MIR16-1 (microRNA 16-1) - Rat Genome Database

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Pathways
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Gene: MIR16-1 (microRNA 16-1) Homo sapiens
Analyze
Symbol: MIR16-1
Name: microRNA 16-1
RGD ID: 1346096
HGNC Page HGNC:31545
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in several processes, including negative regulation of cellular response to growth factor stimulus; regulation of gene expression; and regulation of vasculature development. Acts upstream of or within regulation of glucosylceramide catabolic process. Located in extracellular exosome.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-16-1; MIRN16-1; miRNA16-1
RGD Orthologs
Mouse
Dog
Pig
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381350,048,973 - 50,049,061 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1350,048,973 - 50,049,061 (-)EnsemblGRCh38hg38GRCh38
GRCh371350,623,109 - 50,623,197 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361349,521,109 - 49,521,197 (-)NCBINCBI36Build 36hg18NCBI36
Celera1331,677,674 - 31,677,762 (-)NCBICelera
Cytogenetic Map13q14.2NCBI
HuRef1331,418,104 - 31,418,192 (-)NCBIHuRef
CHM1_11350,590,897 - 50,590,985 (-)NCBICHM1_1
T2T-CHM13v2.01349,269,562 - 49,269,650 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
BMP signaling pathway  (ISO)
branching involved in blood vessel morphogenesis  (IDA)
cellular response to glucose stimulus  (IDA)
cellular response to leukemia inhibitory factor  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (IDA,IGI)
miRNA-mediated gene silencing by mRNA destabilization  (IDA)
miRNA-mediated post-transcriptional gene silencing  (HDA,IDA,IEA)
negative regulation of angiogenesis  (IDA)
negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IDA)
negative regulation of canonical NF-kappaB signal transduction  (IDA)
negative regulation of cell chemotaxis to fibroblast growth factor  (IDA)
negative regulation of cell migration involved in sprouting angiogenesis  (IDA,IMP)
negative regulation of cell population proliferation  (IGI)
negative regulation of cytokine production involved in inflammatory response  (ISS)
negative regulation of endothelial cell chemotaxis  (IDA)
negative regulation of endothelial cell chemotaxis to fibroblast growth factor  (IDA)
negative regulation of endothelial cell proliferation  (IDA)
negative regulation of fibroblast growth factor receptor signaling pathway  (IDA)
negative regulation of G1/S transition of mitotic cell cycle  (IDA,IGI,IMP)
negative regulation of inflammatory response  (IDA)
negative regulation of mesenchymal stem cell proliferation  (IMP)
negative regulation of mitotic cell cycle  (ISS)
negative regulation of placenta blood vessel development  (IDA)
negative regulation of trophoblast cell migration  (IMP)
negative regulation of vascular endothelial growth factor production  (HMP,IMP)
negative regulation of vascular endothelial growth factor signaling pathway  (IDA,IMP)
ossification  (ISO)
positive regulation of apoptotic process  (IDA)
positive regulation of cardiac muscle cell apoptotic process  (ISS)
positive regulation of connective tissue replacement  (ISS)
positive regulation of intrinsic apoptotic signaling pathway  (IGI)
positive regulation of translation  (IGI)
regulation of cell cycle  (ISO)
regulation of glucosylceramide catabolic process  (IGI)
response to bacterium  (ISO)
response to oxygen levels  (ISO)
response to wounding  (ISO)
sensory perception of sound  (ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11679670   PMID:11914277   PMID:12434020   PMID:12624257   PMID:14573789   PMID:15131085   PMID:15183728   PMID:15325244   PMID:15766526   PMID:16166262   PMID:16381832   PMID:17604727  
PMID:17616659   PMID:18320040   PMID:18362358   PMID:18449891   PMID:18483394   PMID:18708755   PMID:18759964   PMID:18766170   PMID:18854308   PMID:19144909   PMID:19148136   PMID:19250063  
PMID:19347735   PMID:19401561   PMID:19498445   PMID:19779621   PMID:19823025   PMID:19865490   PMID:19883312   PMID:20060366   PMID:20159880   PMID:20621999   PMID:20626035   PMID:20647767  
PMID:20876285   PMID:21037258   PMID:21130495   PMID:21205891   PMID:21336967   PMID:21354921   PMID:21400525   PMID:21454377   PMID:21472816   PMID:21532615   PMID:21575235   PMID:21602527  
PMID:21778999   PMID:21885851   PMID:22002311   PMID:22049078   PMID:22049153   PMID:22096249   PMID:22133358   PMID:22139073   PMID:22249219   PMID:22292036   PMID:22564678   PMID:22574716  
PMID:22583478   PMID:22677435   PMID:22684875   PMID:22781767   PMID:22922827   PMID:22940131   PMID:22959509   PMID:23083510   PMID:23104180   PMID:23175429   PMID:23226427   PMID:23233752  
PMID:23260326   PMID:23325924   PMID:23380758   PMID:23487264   PMID:23507142   PMID:23613938   PMID:23649629   PMID:23686310   PMID:23783433   PMID:23897768   PMID:23907579   PMID:23954293  
PMID:23991964   PMID:24026141   PMID:24026226   PMID:24045965   PMID:24086143   PMID:24089558   PMID:24148817   PMID:24285725   PMID:24391925   PMID:24392455   PMID:24418124   PMID:24500260  
PMID:24600978   PMID:24650689   PMID:24710569   PMID:24732594   PMID:24852767   PMID:24885794   PMID:24916701   PMID:24971479   PMID:25033200   PMID:25040181   PMID:25054189   PMID:25227104  
PMID:25249297   PMID:25261849   PMID:25336585   PMID:25367852   PMID:25403480   PMID:25405832   PMID:25435430   PMID:25584808   PMID:25594541   PMID:25641414   PMID:25662703   PMID:25672252  
PMID:25738263   PMID:25743273   PMID:25815587   PMID:25830480   PMID:25888955   PMID:25979194   PMID:26031775   PMID:26071245   PMID:26073083   PMID:26133725   PMID:26223652   PMID:26350536  
PMID:26440600   PMID:26474056   PMID:26499886   PMID:26516702   PMID:26597031   PMID:26640145   PMID:26646931   PMID:26656154   PMID:26722459   PMID:26821018   PMID:26908869   PMID:26918603  
PMID:26968104   PMID:27055667   PMID:27064390   PMID:27305142   PMID:27343180   PMID:27476546   PMID:27605261   PMID:27683052   PMID:27713175   PMID:27748453   PMID:27748823   PMID:27846323  
PMID:27854515   PMID:27857191   PMID:27875659   PMID:27930363   PMID:28082316   PMID:28159509   PMID:28261881   PMID:28299339   PMID:28303998   PMID:28377382   PMID:28431233   PMID:28628119  
PMID:28634901   PMID:28667493   PMID:28798470   PMID:28859135   PMID:28968438   PMID:29044221   PMID:29094504   PMID:29138833   PMID:29180670   PMID:29259008   PMID:29299981   PMID:29355387  
PMID:29359963   PMID:29383679   PMID:29399695   PMID:29484411   PMID:29522280   PMID:29559751   PMID:29687850   PMID:29739419   PMID:29771408   PMID:29880900   PMID:29935185   PMID:29955039  
PMID:30025387   PMID:30132525   PMID:30136280   PMID:30154547   PMID:30178829   PMID:30252587   PMID:30365148   PMID:30536619   PMID:30548945   PMID:30552617   PMID:30582201   PMID:30657555  
PMID:30706130   PMID:30753902   PMID:30861602   PMID:30911942   PMID:30942450   PMID:30957556   PMID:31018244   PMID:31102273   PMID:31232026   PMID:31298377   PMID:31355416   PMID:31379227  
PMID:31383786   PMID:31406207   PMID:31427084   PMID:31568645   PMID:31640928   PMID:31643078   PMID:31648231   PMID:31801064   PMID:31841182   PMID:31872565   PMID:31876684   PMID:32024878  
PMID:32027086   PMID:32054948   PMID:32057163   PMID:32307795   PMID:32345959   PMID:32369253   PMID:32424097   PMID:32486604   PMID:32502422   PMID:32513543   PMID:32513696   PMID:32524326  
PMID:32705237   PMID:32774515   PMID:32954360   PMID:33015786   PMID:33051165   PMID:33095833   PMID:33141998   PMID:33148068   PMID:33155198   PMID:33264723   PMID:33338854   PMID:33411678  
PMID:33467738   PMID:33545201   PMID:33548740   PMID:33751108   PMID:33789312   PMID:33824285   PMID:33836616   PMID:33970852   PMID:33975517   PMID:34022711   PMID:34580516   PMID:34592064  
PMID:34627262   PMID:34791478   PMID:35064090   PMID:35162959   PMID:35536149   PMID:35593364   PMID:35666610   PMID:36029069   PMID:36111932   PMID:36177782   PMID:36202613   PMID:36476595  
PMID:36484570   PMID:36555676   PMID:37055445   PMID:37549238   PMID:37602450   PMID:38514064  


Genomics

Comparative Map Data
MIR16-1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381350,048,973 - 50,049,061 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1350,048,973 - 50,049,061 (-)EnsemblGRCh38hg38GRCh38
GRCh371350,623,109 - 50,623,197 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361349,521,109 - 49,521,197 (-)NCBINCBI36Build 36hg18NCBI36
Celera1331,677,674 - 31,677,762 (-)NCBICelera
Cytogenetic Map13q14.2NCBI
HuRef1331,418,104 - 31,418,192 (-)NCBIHuRef
CHM1_11350,590,897 - 50,590,985 (-)NCBICHM1_1
T2T-CHM13v2.01349,269,562 - 49,269,650 (-)NCBIT2T-CHM13v2.0
Mir16-1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391461,869,329 - 61,869,421 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1461,869,329 - 61,869,421 (-)EnsemblGRCm39 Ensembl
GRCm381461,631,880 - 61,631,972 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1461,631,880 - 61,631,972 (-)EnsemblGRCm38mm10GRCm38
MGSCv371462,250,717 - 62,250,809 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1459,399,318 - 59,399,410 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.16NCBI
MIR16-1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1221,847,020 - 1,847,084 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl221,847,007 - 1,847,093 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha221,876,178 - 1,876,242 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0221,834,663 - 1,834,727 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1221,746,705 - 1,746,769 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0221,795,850 - 1,795,914 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0221,814,295 - 1,814,359 (+)NCBIUU_Cfam_GSD_1.0
MIR16-2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1117,757,601 - 17,757,687 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11117,757,606 - 17,757,684 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh37/hg19 13q11-34(chr13:19053605-115108528)x3 copy number gain See cases [RCV001353184] Chr13:19053605..115108528 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh38/hg38 13q12.3-31.3(chr13:31363472-90575292)x3 copy number gain See cases [RCV000050293] Chr13:31363472..90575292 [GRCh38]
Chr13:31937609..91227546 [GRCh37]
Chr13:30835609..90025547 [NCBI36]
Chr13:13q12.3-31.3		 pathogenic
GRCh38/hg38 13q14.12-31.3(chr13:44967523-92738168)x1 copy number loss See cases [RCV000050891] Chr13:44967523..92738168 [GRCh38]
Chr13:45541658..93390421 [GRCh37]
Chr13:44439658..92188422 [NCBI36]
Chr13:13q14.12-31.3		 pathogenic
GRCh38/hg38 13q12.3-21.33(chr13:30697728-69471973)x1 copy number loss See cases [RCV000051373] Chr13:30697728..69471973 [GRCh38]
Chr13:31271865..70046105 [GRCh37]
Chr13:30169865..68944106 [NCBI36]
Chr13:13q12.3-21.33		 pathogenic
GRCh38/hg38 13q12.11-34(chr13:18946182-114304628)x3 copy number gain See cases [RCV000053726] Chr13:18946182..114304628 [GRCh38]
Chr13:19520322..115070103 [GRCh37]
Chr13:18418322..114088205 [NCBI36]
Chr13:13q12.11-34		 pathogenic
GRCh38/hg38 13q12.11-34(chr13:19837395-114327173)x3 copy number gain See cases [RCV000053731] Chr13:19837395..114327173 [GRCh38]
Chr13:20411535..115085141 [GRCh37]
Chr13:19309535..114110750 [NCBI36]
Chr13:13q12.11-34		 pathogenic
GRCh38/hg38 13q12.3-31.1(chr13:30318913-83610426)x3 copy number gain See cases [RCV000053737] Chr13:30318913..83610426 [GRCh38]
Chr13:30893050..84184561 [GRCh37]
Chr13:29791050..83082562 [NCBI36]
Chr13:13q12.3-31.1		 pathogenic
GRCh38/hg38 13q11-34(chr13:18565048-114327173)x3 copy number gain See cases [RCV000053719] Chr13:18565048..114327173 [GRCh38]
Chr13:19139188..115085141 [GRCh37]
Chr13:18037188..114110750 [NCBI36]
Chr13:13q11-34		 pathogenic
GRCh38/hg38 13q11-34(chr13:18850545-114327173)x3 copy number gain See cases [RCV000053723] Chr13:18850545..114327173 [GRCh38]
Chr13:19296527..115085141 [GRCh37]
Chr13:18194527..114110750 [NCBI36]
Chr13:13q11-34		 pathogenic
GRCh38/hg38 13q13.2-34(chr13:33528097-114327173)x3 copy number gain See cases [RCV000053759] Chr13:33528097..114327173 [GRCh38]
Chr13:34102234..115085141 [GRCh37]
Chr13:33000234..114110750 [NCBI36]
Chr13:13q13.2-34		 pathogenic
GRCh38/hg38 13q14.11-34(chr13:43219125-114327314)x3 copy number gain See cases [RCV000053762] Chr13:43219125..114327314 [GRCh38]
Chr13:43793261..115085141 [GRCh37]
Chr13:42691261..114110891 [NCBI36]
Chr13:13q14.11-34		 pathogenic
GRCh38/hg38 13q14.11-34(chr13:44164751-114327173)x3 copy number gain See cases [RCV000053764] Chr13:44164751..114327173 [GRCh38]
Chr13:44738887..115085141 [GRCh37]
Chr13:43636887..114110750 [NCBI36]
Chr13:13q14.11-34		 pathogenic
GRCh38/hg38 13q14.12-34(chr13:44733046-114327173)x3 copy number gain See cases [RCV000053767] Chr13:44733046..114327173 [GRCh38]
Chr13:45307182..115085141 [GRCh37]
Chr13:44205182..114110750 [NCBI36]
Chr13:13q14.12-34		 pathogenic
GRCh38/hg38 13q13.3-21.31(chr13:36777318-62955876)x1 copy number loss See cases [RCV000133696] Chr13:36777318..62955876 [GRCh38]
Chr13:37351455..63530009 [GRCh37]
Chr13:36249455..62428010 [NCBI36]
Chr13:13q13.3-21.31		 pathogenic
GRCh38/hg38 13q12.11-34(chr13:19833130-114298614)x3 copy number gain See cases [RCV000134104] Chr13:19833130..114298614 [GRCh38]
Chr13:20407270..115064089 [GRCh37]
Chr13:19305270..114082191 [NCBI36]
Chr13:13q12.11-34		 pathogenic
GRCh38/hg38 13q14.11-31.1(chr13:41288493-85137552)x3 copy number gain See cases [RCV000133944] Chr13:41288493..85137552 [GRCh38]
Chr13:41862629..85711687 [GRCh37]
Chr13:40760629..84609688 [NCBI36]
Chr13:13q14.11-31.1		 pathogenic
GRCh38/hg38 13q12.3-21.32(chr13:31553608-65470367)x3 copy number gain See cases [RCV000135808] Chr13:31553608..65470367 [GRCh38]
Chr13:32127745..66044499 [GRCh37]
Chr13:31025745..64942500 [NCBI36]
Chr13:13q12.3-21.32		 pathogenic
GRCh38/hg38 13q11-34(chr13:18445862-114327173)x1 copy number loss See cases [RCV000135610] Chr13:18445862..114327173 [GRCh38]
Chr13:19020001..115085141 [GRCh37]
Chr13:10098739..114110750 [NCBI36]
Chr13:13q11-34		 pathogenic
GRCh38/hg38 13q14.11-31.1(chr13:41143820-85137552)x1 copy number loss See cases [RCV000136526] Chr13:41143820..85137552 [GRCh38]
Chr13:41717956..85711687 [GRCh37]
Chr13:40615956..84609688 [NCBI36]
Chr13:13q14.11-31.1		 pathogenic
GRCh38/hg38 13q14.2-14.3(chr13:48307302-50927473)x1 copy number loss See cases [RCV000136624] Chr13:48307302..50927473 [GRCh38]
Chr13:48881438..51501609 [GRCh37]
Chr13:47779439..50399610 [NCBI36]
Chr13:13q14.2-14.3		 pathogenic
GRCh38/hg38 13q14.2-31.1(chr13:47117587-84300935)x1 copy number loss See cases [RCV000136647] Chr13:47117587..84300935 [GRCh38]
Chr13:47691722..84875070 [GRCh37]
Chr13:46589723..83773071 [NCBI36]
Chr13:13q14.2-31.1		 pathogenic
GRCh38/hg38 13q14.11-34(chr13:40942298-114340331)x1 copy number loss See cases [RCV000137893] Chr13:40942298..114340331 [GRCh38]
Chr13:41516434..115085141 [GRCh37]
Chr13:40414434..114123908 [NCBI36]
Chr13:13q14.11-34		 pathogenic
GRCh38/hg38 13q13.1-31.1(chr13:32531486-86757044)x3 copy number gain See cases [RCV000138339] Chr13:32531486..86757044 [GRCh38]
Chr13:33105623..87409299 [GRCh37]
Chr13:32003623..86207300 [NCBI36]
Chr13:13q13.1-31.1		 pathogenic
GRCh38/hg38 13q12.11-34(chr13:19833130-114327106)x3 copy number gain See cases [RCV000139078] Chr13:19833130..114327106 [GRCh38]
Chr13:20407270..115085141 [GRCh37]
Chr13:19305270..114110683 [NCBI36]
Chr13:13q12.11-34		 pathogenic
GRCh38/hg38 13q11-34(chr13:18456040-114340285)x3 copy number gain See cases [RCV000140004] Chr13:18456040..114340285 [GRCh38]
Chr13:19030180..115105760 [GRCh37]
Chr13:17928180..114123862 [NCBI36]
Chr13:13q11-34		 pathogenic
GRCh38/hg38 13q13.3-14.3(chr13:38514177-51425214)x1 copy number loss See cases [RCV000140788] Chr13:38514177..51425214 [GRCh38]
Chr13:39088314..51999350 [GRCh37]
Chr13:37986314..50897351 [NCBI36]
Chr13:13q13.3-14.3		 pathogenic
GRCh38/hg38 13q13.3-21.32(chr13:37864226-67963788)x1 copy number loss See cases [RCV000140744] Chr13:37864226..67963788 [GRCh38]
Chr13:38438363..68537920 [GRCh37]
Chr13:37336363..67435921 [NCBI36]
Chr13:13q13.3-21.32		 pathogenic
GRCh38/hg38 13q14.2-21.31(chr13:47765202-62058520)x1 copy number loss See cases [RCV000142223] Chr13:47765202..62058520 [GRCh38]
Chr13:48339337..62632653 [GRCh37]
Chr13:47237338..61530654 [NCBI36]
Chr13:13q14.2-21.31		 pathogenic
GRCh38/hg38 13q12.11-34(chr13:19671934-114340331)x3 copy number gain See cases [RCV000142924] Chr13:19671934..114340331 [GRCh38]
Chr13:20246074..115085141 [GRCh37]
Chr13:19144074..114123908 [NCBI36]
Chr13:13q12.11-34		 pathogenic
GRCh38/hg38 13q11-34(chr13:18862146-114342258)x3 copy number gain See cases [RCV000143462] Chr13:18862146..114342258 [GRCh38]
Chr13:19436286..115107733 [GRCh37]
Chr13:18334286..114125835 [NCBI36]
Chr13:13q11-34		 pathogenic
GRCh38/hg38 13q14.2(chr13:48591738-50064488)x3 copy number gain See cases [RCV000143577] Chr13:48591738..50064488 [GRCh38]
Chr13:49165874..50638624 [GRCh37]
Chr13:48063875..49536625 [NCBI36]
Chr13:13q14.2		 uncertain significance
GRCh38/hg38 13q12.3-31.3(chr13:31363472-90575292)x3 copy number gain See cases [RCV000148244] Chr13:31363472..90575292 [GRCh38]
Chr13:31937609..91227546 [GRCh37]
Chr13:30835609..90025547 [NCBI36]
Chr13:13q12.3-31.3		 pathogenic
GRCh38/hg38 13q12.11-34(chr13:19837395-114327173)x3 copy number gain See cases [RCV000148126] Chr13:19837395..114327173 [GRCh38]
Chr13:20411535..115085141 [GRCh37]
Chr13:19309535..114110750 [NCBI36]
Chr13:13q12.11-34		 pathogenic
GRCh37/hg19 13q12.11-34(chr13:19571503-115092569)x3 copy number gain See cases [RCV000240150] Chr13:19571503..115092569 [GRCh37]
Chr13:13q12.11-34		 pathogenic
GRCh37/hg19 13q12.11-34(chr13:19571503-115092510) copy number gain See cases [RCV000449142] Chr13:19571503..115092510 [GRCh37]
Chr13:13q12.11-34		 pathogenic
GRCh37/hg19 13q14.11-31.3(chr13:42457841-91796698)x1 copy number loss See cases [RCV000446747] Chr13:42457841..91796698 [GRCh37]
Chr13:13q14.11-31.3		 pathogenic
GRCh37/hg19 13q13.1-21.31(chr13:32946120-62698217)x1 copy number loss See cases [RCV000446067] Chr13:32946120..62698217 [GRCh37]
Chr13:13q13.1-21.31		 pathogenic
GRCh37/hg19 13q11-34(chr13:19436286-115107733)x3 copy number gain See cases [RCV000445886] Chr13:19436286..115107733 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q14.2-14.3(chr13:48906943-52778614)x1 copy number loss See cases [RCV000448535] Chr13:48906943..52778614 [GRCh37]
Chr13:13q14.2-14.3		 pathogenic
GRCh37/hg19 13q11-34(chr13:19436287-115107733) copy number gain See cases [RCV000510405] Chr13:19436287..115107733 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q14.2-14.3(chr13:47312129-51342279)x1 copy number loss See cases [RCV000511479] Chr13:47312129..51342279 [GRCh37]
Chr13:13q14.2-14.3		 pathogenic
GRCh37/hg19 13q11-34(chr13:19436287-115107733)x3 copy number gain See cases [RCV000511880] Chr13:19436287..115107733 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q11-22.1(chr13:19436286-74045459)x3 copy number gain not provided [RCV000683572] Chr13:19436286..74045459 [GRCh37]
Chr13:13q11-22.1		 pathogenic
NC_000013.11:g.46968080_87381985del40413906 deletion Chromosome 13q14 deletion syndrome [RCV000721955] Chr13:46968080..87381985 [GRCh38]
Chr13:13q14.2-31.2		 pathogenic
Single allele deletion Intellectual disability [RCV000684766] Chr13:48225451..58070399 [GRCh37]
Chr13:13q14.2-21.1		 likely pathogenic
GRCh37/hg19 13q11-34(chr13:19058717-115103529)x3 copy number gain not provided [RCV000738115] Chr13:19058717..115103529 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q11-34(chr13:19031237-115107157)x3 copy number gain not provided [RCV000750643] Chr13:19031237..115107157 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q14.2(chr13:50464624-50699452)x1 copy number loss not provided [RCV000750714] Chr13:50464624..50699452 [GRCh37]
Chr13:13q14.2		 benign
GRCh37/hg19 13q14.2(chr13:50578022-50728452)x3 copy number gain not provided [RCV000750715] Chr13:50578022..50728452 [GRCh37]
Chr13:13q14.2		 benign
GRCh37/hg19 13q11-34(chr13:19436286-115107733)x3 copy number gain not provided [RCV000849129] Chr13:19436286..115107733 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q14.2-21.2(chr13:49586017-61311845)x1 copy number loss not provided [RCV000846575] Chr13:49586017..61311845 [GRCh37]
Chr13:13q14.2-21.2		 uncertain significance
GRCh37/hg19 13q14.2(chr13:50494451-50665381)x3 copy number gain not provided [RCV000847204] Chr13:50494451..50665381 [GRCh37]
Chr13:13q14.2		 uncertain significance
GRCh37/hg19 13q14.12-14.3(chr13:45487628-52639336)x3 copy number gain not provided [RCV001258545] Chr13:45487628..52639336 [GRCh37]
Chr13:13q14.12-14.3		 likely pathogenic
GRCh37/hg19 13p13-q34(chr13:1-115169878) copy number gain Complete trisomy 13 syndrome [RCV002280659] Chr13:1..115169878 [GRCh37]
Chr13:13p13-q34		 pathogenic
GRCh37/hg19 13q14.13-21.31(chr13:45819046-63910212)x1 copy number loss not provided [RCV001795546] Chr13:45819046..63910212 [GRCh37]
Chr13:13q14.13-21.31		 pathogenic
GRCh37/hg19 13p13-q34(chr13:1-115169878)x3 copy number gain See cases [RCV001780076] Chr13:1..115169878 [GRCh37]
Chr13:13p13-q34		 pathogenic
GRCh37/hg19 13q11-34(chr13:19436286-115107733)x3 copy number gain not provided [RCV001834436] Chr13:19436286..115107733 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q14.11-33.3(chr13:42504540-108206269)x3 copy number gain not provided [RCV001829235] Chr13:42504540..108206269 [GRCh37]
Chr13:13q14.11-33.3		 pathogenic
GRCh37/hg19 13q14.11-14.3(chr13:44573371-53324137) copy number loss not specified [RCV002053058] Chr13:44573371..53324137 [GRCh37]
Chr13:13q14.11-14.3		 pathogenic
GRCh37/hg19 13q11-34(chr13:19436286-115107733) copy number gain not specified [RCV002053036] Chr13:19436286..115107733 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q13.1-21.31(chr13:32946120-62698217) copy number loss not specified [RCV002053048] Chr13:32946120..62698217 [GRCh37]
Chr13:13q13.1-21.31		 pathogenic
GRCh37/hg19 13q11-34(chr13:19436286-114981726) copy number gain not specified [RCV002053035] Chr13:19436286..114981726 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q14.11-31.3(chr13:42457841-91796698) copy number loss not specified [RCV002053057] Chr13:42457841..91796698 [GRCh37]
Chr13:13q14.11-31.3		 pathogenic
GRCh37/hg19 13q13.3-31.1(chr13:36376204-80681753) copy number loss not specified [RCV002053052] Chr13:36376204..80681753 [GRCh37]
Chr13:13q13.3-31.1		 pathogenic
GRCh37/hg19 13q11-34(chr13:19253848-115108937)x3 copy number gain not provided [RCV002291540] Chr13:19253848..115108937 [GRCh37]
Chr13:13q11-34		 pathogenic
GRCh37/hg19 13q14.11-21.2(chr13:44076923-60520078)x1 copy number loss not specified [RCV003987012] Chr13:44076923..60520078 [GRCh37]
Chr13:13q14.11-21.2		 pathogenic
GRCh37/hg19 13q13.2-21.1(chr13:35015723-59553519)x3 copy number gain not specified [RCV003987040] Chr13:35015723..59553519 [GRCh37]
Chr13:13q13.2-21.1		 pathogenic
GRCh37/hg19 13q14.2-32.2(chr13:49547974-98214905)x1 copy number loss not specified [RCV003987008] Chr13:49547974..98214905 [GRCh37]
Chr13:13q14.2-32.2		 pathogenic
GRCh37/hg19 13q14.2-14.3(chr13:50181731-54350061)x1 copy number loss not provided [RCV004442840] Chr13:50181731..54350061 [GRCh37]
Chr13:13q14.2-14.3		 uncertain significance
GRCh37/hg19 13q13.2-21.2(chr13:34884647-61309742)x1 copy number loss not provided [RCV003885457] Chr13:34884647..61309742 [GRCh37]
Chr13:13q13.2-21.2		 pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
BMI1hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19903841
HMGA1hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19250063
NFKB1hsa-miR-16-5pMirtarbaseexternal_infoChIP-seqFunctional MTI (Weak)21081469
ACVR2Ahsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20216554
RAB9Bhsa-miR-16-5pMirtarbaseexternal_infoproteomics analysisFunctional MTI (Weak)18362358
PDCD4hsa-miR-16-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)18362358
WT1hsa-miR-16-5pMirtarbaseexternal_infoqRT-PCR//proteomics analysisFunctional MTI (Weak)18362358
ASXL2hsa-miR-16-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18362358
UGDHhsa-miR-16-5pMirtarbaseexternal_infoProteomicsFunctional MTI (Weak)18668040
CDK6hsa-miR-16-5pMirtarbaseexternal_infoqRT-PCR//flow//Luciferase reporter assay//Western Functional MTI18701644
CCND1hsa-miR-16-5pMirtarbaseexternal_infoWestern blot//Luciferase reporter assayFunctional MTI18483394
CCND1hsa-miR-16-5pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19591824
CCND1hsa-miR-16-5pMirtarbaseexternal_infoqRT-PCR//flow//Western blot//Luciferase reporter aFunctional MTI18701644
CCND1hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI18931683
CCND1hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19549910
CCNE1hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23083510
CCNE1hsa-miR-16-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)21199864
CCNE1hsa-miR-16-5pMirtarbaseexternal_infoCLASHFunctional MTI (Weak)23622248
ZNF622hsa-miR-16-5pMirtarbaseexternal_infopSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
ZNF622hsa-miR-16-5pMirtarbaseexternal_infoSequencingFunctional MTI (Weak)20371350
VTI1Bhsa-miR-16-5pMirtarbaseexternal_infopSILAC//ProteomicsFunctional MTI (Weak)18668040
UBE2V1hsa-miR-16-5pMirtarbaseexternal_infopSILACFunctional MTI (Weak)18668040
RARS1hsa-miR-16-5pMirtarbaseexternal_infoNorthern blot//qRT-PCRFunctional MTI (Weak)12434020
RARS1hsa-miR-16-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)15648093
PURAhsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22835829
PTGS2hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23226427
ARL2hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI21199864
BCL2hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI17877811
BCL2hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blot//Functional MTI18449891
BCL2hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI17351108
BCL2hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI17707831
BCL2hsa-miR-16-5pMirtarbaseexternal_infoImmunohistochemistry//Microarray//Western blotFunctional MTI20643754
BCL2hsa-miR-16-5pMirtarbaseexternal_infoWestern blotFunctional MTI20876285
BCL2hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19269153
BCL2hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI16166262
BCL2hsa-miR-16-5pMirtarbaseexternal_infoWestern blotFunctional MTI19903841
CCNT2hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assay;OtherNon-Functional MTI15131085
ZYXhsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI21360639
BRCA1hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI19144710
AKT3hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23233752
VEGFAhsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI23104180
VEGFAhsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assayNon-Functional MTI15131085
VEGFAhsa-miR-16-5pMirtarbaseexternal_infoELISA//Luciferase reporter assayFunctional MTI18320040
VEGFAhsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19144909
SKAP2hsa-miR-16-5pMirtarbaseexternal_infoMicroarray//qRT-PCRFunctional MTI (Weak)18362358
CADM1hsa-miR-16-5pMirtarbaseexternal_infoReporter assay//qRT-PCRFunctional MTI18362358
TPPP3hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assay//Reporter assay;OtherFunctional MTI15131085
MYBhsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//qRT-PCRFunctional MTI21205891
AURKBhsa-miR-16-5pMirtarbaseexternal_infoMicroarray//qRT-PCRFunctional MTI (Weak)19738602
PPM1Dhsa-miR-16-5pMirtarbaseexternal_infoNorthern blot//qRT-PCR//Western blot//Immunoblot//Functional MTI20668064
CHUKhsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI20711193
TP53hsa-miR-16-5pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assayFunctional MTI21205967
NCOR2hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22292036
CCND1hsa-miR-16-5pMirtarbaseexternal_infoWestern blotFunctional MTI20621999
PIM1hsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22970245
IFNGhsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCRFunctional MTI22379033
UNGhsa-miR-16-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23228472
TMEM43hsa-miR-16-5pTarbaseexternal_infoProteomicsPOSITIVE
CCNT2hsa-miR-16-5pTarbaseexternal_infoReporter GeneNEGATIVE
TPPP3hsa-miR-16-5pTarbaseexternal_infoReporter GenePOSITIVE
BCL2hsa-miR-16-5pTarbaseexternal_infoWesternblitPOSITIVE
ALG3hsa-miR-16-5pTarbaseexternal_infoMicroarrayPOSITIVE
ARL2hsa-miR-16-5pTarbaseexternal_infoOtherPOSITIVE
SYNJ1hsa-miR-16-5pTarbaseexternal_infoSequencingPOSITIVE
BIRC5hsa-miR-16-5pOncomiRDBexternal_infoNANA23380758
VEGFAhsa-miR-16-5pOncomiRDBexternal_infoNANA23104180
CDX2hsa-miR-16-5pOncomiRDBexternal_infoNANA22849325
BCL2hsa-miR-16-5pOncomiRDBexternal_infoNANA22260523
PCMT1hsa-miR-16-5pOncomiRDBexternal_infoNANA22033921
VEGFAhsa-miR-16-5pOncomiRDBexternal_infoNANA21778999
CCND1hsa-miR-16-5pOncomiRDBexternal_infoNANA21629246
FGF2hsa-miR-16-5pOncomiRDBexternal_infoNANA21532615
TP53hsa-miR-16-5pOncomiRDBexternal_infoNANA21205967
PPM1Dhsa-miR-16-5pOncomiRDBexternal_infoNANA20668064
ELAVL1hsa-miR-16-5pOncomiRDBexternal_infoNANA20626035
BCL2hsa-miR-16-5pOncomiRDBexternal_infoNANA22966344
CCNE1hsa-miR-16-5pOncomiRDBexternal_infoNANA19944013
BMI1hsa-miR-16-5pOncomiRDBexternal_infoNANA19903841
CCND1hsa-miR-16-5pOncomiRDBexternal_infoNANA19549910
MYBhsa-miR-16-5pOncomiRDBexternal_infoNANA18708755
CCND1hsa-miR-16-5pOncomiRDBexternal_infoNANA18483394
BCL2hsa-miR-16-5pOncomiRDBexternal_infoNANA18449891
BCL2hsa-miR-16-5pOncomiRDBexternal_infoNANA16166262
CCND1hsa-miR-16-1-3pMirtarbaseexternal_infoqRT-PCR//GFP reporter assay//Western blotFunctional MTI18483394
ZYXhsa-miR-16-1-3pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)23175429

Predicted Targets
Summary Value
Count of predictions:14385
Count of gene targets:5889
Count of transcripts:11108
Interacting mature miRNAs:hsa-miR-16-1-3p
Prediction methods:Microtar, Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
Mirn16-1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371350,623,254 - 50,623,338UniSTSGRCh37
Celera1331,677,819 - 31,677,903UniSTS
HuRef1331,418,249 - 31,418,333UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 2
Low 25 12 5 1 57 1 12 2 12 3 14 9 2 6 1
Below cutoff 16 9 8 2 32 1 19 12 22 8 13 14 1 1 6 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000385271
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1350,048,973 - 50,049,061 (-)Ensembl
RefSeq Acc Id: NR_029486
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381350,048,973 - 50,049,061 (-)NCBI
GRCh371350,623,109 - 50,623,197 (-)ENTREZGENE
HuRef1331,418,104 - 31,418,192 (-)ENTREZGENE
CHM1_11350,590,897 - 50,590,985 (-)NCBI
T2T-CHM13v2.01349,269,562 - 49,269,650 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31545 AgrOrtholog
COSMIC MIR16-1 COSMIC
Ensembl Genes ENSG00000208006 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385271 ENTREZGENE
GTEx ENSG00000208006 GTEx
HGNC ID HGNC:31545 ENTREZGENE
Human Proteome Map MIR16-1 Human Proteome Map
miRBase MI0000070 ENTREZGENE
NCBI Gene 406950 ENTREZGENE
OMIM 609704 OMIM
PharmGKB PA164722518 PharmGKB
RNAcentral URS00004BCD9C RNACentral
  URS000056BFD0 RNACentral
  URS000061CB8F RNACentral