FOS (Fos proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: FOS (Fos proto-oncogene, AP-1 transcription factor subunit) Homo sapiens
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Symbol: FOS
Name: Fos proto-oncogene, AP-1 transcription factor subunit
RGD ID: 735729
HGNC Page HGNC:3796
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; R-SMAD binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cellular response to cadmium ion; positive regulation of DNA-templated transcription; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in RNA polymerase II transcription regulator complex and nucleoplasm. Part of protein-DNA complex and transcription factor AP-1 complex. Biomarker of Pick's disease; autosomal dominant polycystic kidney disease; carcinoma (multiple); and intestinal benign neoplasm (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: activator protein 1; AP-1; C-FOS; cellular oncogene c-fos; cellular oncogene fos; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS); FBJ murine osteosarcoma viral oncogene homolog; Fos proto-oncogene, AP-1 trancription factor subunit; G0/G1 switch regulatory protein 7; p55; proto-oncogene c-Fos; transcription factor AP-1 subunit c-Fos; v-fos FBJ murine osteosarcoma viral oncogene homolog
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381475,278,828 - 75,282,230 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1475,278,826 - 75,282,230 (+)EnsemblGRCh38hg38GRCh38
GRCh371475,745,531 - 75,748,933 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,815,284 - 74,818,666 (+)NCBINCBI36Build 36hg18NCBI36
Build 341474,815,283 - 74,818,666NCBI
Celera1455,783,567 - 55,787,023 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,913,924 - 55,917,380 (+)NCBIHuRef
CHM1_11475,683,266 - 75,686,721 (+)NCBICHM1_1
T2T-CHM13v2.01469,488,228 - 69,491,630 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (ISO)
alcohol dependence  (ISO)
alcohol use disorder  (ISO)
alcohol withdrawal syndrome  (ISO)
Alcohol-Related Disorders  (ISO)
Alcoholic Intoxication  (ISO)
amphetamine abuse  (EXP,ISO)
amyotrophic lateral sclerosis type 1  (EXP)
Animal Disease Models  (EXP)
anxiety disorder  (EXP)
autosomal dominant polycystic kidney disease  (IEP)
Binge Drinking  (ISO)
Brain Injuries  (EXP)
Breast Neoplasms  (EXP)
cervical squamous cell carcinoma  (IEP)
cocaine abuse  (ISO)
cocaine dependence  (ISO)
Cocaine-Related Disorders  (EXP,ISO)
Colonic Neoplasms  (IMP)
colorectal adenocarcinoma  (IEP)
colorectal adenoma  (IEP)
Colorectal Neoplasms  (IEP,ISO)
congestive heart failure  (ISO)
endometriosis  (EXP)
epilepsy  (EXP)
Experimental Liver Cirrhosis  (EXP)
extrahepatic cholestasis  (EXP)
Fibrous Dysplasia of Bone  (EXP)
genetic disease  (IAGP)
glomerulonephritis  (ISO)
Heat Stroke  (EXP)
Hematuria  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhage  (EXP)
hepatocellular carcinoma  (EXP)
Hyperalgesia  (EXP,ISO)
Hyperkinesis  (EXP)
hypertension  (EXP,ISO)
Inhalant Abuse  (ISO)
intellectual disability  (IAGP)
juvenile rheumatoid arthritis  (EXP)
Kidney Reperfusion Injury  (ISO)
Lung Neoplasms  (EXP)
middle cerebral artery infarction  (EXP)
morphine dependence  (ISO)
morphine withdrawal syndrome  (ISO)
Neoplastic Cell Transformation  (EXP)
nervous system disease  (EXP)
nicotine dependence  (IEP,ISO)
obesity  (EXP)
ovarian carcinoma  (EXP)
Pick's disease  (IEP)
post-traumatic stress disorder  (ISO)
rectal benign neoplasm  (IEP)
Reperfusion Injury  (EXP,ISO)
status epilepticus  (EXP)
Tendon Injuries  (ISO)
Tongue Neoplasms  (ISO)
tongue squamous cell carcinoma  (IEP)
toxic encephalopathy  (EXP)
trigeminal neuralgia  (EXP)
Wernicke encephalopathy  (ISO)
withdrawal disorder  (EXP)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-pilocarpine  (ISO)
(+)-Pimaric acid  (EXP)
(+)-taxifolin  (ISO)
(+)-Tetrandrine  (ISO)
(-)-alpha-phellandrene  (EXP)
(-)-anisomycin  (EXP)
(-)-citrinin  (EXP)
(-)-demecolcine  (EXP)
(-)-ephedrine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(-)-selegiline  (EXP)
(20R)-protopanaxadiol  (ISO)
(20S)-ginsenoside Rh1  (EXP)
(E)-roxithromycin  (EXP)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-ligustilide  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2,4,5-tetrachlorobenzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-naphthoquinone  (EXP)
1,4-dichlorobenzene  (ISO)
1-(3-chlorophenyl)piperazine  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
1D-myo-inositol 1,4,5-trisphosphate  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-amino-3-hydroxypyridine  (EXP)
2-aminopurine  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
2-nitrotoluene  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
2-trans,6-trans-farnesyl diphosphate  (EXP)
22-Hydroxycholesterol  (EXP)
3',5'-cyclic AMP  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP,ISO)
3-iodobenzyl-5'-N-methylcarboxamidoadenosine  (ISO)
3-Methoxynobiletin  (EXP)
3-phenylprop-2-enal  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol  (ISO)
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide  (ISO)
4-DAMP(1+)  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (EXP)
4-octylphenol  (EXP)
4-tert-Octylphenol  (ISO)
5,6,7-trimethoxyflavone  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-chloro-7-iodoquinolin-8-ol  (EXP)
5-fluorouracil  (EXP)
6-Cyano-7-nitroquinoxaline-2,3-dione  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
8-(3-chlorostyryl)caffeine  (ISO)
8-OH-DPAT  (ISO)
9-Methoxycamptothecin  (EXP)
acebutolol  (EXP)
acephate  (ISO)
acetaldehyde  (EXP,ISO)
acetylsalicylic acid  (EXP,ISO)
acrivastine  (EXP)
acrolein  (EXP)
acrylamide  (EXP,ISO)
acrylonitrile  (EXP)
actinomycin D  (EXP,ISO)
afimoxifene  (EXP)
aflatoxin B1  (EXP,ISO)
AH23848  (EXP)
alcohol  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
alfuzosin  (ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (EXP)
alpha-hexachlorocyclohexane  (ISO)
alpha-naphthoflavone  (EXP)
alpha-phellandrene  (EXP)
alpha-pinene  (EXP)
aluminium atom  (ISO)
aluminium oxide  (EXP)
aluminium(0)  (ISO)
AM-251  (ISO)
amiloride  (EXP,ISO)
amiodarone  (EXP)
ammonium chloride  (ISO)
ammonium hydroxide  (ISO)
amphetamine  (EXP,ISO)
anandamide  (ISO)
andrographolide  (EXP)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimonite  (EXP)
antimycin A  (EXP)
antirheumatic drug  (EXP)
apigenin  (EXP)
apomorphine  (ISO)
arachidonic acid  (EXP,ISO)
arecoline  (ISO)
aristolochic acid A  (EXP)
Aroclor 1254  (ISO)
arsane  (EXP)
arsenic acid  (ISO)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
astressin  (ISO)
ATP  (ISO)
atrazine  (EXP,ISO)
atropine  (EXP,ISO)
avobenzone  (EXP)
Azaspiracid  (EXP)
azathioprine  (EXP)
azithromycin  (EXP)
baclofen  (ISO)
BAPTA  (ISO)
bathocuproine disulfonic acid  (EXP)
Bay-K-8644  (EXP,ISO)
bazedoxifene  (EXP)
beclomethasone  (EXP)
benazepril  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP,ISO)
Benzo[k]fluoranthene  (EXP)
benzofurans  (EXP)
benzophenone  (EXP)
Benzoyl peroxide  (EXP,ISO)
Bergenin  (ISO)
beryllium difluoride  (ISO)
beryllium sulfate  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (EXP)
bicalutamide  (EXP)
bilobalide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
bromochloroacetic acid  (ISO)
bucladesine  (EXP,ISO)
bufalin  (EXP)
bupropion  (EXP)
buta-1,3-diene  (ISO)
butan-1-ol  (EXP,ISO)
butanal  (EXP)
butylated hydroxyanisole  (EXP)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (EXP)
caffeine  (ISO)
Calcimycin  (ISO)
calcitriol  (EXP)
Calphostin C  (ISO)
calyculin a  (EXP,ISO)
camostat  (ISO)
candesartan  (ISO)
cannabidiol  (EXP,ISO)
cannabidiolic acid  (EXP)
Cannabinol  (ISO)
capsaicin  (EXP,ISO)
capsazepine  (ISO)
captan  (ISO)
carbachol  (ISO)
carbamazepine  (EXP,ISO)
carbaryl  (EXP)
carbon nanotube  (EXP,ISO)
carnosine  (ISO)
carrageenan  (ISO)
cefaloridine  (ISO)
celecoxib  (ISO)
cerium trichloride  (ISO)
CGS-21680  (ISO)
chenodeoxycholic acid  (EXP)
chloral hydrate  (ISO)
Chloralose  (ISO)
chlormequat chloride  (ISO)
chloroform  (ISO)
chloropicrin  (EXP)
chloroprene  (ISO)
chlorpromazine  (ISO)
chlorpropamide  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
chromium atom  (EXP)
chromium(6+)  (ISO)
chrysene  (EXP)
chrysin  (EXP)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
Cinobufagin  (EXP)
ciprofibrate  (ISO)
cisapride  (ISO)
cisplatin  (EXP,ISO)
clarithromycin  (EXP)
clofibrate  (ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clotrimazole  (EXP)
clozapine  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (EXP)
cocaine  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP)
copper(II) sulfate  (EXP,ISO)
corilagin  (ISO)
corticosterone  (ISO)
coumestrol  (EXP)
crocidolite asbestos  (EXP,ISO)
CU-O LINKAGE  (EXP)
curcumin  (EXP,ISO)
cyanamide  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (EXP)
cypermethrin  (ISO)
D-cycloserine  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
daidzein  (EXP,ISO)
daidzein 7-O-beta-D-glucoside  (EXP)
DDE  (EXP)
DDT  (EXP,ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dehydroepiandrosterone  (EXP)
dehydroepiandrosterone sulfate  (ISO)
delta-hexachlorocyclohexane  (ISO)
deoxynivalenol  (EXP,ISO)
desipramine  (ISO)
Destruxin B  (EXP)
devazepide  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
dextromethorphan  (ISO)
Diallyl sulfide  (ISO)
diallyl trisulfide  (EXP)
diamminedichloroplatinum  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diarylheptanoid  (ISO)
diazepam  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dichloroacetic acid  (ISO)
dichloromethane  (ISO)
diclofenac  (EXP)
dieckol  (EXP)
dieldrin  (EXP)
diethyl maleate  (EXP,ISO)
diethylstilbestrol  (ISO)
diflunisal  (EXP)
diiodine  (ISO)
diisopropyl fluorophosphate  (ISO)
Dimaprit  (EXP)
dimemorfan  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP,ISO)
dimethylarsinous acid  (EXP)
dimethyldithiocarbamate  (ISO)
dinophysistoxin 1  (EXP)
dioxygen  (EXP,ISO)
diphenylcyclopropenone  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
dipyridamole  (EXP)
diquat  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (EXP)
dizocilpine maleate  (ISO)
dobutamine  (ISO)
donepezil hydrochloride  (ISO)
dopamine  (EXP,ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
ebselen  (EXP)
elemental selenium  (ISO)
ellagic acid  (ISO)
endosulfan  (EXP,ISO)
Enterolactone  (EXP)
entinostat  (EXP)
epoxiconazole  (ISO)
ergotamine  (ISO)
ergothioneine  (ISO)
Erionite  (ISO)
erythromycin A  (EXP)
estra-1,3,5(10)-triene-3,16beta-diol  (ISO)
estriol  (ISO)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
eticlopride(1+)  (ISO)
etoposide  (EXP,ISO)
famotidine  (EXP)
farnesyl diphosphate  (EXP)
fenfluramine  (ISO)
fentanyl  (ISO)
fenthion  (EXP)
ferric oxide  (ISO)
ferroheme b  (ISO)
ferrosoferric oxide  (EXP)
fingolimod hydrochloride  (ISO)
fisetin  (EXP)
Flavokawain A  (ISO)
flecainide  (EXP)
flumequine  (ISO)
fluoranthene  (ISO)
fluoxetine  (EXP,ISO)
flurbiprofen  (EXP,ISO)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (EXP,ISO)
formononetin  (ISO)
fotemustine  (EXP)
fructose  (ISO)
fulvestrant  (EXP,ISO)
furan  (ISO)
furosemide  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-tocopherol  (ISO)
gefitinib  (EXP)
Geniposide pentaacetate  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
geraniol  (EXP)
ginsenoside Rb1  (ISO)
ginsenoside Re  (EXP)
ginsenoside Rg1  (EXP)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glufosinate  (ISO)
glutathione  (ISO)
glycidol  (ISO)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
haloperidol  (ISO)
halothane  (ISO)
helioxanthin  (ISO)
heme b  (ISO)
hemin  (EXP)
heparin  (EXP,ISO)
herbimycin  (ISO)
heroin  (ISO)
hexachlorobenzene  (ISO)
Hexamethonium  (ISO)
histamine  (EXP)
hydralazine  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (EXP)
hydroxyurea  (ISO)
hypochlorous acid  (ISO)
icariin  (ISO)
idazoxan  (ISO)
ifosfamide  (ISO)
imipramine  (ISO)
indapamide  (ISO)
Indeno[1,2,3-cd]pyrene  (EXP)
indole-3-methanol  (ISO)
indometacin  (ISO)
iodoform  (EXP)
ionomycin  (EXP,ISO)
iprodione  (EXP)
irinotecan  (EXP)
iron atom  (ISO)
iron dextran  (ISO)
iron dichloride  (EXP)
iron(0)  (ISO)
iron(III) nitrilotriacetate  (EXP)
isobutanol  (EXP)
isoflurane  (ISO)
isoprenaline  (ISO)
Isorhapontigenin  (ISO)
isotretinoin  (ISO)
istradefylline  (ISO)
josamycin  (EXP)
kaempferol  (EXP,ISO)
kainic acid  (ISO)
kenpaullone  (ISO)
ketamine  (ISO)
ketorolac  (ISO)
KT 5823  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
L-selenocysteine  (EXP)
lanthanum atom  (ISO)
lead diacetate  (ISO)
lead nitrate  (EXP)
lead(0)  (EXP,ISO)
leflunomide  (EXP)
levamisole  (ISO)
Licochalcone B  (EXP,ISO)
lidocaine  (ISO)
linalool  (ISO)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP,ISO)
lithium chloride  (ISO)
lithium hydride  (EXP,ISO)
losartan  (ISO)
lovastatin  (ISO)
luteolin  (EXP,ISO)
luteolin 7-O-beta-D-glucoside  (EXP)
LY294002  (ISO)
lycopene  (EXP)
lysergic acid diethylamide  (ISO)
m-Chlorophenylbiguanide  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (ISO)
masoprocol  (ISO)
mebendazole  (EXP)
mechlorethamine  (EXP,ISO)
MeIQx  (EXP,ISO)
melatonin  (ISO)
menadione  (EXP)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
metformin  (EXP,ISO)
methamidophos  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
methylarsonic acid  (EXP,ISO)
methylglyoxal  (ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP,ISO)
methylphenidate  (EXP,ISO)
metoprolol  (ISO)
metyrapone  (ISO)
miconazole  (ISO)
microcystin-LR  (EXP,ISO)
Midecamycin  (EXP)
mifepristone  (ISO)
mitomycin C  (EXP)
ML-7  (ISO)
modafinil  (ISO)
Mofezolac (TN)  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotophos  (ISO)
monosodium L-glutamate  (ISO)
morin  (ISO)
morphine  (EXP,ISO)
Muconic dialdehyde  (EXP)
muscimol  (ISO)
mycophenolic acid  (EXP)
myricetin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
N-phenylthiourea  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
nabumetone  (EXP)
nafadotride  (ISO)
naloxone  (ISO)
naphthalene  (EXP)
naringin  (ISO)
nefazodone  (EXP)
neurotensin  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel subsulfide  (EXP,ISO)
nickel sulfate  (EXP,ISO)
niclosamide  (EXP,ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nifedipine  (EXP,ISO)
nilotinib  (EXP)
nimodipine  (EXP,ISO)
nimustine  (EXP)
nitrofen  (ISO)
nitrogen dioxide  (ISO)
nitroglycerin  (ISO)
nitroprusside  (ISO)
nobiletin  (ISO)
Nodularin  (EXP)
nomifensine  (ISO)
Nonylphenol  (EXP,ISO)
obeticholic acid  (EXP)
ochratoxin A  (EXP,ISO)
okadaic acid  (EXP,ISO)
olanzapine  (ISO)
omega-conotoxin GVIA  (ISO)
organoselenium compound  (EXP)
oroxylin A  (EXP)
oxaliplatin  (ISO)
oxidopamine  (ISO)
Oxotremorine  (ISO)
oxotremorine M  (EXP)
oxycodone  (ISO)
oxytocin  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (EXP)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (ISO)
palytoxin  (EXP,ISO)
paracetamol  (EXP,ISO)
paraoxon  (EXP)
paraquat  (EXP,ISO)
parathion-methyl  (ISO)
patulin  (ISO)
PCB138  (ISO)
PD 0325901  (ISO)
pentachlorobenzene  (ISO)
pentachlorophenol  (EXP,ISO)
pentetrazol  (ISO)
pentobarbital  (ISO)
Pentoxifylline  (EXP)
perchlorate  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
perindopril  (ISO)
permethrin  (ISO)
peroxynitrous acid  (EXP)
phencyclidine  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenytoin  (ISO)
PhIP  (EXP,ISO)
phorbol 12,13-dibutanoate  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phorone  (ISO)
phosgene  (ISO)
phylloquinone  (EXP)
physostigmine  (ISO)
picrotoxin  (ISO)
picrotoxinin  (ISO)
pimozide  (ISO)
pioglitazone  (ISO)
piperine  (EXP)
piperonyl butoxide  (ISO)
pipoxolan  (ISO)
pirenzepine  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
poly(ethylene)  (EXP)
potassium atom  (ISO)
potassium chloride  (ISO)
potassium chromate  (EXP)
potassium cyanide  (ISO)
prazosin  (ISO)
pregabalin  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (EXP,ISO)
promegestone  (EXP)
propan-2-ol  (EXP)
propanal  (EXP)
propofol  (ISO)
propranolol  (ISO)
prostaglandin E2  (EXP)
protein kinase inhibitor  (ISO)
protoporphyrin  (EXP)
pterostilbene  (ISO)
puerarin  (EXP)
putrescine  (ISO)
pyrethrins  (ISO)
pyridine  (ISO)
pyrimethamine  (EXP)
pyrrolidine dithiocarbamate  (EXP,ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinapril hydrochloride  (ISO)
quinolin-8-ol  (EXP,ISO)
quinolinic acid  (ISO)
quinomethionate  (EXP)
quinpirole  (ISO)
rac-lactic acid  (EXP)
ranitidine  (ISO)
reactive oxygen species  (EXP)
reboxetine  (ISO)
reserpine  (ISO)
resiniferatoxin  (ISO)
resveratrol  (EXP,ISO)
rimonabant  (ISO)
risperidone  (ISO)
ritonavir  (EXP)
Ro 31-8220  (ISO)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 203580  (EXP,ISO)
SB 206553  (ISO)
SB 431542  (EXP)
SCH 23390  (ISO)
SCH772984  (ISO)
sclareol  (EXP,ISO)
scopolamine  (ISO)
selenium atom  (ISO)
selenomethionine  (EXP)
selumetinib  (EXP)
serotonin  (ISO)
serpentine asbestos  (ISO)
sertraline  (EXP,ISO)
Shikonin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
silver(1+) nitrate  (EXP)
simvastatin  (EXP,ISO)
SKF 38393  (ISO)
SL-327  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium azide  (ISO)
sodium chloride  (EXP,ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP,ISO)
sodium fluoride  (ISO)
sodium perchlorate  (ISO)
Soman  (ISO)
spiramycin II  (EXP)
staurosporine  (ISO)
sterigmatocystin  (ISO)
stilben-4-ol  (EXP)
stilbene-4,4'-diol  (EXP)
streptozocin  (ISO)
styrene  (EXP,ISO)
sulfur dioxide  (ISO)
sulindac  (ISO)
sumatriptan  (ISO)
superoxide  (ISO)
tacrine  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP,ISO)
tandospirone citrate  (ISO)
Tanshinone I  (EXP)
taurine  (ISO)
taurolithocholic acid  (EXP)
tauroursodeoxycholic acid  (EXP)
tebufenpyrad  (EXP)
telmisartan  (ISO)
terbufos  (EXP)
terbutaline  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP,ISO)
Tetrachlorobisphenol A  (EXP)
tetrachloroethene  (EXP)
tetrachloromethane  (ISO)
tetramethylpyrazine  (ISO)
tetrathiomolybdate(2-)  (EXP)
tetrodotoxin  (ISO)
thalidomide  (EXP)
thapsigargin  (EXP)
theophylline  (ISO)
thimerosal  (EXP)
thioacetamide  (ISO)
thiourea  (ISO)
thymol  (ISO)
thymol sulfate(1-)  (ISO)
thymoquinone  (ISO)
titanium dioxide  (EXP,ISO)
tocopherol  (ISO)
toluene  (EXP,ISO)
topotecan  (EXP,ISO)
torcetrapib  (EXP)
toremifene  (ISO)
trans-stilbene-4,4'-diol  (EXP)
transplatin  (EXP,ISO)
tranylcypromine  (ISO)
triacsin C  (EXP)
triazolam  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP,ISO)
Tropicamide  (ISO)
trovafloxacin  (ISO)
tubocurarine  (EXP)
tungsten  (ISO)
tunicamycin  (EXP)
tyrphostin AG 1478  (EXP,ISO)
U-73122  (ISO)
uranium atom  (EXP)
urethane  (EXP,ISO)
Ursonic acid  (EXP)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vanadyl sulfate  (EXP)
vancomycin  (ISO)
vanoxerine dihydrochloride  (ISO)
verapamil  (EXP)
veratridine  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)
vitamin D  (EXP)
vitamin E  (ISO)
WIN 55212-2  (ISO)
wortmannin  (EXP,ISO)
xanomeline  (ISO)
Xanthatin  (EXP)
xanthohumol  (ISO)
xanthones  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)
zoledronic acid  (EXP,ISO)
zonisamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to cadmium ion  (IMP)
cellular response to calcium ion  (IEA,ISO)
cellular response to epidermal growth factor stimulus  (IEA,ISO)
cellular response to extracellular stimulus  (IEA)
cellular response to hormone stimulus  (IEA,ISO)
cellular response to hypoxia  (IEA,ISO)
cellular response to parathyroid hormone stimulus  (IEA,ISO)
cellular response to phorbol 13-acetate 12-myristate  (IEA,ISO)
cellular response to prolactin  (IEA,ISO)
cellular response to reactive oxygen species  (IDA,IMP)
cellular response to transforming growth factor beta stimulus  (IEA,ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
cellular response to zinc ion starvation  (IEA,ISO)
conditioned taste aversion  (IEA,ISO)
female pregnancy  (IEA,ISO)
inflammatory response  (TAS)
integrated stress response signaling  (NAS)
mononuclear cell differentiation  (IEA,ISO)
myoblast proliferation  (IEA,ISO)
nervous system development  (IEA,ISO)
osteoclast differentiation  (IEA,ISO)
positive regulation of DNA-templated transcription  (IDA,IMP)
positive regulation of miRNA transcription  (IDA,IEA,ISS)
positive regulation of osteoclast differentiation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IEA,IGI,IMP,ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of gene expression  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,NAS,TAS)
response to activity  (IEA,ISO)
response to cAMP  (IEA,ISO)
response to corticosterone  (IEA,ISO)
response to cytokine  (IEA,ISO)
response to ethanol  (IEA,ISO)
response to gravity  (IEA,ISO)
response to immobilization stress  (IEA,ISO)
response to insulin  (IEA,ISO)
response to light stimulus  (IEA,ISO)
response to lipopolysaccharide  (IEA,ISO)
response to mechanical stimulus  (IEA,ISO)
response to muscle stretch  (IEA,ISO)
response to organic cyclic compound  (IEA,ISO)
response to progesterone  (IEA,ISO)
response to steroid hormone  (IEA,ISO)
response to toxic substance  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)
skeletal muscle cell differentiation  (IEA,ISO)
skeletal muscle cell proliferation  (IEA,ISO)
SMAD protein signal transduction  (IDA)
transcription by RNA polymerase II  (IEA,ISO,TAS)
transforming growth factor beta receptor signaling pathway  (IDA)

Cellular Component

References

References - curated
# Reference Title Reference Citation
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9. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
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37. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
38. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
39. Constitutive activation of transcription factor AP-1 in cervical cancer and suppression of human papillomavirus (HPV) transcription and AP-1 activity in HeLa cells by curcumin. Prusty BK and Das BC, Int J Cancer. 2005 Mar 1;113(6):951-60.
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41. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
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45. Amphetamine and pseudoephedrine cross-tolerance measured by c-Fos protein expression in brains of chronically treated rats. Ruksee N, etal., BMC Neurosci. 2008 Oct 6;9:99. doi: 10.1186/1471-2202-9-99.
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52. Suppression of c-fos induction in the nucleus accumbens prevents acquisition but not expression of morphine-conditioned place preference. Tolliver BK, etal., Eur J Neurosci. 2000 Sep;12(9):3399-406. doi: 10.1046/j.1460-9568.2000.00214.x.
53. Chronic alcohol intake reduces retinoic acid concentration and enhances AP-1 (c-Jun and c-Fos) expression in rat liver. Wang XD, etal., Hepatology. 1998 Sep;28(3):744-50. doi: 10.1002/hep.510280321.
54. Different pattern of brain c-Fos expression following re-exposure to ethanol or sucrose self-administration environment. Wedzony K, etal., Naunyn Schmiedebergs Arch Pharmacol. 2003 Nov;368(5):331-41. doi: 10.1007/s00210-003-0811-7. Epub 2003 Oct 22.
55. Cardiac gene expression profile in rats with terminal heart failure and cachexia. Wellner M, etal., Physiol Genomics. 2005 Feb 10;20(3):256-67. Epub 2004 Dec 28.
56. Binge ethanol effects on prefrontal cortex neurons, spatial working memory and task-induced neuronal activation in male and female rats. West RK, etal., Physiol Behav. 2018 May 1;188:79-85. doi: 10.1016/j.physbeh.2018.01.027. Epub 2018 Jan 31.
57. The galanin receptor-3 antagonist, SNAP 37889, inhibits cue-induced reinstatement of alcohol-seeking and increases c-Fos expression in the nucleus accumbens shell of alcohol-preferring rats. Wilson KE, etal., J Psychopharmacol. 2018 Aug;32(8):911-921. doi: 10.1177/0269881118780015. Epub 2018 Jun 21.
58. Vesicular glutamate transporter-3 contributes to visceral hyperalgesia induced by Trichinella spiralis infection in rats. Yang CQ, etal., Dig Dis Sci. 2012 Apr;57(4):865-72. doi: 10.1007/s10620-011-1970-x. Epub 2011 Dec 9.
59. Paecilomycies japonica reduces repeated nicotine-induced neuronal and behavioral activation in rats. Ye M, etal., BMC Complement Altern Med. 2015 Jul 14;15:227. doi: 10.1186/s12906-015-0739-8.
60. Target organ protection from a novel angiotensin II receptor (AT1) vaccine ATR12181 in spontaneously hypertensive rats. Zhu F, etal., Cell Mol Immunol. 2006 Apr;3(2):107-14.
Additional References at PubMed
PMID:1406655   PMID:1545828   PMID:1589769   PMID:1631061   PMID:1658710   PMID:1827203   PMID:1828107   PMID:1903538   PMID:2414012   PMID:2511004   PMID:2516827   PMID:3027573  
PMID:3555978   PMID:3817017   PMID:6574479   PMID:7540136   PMID:7623830   PMID:7642615   PMID:7665092   PMID:7685215   PMID:7713192   PMID:7816143   PMID:7816602   PMID:7957556  
PMID:7962462   PMID:7994752   PMID:8065335   PMID:8108109   PMID:8151786   PMID:8248197   PMID:8380166   PMID:8397339   PMID:8440710   PMID:8475068   PMID:8480425   PMID:8524278  
PMID:8557686   PMID:8570175   PMID:8617242   PMID:8621941   PMID:8628277   PMID:8710853   PMID:8737385   PMID:8763994   PMID:8816797   PMID:8816798   PMID:8904195   PMID:8971979  
PMID:9057648   PMID:9121455   PMID:9129988   PMID:9130707   PMID:9160889   PMID:9207128   PMID:9334186   PMID:9346889   PMID:9443941   PMID:9468519   PMID:9488446   PMID:9510247  
PMID:9545246   PMID:9642216   PMID:9671405   PMID:9681824   PMID:9685505   PMID:9732876   PMID:9792677   PMID:9872330   PMID:9888853   PMID:9918847   PMID:10027715   PMID:10330159  
PMID:10388555   PMID:10487758   PMID:10488148   PMID:10497212   PMID:10508860   PMID:10523647   PMID:10567390   PMID:10567391   PMID:10581001   PMID:10704222   PMID:10764760   PMID:10777532  
PMID:10799874   PMID:10847592   PMID:10918580   PMID:11053448   PMID:11090181   PMID:11134330   PMID:11260070   PMID:11274169   PMID:11278640   PMID:11287611   PMID:11397794   PMID:11397816  
PMID:11431474   PMID:11641401   PMID:11782371   PMID:11846562   PMID:11891317   PMID:11909859   PMID:11983170   PMID:12052862   PMID:12082260   PMID:12127989   PMID:12147741   PMID:12183893  
PMID:12193410   PMID:12370307   PMID:12419805   PMID:12445807   PMID:12446585   PMID:12477932   PMID:12508121   PMID:12547826   PMID:12592382   PMID:12600988   PMID:12687275   PMID:12692226  
PMID:12705898   PMID:12788789   PMID:12949493   PMID:12972619   PMID:14511403   PMID:14517309   PMID:14522952   PMID:14629301   PMID:14702039   PMID:14727154   PMID:14741347   PMID:14966901  
PMID:15175153   PMID:15188457   PMID:15258149   PMID:15262961   PMID:15276183   PMID:15319445   PMID:15489334   PMID:15507668   PMID:15530430   PMID:15548518   PMID:15588513   PMID:15610731  
PMID:15654976   PMID:15708845   PMID:15718494   PMID:15767669   PMID:15835820   PMID:15844599   PMID:15867431   PMID:15921770   PMID:15926923   PMID:15950906   PMID:16001969   PMID:16008525  
PMID:16023595   PMID:16038047   PMID:16055710   PMID:16123044   PMID:16219292   PMID:16236267   PMID:16243842   PMID:16452503   PMID:16511568   PMID:16552729   PMID:16637060   PMID:16690925  
PMID:16714286   PMID:16828227   PMID:16928824   PMID:17018293   PMID:17080554   PMID:17160021   PMID:17182779   PMID:17203973   PMID:17209045   PMID:17217916   PMID:17226766   PMID:17235455  
PMID:17317669   PMID:17440114   PMID:17495958   PMID:17549045   PMID:17606925   PMID:17636030   PMID:17639289   PMID:17681951   PMID:17703412   PMID:17709345   PMID:17888430   PMID:17915561  
PMID:17926144   PMID:18029348   PMID:18032824   PMID:18042260   PMID:18056707   PMID:18097055   PMID:18158562   PMID:18172215   PMID:18206243   PMID:18252863   PMID:18283312   PMID:18305042  
PMID:18309110   PMID:18316037   PMID:18368600   PMID:18405916   PMID:18422165   PMID:18425349   PMID:18467434   PMID:18500346   PMID:18511550   PMID:18597608   PMID:18599327   PMID:18619508  
PMID:18621151   PMID:18641127   PMID:18644870   PMID:18653705   PMID:18676680   PMID:18725194   PMID:18802113   PMID:18826606   PMID:18838675   PMID:18848838   PMID:18854825   PMID:18923650  
PMID:18957410   PMID:18986987   PMID:19009649   PMID:19013323   PMID:19015316   PMID:19022561   PMID:19028685   PMID:19064921   PMID:19105933   PMID:19135542   PMID:19151755   PMID:19170196  
PMID:19199093   PMID:19215067   PMID:19258923   PMID:19269029   PMID:19274049   PMID:19299513   PMID:19329434   PMID:19384981   PMID:19453261   PMID:19495976   PMID:19513521   PMID:19557575  
PMID:19581295   PMID:19625176   PMID:19692168   PMID:19714312   PMID:19795350   PMID:19859790   PMID:19874574   PMID:19913121   PMID:19921846   PMID:19937979   PMID:19959471   PMID:20012528  
PMID:20042607   PMID:20089855   PMID:20102225   PMID:20195357   PMID:20203690   PMID:20209053   PMID:20211142   PMID:20398657   PMID:20410304   PMID:20459032   PMID:20463008   PMID:20468064  
PMID:20493519   PMID:20498278   PMID:20503287   PMID:20511396   PMID:20531301   PMID:20619839   PMID:20628086   PMID:20628624   PMID:20682178   PMID:20726226   PMID:20869948   PMID:20936779  
PMID:20976196   PMID:21034562   PMID:21106746   PMID:21163924   PMID:21199371   PMID:21303932   PMID:21340718   PMID:21385848   PMID:21423810   PMID:21496113   PMID:21496208   PMID:21607373  
PMID:21655091   PMID:21675959   PMID:21732357   PMID:21757709   PMID:21822357   PMID:21829441   PMID:21873635   PMID:21900206   PMID:21920361   PMID:21937452   PMID:21978922   PMID:21988832  
PMID:22076613   PMID:22077140   PMID:22105363   PMID:22108803   PMID:22308434   PMID:22354777   PMID:22387553   PMID:22474330   PMID:22528769   PMID:22534624   PMID:22537850   PMID:22546605  
PMID:22699663   PMID:22719067   PMID:22772468   PMID:23001723   PMID:23121125   PMID:23128233   PMID:23135283   PMID:23209736   PMID:23301044   PMID:23331079   PMID:23396363   PMID:23400877  
PMID:23418787   PMID:23494858   PMID:23508102   PMID:23549086   PMID:23562910   PMID:23578467   PMID:23593403   PMID:23595228   PMID:23602568   PMID:23602572   PMID:23614275   PMID:23625009  
PMID:23625206   PMID:23660496   PMID:23661758   PMID:23667255   PMID:23744317   PMID:23760290   PMID:23844083   PMID:23919306   PMID:24029232   PMID:24073601   PMID:24184327   PMID:24187576  
PMID:24220339   PMID:24225433   PMID:24244375   PMID:24322891   PMID:24378831   PMID:24386331   PMID:24479681   PMID:24551192   PMID:24630741   PMID:24658403   PMID:24886961   PMID:24909488  
PMID:24952347   PMID:24987920   PMID:25016017   PMID:25064159   PMID:25077945   PMID:25157104   PMID:25241761   PMID:25384976   PMID:25416956   PMID:25544773   PMID:25588078   PMID:25592718  
PMID:25609649   PMID:25647783   PMID:25670814   PMID:25706621   PMID:25903346   PMID:26018080   PMID:26018137   PMID:26112171   PMID:26173738   PMID:26186194   PMID:26209639   PMID:26264872  
PMID:26303532   PMID:26381409   PMID:26387545   PMID:26493679   PMID:26496610   PMID:26514923   PMID:26631725   PMID:26725323   PMID:26858249   PMID:26860974   PMID:26917263   PMID:26988982  
PMID:27102414   PMID:27107012   PMID:27107014   PMID:27474128   PMID:27513856   PMID:27517874   PMID:27558649   PMID:27602752   PMID:27637333   PMID:27965308   PMID:28358415   PMID:28473536  
PMID:28514442   PMID:28566324   PMID:28637007   PMID:28665975   PMID:28728983   PMID:28910941   PMID:29066822   PMID:29130097   PMID:29331016   PMID:29582647   PMID:29858576   PMID:29892012  
PMID:29993138   PMID:29997244   PMID:30021895   PMID:30066839   PMID:30085406   PMID:30124866   PMID:30257388   PMID:30315111   PMID:30353072   PMID:30361264   PMID:30476653   PMID:30515991  
PMID:30586711   PMID:30656892   PMID:30670568   PMID:30767554   PMID:30804502   PMID:30879166   PMID:30893847   PMID:30898623   PMID:31018569   PMID:31182485   PMID:31261535   PMID:31338937  
PMID:31444232   PMID:31467278   PMID:31490237   PMID:31515488   PMID:31573330   PMID:31694235   PMID:31805275   PMID:32042069   PMID:32097665   PMID:32281291   PMID:32289284   PMID:32296036  
PMID:32296183   PMID:32360331   PMID:32482537   PMID:32487998   PMID:32513696   PMID:32542935   PMID:32572902   PMID:32767928   PMID:32814053   PMID:33188281   PMID:33211090   PMID:33297334  
PMID:33308098   PMID:33318581   PMID:33393145   PMID:33604677   PMID:33653978   PMID:33852840   PMID:33961781   PMID:34171102   PMID:34315853   PMID:34610301   PMID:34671206   PMID:34763165  
PMID:34942351   PMID:35140242   PMID:35143939   PMID:35503086   PMID:35537818   PMID:35568340   PMID:35579162   PMID:35580072   PMID:35621221   PMID:36008878   PMID:36099089   PMID:36197962  
PMID:36291102   PMID:36454517   PMID:36629882   PMID:37344157   PMID:37353480   PMID:37460318   PMID:37481710   PMID:37553246   PMID:37564212   PMID:37581569   PMID:37616343   PMID:37909980  
PMID:37965313   PMID:38063270   PMID:38242196  


Genomics

Comparative Map Data
FOS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381475,278,828 - 75,282,230 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1475,278,826 - 75,282,230 (+)EnsemblGRCh38hg38GRCh38
GRCh371475,745,531 - 75,748,933 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,815,284 - 74,818,666 (+)NCBINCBI36Build 36hg18NCBI36
Build 341474,815,283 - 74,818,666NCBI
Celera1455,783,567 - 55,787,023 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,913,924 - 55,917,380 (+)NCBIHuRef
CHM1_11475,683,266 - 75,686,721 (+)NCBICHM1_1
T2T-CHM13v2.01469,488,228 - 69,491,630 (+)NCBIT2T-CHM13v2.0
Fos
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391285,520,664 - 85,524,048 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1285,520,664 - 85,524,047 (+)EnsemblGRCm39 Ensembl
GRCm381285,473,890 - 85,477,274 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1285,473,890 - 85,477,273 (+)EnsemblGRCm38mm10GRCm38
MGSCv371286,814,851 - 86,818,219 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361286,363,004 - 86,366,372 (+)NCBIMGSCv36mm8
Celera1286,933,225 - 86,936,593 (+)NCBICelera
Cytogenetic Map12D2NCBI
cM Map1239.7NCBI
Fos
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,852,188 - 110,855,054 (+)NCBIGRCr8
mRatBN7.26105,121,170 - 105,124,036 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6105,121,170 - 105,124,036 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6105,290,640 - 105,293,508 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06105,589,531 - 105,592,399 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,959,176 - 104,962,044 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06109,300,433 - 109,303,299 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6109,300,433 - 109,303,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06116,249,742 - 116,252,608 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46109,559,135 - 109,562,001 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16109,562,609 - 109,566,002 (+)NCBI
Celera6102,942,464 - 102,945,330 (+)NCBICelera
Cytogenetic Map6q31NCBI
Fos
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955523305,728 - 310,728 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955523307,181 - 310,728 (-)NCBIChiLan1.0ChiLan1.0
FOS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21576,362,508 - 76,366,629 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11475,579,607 - 75,583,133 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01455,832,570 - 55,835,984 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11474,676,316 - 74,679,766 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1474,676,316 - 74,679,766 (+)Ensemblpanpan1.1panPan2
FOS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1848,330,856 - 48,334,273 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl848,331,026 - 48,333,467 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha848,014,730 - 48,018,137 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0848,558,356 - 48,561,763 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl848,558,343 - 48,561,758 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1848,229,017 - 48,232,423 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0848,250,295 - 48,253,702 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0848,649,028 - 48,652,435 (+)NCBIUU_Cfam_GSD_1.0
Fos
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864027,680,843 - 27,684,228 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364884,384,705 - 4,388,122 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364884,384,710 - 4,388,118 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl798,449,349 - 98,455,554 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1798,449,508 - 98,451,971 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27104,293,828 - 104,296,291 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FOS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12452,497,465 - 52,501,161 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2452,497,521 - 52,501,514 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605340,725,132 - 40,728,594 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fos
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473426,423,079 - 26,427,732 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473426,424,053 - 26,427,431 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FOS
23 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q24.3(chr14:73877072-78042422)x1 copy number loss See cases [RCV000051548] Chr14:73877072..78042422 [GRCh38]
Chr14:74343775..78508765 [GRCh37]
Chr14:73413528..77578518 [NCBI36]
Chr14:14q24.3
pathogenic
GRCh38/hg38 14q24.2-32.2(chr14:72787506-99596719)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052293]|See cases [RCV000052293] Chr14:72787506..99596719 [GRCh38]
Chr14:73254214..100063056 [GRCh37]
Chr14:72323967..99132809 [NCBI36]
Chr14:14q24.2-32.2
pathogenic
GRCh37/hg19 14q24.2-q24.3(chr14:73152115..77698582) deletion Intellectual disability, mild [RCV000190520] Chr14:73152115..77698582 [GRCh37]
Chr14:14q24.2-24.3
pathogenic|likely pathogenic
GRCh38/hg38 14q24.1-31.1(chr14:69562099-81975384)x1 copy number loss See cases [RCV000134154] Chr14:69562099..81975384 [GRCh38]
Chr14:70028816..82441728 [GRCh37]
Chr14:69098569..81511481 [NCBI36]
Chr14:14q24.1-31.1
pathogenic
GRCh38/hg38 14q24.3-32.33(chr14:73655772-106879298)x3 copy number gain See cases [RCV000134000] Chr14:73655772..106879298 [GRCh38]
Chr14:74122475..107287505 [GRCh37]
Chr14:73192228..106358550 [NCBI36]
Chr14:14q24.3-32.33
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q24.3(chr14:74986195-76399258)x1 copy number loss See cases [RCV000137114] Chr14:74986195..76399258 [GRCh38]
Chr14:75452898..76865601 [GRCh37]
Chr14:74522651..75935354 [NCBI36]
Chr14:14q24.3
uncertain significance
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q24.3-31.1(chr14:73343213-78835059)x1 copy number loss See cases [RCV000143265] Chr14:73343213..78835059 [GRCh38]
Chr14:73809921..79301402 [GRCh37]
Chr14:72879674..78371155 [NCBI36]
Chr14:14q24.3-31.1
pathogenic|likely pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q23.2-32.33(chr14:62493932-107285437)x3 copy number gain See cases [RCV000448557] Chr14:62493932..107285437 [GRCh37]
Chr14:14q23.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q24.2-32.33(chr14:73750741-107285437)x3 copy number gain See cases [RCV000512497] Chr14:73750741..107285437 [GRCh37]
Chr14:14q24.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33
pathogenic
NM_005252.4(FOS):c.189G>A (p.Thr63=) single nucleotide variant not provided [RCV000894036] Chr14:75279924 [GRCh38]
Chr14:75746627 [GRCh37]
Chr14:14q24.3
benign
NM_005252.4(FOS):c.528G>C (p.Lys176Asn) single nucleotide variant not provided [RCV000882048] Chr14:75280809 [GRCh38]
Chr14:75747512 [GRCh37]
Chr14:14q24.3
benign|likely benign
NM_005252.4(FOS):c.699G>A (p.Pro233=) single nucleotide variant not provided [RCV000969914] Chr14:75280980 [GRCh38]
Chr14:75747683 [GRCh37]
Chr14:14q24.3
likely benign
NM_005252.4(FOS):c.697C>G (p.Pro233Ala) single nucleotide variant not provided [RCV000886627] Chr14:75280978 [GRCh38]
Chr14:75747681 [GRCh37]
Chr14:14q24.3
likely benign
NM_005252.4(FOS):c.981G>A (p.Val327=) single nucleotide variant not provided [RCV000895814] Chr14:75281262 [GRCh38]
Chr14:75747965 [GRCh37]
Chr14:14q24.3
benign
NM_005252.4(FOS):c.42C>A (p.Ser14=) single nucleotide variant not provided [RCV000924790] Chr14:75279024 [GRCh38]
Chr14:75745727 [GRCh37]
Chr14:14q24.3
likely benign
GRCh37/hg19 14q24.3(chr14:74040231-76368547) copy number loss not provided [RCV000767572] Chr14:74040231..76368547 [GRCh37]
Chr14:14q24.3
likely pathogenic
NM_005252.4(FOS):c.798C>T (p.Thr266=) single nucleotide variant not provided [RCV000914080] Chr14:75281079 [GRCh38]
Chr14:75747782 [GRCh37]
Chr14:14q24.3
benign
NM_005252.4(FOS):c.396A>G (p.Leu132=) single nucleotide variant not provided [RCV000898590] Chr14:75280562 [GRCh38]
Chr14:75747265 [GRCh37]
Chr14:14q24.3
likely benign
NM_005252.4(FOS):c.481C>T (p.Leu161=) single nucleotide variant not provided [RCV000929816] Chr14:75280647 [GRCh38]
Chr14:75747350 [GRCh37]
Chr14:14q24.3
likely benign
NM_005252.4(FOS):c.367A>G (p.Ile123Val) single nucleotide variant not provided [RCV000949795] Chr14:75280102 [GRCh38]
Chr14:75746805 [GRCh37]
Chr14:14q24.3
likely benign
NM_005252.4(FOS):c.477G>A (p.Arg159=) single nucleotide variant not provided [RCV000980257] Chr14:75280643 [GRCh38]
Chr14:75747346 [GRCh37]
Chr14:14q24.3
likely benign
NM_005252.4(FOS):c.912G>A (p.Glu304=) single nucleotide variant not provided [RCV000911239] Chr14:75281193 [GRCh38]
Chr14:75747896 [GRCh37]
Chr14:14q24.3
likely benign
GRCh37/hg19 14q22.2-24.3(chr14:54654001-75828024)x3 copy number gain 14q22.2q24.3 duplication [RCV001506967] Chr14:54654001..75828024 [GRCh37]
Chr14:14q22.2-24.3
likely pathogenic
GRCh37/hg19 14q13.3-32.33(chr14:37671058-106985955)x2 copy number gain See cases [RCV002286356] Chr14:37671058..106985955 [GRCh37]
Chr14:14q13.3-32.33
pathogenic
NM_005252.4(FOS):c.343A>G (p.Met115Val) single nucleotide variant Inborn genetic diseases [RCV002968428] Chr14:75280078 [GRCh38]
Chr14:75746781 [GRCh37]
Chr14:14q24.3
uncertain significance
NM_005252.4(FOS):c.608C>T (p.Ala203Val) single nucleotide variant Inborn genetic diseases [RCV002773775] Chr14:75280889 [GRCh38]
Chr14:75747592 [GRCh37]
Chr14:14q24.3
uncertain significance
NM_005252.4(FOS):c.859C>T (p.Arg287Cys) single nucleotide variant Inborn genetic diseases [RCV002728354] Chr14:75281140 [GRCh38]
Chr14:75747843 [GRCh37]
Chr14:14q24.3
uncertain significance
NM_005252.4(FOS):c.748A>G (p.Lys250Glu) single nucleotide variant Inborn genetic diseases [RCV002707388] Chr14:75281029 [GRCh38]
Chr14:75747732 [GRCh37]
Chr14:14q24.3
uncertain significance
NM_005252.4(FOS):c.293T>C (p.Val98Ala) single nucleotide variant Inborn genetic diseases [RCV002703847] Chr14:75280028 [GRCh38]
Chr14:75746731 [GRCh37]
Chr14:14q24.3
uncertain significance
NM_005252.4(FOS):c.1027T>G (p.Phe343Val) single nucleotide variant Inborn genetic diseases [RCV002874191] Chr14:75281308 [GRCh38]
Chr14:75748011 [GRCh37]
Chr14:14q24.3
uncertain significance
NM_005252.4(FOS):c.682C>G (p.Pro228Ala) single nucleotide variant Inborn genetic diseases [RCV002961214] Chr14:75280963 [GRCh38]
Chr14:75747666 [GRCh37]
Chr14:14q24.3
uncertain significance
NM_005252.4(FOS):c.967C>A (p.Leu323Met) single nucleotide variant Inborn genetic diseases [RCV003211319] Chr14:75281248 [GRCh38]
Chr14:75747951 [GRCh37]
Chr14:14q24.3
uncertain significance
NM_005252.4(FOS):c.362A>G (p.Gln121Arg) single nucleotide variant Inborn genetic diseases [RCV003189473] Chr14:75280097 [GRCh38]
Chr14:75746800 [GRCh37]
Chr14:14q24.3
uncertain significance
NM_005252.4(FOS):c.353G>T (p.Gly118Val) single nucleotide variant Inborn genetic diseases [RCV003195017] Chr14:75280088 [GRCh38]
Chr14:75746791 [GRCh37]
Chr14:14q24.3
uncertain significance
NM_005252.4(FOS):c.860G>A (p.Arg287His) single nucleotide variant Inborn genetic diseases [RCV003288301] Chr14:75281141 [GRCh38]
Chr14:75747844 [GRCh37]
Chr14:14q24.3
uncertain significance
GRCh37/hg19 14q23.1-32.33(chr14:58894502-107227240)x3 copy number gain not provided [RCV003485036] Chr14:58894502..107227240 [GRCh37]
Chr14:14q23.1-32.33
pathogenic
GRCh37/hg19 14q24.3(chr14:74883763-77219310)x1 copy number loss not provided [RCV003483211] Chr14:74883763..77219310 [GRCh37]
Chr14:14q24.3
uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR139hsa-miR-139-5pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI23001723
MIR101-2hsa-miR-101-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19133651
MIR101-2hsa-miR-101-3pOncomiRDBexternal_infoNANA19133651
MIR181A2hsa-miR-181a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22956783
MIR222hsa-miR-222-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Functional MTI20299489
MIR222hsa-miR-222-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23400877
MIR222hsa-miR-222-3pOncomiRDBexternal_infoNANA23400877
MIR181A1hsa-miR-181a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22956783
MIR101-1hsa-miR-101-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19133651
MIR222hsa-miR-222-3pMirecordsexternal_infoNANA20299489
MIR101-1hsa-miR-101-3pOncomiRDBexternal_infoNANA19133651
MIR221hsa-miR-221-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blot//Functional MTI20299489
MIR221hsa-miR-221-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23400877
MIR221hsa-miR-221-3pOncomiRDBexternal_infoNANA23400877
MIR221hsa-miR-221-5pMirecordsexternal_infoNANA20299489

Predicted Target Of
Summary Value
Count of predictions:2433
Count of miRNA genes:888
Interacting mature miRNAs:1082
Transcripts:ENST00000303562, ENST00000535987, ENST00000554212, ENST00000554617, ENST00000555242, ENST00000555347, ENST00000555672, ENST00000555686, ENST00000556324, ENST00000557139
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
Fos  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,748,689 - 75,748,849UniSTSGRCh37
GRCh371475,748,724 - 75,748,897UniSTSGRCh37
Build 361474,818,477 - 74,818,650RGDNCBI36
Celera1455,786,775 - 55,786,935UniSTS
Celera1455,786,810 - 55,786,983RGD
HuRef1455,917,132 - 55,917,292UniSTS
HuRef1455,917,167 - 55,917,340UniSTS
GDB:199085  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,747,191 - 75,747,609UniSTSGRCh37
Build 361474,816,944 - 74,817,362RGDNCBI36
Celera1455,785,277 - 55,785,695RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,915,634 - 55,916,052UniSTS
GDB:201707  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,747,189 - 75,747,469UniSTSGRCh37
Build 361474,816,942 - 74,817,222RGDNCBI36
Celera1455,785,275 - 55,785,555RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,915,632 - 55,915,912UniSTS
STS-V01512  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,748,155 - 75,748,346UniSTSGRCh37
Build 361474,817,908 - 74,818,099RGDNCBI36
Celera1455,786,241 - 55,786,432RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,916,598 - 55,916,789UniSTS
GeneMap99-GB4 RH Map14201.19UniSTS
PMC126057P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,745,163 - 75,745,363UniSTSGRCh37
Build 361474,814,916 - 74,815,116RGDNCBI36
Celera1455,783,249 - 55,783,449RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,913,606 - 55,913,806UniSTS
PMC135937P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,746,767 - 75,747,627UniSTSGRCh37
Build 361474,816,520 - 74,817,380RGDNCBI36
Celera1455,784,853 - 55,785,713RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,915,210 - 55,916,070UniSTS
PMC139817P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,745,144 - 75,745,281UniSTSGRCh37
Build 361474,814,897 - 74,815,034RGDNCBI36
Celera1455,783,230 - 55,783,367RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,913,587 - 55,913,724UniSTS
PMC151710P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,746,595 - 75,746,783UniSTSGRCh37
Build 361474,816,348 - 74,816,536RGDNCBI36
Celera1455,784,681 - 55,784,869RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,915,038 - 55,915,226UniSTS
PMC86910P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,745,178 - 75,745,344UniSTSGRCh37
Build 361474,814,931 - 74,815,097RGDNCBI36
Celera1455,783,264 - 55,783,430RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,913,621 - 55,913,787UniSTS
PMC87308P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,748,075 - 75,748,930UniSTSGRCh37
Build 361474,817,828 - 74,818,683RGDNCBI36
Celera1455,786,161 - 55,787,016RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,916,518 - 55,917,373UniSTS
WI-19801  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,748,245 - 75,748,501UniSTSGRCh37
Build 361474,817,998 - 74,818,254RGDNCBI36
Celera1455,786,331 - 55,786,587RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,916,688 - 55,916,944UniSTS
GeneMap99-GB4 RH Map14201.19UniSTS
Whitehead-RH Map14268.5UniSTS
FOS_V40  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,747,863 - 75,748,676UniSTSGRCh37
Build 361474,817,616 - 74,818,429RGDNCBI36
Celera1455,785,949 - 55,786,762RGD
HuRef1455,916,306 - 55,917,119UniSTS
G06585  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,748,385 - 75,748,717UniSTSGRCh37
Build 361474,818,138 - 74,818,470RGDNCBI36
Celera1455,786,471 - 55,786,803RGD
Cytogenetic Map14q24.3UniSTS
HuRef1455,916,828 - 55,917,160UniSTS
BP250015A10G9  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,748,074 - 75,748,590UniSTSGRCh37
Celera1455,786,160 - 55,786,676UniSTS
HuRef1455,916,517 - 55,917,033UniSTS
BP240034A10G4  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,748,411 - 75,748,717UniSTSGRCh37
Celera1455,786,497 - 55,786,803UniSTS
HuRef1455,916,854 - 55,917,160UniSTS
Fos  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371475,748,689 - 75,748,849UniSTSGRCh37
GRCh371475,748,724 - 75,748,897UniSTSGRCh37
Build 361474,818,477 - 74,818,650RGDNCBI36
Celera1455,786,775 - 55,786,935UniSTS
Celera1455,786,810 - 55,786,983RGD
HuRef1455,917,132 - 55,917,292UniSTS
HuRef1455,917,167 - 55,917,340UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High 204 384 134 4 83 1 694 57 153 21 115 190 4 258 335
Medium 2192 2484 1540 572 1319 416 3426 1833 3198 357 1246 1278 159 946 2282 4
Low 38 118 48 46 500 48 235 302 356 36 88 139 9 171 1
Below cutoff 1 1 2 45 1 2 13 5 10 6 2 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029673 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB022275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB022276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF111167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH003773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK097379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290907 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK298659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY212879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC004490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX647104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR542267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI574162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K00650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT583865 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  V01512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000303562   ⟹   ENSP00000306245
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1475,278,828 - 75,282,230 (+)Ensembl
RefSeq Acc Id: ENST00000535987   ⟹   ENSP00000442268
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1475,278,828 - 75,281,636 (+)Ensembl
RefSeq Acc Id: ENST00000554212   ⟹   ENSP00000452443
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1475,278,828 - 75,280,607 (+)Ensembl
RefSeq Acc Id: ENST00000554617   ⟹   ENSP00000450519
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1475,278,826 - 75,280,374 (+)Ensembl
RefSeq Acc Id: ENST00000555242   ⟹   ENSP00000452386
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1475,278,977 - 75,280,789 (+)Ensembl
RefSeq Acc Id: ENST00000555347   ⟹   ENSP00000450886
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1475,280,193 - 75,281,587 (+)Ensembl
RefSeq Acc Id: ENST00000555672   ⟹   ENSP00000452440
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1475,279,670 - 75,281,157 (+)Ensembl
RefSeq Acc Id: ENST00000555686   ⟹   ENSP00000452590
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1475,279,643 - 75,281,684 (+)Ensembl
RefSeq Acc Id: ENST00000556324
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1475,278,828 - 75,279,531 (+)Ensembl
RefSeq Acc Id: ENST00000557139   ⟹   ENSP00000451786
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1475,279,978 - 75,280,667 (+)Ensembl
RefSeq Acc Id: NM_005252   ⟹   NP_005243
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381475,278,828 - 75,282,230 (+)NCBI
GRCh371475,745,477 - 75,748,937 (+)NCBI
Build 361474,815,284 - 74,818,666 (+)NCBI Archive
HuRef1455,913,924 - 55,917,380 (+)ENTREZGENE
CHM1_11475,683,266 - 75,686,721 (+)NCBI
T2T-CHM13v2.01469,488,228 - 69,491,630 (+)NCBI
Sequence:
RefSeq Acc Id: NP_005243   ⟸   NM_005252
- UniProtKB: B4DQ65 (UniProtKB/Swiss-Prot),   A8K4E2 (UniProtKB/Swiss-Prot),   P18849 (UniProtKB/Swiss-Prot),   P01100 (UniProtKB/Swiss-Prot),   Q6FG41 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000452440   ⟸   ENST00000555672
RefSeq Acc Id: ENSP00000452590   ⟸   ENST00000555686
RefSeq Acc Id: ENSP00000450886   ⟸   ENST00000555347
RefSeq Acc Id: ENSP00000452386   ⟸   ENST00000555242
RefSeq Acc Id: ENSP00000451786   ⟸   ENST00000557139
RefSeq Acc Id: ENSP00000442268   ⟸   ENST00000535987
RefSeq Acc Id: ENSP00000306245   ⟸   ENST00000303562
RefSeq Acc Id: ENSP00000450519   ⟸   ENST00000554617
RefSeq Acc Id: ENSP00000452443   ⟸   ENST00000554212
Protein Domains
bZIP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01100-F1-model_v2 AlphaFold P01100 1-380 view protein structure

Promoters
RGD ID:6791592
Promoter ID:HG_KWN:19815
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_005252
Position:
Human AssemblyChrPosition (strand)Source
Build 361474,814,671 - 74,815,387 (+)MPROMDB
RGD ID:6850224
Promoter ID:EP11145
Type:multiple initiation site
Name:HS_FOS
Description:V-fos FBJ murine osteosarcoma viral oncogene homolog.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 51; Mammalian c-fos proto-oncogene.
Experiment Methods:Nuclease protection; transfected or transformed cells; NEDO full length human cDNA sequencing project.; Oligo-capping
Regulation:(induced by or strongly expressed in) mitogen
Position:
Human AssemblyChrPosition (strand)Source
Build 361474,815,284 - 74,815,344EPD
RGD ID:6791593
Promoter ID:HG_KWN:19816
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid
Transcripts:UC001XRO.1,   UC010ASI.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361474,815,806 - 74,817,022 (+)MPROMDB
RGD ID:7228177
Promoter ID:EPDNEW_H19834
Type:initiation region
Name:FOS_1
Description:Fos proto-oncogene, AP-1 transcription factor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381475,278,828 - 75,278,888EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3796 AgrOrtholog
COSMIC FOS COSMIC
Ensembl Genes ENSG00000170345 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000303562 ENTREZGENE
  ENST00000303562.9 UniProtKB/Swiss-Prot
  ENST00000535987.5 UniProtKB/Swiss-Prot
  ENST00000554212.5 UniProtKB/TrEMBL
  ENST00000554617.1 UniProtKB/TrEMBL
  ENST00000555242.1 UniProtKB/TrEMBL
  ENST00000555347.1 UniProtKB/TrEMBL
  ENST00000555672.1 UniProtKB/TrEMBL
  ENST00000555686.1 UniProtKB/Swiss-Prot
  ENST00000557139.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000170345 GTEx
HGNC ID HGNC:3796 ENTREZGENE
Human Proteome Map FOS Human Proteome Map
InterPro AP-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  bZIP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2353 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2353 ENTREZGENE
OMIM 164810 OMIM
PANTHER PTHR23351 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23351:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam bZIP_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA28212 PharmGKB
PRINTS LEUZIPPRFOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BZIP_BASIC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART BRLZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0K0TMT5_HUMAN UniProtKB/TrEMBL
  A0A0K0TMT7_HUMAN UniProtKB/TrEMBL
  A0A0K0TMV9_HUMAN UniProtKB/TrEMBL
  A8K4E2 ENTREZGENE
  B4DQ65 ENTREZGENE
  FOS_HUMAN UniProtKB/Swiss-Prot
  G3V289_HUMAN UniProtKB/TrEMBL
  G3V2V7_HUMAN UniProtKB/TrEMBL
  G3V5J9_HUMAN UniProtKB/TrEMBL
  G3V5N7_HUMAN UniProtKB/TrEMBL
  G3V5N9_HUMAN UniProtKB/TrEMBL
  H0YJM3_HUMAN UniProtKB/TrEMBL
  P01100 ENTREZGENE
  P18849 ENTREZGENE
  Q6FG41 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A8K4E2 UniProtKB/Swiss-Prot
  B4DQ65 UniProtKB/Swiss-Prot
  P18849 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-31 FOS  Fos proto-oncogene, AP-1 transcription factor subunit    Fos proto-oncogene, AP-1 trancription factor subunit  Symbol and/or name change 5135510 APPROVED
2016-05-10 FOS  Fos proto-oncogene, AP-1 trancription factor subunit    FBJ murine osteosarcoma viral oncogene homolog  Symbol and/or name change 5135510 APPROVED