Gene: IL1B (interleukin 1, beta)  Homo sapiens
Symbol: IL1B
Name: interleukin 1, beta
Description: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: catabolin; IL-1; IL-1 beta; IL1-BETA; IL1F2; interleukin-1 beta; OTTHUMP00000162031; OTTHUMP00000203693; OTTHUMP00000203694; OTTHUMP00000203695; preinterleukin 1 beta; pro-interleukin-1-beta
Orthologs: Mus musculus : Il1b (interleukin 1 beta)  MGI
Rattus norvegicus : Il1b (interleukin 1 beta)
Latest Assembly: Human Genome Assembly GRCh37
Position:
MapChrPositionStrandSource
Human Alternate Assembly CHM1_12113,100,800 - 113,107,819-NCBI
Human Genome Assembly HuRef2106,041,964 - 106,048,983-NCBI
Human Genome Assembly GRCh372113,587,337 - 113,594,356-NCBI
Human Genome Assembly Build 362113,303,808 - 113,310,827-NCBI
Human Cytogenetic Map2q14 NCBI
Human Genome Assembly2113,303,567 - 113,310,587 NCBI
Model

Launch Genome Browser (GBrowse) : build 36 (hg18) build 37 (hg19)

Annotation    (Toggle Detail/Summary View)