ZYX (zyxin) - Rat Genome Database

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Keyword

Gene: ZYX (zyxin) Homo sapiens

Symbol:

ZYX

Name:

zyxin

Description:

Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

ESP-2; HED-2; OTTHUMP00000081863; OTTHUMP00000208858; OTTHUMP00000208859; zyxin; zyxin-2

Orthologs:

Mus musculus : Zyx (zyxin) MGI
Rattus norvegicus : Zyx (zyxin)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	7	146,442,186 - 146,452,028	+	NCBI
Human Alternate Assembly CRA_TCAGchr7v2	7	142,480,492 - 142,490,336	+	NCBI
Human Genome Assembly HuRef	7	137,415,678 - 137,425,520	+	NCBI
Human Genome Assembly GRCh37	7	143,078,360 - 143,088,204	+	NCBI
Human Genome Assembly Build 36	7	142,788,482 - 142,798,326	+	NCBI
Human Cytogenetic Map	7	q32		NCBI
Human Genome Assembly	7	142,595,196 - 142,605,039		NCBI