STAT1 (signal transducer and activator of transcription 1, 91kDa)

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Keyword

Gene: STAT1 (signal transducer and activator of transcription 1, 91kDa) Homo sapiens

Symbol:

STAT1

Name:

signal transducer and activator of transcription 1, 91kDa

Description:

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

CANDF7; DKFZp686B04100; ISGF-3; OTTHUMP00000163552; OTTHUMP00000165046; OTTHUMP00000165047; OTTHUMP00000205845; signal transducer and activator of transcription 1; signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription-1; STAT91; transcription factor ISGF-3 components p91/p84

Orthologs:

Mus musculus : Stat1 (signal transducer and activator of transcription 1) MGI
Rattus norvegicus : Stat1 (signal transducer and activator of transcription 1)

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	2	191,219,695 - 191,264,897	-	NCBI
Human Genome Assembly HuRef	2	183,693,413 - 183,738,626	-	NCBI
Human Genome Assembly GRCh37	2	191,833,762 - 191,878,976	-	NCBI
Human Genome Assembly Build 36	2	191,542,121 - 191,587,181	-	NCBI
Human Cytogenetic Map	2	q32.2		NCBI
Human Genome Assembly	2	191,665,769 - 191,704,442		NCBI