Gene: CACNA1B (calcium voltage-gated channel subunit alpha1 B) Homo sapiens
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Symbol: CACNA1B
Name: calcium voltage-gated channel subunit alpha1 B
Description: The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BIII; brain calcium channel III; CACNL1A5; CACNN; calcium channel alpha12.2 subunit; calcium channel, L type, alpha-1 polypeptide; calcium channel, N type; calcium channel, voltage-dependent, alpha 1B subunit, N type; calcium channel, voltage-dependent, L type, alpha 1B subunit; calcium channel, voltage-dependent, N type, alpha 1B subunit; Cav2.2; Cav2.2 voltage-gated Ca2+ channel; DYT23; OTTHUMP00000022714; OTTHUMP00000022715; OTTHUMP00000022716; OTTHUMP00000022718; voltage-dependent N-type calcium channel subunit alpha-1B; voltage-gated calcium channel alpha subunit Cav2.2; voltage-gated calcium channel subunit alpha Cav2.2
Orthologs:
Mus musculus (house mouse) : Cacna1b (calcium channel, voltage-dependent, N type, alpha 1B subunit)  MGI
Rattus norvegicus (Norway rat) : Cacna1b (calcium voltage-gated channel subunit alpha1 B)
Chinchilla lanigera (long-tailed chinchilla) : Cacna1b (calcium voltage-gated channel subunit alpha1 B)
Pan paniscus (bonobo/pygmy chimpanzee) : CACNA1B (calcium voltage-gated channel subunit alpha1 B)
Canis lupus familiaris (dog) : CACNA1B (calcium voltage-gated channel subunit alpha1 B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cacna1b (calcium voltage-gated channel subunit alpha1 B)
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Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,877,789 - 138,124,624 (+)NCBIGRCh38hg38GRCh38
GRCh379140,772,241 - 141,019,076 (+)NCBIGRCh37hg19GRCh37
Build 369139,892,062 - 140,136,449 (+)NCBINCBI36hg18NCBI36
Build 349138,048,077 - 138,292,468NCBI
Cytogenetic Map9q34.3NCBImapview
HuRef9110,240,583 - 110,486,666 (+)NCBI
CHM1_19140,920,972 - 141,166,813 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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Genomics

Comparative Map Data
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miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on CACNA1B
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
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RGD Object Information
RGD ID: 1347795
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2017-05-30
Status: ACTIVE