PROSTANOID BIOSYNTHETIC PATHWAY (PW:0001243)

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Description

Phospholipid derived arachidonic acid can be metabolized via three routes to give rise to a wide range of metabolites collectively referred to as eicosanoids. Of these, the members of the prostanoid subclass are derived from the prostaglandin H2 (PGH2) precursor generated in the cyclooxygenase mediated pathway of arachidonic acid metabolism (lipooxygenases and cytochrome P450 monooxygenases mediate the other two routes to produce leukotriene and other metabolites). The prostanoids bind to and

Pathway Diagram:

Elsevier Inc. PGG2 PGG2 ---> PGH2 Ptgs2 Ptgs1 arachidonic acid ---> PGG2 TXA2 PGF2alpha PGI2 PGE2 PGD2 PGH2 arachidonic acid Ptges2 Ptges3 Ptges Tbxas1 Cbr1 Akr1c3 Akr1b1 Akr1a1 Ptgis Ptgds Hpgds thromboxane A2 signaling pathway prostaglandin F2alpha signaling pathway prostaglandin I2 signaling pathway prostaglandin E2 signaling pathway prostaglandin D2 signaling pathway PGH2 ---> PGD2 PGI2 ---> cardiovascular functions PGE2 ---> inflammatory response PGE2 ---> perception of pain PGE2 ---> cardiovascular functions PGE2 ---> immunomodulation TXA2 ---> cardiovascular functions reproduction PGF2alpha ---> reproduction PGD2 ---> inflammatory response PGD2 ---> immunomodulation immunomodulation inflammatory response perception of pain cardiovascular functions PGH2 ---> TXA2 PGH2 ---> PGE2 PGH2 ---> PGF2alpha PGD2 ---> PGF2alpha PGE2 ---> PGF2alpha Fam213b PGH2 ---> PGI2 cyclooxygenase mediated pathway of arachidonic acid metabolism
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Genes in Pathway:

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prostanoid biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptgs1 prostaglandin-endoperoxide synthase 1 JBrowse link 3 15,560,685 15,582,339 RGD:8552701
RGD:8552712
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:8552701
RGD:8552712
prostacyclin biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptgis prostaglandin I2 synthase JBrowse link 3 163,950,746 163,986,129 RGD:8552712
prostaglandin biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akr1a1 aldo-keto reductase family 1 member A1 JBrowse link 5 135,482,068 135,498,693 RGD:8552778
G Akr1b1 aldo-keto reductase family 1 member B JBrowse link 4 61,706,866 61,720,959 RGD:8552778
G Akr1c3 aldo-keto reductase family 1, member C3 JBrowse link 17 69,761,126 69,778,021 RGD:8552774
G Cbr1 carbonyl reductase 1 JBrowse link 11 33,813,041 33,815,418 RGD:8552774
G Fam213b family with sequence similarity 213, member B JBrowse link 5 172,304,799 172,307,402 RGD:8552775
G Hpgds hematopoietic prostaglandin D synthase JBrowse link 4 95,945,356 95,970,666 RGD:8552701
RGD:8552712
G Ptgds prostaglandin D2 synthase JBrowse link 3 2,686,125 2,689,059 RGD:8552701
RGD:8552712
G Ptges prostaglandin E synthase JBrowse link 3 9,727,408 9,738,752 RGD:8552701
RGD:8552712
G Ptges2 prostaglandin E synthase 2 JBrowse link 3 11,424,195 11,431,379 RGD:8552701
RGD:8552712
G Ptges3 prostaglandin E synthase 3 JBrowse link 7 2,479,267 2,497,024 RGD:8552701
RGD:8552712
thromboxane biosynthetic pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Tbxas1 thromboxane A synthase 1 JBrowse link 4 66,624,181 66,846,745 RGD:8552712

Pathway Gene Annotations

Disease Annotations Associated with Genes in the prostanoid biosynthetic pathway
Disease TermsGene Symbols
Acute Kidney InjuryPtgs2
Acute Lung InjuryPtgs2
AdenocarcinomaPtgs2
Adenocarcinoma of EsophagusPtgs2
Adenomatous Polyposis ColiPtgs2
Adrenal Gland NeoplasmsPtgs2
AlbuminuriaPtgs2
Alcohol Withdrawal DeliriumPtgs2
Alzheimer DiseasePtgs1 , Ptgs2
Amnesia, RetrogradePtgs2
Amyotrophic Lateral SclerosisPtgs2
AnaphylaxisPtgs1 , Ptgs2
Aortic Aneurysm, AbdominalPtgs2
Aortic Valve, Calcification ofPtgs2
Arrhythmias, CardiacPtgs2
ArteriosclerosisPtgs2
Arthritis, ExperimentalPtgs1 , Ptgs2
Arthritis, RheumatoidPtgs1 , Ptgs2
Asphyxia NeonatorumPtgs2
AsthmaPtgs2
Asthma, Aspirin-InducedPtgs2
Asthma, OccupationalPtgs1 , Ptgs2
AtherosclerosisPtgs2
Autistic DisorderPtgs2
Barrett EsophagusPtgs2
Bipolar DisorderPtgs1 , Ptgs2
Bone NeoplasmsPtgs2
Brain InjuriesPtgs1 , Ptgs2
Brain IschemiaPtgs1 , Ptgs2
Breast NeoplasmsPtgs1 , Ptgs2
Bronchial HyperreactivityPtgs1
BurnsPtgs2
CachexiaPtgs2
CarcinomaPtgs1 , Ptgs2
Carcinoma in SituPtgs2
Carcinoma, Ductal, BreastPtgs2
Carcinoma, HepatocellularPtgs2
Carcinoma, Intraductal, NoninfiltratingPtgs2
Carcinoma, Non-Small-Cell LungPtgs2
Carcinoma, Pancreatic DuctalPtgs2
Carcinoma, Renal CellPtgs1 , Ptgs2
Carcinoma, Squamous CellPtgs2
Carcinoma, Squamous Cell of Head and NeckPtgs2
Carcinoma, Transitional CellPtgs2
CardiomyopathiesPtgs2
Cardiovascular DiseasesPtgs2
Cerebral HemorrhagePtgs2
Cervical Intraepithelial NeoplasiaPtgs2
Chemical and Drug Induced Liver InjuryPtgs2
CholangiocarcinomaPtgs2
Cognition DisordersPtgs2
ColitisPtgs2
Colitis, UlcerativePtgs1 , Ptgs2
Colonic NeoplasmsPtgs2
Colorectal NeoplasmsPtgs2
Coronary Artery DiseasePtgs2
CoughPtgs2
Creutzfeldt-Jakob SyndromePtgs1 , Ptgs2
Crohn DiseasePtgs2
CryptorchidismPtgs2
Cystic FibrosisPtgs2
CystitisPtgs2
Demyelinating DiseasesPtgs2
Depressive DisorderPtgs2
Diabetes MellitusPtgs2
Diabetes Mellitus, ExperimentalPtgs1 , Ptgs2
Diabetes Mellitus, Type 2Ptgs2
Diabetic NephropathiesPtgs2
Diabetic NeuropathiesPtgs2
Drug HypersensitivityPtgs1
Drug-Related Side Effects and Adverse ReactionsPtgs2
Duodenal UlcerPtgs2
EdemaPtgs2
Encephalomyelitis, Autoimmune, ExperimentalPtgs1 , Ptgs2
Endometrial NeoplasmsPtgs1 , Ptgs2
EndometriosisPtgs2
EndotoxemiaPtgs2
Esophageal NeoplasmsPtgs1 , Ptgs2
Esophageal Squamous Cell CarcinomaPtgs2
EsophagitisPtgs2
Fatty LiverPtgs2
Fetal Growth RetardationPtgs2
FeverPtgs2
FibrosisPtgs2
FlushingPtgs1
Fractures, BonePtgs2
Gallbladder NeoplasmsPtgs2
GastritisPtgs2
Gastroesophageal RefluxPtgs2
GlaucomaPtgs1
Glaucoma, Open-AnglePtgs2
GlioblastomaPtgs1 , Ptgs2
GliomaPtgs2
GliosarcomaPtgs1 , Ptgs2
Granulosa Cell TumorPtgs2
Graves OphthalmopathyPtgs2
Growth Hormone-Secreting Pituitary AdenomaPtgs2
Heart FailurePtgs1 , Ptgs2
Hepatic EncephalopathyPtgs1
HIV InfectionsPtgs2
Huntington DiseasePtgs2
HydronephrosisPtgs2
HyperalgesiaPtgs1 , Ptgs2
HyperemiaPtgs2
HyperglycemiaPtgs2
Hyperparathyroidism, SecondaryPtgs2
HyperplasiaPtgs2
HypertensionPtgs2
Hypertension, PortalPtgs2
Hypertension, PulmonaryPtgs2
Hypertension, RenovascularPtgs1
Hypertrophy, Left VentricularPtgs2
HypoxiaPtgs2
Idiopathic Pulmonary FibrosisPtgs2
InflammationPtgs2
Inflammatory Bowel DiseasesPtgs2
Influenza in BirdsPtgs2
Influenza, HumanPtgs2
Intestinal ObstructionPtgs2
Intestinal PolypsPtgs1 , Ptgs2
Kidney DiseasesPtgs2
Kidney Failure, ChronicPtgs1 , Ptgs2
Kidney NeoplasmsPtgs2
Laryngeal NeoplasmsPtgs2
Laryngeal PapillomatosisPtgs2
LeiomyosarcomaPtgs2
Leukemia, Lymphocytic, Chronic, B-CellPtgs2
Leukoplakia, OralPtgs2
Liver Cirrhosis, ExperimentalPtgs1 , Ptgs2
Liver Failure, AcutePtgs2
Lung DiseasesPtgs2
Lung NeoplasmsPtgs2
Lupus Erythematosus, SystemicPtgs2
Lymphatic MetastasisPtgs2
Lymphoma, B-CellPtgs2
Mammary Neoplasms, ExperimentalPtgs2
MelanomaPtgs2
Metabolic Syndrome XPtgs2
Mouth DiseasesPtgs2
Mouth NeoplasmsPtgs2
Myocardial InfarctionPtgs2
Myocardial Reperfusion InjuryPtgs2
MyocarditisPtgs2
Nasal PolypsPtgs1 , Ptgs2
Neoplasm MetastasisPtgs2
Neoplasm Recurrence, LocalPtgs2
NeoplasmsPtgs2
Nephrotic SyndromePtgs2
Nervous System DiseasesPtgs2
Neuritis, Autoimmune, ExperimentalPtgs1 , Ptgs2
Neurogenic InflammationPtgs2
ObesityPtgs2
Oral Submucous FibrosisPtgs2
OsteoarthritisPtgs2
Ovarian CystsPtgs1
Ovarian NeoplasmsPtgs1 , Ptgs2
PainPtgs1 , Ptgs2
Pancreatic NeoplasmsPtgs2
PancreatitisPtgs2
PapillomaPtgs2
Parkinsonian DisordersPtgs2
Pericardial EffusionPtgs2
Peripheral Nerve InjuriesPtgs1 , Ptgs2
PleurisyPtgs2
Polycystic Kidney DiseasesPtgs1 , Ptgs2
Precancerous ConditionsPtgs2
Premature BirthPtgs2
ProlactinomaPtgs2
Prostatic HyperplasiaPtgs2
Prostatic Intraepithelial NeoplasiaPtgs2
Prostatic NeoplasmsPtgs2
ProstatitisPtgs2
ProteinuriaPtgs2
Puberty, PrecociousPtgs2
Pulmonary Disease, Chronic ObstructivePtgs2
Pulmonary EmphysemaPtgs2
Pulmonary FibrosisPtgs2
Radiation Injuries, ExperimentalPtgs1 , Ptgs2
Reperfusion InjuryPtgs1 , Ptgs2
Rhinitis, Allergic, PerennialPtgs1
Rhinitis, Allergic, SeasonalPtgs1
SarcoidosisPtgs2
SchizophreniaPtgs2
Scleroderma, SystemicPtgs2
SeizuresPtgs2
Skin DiseasesPtgs2
Skin NeoplasmsPtgs2
Sleep Apnea, ObstructivePtgs2
Sleep DeprivationPtgs1 , Ptgs2
Spinal Cord InjuriesPtgs1 , Ptgs2
Status EpilepticusPtgs2
Stomach NeoplasmsPtgs2
Stomach UlcerPtgs1 , Ptgs2
StrokePtgs2
Subarachnoid HemorrhagePtgs2
ThrombosisPtgs2
Thyroid NeoplasmsPtgs2
Tongue NeoplasmsPtgs2
Urinary Bladder Neck ObstructionPtgs2
Urinary Bladder NeoplasmsPtgs2
Urologic NeoplasmsPtgs2
Uterine Cervical NeoplasmsPtgs1 , Ptgs2
Ventilator-Induced Lung InjuryPtgs2
Wernicke EncephalopathyPtgs2
Wilms TumorPtgs2
Pathway Annotations Associated with Genes in the prostanoid biosynthetic pathway
Pathway TermsGene Symbols
acetylsalicylic acid pharmacodynamics pathwayPtgs1 , Ptgs2
antipyrine drug pathwayPtgs1 , Ptgs2
arachidonic acid metabolic pathwayPtgs1 , Ptgs2
celecoxib pharmacodynamics pathwayPtgs1 , Ptgs2
celecoxib pharmacokinetics pathwayPtgs1 , Ptgs2
cyclooxygenase mediated pathway of arachidonic acid metabolismPtgs1 , Ptgs2
diclofenac pharmacodynamics pathwayPtgs1 , Ptgs2
diflunisal pharmacodynamics pathwayPtgs1 , Ptgs2
electron transport chain pathwayPtgs1
etodolac pharmacodynamics pathwayPtgs1 , Ptgs2
etoposide pharmacodynamics pathwayPtgs1 , Ptgs2
etoposide pharmacokinetics pathwayPtgs1 , Ptgs2
fenoprofen pharmacodynamics pathwayPtgs1 , Ptgs2
flurbiprofen pharmacodynamics pathwayPtgs1 , Ptgs2
ibuprofen pharmacodynamics pathwayPtgs1 , Ptgs2
ibuprofen pharmacokinetics pathwayPtgs1 , Ptgs2
indometacin pharmacodynamics pathwayPtgs1 , Ptgs2
indometacin pharmacodynamics pathwayPtgs1 , Ptgs2
ketoprofen pharmacodynamics pathwayPtgs1 , Ptgs2
ketorolac pharmacodynamics pathwayPtgs1 , Ptgs2
Leishmania infection pathwayPtgs2
leukotriene C4 synthase deficiency pathwayPtgs1 , Ptgs2
lornoxicam pharmacodynamics pathwayPtgs1 , Ptgs2
magnesium salicylate pharmacodynamics pathwayPtgs1 , Ptgs2
mefenamic acid pharmacodynamics pathwayPtgs1 , Ptgs2
meloxicam pharmacodynamics pathwayPtgs1 , Ptgs2
nabumetone pharmacodynamics pathwayPtgs1 , Ptgs2
naproxen pharmacodynamics pathwayPtgs1 , Ptgs2
paracetamol drug pathwayPtgs1 , Ptgs2
piroxicam pharmacodynamics pathwayPtgs1 , Ptgs2
prostanoid biosynthetic pathwayPtgs1 , Ptgs2
salicylic acid pharmacodynamics pathwayPtgs1 , Ptgs2
small cell lung cancer pathwayPtgs2
sodium salicylate pharmacodynamics pathwayPtgs1 , Ptgs2
sphingosine 1-phosphate signaling pathwayPtgs2
sulindac pharmacodynamics pathwayPtgs1 , Ptgs2
tenoxicam pharmacodynamics pathwayPtgs1 , Ptgs2
tiaprofenic acid pharmacodynamics pathwayPtgs1 , Ptgs2
tolmetin pharmacodynamics pathwayPtgs1 , Ptgs2
valdecoxib pharmacodynamics pathwayPtgs1 , Ptgs2
vascular endothelial growth factor signaling pathwayPtgs2

References Associated with the prostanoid biosynthetic pathway:

Ontology Path Diagram:

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