Freund's adjuvant-induced arthritis synovium. Chung JI, etal., Osteoarthritis Cartilage. 2012 Jan 24.
28. A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke. Cipollone F, etal., JAMA. 2004 May 12;291(18):2221-8.
29. Progressive metaplastic and dysplastic changes in mouse pancreas induced by cyclooxygenase-2 overexpression. Colby JK, etal., Neoplasia. 2008 Aug;10(8):782-96.
30. Genetic Variations in Inflammatory Response Genes and Their Association with the Risk of Prostate Cancer. Cui X, etal., Biomed Res Int. 2015;2015:674039. doi: 10.1155/2015/674039. Epub 2015 Dec 14.
31. Prostaglandin-endoperoxide synthase genes COX1 and COX2 - novel modifiers of disease severity in cystic fibrosis patients. Czerska K, etal., J Appl Genet. 2010;51(3):323-30.
32. Different parkinsonism models produce a time-dependent induction of COX-2 in the substantia nigra of rats. de Meira Santos Lima M, etal., Brain Res. 2006 Jul 26;1101(1):117-25. Epub 2006 Jun 15.
33. Cyclooxygenases-1 and -2 are differentially localized to microglia and endothelium in rat EAE and glioma. Deininger MH and Schluesener HJ, J Neuroimmunol. 1999 Mar 1;95(1-2):202-8.
34. Cyclooxygenase (COX)-1 expressing macrophages/microglial cells and COX-2 expressing astrocytes accumulate during oligodendroglioma progression. Deininger MH, etal., Brain Res. 2000 Dec 1;885(1):111-6.
35. Cyclooxygenase-1 and -2 in brains of patients who died with sporadic Creutzfeldt-Jakob disease. Deininger MH, etal., J Mol Neurosci. 2003 Feb;20(1):25-30.
36. Hypoxia-induced hyperreactivity of pulmonary arteries: role of cyclooxygenase-2, isoprostanes, and thromboxane receptors. Delannoy E, etal., Cardiovasc Res. 2010 Feb 1;85(3):582-92. Epub 2009 Aug 26.
37. Protective effect of cyclooxygenase-2 (COX-2) inhibitors but not non-selective cyclooxygenase (COX)-inhibitors on ethanol withdrawal-induced behavioural changes. Dhir A, etal., Addict Biol. 2005 Dec;10(4):329-35.
38. Neuroprotective Effect of Cyclooxygenase Inhibitors in ICV-STZ Induced Sporadic Alzheimer's Disease in Rats. Dhull DK, etal., J Mol Neurosci. 2012 Jan;46(1):223-35. Epub 2011 Jun 24.
39. Celecoxib has Potent Antitumour Effects as a Single Agent and in Combination with BCG Immunotherapy in a Model of Urothelial Cell Carcinoma. Dovedi SJ, etal., Eur Urol. 2008 Sep;54(3):621-30. Epub 2008 Jan 15.
40. Cyclooxygenase-2 (Cox-2) in injured human nerve and a rat model of nerve injury. Durrenberger PF, etal., J Peripher Nerv Syst. 2004 Mar;9(1):15-25.
41. Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension. Eizayaga FX, etal., World J Gastroenterol. 2007 Oct 14;13(38):5065-5070.
42. CpG island hypermethylation at multiple gene sites in diagnosis and prognosis of prostate cancer. Ellinger J, etal., Urology. 2008 Jan;71(1):161-7.
43. Glutamine contributes to ameliorate inflammation after renal ischemia/reperfusion injury in rats. Esposito E, etal., Naunyn Schmiedebergs Arch Pharmacol. 2011 May;383(5):493-508. Epub 2011 Mar 11.
44. Berberine hydrochloride attenuates cyclooxygenase-2 expression in rat small intestinal mucosa during acute endotoxemia. Feng AW, etal., Fitoterapia. 2011 May 27.
45. Glutamine inhibits over-expression of pro-inflammatory genes and down-regulates the nuclear factor kappaB pathway in an experimental model of colitis in the rat. Fillmann H, etal., Toxicology. 2007 Jul 17;236(3):217-26. Epub 2007 Apr 27.
46. Cyclooxygenase-2 inhibition and hypoxia-induced pulmonary hypertension: effects on pulmonary vascular remodeling and contractility. Fredenburgh LE, etal., Trends Cardiovasc Med. 2009 Feb;19(2):31-7.
47. Expression of cyclooxygenase-2 in Wilms tumor: immunohistochemical study using tissue microarray methodology. Fridman E, etal., J Urol. 2006 Oct;176(4 Pt 2):1747-50.
48. Local and systemic expression of inducible nitric oxide synthase in comparison with that of cyclooxygenase-2 in rat carrageenin-induced pleurisy. Fujisawa H, etal., Nitric Oxide. 2005 Mar;12(2):80-8.
49. Delayed progression of pancreatic intraepithelial neoplasia in a conditional Kras(G12D) mouse model by a selective cyclooxygenase-2 inhibitor. Funahashi H, etal., Cancer Res. 2007 Aug 1;67(15):7068-71. Epub 2007 Jul 24.
50. Selective inhibition of cyclooxygenase-2 suppresses metastatic disease without affecting primary tumor growth in a murine model of Ewing sarcoma. Gendy AS, etal., J Pediatr Surg. 2011 Jan;46(1):108-14.
51. COX-2 polymorphisms -765G→C and -1195A→G and hepatocellular carcinoma risk. Gharib AF, etal., Gene. 2014 Jun 15;543(2):234-6. doi: 10.1016/j.gene.2014.04.014. Epub 2014 Apr 8.
52. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
53. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings. Graham GG, etal., Inflammopharmacology. 2013 Jun;21(3):201-32. doi: 10.1007/s10787-013-0172-x. Epub 2013 May 30.
54. Further assessment of the clinically effective dose range of etoricoxib: a randomized, double-blinded, placebo-controlled trial in rheumatoid arthritis. Greenwald M, etal., Curr Med Res Opin. 2011 Oct;27(10):2033-42. Epub 2011 Sep 12.
55. Prognostic Significance and Clinicopathological Associations of COX-2 SNP in Patients with Nonsmall Cell Lung Cancer. Grimminger PP, etal., J Oncol. 2009;2009:139590. Epub 2009 Nov 22.
56. Selective increase of neuronal cyclooxygenase-2 (COX-2) expression in vulnerable brain regions of rats with experimental Wernicke's encephalopathy: effect of nimesulide. Gu B, etal., Metab Brain Dis. 2008 Jun;23(2):175-87. Epub 2008 May 15.
57. COX-2 up-regulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic db/db mice. Guo Z, etal., Cardiovasc Res. 2005 Sep 1;67(4):723-35.
58. Possible role of cyclooxygenase-2 in schistosomal and non-schistosomal-associated bladder cancer. Hammam OA, etal., Medscape J Med. 2008 Mar 11;10(3):60.
59. Up-regulation of VEGF, c-fms and COX-2 expression correlates with severity of cervical cancer precursor (CIN) lesions and invasive disease. Hammes LS, etal., Gynecol Oncol. 2008 Jun 18.
60. Up-regulation of VEGF, c-fms and COX-2 expression correlates with severity of cervical cancer precursor (CIN) lesions and invasive disease. Hammes LS, etal., Gynecol Oncol. 2008 Sep;110(3):445-51. Epub 2008 Jun 20.
61. Transgenic expression of cyclooxygenase-2 in hepatocytes accelerates endotoxin-induced acute liver failure. Han C, etal., J Immunol. 2008 Dec 1;181(11):8027-35. doi: 10.4049/jimmunol.181.11.8027.
62. Cyclooxygenase-2/prostaglandin E2 accelerates the healing of gastric ulcers via EP4 receptors. Hatazawa R, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Oct;293(4):G788-97. Epub 2007 Aug 2.
63. Discovery of a novel COX-2 inhibitor as an orally potent anti-pyretic and anti-inflammatory drug: design, synthesis, and structure-activity relationship. Hayashi S, etal., Biochem Pharmacol. 2011 Oct 1;82(7):755-68. Epub 2011 Jul 2.
64. Effects of a cyclooxygenase 2 inhibitor on fracture healing in a rat model. Herbenick MA, etal., Am J Orthop (Belle Mead NJ). 2008 Jul;37(7):E133-7.
65. Expression of COX-2 is associated with accumulation of p53 in pancreatic cancer: analysis of COX-2 and p53 expression in premalignant and malignant ductal pancreatic lesions. Hermanova M, etal., Eur J Gastroenterol Hepatol. 2008 Aug;20(8):732-9.
66. Activity of the cyclooxygenase 2-prostaglandin-E prostanoid receptor pathway in mice exposed to house dust mite aeroallergens, and impact of exogenous prostaglandin E2. Herrerias A, etal., J Inflamm (Lond). 2009 Oct 30;6:30.
67. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. Hildebrandt MA, etal., PLoS One. 2010 Aug 25;5(8):e12402.
68. Prostanoids as regulators of innate and adaptive immunity. Hirata T and Narumiya S, Adv Immunol. 2012;116:143-74. doi: 10.1016/B978-0-12-394300-2.00005-3.
69. Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy. Holtman L, etal., Epilepsy Res. 2010 Sep;91(1):49-56.
70. Cyclo-oxygenases and prostaglandins in acute inflammatory demyelination of the peripheral nerve. Hu W, etal., Neurology. 2003 Dec 23;61(12):1774-9.
71. Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus. Hugyecz M, etal., Brain Res. 2011 Aug 2;1404:31-8. Epub 2011 Jun 12.
72. Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. Iadecola C, etal., Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1294-9.
73. Cardiovascular events in early RA are a result of inflammatory burden and traditional risk factors: a five year prospective study. Innala L, etal., Arthritis Res Ther. 2011 Aug 15;13(4):R131.
74. Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndrome. Ishiura Y, etal., Cough. 2010 Aug 9;6:7.
75. COX-2 inhibition attenuates cough reflex sensitivity to inhaled capsaicin in patients with asthma. Ishiura Y, etal., J Investig Allergol Clin Immunol. 2009;19(5):370-4.
76. Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea. Jelic S, etal., Circulation. 2008 Apr 29;117(17):2270-8. Epub 2008 Apr 14.
77. [Expressions and clinical significances of c-met, c-erbB-2, COX-2, and IL-6 in the biliary tract cancers] Joo HH, etal., Korean J Gastroenterol. 2007 Dec;50(6):370-8.
78. The pathophysiological roles of COX-1 and COX-2 in the intestinal smooth muscle contractility under the anaphylactic condition. Kadowaki H, etal., Biomed Res. 2008 Apr;29(2):113-7.
79. Suppressing inflammatory cascade by cyclo-oxygenase inhibitors attenuates quinolinic acid induced Huntington's disease-like alterations in rats. Kalonia H and Kumar A, Life Sci. 2011 Apr 25;88(17-18):784-91. Epub 2011 Feb 26.
80. Correlation of COX-2 expression in stromal cells with high stage, high grade, and poor prognosis in urothelial carcinoma of upper urinary tracts. Kang CH, etal., Urology. 2008 Jul;72(1):153-7. Epub 2008 Apr 8.
81. Rofecoxib inhibits cyclooxygenase 2 expression and activity and reduces cell proliferation in Barrett's esophagus. Kaur BS, etal., Gastroenterology. 2002 Jul;123(1):60-7.
82. Diclofenac, a selective COX-2 inhibitor, inhibits DMH-induced colon tumorigenesis through suppression of MCP-1, MIP-1alpha and VEGF. Kaur J and Sanyal SN, Mol Carcinog. 2011 Jan 25. doi: 10.1002/mc.20736.
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PMID:35724768   PMID:35806269   PMID:35818213   PMID:35910805   PMID:36050601   PMID:36362060   PMID:36375380   PMID:36424410   PMID:36757813   PMID:36799289   PMID:36978255   PMID:37113134  
PMID:37171246   PMID:37340393   PMID:37540709   PMID:37547718   PMID:37603513   PMID:37830191   PMID:37894811   PMID:37937500   PMID:37973216   PMID:37982895   PMID:38063088   PMID:38289394  
PMID:38313170   PMID:38334650   PMID:38426619   PMID:38524634   PMID:38555391   PMID:38583031  


Genomics

Comparative Map Data
PTGS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381186,671,791 - 186,680,423 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1186,671,791 - 186,680,922 (-)EnsemblGRCh38hg38GRCh38
GRCh371186,640,923 - 186,649,555 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361184,907,592 - 184,916,179 (-)NCBINCBI36Build 36hg18NCBI36
Build 341183,372,625 - 183,381,213NCBI
Celera1159,751,694 - 159,760,309 (-)NCBICelera
Cytogenetic Map1q31.1NCBI
HuRef1157,875,712 - 157,884,327 (-)NCBIHuRef
CHM1_11188,062,673 - 188,071,288 (-)NCBICHM1_1
T2T-CHM13v2.01186,026,616 - 186,035,248 (-)NCBIT2T-CHM13v2.0
Ptgs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391149,975,851 - 149,983,978 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1149,975,782 - 149,983,978 (+)EnsemblGRCm39 Ensembl
GRCm381150,100,031 - 150,108,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1150,100,031 - 150,108,227 (+)EnsemblGRCm38mm10GRCm38
MGSCv371151,947,254 - 151,955,147 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361151,862,342 - 151,870,235 (+)NCBIMGSCv36mm8
Celera1152,546,728 - 152,554,611 (+)NCBICelera
Cytogenetic Map1G1NCBI
cM Map163.84NCBI
Ptgs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81364,714,063 - 64,722,320 (+)NCBIGRCr8
mRatBN7.21362,163,936 - 62,172,193 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1362,163,932 - 62,172,188 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1364,798,537 - 64,804,239 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01366,083,346 - 66,089,057 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01363,344,882 - 63,350,588 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01367,351,230 - 67,356,920 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1367,351,087 - 67,359,335 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01372,315,959 - 72,324,483 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41364,427,288 - 64,432,978 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11364,441,245 - 64,449,480 (+)NCBI
Celera1362,129,439 - 62,135,131 (+)NCBICelera
Cytogenetic Map13q21NCBI
Ptgs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540625,079,945 - 25,086,171 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540625,077,988 - 25,086,259 (-)NCBIChiLan1.0ChiLan1.0
PTGS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2163,030,462 - 63,041,820 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1162,713,923 - 62,723,110 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01162,205,534 - 162,214,130 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11166,355,845 - 166,364,517 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,355,845 - 166,364,519 (-)Ensemblpanpan1.1panPan2
PTGS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1719,668,079 - 19,674,903 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl719,668,082 - 19,674,903 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha719,190,741 - 19,197,565 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0719,405,501 - 19,412,325 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl719,405,504 - 19,412,176 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1719,311,510 - 19,318,356 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0719,420,827 - 19,427,651 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0719,552,954 - 19,559,778 (-)NCBIUU_Cfam_GSD_1.0
Ptgs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934485,975,505 - 85,982,237 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049364813,821,564 - 3,828,086 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9127,850,015 - 127,858,884 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19127,850,164 - 127,858,866 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29140,251,667 - 140,260,362 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PTGS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12542,733,535 - 42,742,463 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2542,734,771 - 42,742,429 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605543,903,786 - 43,913,892 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptgs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248146,897,857 - 6,903,728 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248146,897,818 - 6,904,890 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PTGS2
23 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q25.3-31.1(chr1:182137726-186931125)x1 copy number loss See cases [RCV000053949] Chr1:182137726..186931125 [GRCh38]
Chr1:182106861..186900257 [GRCh37]
Chr1:180373484..185166880 [NCBI36]
Chr1:1q25.3-31.1		 pathogenic
GRCh38/hg38 1q25.2-32.1(chr1:179032905-199724897)x1 copy number loss See cases [RCV000053948] Chr1:179032905..199724897 [GRCh38]
Chr1:179002040..199694025 [GRCh37]
Chr1:177268663..197960648 [NCBI36]
Chr1:1q25.2-32.1		 pathogenic
NM_000963.3(PTGS2):c.1444G>A (p.Gly482Ser) single nucleotide variant Malignant melanoma [RCV000064390] Chr1:186674724 [GRCh38]
Chr1:186643856 [GRCh37]
Chr1:184910479 [NCBI36]
Chr1:1q31.1		 not provided
GRCh38/hg38 1q25.2-31.3(chr1:176595962-196301688)x1 copy number loss See cases [RCV000134144] Chr1:176595962..196301688 [GRCh38]
Chr1:176565098..196270818 [GRCh37]
Chr1:174831721..194537441 [NCBI36]
Chr1:1q25.2-31.3		 pathogenic
GRCh38/hg38 1q24.3-31.1(chr1:171039975-186875957)x3 copy number gain See cases [RCV000134876] Chr1:171039975..186875957 [GRCh38]
Chr1:171009116..186845089 [GRCh37]
Chr1:169275740..185111712 [NCBI36]
Chr1:1q24.3-31.1		 pathogenic
GRCh38/hg38 1q31.1(chr1:185959703-187743891)x3 copy number gain See cases [RCV000138114] Chr1:185959703..187743891 [GRCh38]
Chr1:185928835..187713022 [GRCh37]
Chr1:184195458..185979645 [NCBI36]
Chr1:1q31.1		 uncertain significance
GRCh38/hg38 1q24.3-31.2(chr1:170929720-191065409)x1 copy number loss See cases [RCV000142369] Chr1:170929720..191065409 [GRCh38]
Chr1:170898861..191034539 [GRCh37]
Chr1:169165485..189301162 [NCBI36]
Chr1:1q24.3-31.2		 pathogenic
GRCh38/hg38 1q31.1(chr1:185977899-187712734)x3 copy number gain See cases [RCV000142712] Chr1:185977899..187712734 [GRCh38]
Chr1:185947031..187681865 [GRCh37]
Chr1:184213654..185948488 [NCBI36]
Chr1:1q31.1		 uncertain significance
GRCh38/hg38 1q24.2-31.1(chr1:170036068-187555148)x1 copy number loss See cases [RCV000143688] Chr1:170036068..187555148 [GRCh38]
Chr1:170005209..187524280 [GRCh37]
Chr1:168271833..185790903 [NCBI36]
Chr1:1q24.2-31.1		 pathogenic
GRCh37/hg19 1q25.3-31.2(chr1:181572003-191524283)x1 copy number loss See cases [RCV000240242] Chr1:181572003..191524283 [GRCh37]
Chr1:1q25.3-31.2		 pathogenic
GRCh37/hg19 1q25.2-32.1(chr1:179413479-201764737)x1 copy number loss See cases [RCV000445748] Chr1:179413479..201764737 [GRCh37]
Chr1:1q25.2-32.1		 pathogenic
GRCh37/hg19 1q25.2-32.1(chr1:179073386-200192265)x1 copy number loss See cases [RCV000448809] Chr1:179073386..200192265 [GRCh37]
Chr1:1q25.2-32.1		 pathogenic
GRCh37/hg19 1q24.3-31.3(chr1:171990029-195086758)x1 copy number loss See cases [RCV000448686] Chr1:171990029..195086758 [GRCh37]
Chr1:1q24.3-31.3		 pathogenic
GRCh37/hg19 1q25.2-32.1(chr1:179011314-199022759)x1 copy number loss See cases [RCV000512128] Chr1:179011314..199022759 [GRCh37]
Chr1:1q25.2-32.1		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44		 pathogenic
GRCh37/hg19 1q25.1-31.1(chr1:173131908-187406532)x1 copy number loss not provided [RCV000736735] Chr1:173131908..187406532 [GRCh37]
Chr1:1q25.1-31.1		 pathogenic
GRCh37/hg19 1q31.1(chr1:186307064-186835137)x3 copy number gain not provided [RCV000736772] Chr1:186307064..186835137 [GRCh37]
Chr1:1q31.1		 benign
GRCh37/hg19 1q25.3-41(chr1:185644663-221698833)x3 copy number gain not provided [RCV000749265] Chr1:185644663..221698833 [GRCh37]
Chr1:1q25.3-41		 pathogenic
NM_000963.4(PTGS2):c.720T>C (p.Tyr240=) single nucleotide variant not provided [RCV000943746] Chr1:186676836 [GRCh38]
Chr1:186645968 [GRCh37]
Chr1:1q31.1		 likely benign
NM_000963.4(PTGS2):c.258C>T (p.Asn86=) single nucleotide variant not provided [RCV000937152] Chr1:186679113 [GRCh38]
Chr1:186648245 [GRCh37]
Chr1:1q31.1		 likely benign
NM_000963.4(PTGS2):c.1257+8T>C single nucleotide variant not provided [RCV000927029] Chr1:186675890 [GRCh38]
Chr1:186645022 [GRCh37]
Chr1:1q31.1		 likely benign
NM_000963.4(PTGS2):c.*427T>C single nucleotide variant Cholangiocarcinoma [RCV003312793] Chr1:186673926 [GRCh38]
Chr1:186643058 [GRCh37]
Chr1:1q31.1		 other
NM_000963.4(PTGS2):c.640-9A>C single nucleotide variant not provided [RCV000937875] Chr1:186676925 [GRCh38]
Chr1:186646057 [GRCh37]
Chr1:1q31.1		 likely benign
GRCh37/hg19 1q25.3-44(chr1:182388773-249111240)x3 copy number gain not provided [RCV000845852] Chr1:182388773..249111240 [GRCh37]
Chr1:1q25.3-44		 pathogenic
NM_000963.4(PTGS2):c.1209T>C (p.His403=) single nucleotide variant not provided [RCV000961339] Chr1:186675946 [GRCh38]
Chr1:186645078 [GRCh37]
Chr1:1q31.1		 benign
NM_000963.4(PTGS2):c.900T>C (p.Asp300=) single nucleotide variant not provided [RCV000961340] Chr1:186676537 [GRCh38]
Chr1:186645669 [GRCh37]
Chr1:1q31.1		 benign
NR_125801.1(PACERR):n.536C>G single nucleotide variant Cholangiocarcinoma [RCV003312794] Chr1:186681189 [GRCh38]
Chr1:186650321 [GRCh37]
Chr1:1q31.1		 other
NM_000963.4(PTGS2):c.457+9G>A single nucleotide variant not provided [RCV000953012] Chr1:186678252 [GRCh38]
Chr1:186647384 [GRCh37]
Chr1:1q31.1		 benign
NM_000963.4(PTGS2):c.390C>T (p.Asn130=) single nucleotide variant not provided [RCV000953013] Chr1:186678328 [GRCh38]
Chr1:186647460 [GRCh37]
Chr1:1q31.1		 likely benign
NM_000963.4(PTGS2):c.1098A>G (p.Glu366=) single nucleotide variant not provided [RCV000926254] Chr1:186676057 [GRCh38]
Chr1:186645189 [GRCh37]
Chr1:1q31.1		 likely benign
NM_000963.4(PTGS2):c.1755C>A (p.Arg585=) single nucleotide variant not provided [RCV000894301] Chr1:186674413 [GRCh38]
Chr1:186643545 [GRCh37]
Chr1:1q31.1		 benign
NM_000963.4(PTGS2):c.1767T>C (p.Asp589=) single nucleotide variant not provided [RCV000911775] Chr1:186674401 [GRCh38]
Chr1:186643533 [GRCh37]
Chr1:1q31.1		 likely benign
NM_000963.4(PTGS2):c.1497G>A (p.Arg499=) single nucleotide variant not provided [RCV000890505] Chr1:186674671 [GRCh38]
Chr1:186643803 [GRCh37]
Chr1:1q31.1		 likely benign
GRCh37/hg19 1q31.1(chr1:186137950-187028283)x3 copy number gain not provided [RCV002473872] Chr1:186137950..187028283 [GRCh37]
Chr1:1q31.1		 uncertain significance
GRCh37/hg19 1q25.2-32.1(chr1:177551193-199599056)x1 copy number loss not provided [RCV001005157] Chr1:177551193..199599056 [GRCh37]
Chr1:1q25.2-32.1		 pathogenic
NC_000001.10:g.(?_130980840)_(248900000_?)dup duplication Gastrointestinal stromal tumor [RCV001300221]|Parathyroid carcinoma [RCV001341077] Chr1:130980840..248900000 [GRCh37]
Chr1:1q12-44		 uncertain significance
GRCh37/hg19 1q25.2-32.1(chr1:179073386-200192265) copy number loss not specified [RCV002053769] Chr1:179073386..200192265 [GRCh37]
Chr1:1q25.2-32.1		 pathogenic
GRCh37/hg19 1q24.3-31.3(chr1:171990029-195086758) copy number loss not specified [RCV002053736] Chr1:171990029..195086758 [GRCh37]
Chr1:1q24.3-31.3		 pathogenic
GRCh37/hg19 1q25.2-32.1(chr1:179413479-201764737) copy number loss not specified [RCV002053780] Chr1:179413479..201764737 [GRCh37]
Chr1:1q25.2-32.1		 pathogenic
GRCh37/hg19 1q25.2-31.1(chr1:178522021-190322133)x1 copy number loss not provided [RCV001836604] Chr1:178522021..190322133 [GRCh37]
Chr1:1q25.2-31.1		 pathogenic
NC_000001.10:g.(?_185703912)_(186957640_?)dup duplication not provided [RCV003122652] Chr1:185703912..186957640 [GRCh37]
Chr1:1q25.3-31.1		 uncertain significance
GRCh37/hg19 1q25.2-31.2(chr1:179727182-192260142)x1 copy number loss not provided [RCV002473949] Chr1:179727182..192260142 [GRCh37]
Chr1:1q25.2-31.2		 pathogenic
NM_000963.4(PTGS2):c.533A>G (p.Gln178Arg) single nucleotide variant not specified [RCV004128638] Chr1:186677755 [GRCh38]
Chr1:186646887 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_000963.4(PTGS2):c.1306G>T (p.Ala436Ser) single nucleotide variant not specified [RCV004087390] Chr1:186675348 [GRCh38]
Chr1:186644480 [GRCh37]
Chr1:1q31.1		 uncertain significance
GRCh37/hg19 1q25.3-32.3(chr1:181453460-213107248)x3 copy number gain not provided [RCV002475637] Chr1:181453460..213107248 [GRCh37]
Chr1:1q25.3-32.3		 pathogenic
NM_000963.4(PTGS2):c.1586C>T (p.Ala529Val) single nucleotide variant not specified [RCV004172260] Chr1:186674582 [GRCh38]
Chr1:186643714 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_000963.4(PTGS2):c.1413G>C (p.Lys471Asn) single nucleotide variant not specified [RCV004130927] Chr1:186674755 [GRCh38]
Chr1:186643887 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_000963.4(PTGS2):c.1423G>A (p.Ala475Thr) single nucleotide variant not specified [RCV004174670] Chr1:186674745 [GRCh38]
Chr1:186643877 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_000963.4(PTGS2):c.1742C>G (p.Ala581Gly) single nucleotide variant not specified [RCV004282751] Chr1:186674426 [GRCh38]
Chr1:186643558 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_000963.4(PTGS2):c.380C>G (p.Ala127Gly) single nucleotide variant not specified [RCV004285071] Chr1:186678338 [GRCh38]
Chr1:186647470 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_000963.4(PTGS2):c.1733C>G (p.Thr578Ser) single nucleotide variant not specified [RCV004348363] Chr1:186674435 [GRCh38]
Chr1:186643567 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_000963.4(PTGS2):c.217A>G (p.Thr73Ala) single nucleotide variant not specified [RCV004362031] Chr1:186679154 [GRCh38]
Chr1:186648286 [GRCh37]
Chr1:1q31.1		 uncertain significance
GRCh37/hg19 1q24.2-31.1(chr1:167994071-187711459)x1 copy number loss not specified [RCV003987250] Chr1:167994071..187711459 [GRCh37]
Chr1:1q24.2-31.1		 pathogenic
NM_000963.4(PTGS2):c.1733C>T (p.Thr578Ile) single nucleotide variant not specified [RCV004515728] Chr1:186674435 [GRCh38]
Chr1:186643567 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_000963.4(PTGS2):c.1784T>C (p.Val595Ala) single nucleotide variant not specified [RCV004515729] Chr1:186674384 [GRCh38]
Chr1:186643516 [GRCh37]
Chr1:1q31.1		 uncertain significance
NM_000963.4(PTGS2):c.299G>A (p.Ser100Asn) single nucleotide variant not specified [RCV004515730] Chr1:186679072 [GRCh38]
Chr1:186648204 [GRCh37]
Chr1:1q31.1		 uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR101-2hsa-miR-101-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19133256
MIR101-2hsa-miR-101-3pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI23013439
MIR101-2hsa-miR-101-3pOncomiRDBexternal_infoNANA23013439
MIR16-1hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23226427
MIR26Bhsa-miR-26b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blot//Reporter Functional MTI20100477
MIR26Bhsa-miR-26b-5pTarbaseexternal_infoReporter GenePOSITIVE
MIR26Bhsa-miR-26b-5pOncomiRDBexternal_infoNANA23374284
MIR137hsa-miR-137Mirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22406049
MIR101-1hsa-miR-101-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19133256
MIR101-1hsa-miR-101-3pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI23013439
MIR101-1hsa-miR-101-3pOncomiRDBexternal_infoNANA23013439
MIR16-2hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23226427

Predicted Target Of
Summary Value
Count of predictions:1967
Count of miRNA genes:906
Interacting mature miRNAs:1072
Transcripts:ENST00000367468, ENST00000466691, ENST00000490885, ENST00000559627, ENST00000559800
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
G63797  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,650,272 - 186,650,723UniSTSGRCh37
Build 361184,916,895 - 184,917,346RGDNCBI36
Celera1159,761,022 - 159,761,473RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,885,040 - 157,885,491UniSTS
G63796  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,649,852 - 186,650,329UniSTSGRCh37
Build 361184,916,475 - 184,916,952RGDNCBI36
Celera1159,760,602 - 159,761,079RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,884,620 - 157,885,097UniSTS
G63795  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,649,474 - 186,649,906UniSTSGRCh37
Build 361184,916,097 - 184,916,529RGDNCBI36
Celera1159,760,224 - 159,760,656RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,884,242 - 157,884,674UniSTS
G63807  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,649,248 - 186,649,587UniSTSGRCh37
Build 361184,915,871 - 184,916,210RGDNCBI36
Celera1159,759,998 - 159,760,337RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,884,016 - 157,884,355UniSTS
G63794  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,648,142 - 186,648,604UniSTSGRCh37
Build 361184,914,765 - 184,915,227RGDNCBI36
Celera1159,758,892 - 159,759,354RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,882,910 - 157,883,372UniSTS
G63806  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,647,381 - 186,647,639UniSTSGRCh37
Build 361184,914,004 - 184,914,262RGDNCBI36
Celera1159,758,131 - 159,758,389RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,882,149 - 157,882,407UniSTS
G63790  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,644,339 - 186,644,614UniSTSGRCh37
Build 361184,910,962 - 184,911,237RGDNCBI36
Celera1159,755,089 - 159,755,364RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,879,107 - 157,879,382UniSTS
G63789  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,643,522 - 186,643,926UniSTSGRCh37
Build 361184,910,145 - 184,910,549RGDNCBI36
Celera1159,754,272 - 159,754,676RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,878,290 - 157,878,694UniSTS
G63792  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,645,956 - 186,646,409UniSTSGRCh37
Build 361184,912,579 - 184,913,032RGDNCBI36
Celera1159,756,706 - 159,757,159RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,880,724 - 157,881,177UniSTS
G63793  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,645,540 - 186,645,927UniSTSGRCh37
Build 361184,912,163 - 184,912,550RGDNCBI36
Celera1159,756,290 - 159,756,677RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,880,308 - 157,880,695UniSTS
G63791  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,644,967 - 186,645,422UniSTSGRCh37
Build 361184,911,590 - 184,912,045RGDNCBI36
Celera1159,755,717 - 159,756,172RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,879,735 - 157,880,190UniSTS
GDB:455285  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,643,613 - 186,643,810UniSTSGRCh37
Build 361184,910,236 - 184,910,433RGDNCBI36
Celera1159,754,363 - 159,754,560RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,878,381 - 157,878,578UniSTS
G65466  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,642,429 - 186,642,927UniSTSGRCh37
Build 361184,909,052 - 184,909,550RGDNCBI36
Celera1159,753,179 - 159,753,677RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,877,197 - 157,877,695UniSTS
G65467  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,642,122 - 186,642,643UniSTSGRCh37
Build 361184,908,745 - 184,909,266RGDNCBI36
Celera1159,752,872 - 159,753,393RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,876,890 - 157,877,411UniSTS
G65468  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,641,748 - 186,642,284UniSTSGRCh37
Build 361184,908,371 - 184,908,907RGDNCBI36
Celera1159,752,498 - 159,753,034RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,876,516 - 157,877,052UniSTS
G65469  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,641,333 - 186,641,877UniSTSGRCh37
Build 361184,907,956 - 184,908,500RGDNCBI36
Celera1159,752,083 - 159,752,627RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,876,101 - 157,876,645UniSTS
G65470  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,641,054 - 186,641,450UniSTSGRCh37
Build 361184,907,677 - 184,908,073RGDNCBI36
Celera1159,751,804 - 159,752,200RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,875,822 - 157,876,218UniSTS
G65471  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,640,694 - 186,641,271UniSTSGRCh37
Build 361184,907,317 - 184,907,894RGDNCBI36
Celera1159,751,444 - 159,752,021RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,875,462 - 157,876,039UniSTS
G65464  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,650,636 - 186,651,232UniSTSGRCh37
Build 361184,917,259 - 184,917,855RGDNCBI36
Celera1159,761,386 - 159,761,982RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,885,404 - 157,886,000UniSTS
G65465  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,643,155 - 186,643,649UniSTSGRCh37
Build 361184,909,778 - 184,910,272RGDNCBI36
Celera1159,753,905 - 159,754,399RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,877,923 - 157,878,417UniSTS
D1S3433  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,641,919 - 186,642,262UniSTSGRCh37
Build 361184,908,542 - 184,908,885RGDNCBI36
Celera1159,752,669 - 159,753,012RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,876,687 - 157,877,030UniSTS
TNG Radiation Hybrid Map189349.0UniSTS
Stanford-G3 RH Map17267.0UniSTS
Whitehead-YAC Contig Map1 UniSTS
NCBI RH Map11573.4UniSTS
GeneMap99-G3 RH Map17223.0UniSTS
G67929  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,648,041 - 186,648,449UniSTSGRCh37
Build 361184,914,664 - 184,915,072RGDNCBI36
Celera1159,758,791 - 159,759,199RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,882,809 - 157,883,217UniSTS
G67930  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,645,558 - 186,646,015UniSTSGRCh37
Build 361184,912,181 - 184,912,638RGDNCBI36
Celera1159,756,308 - 159,756,765RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,880,326 - 157,880,783UniSTS
csnpptgs2-pcr10-1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,643,345 - 186,644,008UniSTSGRCh37
Build 361184,909,968 - 184,910,631RGDNCBI36
Celera1159,754,095 - 159,754,758RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,878,113 - 157,878,776UniSTS
csnpptgs2-pcr6-1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,645,769 - 186,646,235UniSTSGRCh37
Build 361184,912,392 - 184,912,858RGDNCBI36
Celera1159,756,519 - 159,756,985RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,880,537 - 157,881,003UniSTS
csnpptgs2-pcr8-1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,644,810 - 186,645,387UniSTSGRCh37
Build 361184,911,433 - 184,912,010RGDNCBI36
Celera1159,755,560 - 159,756,137RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,879,578 - 157,880,155UniSTS
PMC100312P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,649,358 - 186,649,963UniSTSGRCh37
Build 361184,915,981 - 184,916,586RGDNCBI36
Celera1159,760,108 - 159,760,713RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,884,126 - 157,884,731UniSTS
PMC309638P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,649,550 - 186,649,855UniSTSGRCh37
Build 361184,916,173 - 184,916,478RGDNCBI36
Celera1159,760,300 - 159,760,605RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,884,318 - 157,884,623UniSTS
PTGS2_236  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,640,835 - 186,641,651UniSTSGRCh37
Build 361184,907,458 - 184,908,274RGDNCBI36
Celera1159,751,585 - 159,752,401RGD
HuRef1157,875,603 - 157,876,419UniSTS
SHGC-76038  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,641,080 - 186,641,352UniSTSGRCh37
Build 361184,907,703 - 184,907,975RGDNCBI36
Celera1159,751,830 - 159,752,102RGD
Cytogenetic Map1q25.2-q25.3UniSTS
HuRef1157,875,848 - 157,876,120UniSTS
TNG Radiation Hybrid Map189349.0UniSTS
GeneMap99-GB4 RH Map1639.22UniSTS
PTGS2-235F  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371186,646,850 - 186,648,536UniSTSGRCh37
Celera1159,757,600 - 159,759,286UniSTS
HuRef1157,881,618 - 157,883,304UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 1 1 2 4
Medium 732 872 210 39 327 39 414 163 151 82 279 652 12 1 269 297 3
Low 1464 1741 1307 418 1018 282 2734 1022 2679 289 808 825 140 832 1614 1
Below cutoff 215 371 192 153 387 131 1188 991 882 40 349 91 22 103 867 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_028206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000963 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF044206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF276953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ634912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL033533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY151286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY229989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY382629 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY462100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM978796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D28235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA277667 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC025790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI519548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM473188 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF455116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L15326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L34209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M90100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U04636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U20548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U44805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000367468   ⟹   ENSP00000356438
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1186,671,791 - 186,680,423 (-)Ensembl
RefSeq Acc Id: ENST00000466691
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1186,674,496 - 186,675,869 (-)Ensembl
RefSeq Acc Id: ENST00000490885
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1186,672,893 - 186,680,423 (-)Ensembl
RefSeq Acc Id: ENST00000559627   ⟹   ENSP00000454130
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1186,674,353 - 186,680,290 (-)Ensembl
RefSeq Acc Id: ENST00000559800
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1186,678,270 - 186,680,423 (-)Ensembl
RefSeq Acc Id: ENST00000680451   ⟹   ENSP00000506242
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1186,671,791 - 186,680,922 (-)Ensembl
RefSeq Acc Id: ENST00000681605   ⟹   ENSP00000504900
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1186,671,791 - 186,680,423 (-)Ensembl
RefSeq Acc Id: NM_000963   ⟹   NP_000954
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381186,671,791 - 186,680,423 (-)NCBI
GRCh371186,640,944 - 186,649,559 (-)ENTREZGENE
Build 361184,907,592 - 184,916,179 (-)NCBI Archive
HuRef1157,875,712 - 157,884,327 (-)ENTREZGENE
CHM1_11188,062,673 - 188,071,288 (-)NCBI
T2T-CHM13v2.01186,026,616 - 186,035,248 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_000954   ⟸   NM_000963
- Peptide Label: precursor
- UniProtKB: A8K802 (UniProtKB/Swiss-Prot),   Q16876 (UniProtKB/Swiss-Prot),   P35354 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000454130   ⟸   ENST00000559627
RefSeq Acc Id: ENSP00000356438   ⟸   ENST00000367468
RefSeq Acc Id: ENSP00000506242   ⟸   ENST00000680451
RefSeq Acc Id: ENSP00000504900   ⟸   ENST00000681605
Protein Domains
EGF-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35354-F1-model_v2 AlphaFold P35354 1-604 view protein structure

Promoters
RGD ID:6786343
Promoter ID:HG_KWN:6588
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3
Transcripts:OTTHUMT00000086159
Position:
Human AssemblyChrPosition (strand)Source
Build 361184,911,791 - 184,912,542 (-)MPROMDB
RGD ID:6784961
Promoter ID:HG_KWN:6589
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   Lymphoblastoid
Transcripts:OTTHUMT00000086157,   OTTHUMT00000086158,   UC009WYO.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361184,916,046 - 184,916,546 (-)MPROMDB
RGD ID:6858410
Promoter ID:EPDNEW_H2370
Type:initiation region
Name:PTGS2_1
Description:prostaglandin-endoperoxide synthase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381186,680,423 - 186,680,483EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9605 AgrOrtholog
COSMIC PTGS2 COSMIC
Ensembl Genes ENSG00000073756 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000367468 ENTREZGENE
  ENST00000367468.10 UniProtKB/Swiss-Prot
  ENST00000559627.1 UniProtKB/TrEMBL
  ENST00000680451.1 UniProtKB/Swiss-Prot
  ENST00000681605.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.640.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000073756 GTEx
HGNC ID HGNC:9605 ENTREZGENE
Human Proteome Map PTGS2 Human Proteome Map
InterPro EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_animal UniProtKB/Swiss-Prot
  Haem_peroxidase_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_peroxidase_sf_animal UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5743 UniProtKB/Swiss-Prot
NCBI Gene 5743 ENTREZGENE
OMIM 600262 OMIM
PANTHER PROSTAGLANDIN G/H SYNTHASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11903:SF8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam An_peroxidase UniProtKB/Swiss-Prot
  EGF UniProtKB/TrEMBL
PharmGKB PA293 PharmGKB, RGD
PRINTS ANPEROXIDASE UniProtKB/Swiss-Prot
PROSITE EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PEROXIDASE_3 UniProtKB/Swiss-Prot
Superfamily-SCOP EGF/Laminin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A7P0T828_HUMAN UniProtKB/TrEMBL
  A8K802 ENTREZGENE
  D9MWI3_HUMAN UniProtKB/TrEMBL
  P35354 ENTREZGENE, UniProtKB/Swiss-Prot
  Q16876 ENTREZGENE
  Q6ZYK7_HUMAN UniProtKB/TrEMBL
  Q9NNY7_HUMAN UniProtKB/TrEMBL
UniProt Secondary A8K802 UniProtKB/Swiss-Prot
  Q16876 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-02 PTGS2  prostaglandin-endoperoxide synthase 2  PTGS2  prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)  Symbol and/or name change 5135510 APPROVED