RGD Reference Report - Different parkinsonism models produce a time-dependent induction of COX-2 in the substantia nigra of rats. - Rat Genome Database

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Different parkinsonism models produce a time-dependent induction of COX-2 in the substantia nigra of rats.

Authors: De Meira Santos Lima, M  Braga Reksidler, A  Marques Zanata, S  Bueno Machado, H  Tufik, S  Vital, MA 
Citation: de Meira Santos Lima M, etal., Brain Res. 2006 Jul 26;1101(1):117-25. Epub 2006 Jun 15.
RGD ID: 5688269
Pubmed: PMID:16781689   (View Abstract at PubMed)
DOI: DOI:10.1016/j.brainres.2006.05.016   (Journal Full-text)

The present study investigated the effects on general activity, COX-2 and TH protein expression of intranigral neurotoxins LPS, MPTP or 6-OHDA infusion in rats. Results indicate that LPS produced an increase in locomotion frequency (3 and 7 days after surgery) and a strong up-regulation of COX-2 protein 16 and 24 h after surgery, as observed in the substantia nigra (SN). The MPTP model generated impairment in locomotion frequency 24 h after surgery. Besides, MPTP caused a marked up-regulation in COX-2 protein observed in the SN 16 h after surgery. Moreover, the 6-OHDA model produced severe motor impairment indicated by the decrease in locomotion (24 h) and rearing (24 h, 3 and 7 days) frequencies and also an increase in latency (24 h, 3 and 7 days) and immobility (24 h and 3 days) times. We also demonstrated an up-regulation of COX-2, which occurred in the SN 4-24 h after surgery. TH protein did not appear to be reduced in the striatum in the groups lesioned with the neurotoxins. In contrast, the TH content of SN was significantly reduced in the groups lesioned with the very same neurotoxins. For all the models analyzed, we observed no statistical differences in the expression of COX-2 in the striatum along the time-points. The results of the present study suggest that COX-2 induction patterns differ in function of the neurotoxin tested. Such time-dependent induction has been found to be relatively constant, a fact of great significance considering the importance of the neuroinflammatory process in Parkinson's disease.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PTGS2HumanParkinsonism  ISOPtgs2 (Rattus norvegicus) RGD 
Ptgs2RatParkinsonism  IDA  RGD 
Ptgs2MouseParkinsonism  ISOPtgs2 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ptgs2  (prostaglandin-endoperoxide synthase 2)

Genes (Mus musculus)
Ptgs2  (prostaglandin-endoperoxide synthase 2)

Genes (Homo sapiens)
PTGS2  (prostaglandin-endoperoxide synthase 2)


Additional Information