Gene: TIMP1 (TIMP metallopeptidase inhibitor 1)  Homo sapiens
Symbol: TIMP1
Name: TIMP metallopeptidase inhibitor 1
Description: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CLGI; collagenase inhibitor; EPA; EPO; erythroid potentiating activity; erythroid-potentiating activity; fibroblast collagenase inhibitor; FLJ90373; HCI; metalloproteinase inhibitor 1; OTTHUMP00000023214; OTTHUMP00000023216; TIMP; TIMP-1; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor); tissue inhibitor of metalloproteinases 1
Orthologs: Mus musculus : Timp1 (tissue inhibitor of metalloproteinase 1)  MGI
Rattus norvegicus : Timp1 (TIMP metallopeptidase inhibitor 1)
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_1X47,361,258 - 47,365,758+NCBI
Human Genome Assembly HuRefX45,154,211 - 45,158,632+NCBI
Human Genome Assembly GRCh37X47,441,690 - 47,446,190+NCBI
Human Genome Assembly Build 36X47,326,634 - 47,331,134+NCBI
Human Cytogenetic MapXp11.3-p11.23 NCBI
Human Genome AssemblyX47,198,084 - 47,202,441 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

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Genomics

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QTLs in Region (Human Genome Assembly GRCh37)

Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

External Database Links
Nomenclature History
  
More on TIMP1
Entrez Gene
Ensembl Gene
Genome Browser: (hg18) (hg19)
HGNC Report
NCBI Map Viewer
Vista
Vista + UCSC

RGD Object Information
RGD ID: 1347215
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2013-05-14
Status: ACTIVE



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