RGD Reference Report - Cyclooxygenase-2 contributes to VX-induced cell death in cultured cortical neurons. - Rat Genome Database

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Cyclooxygenase-2 contributes to VX-induced cell death in cultured cortical neurons.

Authors: Tenn, CC  Weiss, MT  Beaup, C  Peinnequin, A  Wang, Y  Dorandeu, F 
Citation: Tenn CC, etal., Toxicol Lett. 2012 Jan 28;210(1):71-77.
RGD ID: 5688265
Pubmed: PMID:22306367   (View Abstract at PubMed)
DOI: DOI:10.1016/j.toxlet.2012.01.016   (Journal Full-text)

The link between cell death and increased cyclooxygenases-2 (COX-2) activity has not been clearly established. In this study, we examined whether COX-2 activation contributed to the mechanism of neurotoxicity produced by an organophosphorous nerve agent in cultured rat cortical neurons. Exposure of neuronal cells to the nerve agent, VX resulted in an increase in COX enzyme activity in the culture media. A concentration dependent increase in the activity levels of COX-2 enzyme was observed while there was little to no effect on COX-1. In addition, COX-2 mRNA and protein levels increased several hours post-VX exposure. Pre-treatment of the cortical cells with the COX-2 selective inhibitor, NS 398 resulted in a decrease in both the enzyme activity and prostaglandin (PGE(2) and PGF(2alpha)) release, as well as in a reduction in cell death. These findings indicate that the increase in COX-2 activity may contribute to the mechanism of VX-induced neurotoxicity in cultured rat cortical neuron.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cellular response to organonitrogen compound  IEP 5688265nerve agent VXRGD 
positive regulation of apoptotic process  IMP 5688265 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ptgs2  (prostaglandin-endoperoxide synthase 2)


Additional Information