ABCB11 (ATP-binding cassette, sub-family B (MDR/TAP), member 11)

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Keyword

Gene: ABCB11 (ATP-binding cassette, sub-family B (MDR/TAP), member 11) Homo sapiens

Symbol:

ABCB11

Name:

ATP-binding cassette, sub-family B (MDR/TAP), member 11

Description:

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008]

Type:

protein-coding

RefSeq Status:

REVIEWED

Also known as:

ABC member 16, MDR/TAP subfamily; ABC16; ATP-binding cassette sub-family B member 11; bile salt export pump; BRIC2; BSEP; OTTHUMP00000204927; PFIC-2; PFIC2; PGY4; progressive familial intrahepatic cholestasis 2; sister p-glycoprotein; SPGP

Orthologs:

Mus musculus : Abcb11 (ATP-binding cassette, sub-family B (MDR/TAP), member 11) MGI

Latest Assembly:

Human Genome Assembly GRCh37

Position:

Map	Chr	Position	Strand	Source
Human Alternate Assembly CHM1_1	2	169,175,334 - 169,283,252	-	NCBI
Human Genome Assembly HuRef	2	161,675,981 - 161,784,996	-	NCBI
Human Genome Assembly GRCh37	2	169,779,449 - 169,887,833	-	NCBI
Human Genome Assembly Build 36	2	169,487,695 - 169,596,079	-	NCBI
Human Cytogenetic Map	2	q24		NCBI
Human Genome Assembly	2	169,604,955 - 169,713,340		NCBI