Gene: TNC (tenascin C)  Homo sapiens Symbol: TNC Name: tenascin C Description: This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011] Type: protein-coding RefSeq Status: REVIEWED Also known as: 150-225; cytotactin; glioma-associated-extracellular matrix antigen; GMEM; GP; GP 150-225; hexabrachion (tenascin); HXB; JI; MGC167029; myotendinous antigen; neuronectin; OTTHUMP00000022738; OTTHUMP00000237658; OTTHUMP00000237659; OTTHUMP00000237669; OTTHUMP00000237695; tenascin; tenascin-C isoform 14/AD1/16; TN; TN-C Orthologs: Mus musculus : Tnc (tenascin C)  MGI Rattus norvegicus : Tnc (tenascin C) Latest Assembly: Human Genome Assembly GRCh37 Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 9 117,793,844 - 117,892,746 - NCBI Human Genome Assembly HuRef 9 87,386,539 - 87,484,951 - NCBI Human Genome Assembly GRCh37 9 117,781,854 - 117,880,536 - NCBI Human Genome Assembly Build 36 9 116,822,626 - 116,920,307 - NCBI Human Cytogenetic Map 9 q33   NCBI Human Genome Assembly 9 114,862,366 - 114,959,993   NCBI Model Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19) Annotation    (Toggle Detail/Summary View) Disease Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) Alveolitis, Extrinsic Allergic   IEP   4889595 protein:increased expression:respiratory system fluid/secretion RGD   Asbestosis   IEP   4889594 protein:increased expression:pleura RGD   Asthma   ISS RGD:1615156 4889565   RGD   Asthma   IAGP   4889589 DNA:SNPs: :multiple (human) RGD   Asthma   IEP   4889572 protein:increased expression:bronchus basement membrane RGD   Asthma   IAGP   4889569 DNA:SNP:exon:p.L1677I (human) RGD   Cholangiocarcinoma Severity ISS RGD:621057 4889598   RGD   Conjunctivitis, Allergic   IAGP   4889589 DNA:SNPs: :multiple (human) RGD   Diabetes Mellitus, Experimental   ISS RGD:621057 4889609   RGD   Empyema, Pleural   IEP   4889594 protein:increased expression:pleura RGD   Glioblastoma   IEP   4889612   RGD   Glioma   ISS RGD:1354144 4889612 protein:increased expression:brain RGD   Hyperoxia   ISS RGD:1615156 4889566 protein:increased expression:lung RGD   Hypertension, Pulmonary   IEP   4889562 protein:increased expression:plasma RGD   Hypertension, Pulmonary   IEP   4889567   RGD   Hypertension, Pulmonary Severity ISS RGD:621057 4889564   RGD   Hypertension, Pulmonary   ISS RGD:621057 4889570   RGD   Lung Diseases   ISS RGD:1615156 4889568 Acute Lung Injury RGD   Lung Diseases   ISS RGD:1615156 4889561 Acute Lung Injury RGD   Lung Neoplasms   IEP   4889612 protein:increased expression:lung RGD   Mesothelioma Disease_progression IEP   4889571   RGD   Mesothelioma   IEP   4889612   RGD   Myocardial Infarction   ISS RGD:621057 4889618 protein:increased expression:heart, fibroblast RGD   Myocardial Reperfusion Injury   ISS RGD:621057 4889599   RGD   Nasal Polyps   IEP   4889591 protein:increased expression:nasal cavity epithelium RGD   Neoplasm Metastasis   IEP   4889612 associated with Carcinoma, Renal Cell;protein:increased expression:lung RGD   Pneumonia   IEP   4889573 protein:increased expression:serum, respiratory system fluid/secretion RGD   Polycystic Kidney Diseases   ISS RGD:621057 4889614 protein:increased expression:kidney RGD   Sarcoidosis, Pulmonary   IEP   4889595 protein:increased expression:respiratory system fluid/secretion RGD   Spinal Cord Injuries   ISS RGD:621057 4889619 mRNA:increased expression:spinal cord RGD   Subarachnoid Hemorrhage   ISS RGD:621057 4889600 protein:increased expression:basilar artery RGD   Tuberculosis, Pleural   IEP   4889594 protein:increased expression:pleura RGD   Vasospasm, Intracranial   IEP   4889600 associated with Subarachnoid Hemorrhage;protein:increased expression:serum RGD   Gene-Chemical Interaction Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) (+)-pilocarpine increases expression ISO RGD:621057 6480464 Pilocarpine results in increased expression of TNC mRNA CTD PMID:14656328 11-deoxycorticosterone multiple interactions ISO RGD:621057 6480464 Spironolactone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNC mRNA]; more ... CTD PMID:21135038 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO   6480464 Tetrachlorodibenzodioxin affects the expression of TNC mRNA CTD PMID:16611356 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO   6480464 Tetrachlorodibenzodioxin results in decreased expression of TNC mRNA CTD PMID:15034205 PMID:17586704 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO   6480464 AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TNC mRNA] CTD PMID:15034205 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO   6480464 Tetrachlorodibenzodioxin affects the expression of TNC mRNA CTD PMID:16611356 PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO   6480464 Tetrachlorodibenzodioxin results in increased expression of TNC mRNA CTD PMID:15251184 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO   6480464 Tetrachlorodibenzodioxin results in decreased expression of TNC mRNA CTD PMID:17586704 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO   6480464 [Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of TNC mRNA CTD PMID:15251184 2,4,6-trinitrobenzenesulfonic acid increases expression ISO   6480464 Trinitrobenzenesulfonic Acid results in increased expression of TNC mRNA CTD PMID:18200517 2,4,6-trinitrobenzenesulfonic acid multiple interactions ISO   6480464 Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNC mRNA] CTD PMID:18200517 2,6-di-tert-butyl-4-methylphenol increases expression ISO   6480464 Butylated Hydroxytoluene results in increased expression of TNC mRNA CTD PMID:19925653 2-methylcholine affects expression EXP   6480464 beta-methylcholine affects the expression of TNC mRNA CTD PMID:21179406 3,4-methylenedioxymethamphetamine decreases expression ISO   6480464 N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of TNC mRNA CTD PMID:20188158 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP   6480464 [Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TNC mRNA CTD PMID:16997883 3-methylcholanthrene decreases expression ISO   6480464 Methylcholanthrene results in decreased expression of TNC mRNA CTD PMID:20713471 5-aza-2'-deoxycytidine multiple interactions ISO   6480464 [Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of TNC mRNA CTD PMID:15251184 5-aza-2'-deoxycytidine increases expression ISO   6480464 decitabine results in increased expression of TNC mRNA CTD PMID:15251184 8-bromo-3',5'-cyclic AMP multiple interactions EXP   6480464 [Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TNC mRNA CTD PMID:16997883 alachlor increases expression ISO RGD:621057 6480464 alachlor results in increased expression of TNC mRNA CTD PMID:12419858 all-trans-retinoic acid increases expression EXP   6480464 Tretinoin results in increased expression of TNC mRNA CTD PMID:21934132 arsenite(3-) decreases expression ISO   6480464 arsenite results in decreased expression of TNC mRNA CTD PMID:18929588 arsenite(3-) multiple interactions ISO   6480464 TRP53 protein affects the reaction [arsenite results in decreased expression of TNC mRNA] CTD PMID:18929588 benzo[a]pyrene decreases expression EXP   6480464 Benzo(a)pyrene results in decreased expression of TNC mRNA CTD PMID:20064835 benzo[a]pyrene decreases expression ISO   6480464 Benzo(a)pyrene results in decreased expression of TNC mRNA CTD PMID:15034205 more ... benzo[a]pyrene increases expression ISO   6480464 Benzo(a)pyrene results in increased expression of TNC mRNA CTD PMID:22228805 benzo[a]pyrene decreases expression ISO   6480464 Benzo(a)pyrene results in decreased expression of TNC mRNA CTD PMID:20713471 PMID:21569818 benzo[a]pyrene decreases expression ISO   6480464 Benzo(a)pyrene results in decreased expression of TNC mRNA CTD PMID:20713471 butane-2,3-dione increases expression ISO RGD:621057 6480464 Diacetyl results in increased expression of TNC protein CTD PMID:21464978 carmustine affects response to substance EXP   6480464 TNC mRNA affects the susceptibility to Carmustine CTD PMID:16365179 chloroprene decreases expression ISO   6480464 Chloroprene results in decreased expression of TNC mRNA CTD PMID:23125180 choline multiple interactions ISO   6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNC mRNA CTD PMID:20938992 cisplatin decreases expression ISO   6480464 Cisplatin results in decreased expression of TNC mRNA CTD PMID:21151649 cisplatin decreases expression ISO RGD:621057 6480464 Cisplatin results in decreased expression of TNC mRNA CTD PMID:22023808 copper atom multiple interactions ISO   6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of TNC mRNA CTD PMID:15467011 copper(0) multiple interactions ISO   6480464 [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of TNC mRNA CTD PMID:15467011 corticosterone decreases expression ISO RGD:621057 6480464 Corticosterone results in decreased expression of TNC mRNA CTD PMID:15755911 curcumin multiple interactions ISO   6480464 Curcumin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNC mRNA] CTD PMID:18200517 cyclosporin A increases expression EXP   6480464 Cyclosporine results in increased expression of TNC mRNA CTD PMID:20106945 cyclosporin A decreases expression EXP   6480464 Cyclosporine results in decreased expression of TNC mRNA CTD PMID:22147139 dexamethasone multiple interactions EXP   6480464 [Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of TNC mRNA CTD PMID:16997883 diazepam decreases expression EXP   6480464 Diazepam results in decreased expression of TNC mRNA CTD PMID:19114084 dopamine increases expression ISO RGD:621057 6480464 Dopamine results in increased expression of TNC mRNA CTD PMID:21983523 doxorubicin increases expression ISO   6480464 Doxorubicin results in increased expression of TNC mRNA CTD PMID:15033991 fenoldopam increases expression ISO RGD:621057 6480464 Fenoldopam results in increased expression of TNC mRNA CTD PMID:21983523 folic acid multiple interactions ISO   6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNC mRNA CTD PMID:20938992 formaldehyde decreases expression EXP   6480464 Formaldehyde results in decreased expression of TNC mRNA CTD PMID:20655997 ibuprofen increases expression EXP   6480464 Ibuprofen results in increased expression of TNC mRNA CTD PMID:17070997 L-methionine multiple interactions ISO   6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TNC mRNA CTD PMID:20938992 lead diacetate decreases expression ISO RGD:621057 6480464 lead acetate results in decreased expression of TNC mRNA CTD PMID:11578147 lithium chloride increases expression EXP   6480464 Lithium Chloride results in increased expression of TNC mRNA CTD PMID:15711924 losartan decreases expression ISO RGD:621057 6480464 Losartan results in decreased expression of TNC mRNA CTD PMID:15100363 methotrexate increases expression EXP   6480464 Methotrexate results in increased expression of TNC mRNA CTD PMID:17400583 N-methyl-N'-nitro-N-nitrosoguanidine increases expression EXP   6480464 Methylnitronitrosoguanidine results in increased expression of TNC mRNA CTD PMID:12634122 N-nitrosodiethylamine multiple interactions ISO RGD:621057 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TNC mRNA CTD PMID:18164116 naphthalene increases expression ISO   6480464 naphthalene results in increased expression of TNC protein; more ... CTD PMID:18978301 nickel atom increases expression ISO   6480464 Nickel results in increased expression of TNC mRNA CTD PMID:12540486 nickel sulfate increases expression ISO   6480464 nickel sulfate results in increased expression of TNC mRNA CTD PMID:16100012 ozone multiple interactions ISO   6480464 TTPA protein affects the reaction [Ozone results in increased expression of TNC mRNA] CTD PMID:19555225 ozone increases expression ISO   6480464 Ozone results in increased expression of TNC mRNA CTD PMID:19555225 phorbol 13-acetate 12-myristate multiple interactions EXP   6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TNC mRNA CTD PMID:16979875 pirinixic acid decreases expression ISO   6480464 pirinixic acid results in decreased expression of TNC mRNA CTD PMID:17426115 quercetin affects expression ISO RGD:621057 6480464 Quercetin affects the expression of TNC mRNA CTD PMID:18178720 raloxifene affects expression EXP   6480464 Raloxifene affects the expression of TNC mRNA CTD PMID:14699072 raloxifene multiple interactions EXP   6480464 [Raloxifene co-treated with ESR2 protein] results in increased expression of TNC mRNA CTD PMID:19059307 simvastatin decreases expression ISO RGD:621057 6480464 Simvastatin results in decreased expression of TNC mRNA CTD PMID:16414398 spironolactone multiple interactions ISO RGD:621057 6480464 Spironolactone inhibits the reaction [[Desoxycorticosterone co-treated with Sodium Chloride, Dietary] results in increased expression of TNC mRNA] CTD PMID:21135038 tamoxifen multiple interactions EXP   6480464 [Tamoxifen co-treated with ESR2 protein] results in increased expression of TNC mRNA CTD PMID:19059307 temozolomide affects response to substance EXP   6480464 TNC mRNA affects the susceptibility to temozolomide CTD PMID:16365179 tert-butyl hydroperoxide increases expression EXP   6480464 tert-Butylhydroperoxide results in increased expression of TNC mRNA CTD PMID:15336504 tetrachloromethane affects expression ISO   6480464 Carbon Tetrachloride affects the expression of TNC mRNA CTD PMID:17484886 tetrachloromethane multiple interactions ISO   6480464 PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TNC mRNA] CTD PMID:18038451 valproic acid increases expression EXP   6480464 Valproic Acid results in increased expression of TNC mRNA CTD PMID:19101580 zidovudine multiple interactions EXP   6480464 [Zidovudine co-treated with IFNA1 protein] results in decreased expression of TNC mRNA CTD PMID:20370541 zinc atom multiple interactions EXP   6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TNC mRNA CTD PMID:16979875 zinc(0) multiple interactions EXP   6480464 [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TNC mRNA CTD PMID:16979875 Gene Ontology Annotations Biological Process Term Qualifier Evidence With Reference Notes Source Original Reference(s) cell adhesion   IEA UniProtKB-KW:KW-0130 2290271 GO_REF:0000037 UniProtKB GO_REF:0000037 mesenchymal-epithelial cell signaling involved in prostate gland development   IEA Ensembl:ENSMUSP00000103000 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 neuromuscular junction development   IEA Ensembl:ENSMUSP00000103000 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 peripheral nervous system axon regeneration   IEA Ensembl:ENSMUSP00000103000 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of cell proliferation   IEA Ensembl:ENSMUSP00000103000 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 positive regulation of gene expression   IEA Ensembl:ENSMUSP00000103000 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 prostate gland epithelium morphogenesis   IEA Ensembl:ENSMUSP00000103000 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 response to wounding   IEP   2290271 PMID:16891397 BHF-UCL PMID:16891397 Cellular Component Term Qualifier Evidence With Reference Notes Source Original Reference(s) basement membrane   IEA Ensembl:ENSMUSP00000103000 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 extracellular matrix colocalizes_with IDA   2290271 PMID:20551380 BHF-UCL PMID:20551380 extracellular matrix colocalizes_with ISS UniProtKB:Q29116 2290271 PMID:22261194 BHF-UCL PMID:22261194 extracellular region   TAS   2290271 Reactome:REACT_13495 Reactome Reactome:REACT_13495 extracellular region   TAS   2290271 Reactome:REACT_13568 Reactome Reactome:REACT_13568 extracellular region   TAS   2290271 Reactome:REACT_13633 Reactome Reactome:REACT_13633 extracellular space   IDA   2290271 PMID:20551380 BHF-UCL PMID:20551380 interstitial matrix   IEA Ensembl:ENSMUSP00000103000 2290271 GO_REF:0000019 ENSEMBL GO_REF:0000019 Molecular Function Term Qualifier Evidence With Reference Notes Source Original Reference(s) syndecan binding   IPI   2290271 PMID:8769660 MGI PMID:8769660 Molecular Pathway Annotations Term Qualifier Evidence With Reference Notes Source Original Reference(s) cell-extracellular matrix signaling pathway   IEA RGD:1354144 6907045   KEGG hsa:04512 syndecan signaling pathway   EXP   6484113   PID PID:200134 External Database Links KEGG Pathway ECM-receptor interaction Focal adhesion PI3K-Akt signaling pathway Pathway Interaction Database Alpha9 beta1 integrin signaling events (PID:200093) Beta1 integrin cell surface interactions (PID:200016) Beta3 integrin cell surface interactions (PID:200043) Syndecan-4-mediated signaling events (PID:200134) Disease Annotations Alveolitis, Extrinsic Allergic  (IEP) Asbestosis  (IEP) Asthma  (IAGP,IEP,ISS) Cholangiocarcinoma  (ISS) Conjunctivitis, Allergic  (IAGP) Diabetes Mellitus, Experimental  (ISS) Empyema, Pleural  (IEP) Glioblastoma  (IEP) Glioma  (ISS) Hyperoxia  (ISS) Hypertension, Pulmonary  (IEP,ISS) Lung Diseases  (ISS) Lung Neoplasms  (IEP) Mesothelioma  (IEP) Myocardial Infarction  (ISS) Myocardial Reperfusion Injury  (ISS) Nasal Polyps  (IEP) Neoplasm Metastasis  (IEP) Pneumonia  (IEP) Polycystic Kidney Diseases  (ISS) Sarcoidosis, Pulmonary  (IEP) Spinal Cord Injuries  (ISS) Subarachnoid Hemorrhage  (ISS) Tuberculosis, Pleural  (IEP) Vasospasm, Intracranial  (IEP) Gene-Chemical Interaction Annotations (+)-pilocarpine  (ISO) 11-deoxycorticosterone  (ISO) 2,3,7,8-tetrachlorodibenzodioxine  (ISO) 2,4,6-trinitrobenzenesulfonic acid  (ISO) 2,6-di-tert-butyl-4-methylphenol  (ISO) 2-methylcholine  (EXP) 3,4-methylenedioxymethamphetamine  (ISO) 3-isobutyl-1-methyl-7H-xanthine  (EXP) 3-methylcholanthrene  (ISO) 5-aza-2'-deoxycytidine  (ISO) 8-bromo-3',5'-cyclic AMP  (EXP) alachlor  (ISO) all-trans-retinoic acid  (EXP) arsenite(3-)  (ISO) benzo[a]pyrene  (EXP,ISO) butane-2,3-dione  (ISO) carmustine  (EXP) chloroprene  (ISO) choline  (ISO) cisplatin  (ISO) copper atom  (ISO) copper(0)  (ISO) corticosterone  (ISO) curcumin  (ISO) cyclosporin A  (EXP) dexamethasone  (EXP) diazepam  (EXP) dopamine  (ISO) doxorubicin  (ISO) fenoldopam  (ISO) folic acid  (ISO) formaldehyde  (EXP) ibuprofen  (EXP) L-methionine  (ISO) lead diacetate  (ISO) lithium chloride  (EXP) losartan  (ISO) methotrexate  (EXP) N-methyl-N'-nitro-N-nitrosoguanidine  (EXP) N-nitrosodiethylamine  (ISO) naphthalene  (ISO) nickel atom  (ISO) nickel sulfate  (ISO) ozone  (ISO) phorbol 13-acetate 12-myristate  (EXP) pirinixic acid  (ISO) quercetin  (ISO) raloxifene  (EXP) simvastatin  (ISO) spironolactone  (ISO) tamoxifen  (EXP) temozolomide  (EXP) tert-butyl hydroperoxide  (EXP) tetrachloromethane  (ISO) valproic acid  (EXP) zidovudine  (EXP) zinc atom  (EXP) zinc(0)  (EXP) Gene Ontology Annotations Biological Process cell adhesion  (IEA) mesenchymal-epithelial cell signaling involved in prostate gland development  (IEA) neuromuscular junction development  (IEA) peripheral nervous system axon regeneration  (IEA) positive regulation of cell proliferation  (IEA) positive regulation of gene expression  (IEA) prostate gland epithelium morphogenesis  (IEA) response to wounding  (IEP) Cellular Component basement membrane  (IEA) extracellular matrix  (IDA,ISS) extracellular region  (TAS) extracellular space  (IDA) interstitial matrix  (IEA) Molecular Function syndecan binding  (IPI) Molecular Pathway Annotations cell-extracellular matrix signaling pathway  (IEA) syndecan signaling pathway  (EXP) External Database Links KEGG Pathway ECM-receptor interaction Focal adhesion PI3K-Akt signaling pathway Pathway Interaction Database Alpha9 beta1 integrin signaling events (PID:200093) Beta1 integrin cell surface interactions (PID:200016) Beta3 integrin cell surface interactions (PID:200043) Syndecan-4-mediated signaling events (PID:200134) References - curated 1. Avivi-Green C, etal., Am J Respir Crit Care Med. 2006 Aug 15;174(4):420-7. Epub 2006 May 11. 2. Carey WA, etal., Am J Physiol Lung Cell Mol Physiol. 2010 Sep 10. 3. Correia-Pinto J, etal., Basic Res Cardiol. 2009 Sep;104(5):535-45. Epub 2009 Mar 14. 4. Deckner M, etal., Exp Neurol. 2000 Dec;166(2):350-62. 5. Dumur CI, etal., Exp Mol Pathol. 2010 Dec;89(3):227-35. Epub 2010 Sep 9. 6. GOA_HUMAN data from the GO Consortium 7. Hisatomi K, etal., Intern Med. 2009;48(17):1501-7. Epub 2009 Sep 1. 8. Ihida-Stansbury K, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Oct;291(4):L694-702. Epub 2006 Jun 16. 9. Imanaka-Yoshida K, etal., Lab Invest. 2001 Jul;81(7):1015-24. 10. Kaarteenaho-Wiik R, etal., Histopathology. 2003 Mar;42(3):280-91. 11. Kaarteenaho-Wiik R, etal., J Histochem Cytochem. 2000 Sep;48(9):1257-68. 12. Kaarteenaho-Wiik R, etal., Lung. 1998;176(6):371-80. 13. Laitinen A, etal., Am J Respir Crit Care Med. 1997 Sep;156(3 Pt 1):951-8. 14. Matsuda A, etal., Hum Mol Genet. 2005 Oct 1;14(19):2779-86. Epub 2005 Aug 22. 15. Nakahara H, etal., Eur J Immunol. 2006 Dec;36(12):3334-45. 16. Nishimura T, etal., Histol Histopathol. 2008 Feb;23(2):157-66. 17. Orsmark-Pietras C, etal., Hum Mol Genet. 2008 Jun 1;17(11):1673-82. Epub 2008 Feb 27. 18. Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology 19. Pipeline to import Pathway Interaction Database annotations from NCI into RGD 20. RGD automated import pipeline for gene-chemical interactions 21. Schermuly RT, etal., Am J Respir Crit Care Med. 2005 Aug 1;172(3):358-63. Epub 2005 May 5. 22. Schumann C, etal., Biomarkers. 2010 Sep;15(6):523-32. 23. Silacci M, etal., Protein Eng Des Sel. 2006 Oct;19(10):471-8. Epub 2006 Aug 22. 24. Sun G, etal., Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2003 May;17(5):279-80. 25. Suzuki H, etal., Neurol Res. 2010 Mar;32(2):179-84. Epub 2009 Jul 8. 26. Taki J, etal., J Nucl Med. 2010 Jul;51(7):1116-22. Epub 2010 Jun 16. 27. Turan Akay M and Arzu Kockaya E, Cell Biochem Funct. 2005 Nov-Dec;23(6):435-45. 28. Whitehead GS, etal., Immunogenetics. 2006 Oct;58(10):793-804. Epub 2006 Sep 26. References - uncurated PubMed 10103110   10953015   11313993   11470832   11668187   11714809   11850444   11920587   11948127   12168675   12182416   12209613   12351514   12388760   12477932   12557222   12759243   1279805   1385416   14618612   14981900   15001984   15024713   15059978   15073129   15178565   15239346   15342556   15455729   15469480   15511229   15530854   15558324   15816617   15844597   15892123   15983124   16091738   16100012   16144346   16157221   16245312   16259977   16292494   16335952   16388320   16461331   16493581   16891397   16926030   16996565   17013087   1704365   1707164   17083689   17181107   17188181   17188391   1719530   17202312   17311283   17584833   17616673   17681310   17901052   17983425   18029348   18061975   18062933   18173448   18177748   18353721   18502153   18504437   18695899   18751374   18757408   18794852   18815154   19070467   19147558   19287959   19326143   19405959   19459858   19484261   19561617   19581738   19688689   19748582   19887451   19944367   20042668   20083228   20107185   20232238   20346360   20379614   20453000   20583170   20613589   20622113   20651280   20653781   20678196   20708078   20727496   20729912   21039988   21091771   21183183   21281808   21298289   21350305   21403679   21496259   21501293   21512282   21559807   21762512   21839747   21862932   21885141   21951663   21997179   22039306   22110694   22118674   22219177   22495383   22511780   22699754   22760918   22851489   22951722   23064399   23192621   23485472   2466295   7499434   7523411   7524681   7531707   7541634   7559467   7693733   7694284   8548761   8769660   8798654   8824254   9314546   9341124   9565552 RGD Disease Portals TNC has been annotated in the following RGD Disease Portals. Biological Process Cancer Diseases Cancer Pathways Cardiovascular Diseases Cardiovascular Pathways Diabetes Diseases Diabetes Pathways Immune and Inflammatory Diseases Immune and Inflammatory Pathways Biological Process Neurological Diseases Neurological Pathways Obesity Diseases Obesity Pathways Respiratory Diseases Respiratory Pathways Genomics Comparative Map Data TNC   (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 9 117,793,844 - 117,892,746 - NCBI Human Genome Assembly HuRef 9 87,386,539 - 87,484,951 - NCBI Human Genome Assembly GRCh37 9 117,781,854 - 117,880,536 - NCBI Human Genome Assembly Build 36 9 116,822,626 - 116,920,307 - NCBI Human Cytogenetic Map 9 q33   NCBI Human Genome Assembly 9 114,862,366 - 114,959,993   NCBI Tnc   (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 4 63,959,785 - 64,047,015 - NCBI Mouse cM Map 4 34.06   NCBI Mouse Celera Assembly 4 62,620,454 - 62,707,711 - NCBI Mouse Genome Assembly Build 37 4 63,620,819 - 63,681,760 - NCBI Mouse Genome Assembly Build 36.1 4 63,620,819 - 63,681,760 - NCBI Mouse Cytogenetic Map 4 C1   NCBI Tnc   (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 5     NCBI RGSC Genome Assembly v5.0 5 83,890,952 - 83,950,462 - NCBI Rat Celera Assembly 5 76,306,295 - 76,365,869 - NCBI Position Markers D9S51   Map Chr Position Strand Source Human deCODE Assembly Map 9 121.49   UniSTS Human Genome Assembly HuRef 9 87,461,685 - 87,461,840   UniSTS Human Genome Assembly GRCh37 9 117,857,073 - 117,857,228   UniSTS Human Celera Assembly 9 88,504,519 - 88,504,674   RGD Human Genome Assembly Build 36 9 116,896,894 - 116,897,049   RGD Human Cytogenetic Map 9 q33   UniSTS Marshfield Human Genetic Map 9 123.33   UniSTS Marshfield Human Genetic Map 9 123.33   RGD G15905   Map Chr Position Strand Source Human Genome Assembly HuRef 9 87,387,526 - 87,387,719   UniSTS Human Genome Assembly GRCh37 9 117,782,840 - 117,783,033   UniSTS Human Celera Assembly 9 88,430,308 - 88,430,501   RGD Human Genome Assembly Build 36 9 116,822,661 - 116,822,854   RGD Human Cytogenetic Map 9 q33   UniSTS STS-AA029758   Map Chr Position Strand Source Human GeneMap99-GB4 RH Map 9 356.94   UniSTS Human Genome Assembly HuRef 9 87,386,589 - 87,386,823   UniSTS Human Genome Assembly GRCh37 9 117,781,904 - 117,782,138   UniSTS Human Celera Assembly 9 88,429,372 - 88,429,606   RGD Human Genome Assembly Build 36 9 116,821,725 - 116,821,959   RGD Human Cytogenetic Map 9 q33   UniSTS RH46318   Map Chr Position Strand Source Human Genome Assembly HuRef 9 87,460,634 - 87,460,766   UniSTS Human Genome Assembly GRCh37 9 117,856,022 - 117,856,154   UniSTS Human Celera Assembly 9 88,503,468 - 88,503,600   RGD Human Genome Assembly Build 36 9 116,895,843 - 116,895,975   RGD Human Cytogenetic Map 9 q33   UniSTS RH92351   Map Chr Position Strand Source Human GeneMap99-GB4 RH Map 9 367.55   UniSTS Human Genome Assembly HuRef 9 87,414,370 - 87,414,504   UniSTS Human Genome Assembly GRCh37 9 117,809,693 - 117,809,827   UniSTS Human Celera Assembly 9 88,457,162 - 88,457,296   RGD Human Genome Assembly Build 36 9 116,849,514 - 116,849,648   RGD Human Cytogenetic Map 9 q33   UniSTS RH121986   Map Chr Position Strand Source Human TNG Radiation Hybrid Map 9 44291.0   UniSTS Human Genome Assembly HuRef 9 87,460,558 - 87,460,815   UniSTS Human Genome Assembly GRCh37 9 117,855,946 - 117,856,203   UniSTS Human Celera Assembly 9 88,503,392 - 88,503,649   RGD Human Genome Assembly Build 36 9 116,895,767 - 116,896,024   RGD Human Cytogenetic Map 9 q33   UniSTS G66894   Map Chr Position Strand Source Human Genome Assembly HuRef 9 87,465,784 - 87,465,933   UniSTS Human Genome Assembly GRCh37 9 117,861,379 - 117,861,528   UniSTS Human Celera Assembly 9 88,508,630 - 88,508,779   RGD Human Genome Assembly Build 36 9 116,901,200 - 116,901,349   RGD Human Cytogenetic Map 9 q33   UniSTS STS-M55618   Map Chr Position Strand Source Human NCBI RH Map 9 1004.2   UniSTS Human GeneMap99-GB4 RH Map 9 357.94   UniSTS Human Genome Assembly HuRef 9 87,387,699 - 87,387,885   UniSTS Human Genome Assembly GRCh37 9 117,783,013 - 117,783,199   UniSTS Human Celera Assembly 9 88,430,481 - 88,430,667   RGD Human Genome Assembly Build 36 9 116,822,834 - 116,823,020   RGD Human Cytogenetic Map 9 q33   UniSTS WI-18981   Map Chr Position Strand Source Human NCBI RH Map 9 1004.2   UniSTS Human Whitehead-RH Map 9 435.2   UniSTS Human GeneMap99-GB4 RH Map 9 357.94   UniSTS Human Genome Assembly HuRef 9 87,387,692 - 87,387,962   UniSTS Human Genome Assembly GRCh37 9 117,783,006 - 117,783,276   UniSTS Human Celera Assembly 9 88,430,474 - 88,430,744   RGD Human Genome Assembly Build 36 9 116,822,827 - 116,823,097   RGD Human Cytogenetic Map 9 q33   UniSTS RH48393   Map Chr Position Strand Source Human NCBI RH Map 9 1004.2   UniSTS Human GeneMap99-GB4 RH Map 9 357.94   UniSTS Human Genome Assembly HuRef 9 87,388,875 - 87,389,045   UniSTS Human Genome Assembly GRCh37 9 117,784,190 - 117,784,360   UniSTS Human Celera Assembly 9 88,431,657 - 88,431,827   RGD Human Genome Assembly Build 36 9 116,824,011 - 116,824,181   RGD Human Cytogenetic Map 9 q33   UniSTS RH67973   Map Chr Position Strand Source Human GeneMap99-GB4 RH Map 9 357.94   UniSTS Human Genome Assembly HuRef 9 87,387,698 - 87,387,884   UniSTS Human Genome Assembly GRCh37 9 117,783,012 - 117,783,198   UniSTS Human Celera Assembly 9 88,430,480 - 88,430,666   RGD Human Genome Assembly Build 36 9 116,822,833 - 116,823,019   RGD Human Cytogenetic Map 9 q33   UniSTS STS-U44098   Map Chr Position Strand Source Human GeneMap99-GB4 RH Map 9 357.94   UniSTS Human Genome Assembly HuRef 9 87,476,674 - 87,476,793   UniSTS Human Genome Assembly GRCh37 9 117,872,269 - 117,872,388   UniSTS Human Celera Assembly 9 88,519,520 - 88,519,639   RGD Human Genome Assembly Build 36 9 116,912,090 - 116,912,209   RGD Human Cytogenetic Map 9 q33   UniSTS D9S1713   Map Chr Position Strand Source Human Whitehead-YAC Contig Map 9     UniSTS Human Whitehead-RH Map 9 436.9   UniSTS Human GeneMap99-GB4 RH Map 9 356.93   UniSTS Human Genome Assembly HuRef 9 87,387,851 - 87,387,954   UniSTS Human Genome Assembly GRCh37 9 117,783,165 - 117,783,268   UniSTS Human Celera Assembly 9 88,430,633 - 88,430,736   RGD Human Genome Assembly Build 36 9 116,822,986 - 116,823,089   RGD Human Cytogenetic Map 9 q33   UniSTS AFM206ZE3   Map Chr Position Strand Source Human Whitehead-YAC Contig Map 9     UniSTS Human Genome Assembly HuRef 9 87,454,369 - 87,454,482   UniSTS Human Genome Assembly GRCh37 9 117,849,763 - 117,849,870   UniSTS Human Celera Assembly 9 88,497,232 - 88,497,318   RGD Human Genome Assembly Build 36 9 116,889,584 - 116,889,691   RGD Human Cytogenetic Map 9 q33   UniSTS D11S2921   Map Chr Position Strand Source Human Cytogenetic Map 16 q22.1   UniSTS Human Cytogenetic Map 1 p36.1   UniSTS Human Cytogenetic Map 3 p24.2   UniSTS Human Cytogenetic Map 1 q23.3   UniSTS Human Cytogenetic Map 9 q34.3   UniSTS Human Cytogenetic Map 1 p36.31   UniSTS Human Cytogenetic Map 3 p25.3   UniSTS Human Cytogenetic Map 11 p15.4   UniSTS Human Cytogenetic Map 7 p14.1   UniSTS Human Cytogenetic Map 2 q22.3   UniSTS Human Cytogenetic Map 9 q22.33   UniSTS Human Cytogenetic Map 15 q13.2   UniSTS Human Cytogenetic Map 16 q24.3   UniSTS Human Cytogenetic Map 5 q31   UniSTS Human Cytogenetic Map 19 q13.11   UniSTS Human Cytogenetic Map 17 p11.2   UniSTS Human Cytogenetic Map 19 q13.3   UniSTS Human Cytogenetic Map 22 q13.33   UniSTS Human Cytogenetic Map 14 q13.2   UniSTS Human Cytogenetic Map 2 p25.1   UniSTS Human Cytogenetic Map 10 q24.33   UniSTS Human Cytogenetic Map 5 q23.3-q31.1   UniSTS Human Cytogenetic Map 8 p21.3   UniSTS Human Cytogenetic Map 22 q13.1   UniSTS Human Cytogenetic Map 1 p32.3   UniSTS Human Cytogenetic Map 17 q11   UniSTS Human Cytogenetic Map 1 q24   UniSTS Human Cytogenetic Map 11 q14   UniSTS Human Cytogenetic Map 17 q25   UniSTS Human Cytogenetic Map X q13.1   UniSTS Human Cytogenetic Map 2 q11.2   UniSTS Human Cytogenetic Map 9 p13.3   UniSTS Human Cytogenetic Map 19 p13.2   UniSTS Human Cytogenetic Map 2 q32.3   UniSTS Human Cytogenetic Map 17 q21.31   UniSTS Human Cytogenetic Map 19 q13.12   UniSTS Human Cytogenetic Map 4 q32.1   UniSTS Human Cytogenetic Map 7 q34   UniSTS Human Cytogenetic Map 13 q12   UniSTS Human Cytogenetic Map 12 p13.31   UniSTS Human Cytogenetic Map 3 p21.1   UniSTS Human Cytogenetic Map 3 q12.3   UniSTS Human Cytogenetic Map 14 q24.3   UniSTS Human Cytogenetic Map 6 q22   UniSTS Human Cytogenetic Map 22 q13.2   UniSTS Human Cytogenetic Map 19 q13.42   UniSTS Human Cytogenetic Map 17 q12   UniSTS Human Cytogenetic Map 20 q11   UniSTS Human Cytogenetic Map 8 q22.1   UniSTS Human Cytogenetic Map 5 q23.3   UniSTS Human Cytogenetic Map 20 q11.22   UniSTS Human Cytogenetic Map 1 p36.11   UniSTS Human Cytogenetic Map 19 q13.43   UniSTS Human Cytogenetic Map 17 q21   UniSTS Human Cytogenetic Map 11 q25   UniSTS Human Cytogenetic Map 3 p21.3   UniSTS Human Cytogenetic Map 1 q32.3   UniSTS Human Cytogenetic Map 2 q37.3   UniSTS Human Cytogenetic Map 12 q21.33   UniSTS Human Cytogenetic Map 7 p22.3   UniSTS Human Cytogenetic Map 4 p16.3   UniSTS Human Cytogenetic Map 17 p13.3   UniSTS Human Cytogenetic Map 1 p35.1   UniSTS Human Cytogenetic Map X p11.4-p11.3   UniSTS Human Cytogenetic Map 17 q11.2   UniSTS Human Cytogenetic Map 1 p36.33   UniSTS Human Cytogenetic Map 19 p13.3   UniSTS Human Cytogenetic Map 1 q24.1   UniSTS Human Cytogenetic Map 14 q11.2   UniSTS Human Cytogenetic Map 16 p11.2   UniSTS Human Cytogenetic Map 11 q24.2   UniSTS Human Cytogenetic Map 10 p15.1   UniSTS Human Cytogenetic Map 18 p11.31   UniSTS Human Cytogenetic Map 12 p13.32   UniSTS Human Cytogenetic Map 19 p13.11   UniSTS Human Cytogenetic Map 11 q13.5   UniSTS Human Cytogenetic Map 1 p22   UniSTS Human Cytogenetic Map 2 q14   UniSTS Human Cytogenetic Map 16 q24   UniSTS Human Cytogenetic Map 16 p13.3   UniSTS Human Cytogenetic Map 7 p22   UniSTS Human Cytogenetic Map 14 q32.33   UniSTS Human Cytogenetic Map 8 p11.21   UniSTS Human Cytogenetic Map 8 q24.11   UniSTS Human Cytogenetic Map 4 q12   UniSTS Human Cytogenetic Map 9 q22.31   UniSTS Human Cytogenetic Map 17 p13.2   UniSTS Human Cytogenetic Map 11 p15.5   UniSTS Human Cytogenetic Map 2 p11.2   UniSTS Human Cytogenetic Map 7 q11.23   UniSTS Human Cytogenetic Map 5 q31.1   UniSTS Human Cytogenetic Map 2 q33-q34   UniSTS Human Cytogenetic Map 17 q22.2   UniSTS Human Cytogenetic Map 8 q24.13   UniSTS Human Cytogenetic Map 22 q11.2   UniSTS Human Cytogenetic Map 6 p22.1   UniSTS Human Cytogenetic Map Y p11.2   UniSTS Human Cytogenetic Map 19 q13.2   UniSTS Human Cytogenetic Map 18 p11.21   UniSTS Human Cytogenetic Map 10 q22   UniSTS Human Cytogenetic Map 5 q35.3   UniSTS Human Cytogenetic Map 10 q23.1   UniSTS Human Cytogenetic Map 2 q37   UniSTS Human Cytogenetic Map 18 pter-p11.3   UniSTS Human Cytogenetic Map 8 q22.3   UniSTS Human Cytogenetic Map 6 p21.33   UniSTS Human Cytogenetic Map 7 q22.1   UniSTS Human Cytogenetic Map 2 q21.3   UniSTS Human Cytogenetic Map 2 q21.1   UniSTS Human Cytogenetic Map 8 p21.2   UniSTS Human Cytogenetic Map X q22.1   UniSTS Human Cytogenetic Map 10 q22.2   UniSTS Human Cytogenetic Map 1 p34.2   UniSTS Human Cytogenetic Map 19 q13.41   UniSTS Human Cytogenetic Map 14 q32.12   UniSTS Human Cytogenetic Map 3 q21.3   UniSTS Human Cytogenetic Map 4 q34.1   UniSTS Human Cytogenetic Map 10 p13   UniSTS Human Cytogenetic Map 17 q25.3   UniSTS Human Cytogenetic Map 3 q13.31   UniSTS Human Cytogenetic Map 7 q21.12   UniSTS Human Cytogenetic Map 15 q22.2   UniSTS Human Cytogenetic Map 8 p23.1   UniSTS Human Cytogenetic Map 5 q32   UniSTS Human Cytogenetic Map 20 q13.12   UniSTS Human Cytogenetic Map 12 q23.2   UniSTS Human Cytogenetic Map 6 p22   UniSTS Human Cytogenetic Map 11 q12.3   UniSTS Human Cytogenetic Map 11 p13   UniSTS Human Cytogenetic Map 1 q21.3   UniSTS Human Cytogenetic Map 16 p13.13   UniSTS Human Cytogenetic Map 1 p34   UniSTS Human Cytogenetic Map 1 p36.21   UniSTS Human Cytogenetic Map 12 q13   UniSTS Human Cytogenetic Map 19 q13.31   UniSTS Human Cytogenetic Map 19 q13.4   UniSTS Human Cytogenetic Map 4 p14   UniSTS Human Cytogenetic Map 1 q44   UniSTS Human Cytogenetic Map 19 p13.1-p12   UniSTS Human Cytogenetic Map 7 q22   UniSTS Human Cytogenetic Map 8 q24   UniSTS Human Cytogenetic Map 18 p11.31-p11.21   UniSTS Human Cytogenetic Map 21 q22.3   UniSTS Human Cytogenetic Map 7 p21.2   UniSTS Human Cytogenetic Map 12 q23-q24.1   UniSTS Human Cytogenetic Map 15 q15.1   UniSTS Human Cytogenetic Map 10 q11.23   UniSTS Human Cytogenetic Map 5 q14.1   UniSTS Human Cytogenetic Map 5 p15.33   UniSTS Human Cytogenetic Map 1 q21   UniSTS Human Cytogenetic Map 22 q11.21   UniSTS Human Cytogenetic Map 8 q24.3   UniSTS Human Cytogenetic Map 1 q42.1   UniSTS Human Cytogenetic Map 12 p13   UniSTS Human Cytogenetic Map 15 q21   UniSTS Human Cytogenetic Map 6 p21.3   UniSTS Human Cytogenetic Map 8 p11.22   UniSTS Human Cytogenetic Map 2 q12.3   UniSTS Human Cytogenetic Map 19 q13.3-q13.4   UniSTS Human Cytogenetic Map 15 q11.2   UniSTS Human Cytogenetic Map 5 q35   UniSTS Human Cytogenetic Map 8 p23-p22   UniSTS Human Cytogenetic Map 12 p11   UniSTS Human Cytogenetic Map 17 q21-q22   UniSTS Human Cytogenetic Map 12 q13.12   UniSTS Human Cytogenetic Map 2 q36.1   UniSTS Human Cytogenetic Map 11 p13-p12   UniSTS Human Cytogenetic Map X p22.33   UniSTS Human Cytogenetic Map Y p11.3   UniSTS Human Cytogenetic Map 2 q12.1   UniSTS Human Cytogenetic Map 3 p21.31   UniSTS Human Cytogenetic Map 3 q26.32   UniSTS Human Cytogenetic Map 7 q11.21   UniSTS Human Cytogenetic Map 10 q11.22   UniSTS Human Cytogenetic Map 17 p12   UniSTS Human Cytogenetic Map 3 p25.1   UniSTS Human Cytogenetic Map 14 q32   UniSTS Human Cytogenetic Map 5 q12-q13   UniSTS Human Cytogenetic Map 6 p23   UniSTS Human Cytogenetic Map 20 p12.3-p11.21   UniSTS Human Cytogenetic Map 17 q11.2-q12   UniSTS Human Cytogenetic Map 11 q23.3   UniSTS Human Cytogenetic Map 12 q13.3   UniSTS Human Cytogenetic Map 10 q23-q24   UniSTS Human Cytogenetic Map 14 q21.3   UniSTS Human Cytogenetic Map 11 q13   UniSTS Human Cytogenetic Map 12 q13-q14   UniSTS Human Cytogenetic Map 6 q14.1   UniSTS Human Cytogenetic Map 3 q26.33   UniSTS Human Cytogenetic Map X p22.2   UniSTS Human Cytogenetic Map 1 p31   UniSTS Human Cytogenetic Map 15 q15-q21.1   UniSTS Human Cytogenetic Map 9 q32   UniSTS Human Cytogenetic Map 17 p13   UniSTS Human Cytogenetic Map 7 q21-q22   UniSTS Human Cytogenetic Map 16 q24.1   UniSTS Human Cytogenetic Map 2 q33.3   UniSTS Human Cytogenetic Map 11 q22.1   UniSTS Human Cytogenetic Map 1 p13.3   UniSTS Human Cytogenetic Map 20 p13   UniSTS Human Cytogenetic Map 6 p21.1   UniSTS Human Cytogenetic Map 7 q36.3   UniSTS Human Cytogenetic Map 5 q12.3   UniSTS Human Cytogenetic Map 2 q33.2   UniSTS Human Cytogenetic Map 12 q22   UniSTS Human Cytogenetic Map 21 p11.1   UniSTS Human Cytogenetic Map 14 q23.2   UniSTS Human Cytogenetic Map 6 p22.3-p22.1   UniSTS Human Cytogenetic Map 7 p11.2   UniSTS Human Cytogenetic Map 6 q15   UniSTS Human Cytogenetic Map X q25-q26.3   UniSTS Human Cytogenetic Map 10 q22.3   UniSTS Human Cytogenetic Map 12 q24.31-q24.32   UniSTS Human Cytogenetic Map 16 p12.3   UniSTS Human Cytogenetic Map 9 q33.2   UniSTS Human Cytogenetic Map 15 q23   UniSTS Human Cytogenetic Map 12 p12.2-p11.2   UniSTS Human Cytogenetic Map 2 q14.3   UniSTS Human Cytogenetic Map X p11   UniSTS Human Cytogenetic Map 19 q13   UniSTS Human Cytogenetic Map 17 q22   UniSTS Human Cytogenetic Map 3 q21   UniSTS Human Cytogenetic Map 20 q13.2   UniSTS Human Cytogenetic Map 10 q26   UniSTS Human Cytogenetic Map 6 q22.31   UniSTS Human Cytogenetic Map 3 q27.1   UniSTS Human Cytogenetic Map 7 p13   UniSTS Human Cytogenetic Map 22 q13   UniSTS Human Cytogenetic Map 11 q13.1   UniSTS Human Cytogenetic Map 18 p11.32   UniSTS Human Cytogenetic Map 12 q15   UniSTS Human Cytogenetic Map X q22.3   UniSTS Human Cytogenetic Map 2 p25.3   UniSTS Human Cytogenetic Map 16 q21   UniSTS Human Cytogenetic Map 11 q23.1   UniSTS Human Cytogenetic Map 3 q13.13   UniSTS Human Cytogenetic Map 12 q24.31   UniSTS Human Cytogenetic Map 3 q27.3   UniSTS Human Cytogenetic Map 4 p13   UniSTS Human Cytogenetic Map 16 p12.1   UniSTS Human Cytogenetic Map 14 q32.11   UniSTS Human Cytogenetic Map 7 p14.3   UniSTS Human Cytogenetic Map 16 q12.1   UniSTS Human Cytogenetic Map 15 q25.2   UniSTS Human Cytogenetic Map 9 q21.13   UniSTS Human Cytogenetic Map 2 p23.3   UniSTS Human Cytogenetic Map 3 q29   UniSTS Human Cytogenetic Map 15 q22.31   UniSTS Human Cytogenetic Map 16 q22.2   UniSTS Human Cytogenetic Map 19 p13.12   UniSTS Human Cytogenetic Map 20 q13.1   UniSTS Human Cytogenetic Map 3 p14.3   UniSTS Human Cytogenetic Map 10 q23.33   UniSTS Human Cytogenetic Map 12 p12   UniSTS Human Cytogenetic Map 9 p24.1-p23   UniSTS Human Cytogenetic Map 15 q22   UniSTS Human Cytogenetic Map 6 p25   UniSTS Human Cytogenetic Map X q12-q13   UniSTS Human Cytogenetic Map 2 p16.1   UniSTS Human Cytogenetic Map 14 q23   UniSTS Human Cytogenetic Map 2 q31.1   UniSTS Human Cytogenetic Map 17 q23.3   UniSTS Human Cytogenetic Map 1 q42.1-q43   UniSTS Human Cytogenetic Map 7 q31.1-q31.3   UniSTS Human Cytogenetic Map 20 q11.21   UniSTS Human Cytogenetic Map 20 q12-q13.12   UniSTS Human Cytogenetic Map 1 q24-q25.3   UniSTS Human Cytogenetic Map 20 p12.1   UniSTS Human Cytogenetic Map 14 q32.31   UniSTS Human Cytogenetic Map 1 p13.2   UniSTS Human Cytogenetic Map 2 p13.3   UniSTS Human Cytogenetic Map 6 q25.1-q26   UniSTS Human Cytogenetic Map 12 q13.11-q14.3   UniSTS Human Cytogenetic Map 7 p11   UniSTS Human Cytogenetic Map 12 p11.22   UniSTS Human Cytogenetic Map 17 q23.1   UniSTS Human Cytogenetic Map 1 p36.13   UniSTS Human Cytogenetic Map 9 q34.11   UniSTS Human Cytogenetic Map 2 p15   UniSTS Human Cytogenetic Map 9 p11   UniSTS Human Cytogenetic Map 6 p24.3   UniSTS Human Cytogenetic Map 9 p24.1   UniSTS Human Cytogenetic Map 12 p13.2   UniSTS Human Cytogenetic Map 6 p22.2   UniSTS Human Cytogenetic Map 12 q24.2-q24.31   UniSTS Human Cytogenetic Map 22 q12.2   UniSTS Human Cytogenetic Map 11 p11.11   UniSTS Human Cytogenetic Map 11 q22-q23   UniSTS Human Cytogenetic Map 11 q14.1   UniSTS Human Cytogenetic Map 1 q32.1   UniSTS Human Cytogenetic Map 15 q22-q23   UniSTS Human Cytogenetic Map 9 p21   UniSTS Human Cytogenetic Map 15 q13.1   UniSTS Human Cytogenetic Map 15 q22-qter   UniSTS Human Cytogenetic Map 10 q25   UniSTS Human Cytogenetic Map 6 p22.3   UniSTS Human Cytogenetic Map 6 p25.2   UniSTS Human Cytogenetic Map 5 p15.1   UniSTS Human Cytogenetic Map 2 p21   UniSTS Human Cytogenetic Map 22 q13.31   UniSTS Human Cytogenetic Map 21 q22.2   UniSTS Human Cytogenetic Map 19 q13.33   UniSTS Human Cytogenetic Map 14 q24.1   UniSTS Human Cytogenetic Map 13 q34   UniSTS Human Cytogenetic Map 18 q11.2   UniSTS Human Cytogenetic Map 6 q25.1   UniSTS Human Cytogenetic Map 20 q11.23   UniSTS Human Cytogenetic Map 1 q21.1   UniSTS Human Cytogenetic Map 17 q24.3   UniSTS Human Cytogenetic Map 16 q11.2   UniSTS Human Cytogenetic Map 16 p12.2   UniSTS Human Cytogenetic Map 11 q24   UniSTS Human Cytogenetic Map 2 q23.3   UniSTS Human Cytogenetic Map 1 p31.1   UniSTS Human Cytogenetic Map 18 q23   UniSTS Human Cytogenetic Map 11 q13.4   UniSTS Human Cytogenetic Map 7 p21.1   UniSTS Human Cytogenetic Map 2 q37.1   UniSTS Human Cytogenetic Map 8 p11.2   UniSTS Human Cytogenetic Map 9 q33.3   UniSTS Human Cytogenetic Map 4 q22.1   UniSTS Human Cytogenetic Map 2 q21.2   UniSTS Human Cytogenetic Map 15 q13.3   UniSTS Human Cytogenetic Map 7 p15.3   UniSTS Human Cytogenetic Map 3 p22.2   UniSTS Human Cytogenetic Map 11 q13.2   UniSTS Human Cytogenetic Map 19 p13.2-cen   UniSTS Human Cytogenetic Map 19 p13.3-p13.2   UniSTS Human Cytogenetic Map 13 q32.3   UniSTS Human Cytogenetic Map 9 q33   UniSTS Human Cytogenetic Map 1 p36-p35   UniSTS Human Cytogenetic Map 19 q13.1   UniSTS Human Cytogenetic Map X q25   UniSTS Human Cytogenetic Map 12 q23   UniSTS Human Cytogenetic Map 21 q22.13   UniSTS Human Cytogenetic Map 2 q24.2   UniSTS Human Cytogenetic Map 7 q31.1-q31.2   UniSTS Human Cytogenetic Map 22 q11.23   UniSTS Human Cytogenetic Map X q24   UniSTS Human Cytogenetic Map 4 q25-q27   UniSTS Human Cytogenetic Map 3 q25.33   UniSTS Human Cytogenetic Map X q26.2   UniSTS Human Cytogenetic Map 8 q13.2   UniSTS Human Cytogenetic Map 8 q13.1   UniSTS Human Cytogenetic Map 8 q22.2   UniSTS Human Cytogenetic Map 6 q21   UniSTS Human Cytogenetic Map 5 q23.1   UniSTS Human Cytogenetic Map 4 q13.3   UniSTS Human Cytogenetic Map 3 p26.1   UniSTS Human Cytogenetic Map 1 q21.2   UniSTS Human Cytogenetic Map 17 p13.1   UniSTS Human Cytogenetic Map 3 p22-p21.3   UniSTS Human Cytogenetic Map 12 q   UniSTS Human Cytogenetic Map X q21.3   UniSTS Human Cytogenetic Map 12 q12   UniSTS Human Cytogenetic Map 20 p11   UniSTS Human Cytogenetic Map 6 p12.3   UniSTS Human Cytogenetic Map 5 p13.1-p12   UniSTS Human Cytogenetic Map 1 p36.22   UniSTS Human Cytogenetic Map 9 q34   UniSTS Human Cytogenetic Map 7 q21.13   UniSTS Human Cytogenetic Map 20 q13.33   UniSTS Human Cytogenetic Map 3 p21.1-p14.3   UniSTS Human Cytogenetic Map 2 q33.1   UniSTS Human Cytogenetic Map 7 q36.1   UniSTS Human Cytogenetic Map 10 q24.31   UniSTS Human Cytogenetic Map 2 p25.1-p24.1   UniSTS Human Cytogenetic Map 3 q23   UniSTS Human Cytogenetic Map 13 q12.11   UniSTS Human Cytogenetic Map 12 q14.3   UniSTS Human Cytogenetic Map 13 q14.13   UniSTS Human Cytogenetic Map 11 p15   UniSTS Human Cytogenetic Map 6 q14.3-q16.1   UniSTS Human Cytogenetic Map 16 p13.2   UniSTS Human Cytogenetic Map 16 q22.3   UniSTS Human Cytogenetic Map 1 p32-p31   UniSTS Human Cytogenetic Map 12 q13.13   UniSTS Human Cytogenetic Map 8 p11   UniSTS Human Cytogenetic Map 6 q25   UniSTS Human Cytogenetic Map 8 p11.23   UniSTS Human Cytogenetic Map 9 p24.3   UniSTS Human Cytogenetic Map 7 q35   UniSTS Human Cytogenetic Map 11 q22.3   UniSTS Human Cytogenetic Map 16 p12   UniSTS Human Cytogenetic Map 6 q14.3   UniSTS Human Cytogenetic Map 7 q36   UniSTS Human Cytogenetic Map 1 q22   UniSTS Human Cytogenetic Map 10 p15.3   UniSTS Human Cytogenetic Map 8 p12   UniSTS Human Cytogenetic Map 13 q12.2   UniSTS Human Cytogenetic Map 7 p22.1   UniSTS Human Cytogenetic Map 6 p21.2   UniSTS Human Cytogenetic Map 18 q21.1   UniSTS Human Cytogenetic Map 10 p11.21   UniSTS Human Cytogenetic Map 10 p14   UniSTS Human Cytogenetic Map 3 p26   UniSTS Human Cytogenetic Map 9 q22.3   UniSTS Human Cytogenetic Map 17 q21.1-q21.3   UniSTS Human Cytogenetic Map 6 q11.1   UniSTS Human Cytogenetic Map 5 q13.2   UniSTS Human Cytogenetic Map 3 q21.1   UniSTS Human Cytogenetic Map 1 q32   UniSTS Human Cytogenetic Map 22 q13.1-q13.2   UniSTS Human Cytogenetic Map 19 p12   UniSTS Human Cytogenetic Map 9 q32-q33.3   UniSTS Human Cytogenetic Map 8 q21.2   UniSTS Human Cytogenetic Map 18 q12.1   UniSTS Human Cytogenetic Map 12 p13.2-p12.3   UniSTS Human Cytogenetic Map 1 p36.3-p36.2   UniSTS Human Cytogenetic Map 5 q11.2   UniSTS Human Cytogenetic Map 1 q25.2   UniSTS Human Cytogenetic Map 3 q13.2   UniSTS Human Cytogenetic Map 8 p22   UniSTS Human Cytogenetic Map 1 q25.1   UniSTS Human Cytogenetic Map 18 q21.32   UniSTS Human Cytogenetic Map 17 q21.2   UniSTS Human Cytogenetic Map 15 q26.2   UniSTS Human Cytogenetic Map 14 q22.1   UniSTS Human Cytogenetic Map 5 p15.2   UniSTS Human Cytogenetic Map 12 q23.1   UniSTS Human Cytogenetic Map 10 q24.2   UniSTS Human Cytogenetic Map 15 q15.3   UniSTS Human Cytogenetic Map 1 p22.2   UniSTS Human Cytogenetic Map 7 q32   UniSTS Human Cytogenetic Map 5 p13   UniSTS Human Cytogenetic Map 16 q23.2   UniSTS Human Cytogenetic Map 10 q24-q25   UniSTS Human Cytogenetic Map 7 p11.1   UniSTS Human Cytogenetic Map 14 q11.2-q21   UniSTS Human Cytogenetic Map 14 q12   UniSTS Human Cytogenetic Map 12 q24.13   UniSTS Human Cytogenetic Map 10 q21-q22   UniSTS Human Cytogenetic Map 4 q22   UniSTS Human Cytogenetic Map 9 q22.2   UniSTS Human Cytogenetic Map 10 q23.31   UniSTS Human Cytogenetic Map 2 p13.1   UniSTS Human Cytogenetic Map 2 p24.1   UniSTS Human Cytogenetic Map 19 p13   UniSTS Human Cytogenetic Map 7 p13-p11.1   UniSTS Human Cytogenetic Map 7 q21.1-q22   UniSTS Human Cytogenetic Map 1 p36.3   UniSTS Human Cytogenetic Map 15 q26.1   UniSTS Human Cytogenetic Map 2 q32.1   UniSTS Human Cytogenetic Map 5 p14.3   UniSTS Human Cytogenetic Map X p22.13   UniSTS Human Cytogenetic Map 13 q14.2   UniSTS Human Cytogenetic Map 15 q   UniSTS Human Cytogenetic Map 7 q   UniSTS Human Cytogenetic Map 17 q25.1   UniSTS Human Cytogenetic Map 10 q23   UniSTS Human Cytogenetic Map 5 p12   UniSTS Human Cytogenetic Map 11 p11.2   UniSTS Human Cytogenetic Map 10 q11.21   UniSTS Human Cytogenetic Map 20 q13.13   UniSTS Human Cytogenetic Map 13 q22.1   UniSTS Human Cytogenetic Map 15 q21.2   UniSTS Human Cytogenetic Map X q28   UniSTS Human Cytogenetic Map 9 p13.1   UniSTS Human Cytogenetic Map 9 q34.13   UniSTS QTLs in Region (Human Genome Assembly GRCh37) The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer RGD ID Symbol Name LOD P Value Trait Sub Trait Chr Start Stop Species 1357307 AASTH12_H Allergic/atopic asthma related QTL 12 (human) 1.18 .009 Reversible airflow obstruction ETS negative 9 81868950 119067547 Human 1558701 SCL7_H Serum cholesterol level QTL 7 (human) 1.4 Lipid level HDL cholesterol 9 100089243 126089243 Human 2293426 PRSTS215_H Prostate tumor susceptibility QTL 215 (human) .008 Prostate tumor susceptibility 9 102236356 128236356 Human 2314724 GLUCO68_H Glucose level QTL 68 (human) 2.32 .04 Glucose level insulin sensitivity 9 102236356 128236356 Human 2314825 INSUL24_H Insulin level QTL 24 (human) 1.58 .027 Insulin level 9 102236356 128236356 Human 1357388 BW62_H Body weight QTL 62 (human) 2.3 Body weight BMI before exercise training 9 103142353 139099308 Human 2314740 GLUCO81_H Glucose level QTL 81 (human) 1 .005 Glucose level non-insulin dependent 9 111993285 137993285 Human 1358832 MULTSCL7_H Multiple sclerosis susceptibility QTL 7 (human) Multiple sclerosis susceptibility 9 113808963 139808963 Human 1643565 GLUCO28_H Glucose level QTL 28 (human) 1.4 .006 Glucose level non-insulin-dependent 9 113808963 139808963 Human Sequence Nucleotide Sequences Nucleotide RefSeqs NG_029637 (Get FASTA) Search GEO for Microarray Profiles   NM_002160 (Get FASTA) Search GEO for Microarray Profiles GenBank Nucleotide AB210038 (Get FASTA) Search GEO for Microarray Profiles   ABBA01042657 (Get FASTA) Search GEO for Microarray Profiles   ABBA01042658 (Get FASTA) Search GEO for Microarray Profiles   AI266750 (Get FASTA) Search GEO for Microarray Profiles   AI964017 (Get FASTA) Search GEO for Microarray Profiles   AK304015 (Get FASTA) Search GEO for Microarray Profiles   AL162425 (Get FASTA) Search GEO for Microarray Profiles   AMYH01021675 (Get FASTA) Search GEO for Microarray Profiles   BC151843 (Get FASTA) Search GEO for Microarray Profiles   BP278052 (Get FASTA) Search GEO for Microarray Profiles   BP279008 (Get FASTA) Search GEO for Microarray Profiles   BQ575939 (Get FASTA) Search GEO for Microarray Profiles   BQ880861 (Get FASTA) Search GEO for Microarray Profiles   BU860660 (Get FASTA) Search GEO for Microarray Profiles   BX100095 (Get FASTA) Search GEO for Microarray Profiles   BX641111 (Get FASTA) Search GEO for Microarray Profiles   CH471090 (Get FASTA) Search GEO for Microarray Profiles   CX871573 (Get FASTA) Search GEO for Microarray Profiles   GU473235 (Get FASTA) Search GEO for Microarray Profiles   M24630 (Get FASTA) Search GEO for Microarray Profiles   M55618 (Get FASTA) Search GEO for Microarray Profiles   X56160 (Get FASTA) Search GEO for Microarray Profiles   X78565 (Get FASTA) Search GEO for Microarray Profiles   X80280 (Get FASTA) Search GEO for Microarray Profiles Reference Sequences RefSeq Acc Id: NM_002160 RefSeq Status: REVIEWED Type: CODING Protein Acc Id: NP_002151 Peptide Label: precursor Position: Map Chr Position Strand Source Human Alternate Assembly CHM1_1 9 117,793,844 - 117,892,746 - NCBI Human Genome Assembly HuRef 9 87,386,539 - 87,484,951 - NCBI Human Genome Assembly GRCh37 9 117,781,854 - 117,880,536 - NCBI Human Genome Assembly Build 36 9 116,822,626 - 116,920,307 - NCBI Archive Protein Sequences Protein RefSeqs NP_002151 (Get FASTA) GenBank Protein AAA52703 (Get FASTA)   AAA88083 (Get FASTA)   AAI51844 (Get FASTA)   ADD10730 (Get FASTA)   BAE06120 (Get FASTA)   BAG64930 (Get FASTA)   CAA39628 (Get FASTA)   CAA55309 (Get FASTA)   CAE46051 (Get FASTA)   EAW87434 (Get FASTA)   EAW87435 (Get FASTA)   P24821 (Get FASTA) Promoters RGD ID: 6808309 Promoter ID: HG_KWN:64665 Type: Non-CpG SO ACC ID: SO:0000170 Source: MPROMDB Tissues & Cell Lines: CD4+TCell,   Lymphoblastoid Transcripts: OTTHUMT00000055419 Position: Map Chr Position Strand Source Human Genome Assembly Build 36 9 116,838,231 - 116,838,912 - MPROMDB Additional Information External Database Links Database Acc Id Source(s) COSMIC TNC COSMIC Ensembl Genes ENSG00000041982 ENTREZGENE Ensembl Protein ENSP00000265131 ENTREZGENE Ensembl Transcript ENST00000350763 ENTREZGENE Entrez Gene 3371 ENTREZGENE Gene3D-CATH Fibrinogen_a/b/g_C_1 UniProtKB/Swiss-Prot   Fibrinogen_a/b/g_C_2 UniProtKB/Swiss-Prot   Ig-like_fold UniProtKB/Swiss-Prot Germonline ENSG00000041982 HGNC ID 5318 ENTREZGENE HomoloGene Group ID 55636 ENTREZGENE HPRD ID 01756 ENTREZGENE InterPro EGF-like_reg_CS UniProtKB/Swiss-Prot   EGF_3 UniProtKB/Swiss-Prot   EGF_extracell UniProtKB/Swiss-Prot   Fibrinogen_a/b/g_C UniProtKB/Swiss-Prot   Fibrinogen_a/b/g_C_1 UniProtKB/Swiss-Prot   Fibrinogen_a/b/g_C_2 UniProtKB/Swiss-Prot   Fibronectin_type3 UniProtKB/Swiss-Prot   Ig-like_fold UniProtKB/Swiss-Prot KEGG Report hsa:3371 ENTREZGENE, UniProtKB/Swiss-Prot OMIM 187380 OMIM Pfam EGF_2 UniProtKB/Swiss-Prot   Fibrinogen_C UniProtKB/Swiss-Prot   fn3 UniProtKB/Swiss-Prot   hEGF UniProtKB/Swiss-Prot PharmGKB PA35103 PharmGKB PROSITE EGF_1 UniProtKB/Swiss-Prot   EGF_2 UniProtKB/Swiss-Prot   EGF_3 UniProtKB/Swiss-Prot   FIBRINOGEN_C_1; FALSE_NEG UniProtKB/Swiss-Prot   FIBRINOGEN_C_2 UniProtKB/Swiss-Prot   FN3 UniProtKB/Swiss-Prot SMART EGF UniProtKB/Swiss-Prot   FBG UniProtKB/Swiss-Prot   FN3 UniProtKB/Swiss-Prot Superfamily-SCOP Fibrinogen_a/b/g_C UniProtKB/Swiss-Prot   FN_III-like UniProtKB/Swiss-Prot UniGene Hs.143250 ENTREZGENE   Hs.734766 ENTREZGENE UniProt B4E1W8_HUMAN UniProtKB/TrEMBL   E9PC84_HUMAN UniProtKB/TrEMBL   F5H5D6_HUMAN UniProtKB/TrEMBL   F5H7V9_HUMAN UniProtKB/TrEMBL   H0YGZ3_HUMAN UniProtKB/TrEMBL   J3QSU6_HUMAN UniProtKB/TrEMBL   Q4LE33_HUMAN UniProtKB/TrEMBL   TENA_HUMAN UniProtKB/Swiss-Prot Nomenclature History Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status 2011-08-16 TNC  tenascin C  TNC  tenascin C  Symbol and/or name change 39860 APPROVED 2011-07-27 TNC  tenascin C  TNC  tenascin C  Symbol and/or name change 39860 APPROVED

More on TNC Entrez Gene Ensembl Gene Genome Browser: (hg18) (hg19) HGNC Report NCBI Map Viewer Vista Vista + UCSC RGD Object Information RGD ID: 1354144 Created: 2005-03-08 Species: Homo sapiens Last Modified: 2013-05-28 Status: ACTIVE