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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731006
Species: Homo sapiens
RGD Object: Gene
Symbol: PTGS2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:53063
Term: 2,4,6-trinitrobenzenesulfonic acid
Definition: The arenesulfonic acid that is benzenesulfonic acid with three nitro substituents in the 2-, 4- and 6-positions.
Chemical ID: MESH:D014302
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTGS2decreases expressionISOPtgs2 (Mus musculus)6480464CTDTrinitrobenzenesulfonic Acid results in decreased expression of PTGS2 mRNAPMID:25307695
PTGS2increases expressionISOPtgs2 (Rattus norvegicus)6480464CTDTrinitrobenzenesulfonic Acid results in increased expression of PTGS2; Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA; Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 proteinPMID:11137876 PMID:11698051 PMID:11820457 PMID:16474422 PMID:16782535 PMID:16804969 PMID:17276891 PMID:17375077 PMID:19234664 PMID:21513799 PMID:21893697 PMID:22039321 PMID:24316276 PMID:24831514 PMID:25526689 PMID:30365937
PTGS2increases expressionISOPtgs2 (Mus musculus)6480464CTDTrinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA; Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 proteinPMID:11717450 PMID:15973123 PMID:17375199 PMID:18200517 PMID:19956958 PMID:20923188 PMID:25576893
PTGS2multiple interactionsISOPtgs2 (Rattus norvegicus)6480464CTDAlendronate affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]; Ampicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]]; Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]; bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]; Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]; Dexamethasone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]; Dexamethasone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]; Genistein inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]; Genistein inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]; Isatin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2]; nitroaspirin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]; Resveratrol inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]; Smoke promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]; Smoke promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]PMID:11137876 PMID:16474422 PMID:16782535 PMID:16804969 PMID:17375077 PMID:19234664 PMID:21893697 PMID:22039321 PMID:24316276 PMID:24831514 PMID:30365937
PTGS2multiple interactionsISOPtgs2 (Mus musculus)6480464CTDCurcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]; Huangqin-Tang inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]; lancemaside A inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]; seryl-leucyl-isoleucyl-glycyl--arginyl-leucinamide inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 mRNA]; soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of PTGS2 protein]PMID:11717450 PMID:18200517 PMID:19956958 PMID:20923188 PMID:25576893
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