RGD Reference Report - Expression of cyclooxygenase-1 and -2 in human breast cancer. - Rat Genome Database

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Expression of cyclooxygenase-1 and -2 in human breast cancer.

Authors: Yoshimura, N  Sano, H  Okamoto, M  Akioka, K  Ushigome, H  Kadotani, Y  Yoshimura, R  Nobori, S  Higuchi, A  Ohmori, Y  Nakamura, K 
Citation: Yoshimura N, etal., Surg Today. 2003;33(11):805-11.
RGD ID: 2300210
Pubmed: PMID:14605950   (View Abstract at PubMed)
DOI: DOI:10.1007/s00595-003-2606-3   (Journal Full-text)

PURPOSE: We investigated the expression of cyclooxygenase (Cox-1 and Cox-2) in mammary tissues from patients with breast cancer. METHODS: We used reverse transcriptase-polymerase chain reaction (RT-PCR) and immunohistochemistry. RESULTS: The cancer cells showed very weak expression of Cox-1, but strong expression of immunoreactive Cox-2. In contrast, immunoreactive Cox-2 was very weak in all of the benign mammary tumors examined, including fibroadenoma (FA) and mastopathy (MP). Immunoreactive Cox-1 was also very weak in these benign tumors. The extent and intensity of immunoreactive Cox-2 polypeptides was significantly greater in the cancer cells than in the FA cells or MP cells. RT-PCR analysis showed enhanced expression of Cox-2, but not Cox-1 in breast cancer tissue, and faint expression of Cox-2 in benign tissue. CONCLUSIONS: These results demonstrated that human breast cancer cells generated Cox-2, indicating that Cox-2 might play an important role in the proliferation of breast cancer cells.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
PTGS2HumanBreast Neoplasms  IEP mRNA and protein:increased expression:breastRGD 
Ptgs2RatBreast Neoplasms  ISOPTGS2 (Homo sapiens)mRNA and protein:increased expression:breastRGD 
Ptgs2MouseBreast Neoplasms  ISOPTGS2 (Homo sapiens)mRNA and protein:increased expression:breastRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ptgs2  (prostaglandin-endoperoxide synthase 2)

Genes (Mus musculus)
Ptgs2  (prostaglandin-endoperoxide synthase 2)

Genes (Homo sapiens)
PTGS2  (prostaglandin-endoperoxide synthase 2)


Additional Information