IL5 (interleukin 5 (colony-stimulating factor, eosinophil))

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Keyword

Gene: IL5 (interleukin 5 (colony-stimulating factor, eosinophil)) Homo sapiens

Symbol:

IL5

Name:

interleukin 5 (colony-stimulating factor, eosinophil)

Description:

The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

B cell differentiation factor I; B-cell differentiation factor I; EDF; eosinophil differentiation factor; IL-5; interleukin-5; OTTHUMP00000065830; T-cell replacing factor; TRF

Orthologs:

Mus musculus : Il5 (interleukin 5) MGI
Rattus norvegicus : Il5 (interleukin 5)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	5	132,153,910 - 132,155,988	-	NCBI
Human Genome Assembly HuRef	5	127,069,401 - 127,071,479	-	NCBI
Human Genome Assembly GRCh37	5	131,877,136 - 131,879,214	-	NCBI
Human Genome Assembly Build 36	5	131,905,035 - 131,907,113	-	NCBI
Human Cytogenetic Map	5	q31.1		NCBI
Human Genome Assembly	5	131,905,034 - 131,907,113		NCBI