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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oxo fatty acid
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Accession:CHEBI:59644 term browser browse the term
Definition:Any fatty acid containing at least one aldehydic or ketonic group in addition to the carboxylic acid group.
Synonyms:related_synonym: oxo fatty acids
 xref: PMID:6434570;   PMID:8454196;   PMID:8638935


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13-oxo-9,11-octadecadienoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gsta1 glutathione S-transferase alpha 1 affects metabolic processing ISO GSTA1 protein affects the metabolism of 13-oxo-9,11-octadecadienoic acid CTD PMID:12031293 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gsta4 glutathione S-transferase alpha 4 affects metabolic processing ISO GSTA4 protein affects the metabolism of 13-oxo-9,11-octadecadienoic acid CTD PMID:12031293 NCBI chr 8:85,497,557...85,514,732
Ensembl chr 8:85,497,557...85,518,879
JBrowse link
15-oxo-ETE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmox1 heme oxygenase 1 increases expression ISO 15-keto-5,8,11,13-eicosatetraenoic acid results in increased expression of HMOX1 protein CTD PMID:25450232 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions
decreases activity
ISO [15-keto-5,8,11,13-eicosatetraenoic acid results in decreased activity of IKBKB protein] which results in decreased phosphorylation of NFKBIA protein CTD PMID:25450232 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 15-keto-5,8,11,13-eicosatetraenoic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] CTD PMID:25450232 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 15-keto-5,8,11,13-eicosatetraenoic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:25450232 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [15-keto-5,8,11,13-eicosatetraenoic acid results in decreased activity of IKBKB protein] which results in decreased phosphorylation of NFKBIA protein CTD PMID:25450232 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO 15-keto-5,8,11,13-eicosatetraenoic acid results in increased expression of NQO1 protein CTD PMID:25450232 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO 15-keto-5,8,11,13-eicosatetraenoic acid results in decreased expression of TNF mRNA
15-keto-5,8,11,13-eicosatetraenoic acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD PMID:25450232 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
5-aminolevulinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase increases metabolic processing
multiple interactions
ISO ALAD protein results in increased metabolism of Aminolevulinic Acid
ALAD gene SNP affects the reaction [ALAD protein results in increased metabolism of Aminolevulinic Acid]
CTD PMID:8687997, PMID:30025905 NCBI chr 5:78,368,867...78,379,206
Ensembl chr 5:78,368,867...78,379,346
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 decreases expression ISO Aminolevulinic Acid results in decreased expression of ALAS1 mRNA CTD PMID:22859313 NCBI chr 8:114,927,704...114,941,038
Ensembl chr 8:114,927,722...114,940,177
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO Aminolevulinic Acid analog results in increased expression of BAX mRNA CTD PMID:20676910 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Aminolevulinic Acid analog results in decreased expression of BCL2 mRNA CTD PMID:20676910 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
EXP
ISO
3-methyladenine inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP3 protein] CTD PMID:11281435, PMID:17245620, PMID:20426806 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
ISO Aminolevulinic Acid analog results in increased activity of CASP8 protein
pyrazolanthrone inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP8 protein]
CTD PMID:21138480 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO
EXP
pyrazolanthrone inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP9 protein]
3-methyladenine inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP9 protein]
CTD PMID:17245620, PMID:20426806, PMID:21138480 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 increases expression
multiple interactions
ISO Aminolevulinic Acid results in increased expression of CYP2A5 mRNA
NFE2L2 gene mutant form inhibits the reaction [Aminolevulinic Acid results in increased expression of CYP2A5 mRNA]
CTD PMID:22859313 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Fadd Fas associated via death domain multiple interactions
increases phosphorylation
ISO 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [Aminolevulinic Acid analog results in increased phosphorylation of FADD protein]; FADD mutant form inhibits the reaction [Aminolevulinic Acid analog results in increased cleavage of PARP1 protein]; pyrazolanthrone inhibits the reaction [Aminolevulinic Acid analog results in increased phosphorylation of FADD protein] CTD PMID:21138480 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
JBrowse link
G Fech ferrochelatase multiple interactions ISO [Aminolevulinic Acid results in decreased activity of FECH protein] which results in increased abundance of Iron CTD PMID:15078340 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO NFE2L2 gene mutant form promotes the reaction [Aminolevulinic Acid results in increased expression of HMOX1 mRNA] CTD PMID:22859313 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Mag myelin-associated glycoprotein decreases expression EXP Aminolevulinic Acid results in decreased expression of MAG protein CTD PMID:18665889 NCBI chr 1:89,345,325...89,360,905
Ensembl chr 1:89,345,429...89,360,733
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases activity EXP Aminolevulinic Acid analog results in increased activity of MAPK1 protein CTD PMID:20426806 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases activity EXP Aminolevulinic Acid analog results in increased activity of MAPK3 protein CTD PMID:20426806 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp1 matrix metallopeptidase 1 affects expression
multiple interactions
ISO Aminolevulinic Acid affects the expression of MMP1 mRNA; Aminolevulinic Acid affects the expression of MMP1 protein
Sodium Azide inhibits the reaction [Aminolevulinic Acid affects the expression of MMP1 protein]
CTD PMID:12542540 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity
multiple interactions
EXP Aminolevulinic Acid analog results in increased activity of MMP2 protein
Chitosan inhibits the reaction [Aminolevulinic Acid analog results in increased activity of MMP2 protein]
CTD PMID:18806744 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp3 matrix metallopeptidase 3 affects expression
multiple interactions
ISO Aminolevulinic Acid affects the expression of MMP3 mRNA; Aminolevulinic Acid affects the expression of MMP3 protein
Sodium Azide inhibits the reaction [Aminolevulinic Acid affects the expression of MMP3 protein]
CTD PMID:12542540 NCBI chr 8:5,676,608...5,698,579
Ensembl chr 8:5,676,665...5,698,579
JBrowse link
G Mpz myelin protein zero decreases expression EXP Aminolevulinic Acid results in decreased expression of MPZ protein CTD PMID:18665889 NCBI chr13:89,524,204...89,530,070
Ensembl chr13:89,524,329...89,530,068
JBrowse link
G Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 decreases expression EXP Aminolevulinic Acid results in decreased expression of NDUFB8 protein CTD PMID:18665889 NCBI chr 1:264,298,671...264,303,712
Ensembl chr 1:264,298,669...264,303,762
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO NFE2L2 gene mutant form inhibits the reaction [Aminolevulinic Acid results in increased expression of CYP2A5 mRNA]; NFE2L2 gene mutant form promotes the reaction [Aminolevulinic Acid results in increased expression of HMOX1 mRNA] CTD PMID:22859313 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO FADD mutant form inhibits the reaction [Aminolevulinic Acid analog results in increased cleavage of PARP1 protein] CTD PMID:21138480 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pmp22 peripheral myelin protein 22 decreases expression EXP Aminolevulinic Acid results in decreased expression of PMP22 protein CTD PMID:18665889 NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases activity EXP Aminolevulinic Acid analog results in increased activity of PRKAA1 protein CTD PMID:20426806 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO Aminolevulinic Acid analog affects the localization of RELA protein CTD PMID:21138480 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Tp53 tumor protein p53 increases expression ISO Aminolevulinic Acid analog results in increased expression of TP53 CTD PMID:17311614 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Urod uroporphyrinogen decarboxylase decreases activity
multiple interactions
ISO Aminolevulinic Acid results in decreased activity of UROD protein
Hexachlorobenzene promotes the reaction [Aminolevulinic Acid results in decreased activity of UROD protein]
CTD PMID:8937451 NCBI chr 5:135,855,429...135,859,515
Ensembl chr 5:135,855,433...135,859,643
JBrowse link
5-oxo-ETE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf2 colony stimulating factor 2 increases secretion ISO 5-oxo-6,8,11,14-eicosatetraenoic acid results in increased secretion of CSF2 protein CTD PMID:15136573 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
9-oxononanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha decreases activity EXP 9-oxononanoic acid results in decreased activity of ACACA protein CTD PMID:2892534 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
acetoacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 increases secretion ISO acetoacetic acid results in increased secretion of CCL2 protein CTD PMID:17665966 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Il6 interleukin 6 increases secretion ISO acetoacetic acid results in increased secretion of IL6 protein CTD PMID:17665966 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Slc13a5 solute carrier family 13 member 5 decreases abundance ISO SLC13A5 protein results in decreased abundance of acetoacetic acid CTD PMID:32634519 NCBI chr10:58,806,581...58,835,549
Ensembl chr10:58,810,058...58,834,538
JBrowse link
acetoacetyl-CoA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 affects binding ISO acetoacetyl CoA binds to HSD17B2 protein CTD PMID:25526675 NCBI chr19:50,246,404...50,317,892
Ensembl chr19:50,246,402...50,317,891
JBrowse link
leptomycin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO leptomycin B inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein] CTD PMID:10497241 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
ISO leptomycin B inhibits the reaction [gefitinib results in decreased phosphorylation of AKT1 protein]
leptomycin B results in increased phosphorylation of AKT1 protein
CTD PMID:28942004 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of APAF1 mRNA CTD PMID:20803015 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Ar androgen receptor multiple interactions ISO leptomycin B inhibits the reaction [SB 216763 results in decreased localization of AR protein] CTD PMID:21980429 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Bach1 BTB domain and CNC homolog 1 affects localization
multiple interactions
ISO leptomycin B affects the localization of BACH1 protein
leptomycin B inhibits the reaction [Cadmium Chloride affects the localization of BACH1 protein]; leptomycin B inhibits the reaction [Cadmium results in decreased activity of BACH1 protein]
CTD PMID:14504288 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO leptomycin B inhibits the reaction [Tretinoin results in increased expression of BAX protein] CTD PMID:14592536 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO leptomycin B inhibits the reaction [Tretinoin results in decreased expression of BCL2 protein] CTD PMID:14592536 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO leptomycin B inhibits the reaction [Tretinoin results in decreased expression of BCL2L1 protein] CTD PMID:14592536 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 affects localization ISO leptomycin B affects the localization of BIRC2 protein CTD PMID:15265700 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 affects localization ISO leptomycin B affects the localization of BIRC3 protein CTD PMID:15265700 NCBI chr 8:6,048,590...6,076,828
Ensembl chr 8:6,048,969...6,076,598
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO [epigallocatechin gallate co-treated with leptomycin B] results in decreased expression of BIRC5 mRNA; [epigallocatechin gallate co-treated with leptomycin B] results in decreased expression of BIRC5 protein; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of BIRC5 mRNA; leptomycin B promotes the reaction [gefitinib results in decreased expression of BIRC5 protein]; TP53 gene mutant form inhibits the reaction [leptomycin B results in decreased expression of BIRC5 protein]
leptomycin B results in decreased expression of BIRC5 mRNA; leptomycin B results in decreased expression of BIRC5 protein
CTD PMID:20803015, PMID:25922640, PMID:28942004 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions
decreases expression
ISO [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of BRCA1 mRNA
leptomycin B results in decreased expression of BRCA1 mRNA
CTD PMID:20803015 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO leptomycin B results in increased expression of BTG2 mRNA CTD PMID:20803015 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Casp1 caspase 1 multiple interactions ISO leptomycin B inhibits the reaction [[Lipopolysaccharides co-treated with aluminum sulfate] results in increased activity of CASP1 protein] CTD PMID:23430110 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases secretion
multiple interactions
ISO leptomycin B results in increased secretion of CCL2 protein
polydatin inhibits the reaction [leptomycin B results in increased secretion of CCL2 protein]
CTD PMID:21967610 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO leptomycin B results in decreased expression of CCNB2 mRNA CTD PMID:20803015 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO leptomycin B inhibits the reaction [kahweol results in increased degradation of CCND1 protein] CTD PMID:27424123 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne2 cyclin E2 decreases expression ISO leptomycin B results in decreased expression of CCNE2 mRNA CTD PMID:20803015 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Cdc25a cell division cycle 25A decreases expression ISO leptomycin B results in decreased expression of CDC25A mRNA CTD PMID:20803015 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO leptomycin B results in decreased expression of CDC25C mRNA CTD PMID:20803015 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO leptomycin B results in decreased expression of CDK1 mRNA CTD PMID:20803015 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
ISO [epigallocatechin gallate co-treated with leptomycin B] results in increased expression of CDKN1A mRNA; [epigallocatechin gallate co-treated with leptomycin B] results in increased expression of CDKN1A protein; leptomycin B inhibits the reaction [gefitinib results in decreased expression of CDKN1A protein]; TP53 gene mutant form inhibits the reaction [leptomycin B results in increased expression of CDKN1A protein]
leptomycin B results in increased expression of CDKN1A mRNA; leptomycin B results in increased expression of CDKN1A protein
CTD PMID:20803015, PMID:25922640, PMID:28942004 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO leptomycin B results in decreased expression of CHEK1 mRNA CTD PMID:20803015 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of CHEK2 mRNA CTD PMID:20803015 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion
multiple interactions
ISO leptomycin B results in decreased secretion of CXCL10 protein
acteoside promotes the reaction [leptomycin B results in decreased secretion of CXCL10 protein]; Quercetin promotes the reaction [leptomycin B results in decreased secretion of CXCL10 protein]
CTD PMID:21967610 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions
decreases expression
ISO [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of DNMT1 mRNA
leptomycin B results in decreased expression of DNMT1 mRNA
CTD PMID:20803015 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO leptomycin B results in decreased expression of E2F1 mRNA CTD PMID:20803015 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G E2f3 E2F transcription factor 3 increases expression ISO leptomycin B results in increased expression of E2F3 mRNA CTD PMID:20803015 NCBI chr17:36,334,136...36,408,831
Ensembl chr17:36,334,147...36,408,831
JBrowse link
G Ei24 EI24, autophagy associated transmembrane protein increases expression ISO leptomycin B results in increased expression of EI24 mRNA CTD PMID:20803015 NCBI chr 8:39,254,883...39,271,238
Ensembl chr 8:39,254,889...39,266,959
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO leptomycin B inhibits the reaction [Estradiol results in increased degradation of ESR1 protein] CTD PMID:15899841 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO leptomycin B results in decreased localization of and results in increased phosphorylation of FGF1 protein CTD PMID:15574884 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Foxo1 forkhead box O1 affects localization ISO leptomycin B affects the localization of FOXO1 protein CTD PMID:26026911 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO leptomycin B results in increased expression of GADD45A mRNA CTD PMID:20803015 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
multiple interactions
ISO leptomycin B results in increased expression of GPX1 mRNA
[epigallocatechin gallate co-treated with leptomycin B] results in increased expression of GPX1 mRNA
CTD PMID:25922640 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO leptomycin B promotes the reaction [Bortezomib results in increased expression of H2AX protein modified form] CTD PMID:16778179 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hax1 HCLS1 associated protein X-1 affects localization ISO leptomycin B affects the localization of HAX1 protein CTD PMID:23164465 NCBI chr 2:189,330,900...189,333,305
Ensembl chr 2:189,330,902...189,333,322
JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of HK2 mRNA CTD PMID:20803015 NCBI chr 4:113,559,396...113,609,897
Ensembl chr 4:113,559,427...113,610,243
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein multiple interactions ISO leptomycin B inhibits the reaction [sodium arsenite affects the localization of ID3 protein] CTD PMID:23523789 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO leptomycin B inhibits the reaction [[Lipopolysaccharides co-treated with aluminum sulfate] results in increased expression of IL1B protein] CTD PMID:23430110 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of IL6 mRNA CTD PMID:20803015 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO leptomycin B results in increased phosphorylation of MAPK1 protein
leptomycin B inhibits the reaction [gefitinib results in decreased phosphorylation of MAPK1 protein]
CTD PMID:28942004 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO leptomycin B inhibits the reaction [gefitinib results in decreased phosphorylation of MAPK3 protein]
leptomycin B results in increased phosphorylation of MAPK3 protein
CTD PMID:28942004 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO leptomycin B results in increased expression of MDM2 mRNA CTD PMID:20803015 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mdm4 MDM4 regulator of p53 multiple interactions ISO [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of MDM4 mRNA CTD PMID:20803015 NCBI chr13:49,786,776...49,828,780
Ensembl chr13:49,792,794...49,828,720
JBrowse link
G Myh4 myosin heavy chain 4 multiple interactions EXP leptomycin B promotes the reaction [Potassium Chloride affects the localization of MYH4 protein] CTD PMID:29293066 NCBI chr10:53,778,456...53,801,605
Ensembl chr10:53,713,938...53,848,347
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of NFKB1 mRNA CTD PMID:20803015 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP leptomycin B inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:25341891 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO leptomycin B inhibits the reaction [Tretinoin affects the localization of [NR4A1 protein binds to RXRA protein]] CTD PMID:14592536 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions ISO leptomycin B inhibits the reaction [sodium arsenite affects the localization of NR4A2 protein] CTD PMID:23283970 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Nup62 nucleoporin 62 multiple interactions EXP leptomycin B inhibits the reaction [Phenylephrine results in decreased expression of NUP62 protein] CTD PMID:25341891 NCBI chr 1:100,811,140...100,827,119
Ensembl chr 1:100,811,755...100,827,111
JBrowse link
G Pidd1 p53-induced death domain protein 1 increases expression ISO leptomycin B results in increased expression of PIDD1 mRNA CTD PMID:20803015 NCBI chr 1:214,418,751...214,423,959
Ensembl chr 1:214,419,240...214,423,881
JBrowse link
G Pml PML nuclear body scaffold multiple interactions ISO leptomycin B inhibits the reaction [Lipopolysaccharides results in increased localization of PML protein] CTD PMID:23430110 NCBI chr 8:63,002,515...63,034,310
Ensembl chr 8:63,004,870...63,034,226
JBrowse link
G Prc1 protein regulator of cytokinesis 1 decreases expression ISO leptomycin B results in decreased expression of PRC1 mRNA CTD PMID:20803015 NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746
JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of PRKCA mRNA CTD PMID:20803015 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Pttg1 PTTG1 regulator of sister chromatid separation, securin decreases expression ISO leptomycin B results in decreased expression of PTTG1 mRNA CTD PMID:20803015 NCBI chr10:29,014,332...29,026,088
Ensembl chr10:29,020,049...29,026,002
JBrowse link
G Ranbp1 RAN binding protein 1 affects localization
multiple interactions
EXP leptomycin B affects the localization of RANBP1 protein
leptomycin B inhibits the reaction [Phenylephrine affects the localization of and affects the expression of RANBP1 protein]
CTD PMID:10421839, PMID:25341891 NCBI chr11:86,890,585...86,898,818
Ensembl chr11:86,890,585...86,898,818
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit affects localization ISO leptomycin B affects the localization of RELA protein CTD PMID:25704882 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 decreases activity ISO leptomycin B results in decreased activity of RPS6KB2 protein CTD PMID:12087098 NCBI chr 1:219,406,201...219,412,888
Ensembl chr 1:219,406,202...219,412,888
JBrowse link
G Rxra retinoid X receptor alpha multiple interactions ISO leptomycin B inhibits the reaction [Tretinoin affects the localization of [NR4A1 protein binds to RXRA protein]] CTD PMID:14592536 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Sesn1 sestrin 1 increases expression ISO leptomycin B results in increased expression of SESN1 mRNA CTD PMID:20803015 NCBI chr20:46,667,116...46,758,306
Ensembl chr20:46,667,121...46,758,305
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]; leptomycin B inhibits the reaction [arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]] CTD PMID:26354774 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]; leptomycin B inhibits the reaction [arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD3 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD3 protein]] CTD PMID:26354774 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smad4 SMAD family member 4 multiple interactions ISO [leptomycin B results in decreased activity of XPO1 protein] which results in decreased export of SMAD4 protein CTD PMID:26354774 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions
ISO leptomycin B results in increased expression of SOD2 mRNA
[epigallocatechin gallate co-treated with leptomycin B] results in increased expression of SOD2 mRNA
CTD PMID:25922640 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stat4 signal transducer and activator of transcription 4 affects localization ISO leptomycin B affects the localization of STAT4 protein CTD PMID:15004198 NCBI chr 9:54,340,649...54,457,753
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stk4 serine/threonine kinase 4 multiple interactions ISO leptomycin B promotes the reaction [Bortezomib results in increased activity of STK4 protein] CTD PMID:16778179 NCBI chr 3:160,467,552...160,546,540
Ensembl chr 3:160,467,552...160,546,540
JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]; leptomycin B inhibits the reaction [arsenite inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD2 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [TGFB2 protein affects the localization of SMAD3 protein]] CTD PMID:26354774 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tnfrsf26 tumor necrosis factor receptor superfamily, member 26 increases expression
multiple interactions
ISO leptomycin B results in increased expression of TNFRSF10D mRNA
[leptomycin B co-treated with TP53 gene mutant form] results in increased expression of TNFRSF10D mRNA
CTD PMID:20803015 NCBI chr 1:216,808,642...216,829,361
Ensembl chr 1:216,808,632...216,828,651
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases response to substance
increases expression
affects expression
decreases degradation
ISO
EXP
3,4,5,3',4'-pentachlorobiphenyl inhibits the reaction [leptomycin B results in increased expression of TP53 protein]; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of BRCA1 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of CHEK2 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of DNMT1 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of HK2 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of MDM4 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of PRKCA mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of TP63 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of APAF1 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of BIRC5 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of IL6 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of NFKB1 mRNA; [leptomycin B co-treated with TP53 gene mutant form] results in increased expression of TNFRSF10D mRNA; [sodium arsenite co-treated with leptomycin B] results in increased phosphorylation of TP53 protein; leptomycin B affects the localization of and results in decreased degradation of TP53 protein; leptomycin B inhibits the reaction [Cycloheximide results in increased degradation of TP53 protein]; leptomycin B inhibits the reaction [sodium arsenite affects the localization of TP53 protein]; leptomycin B inhibits the reaction [sodium arsenite results in increased degradation of TP53 protein mutant form]; leptomycin B inhibits the reaction [TP53 protein results in increased susceptibility to trichostatin A]; PCB 180 promotes the reaction [leptomycin B results in increased expression of TP53 protein]; Pravastatin inhibits the reaction [leptomycin B results in decreased degradation of TP53 protein]; TP53 gene mutant form inhibits the reaction [leptomycin B results in decreased expression of BIRC5 protein]; TP53 gene mutant form inhibits the reaction [leptomycin B results in increased expression of CDKN1A protein]
TP53 gene mutant form results in increased susceptibility to leptomycin B
alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [leptomycin B results in increased expression of TP53 protein]]; Tetrachlorodibenzodioxin inhibits the reaction [leptomycin B results in increased expression of TP53 protein]
leptomycin B affects the expression of TP53 protein
CTD PMID:11751435, PMID:15459018, PMID:15625077, PMID:16467109, PMID:19010883, PMID:19751709, PMID:20803015, PMID:21454520, PMID:24792400, PMID:31645432 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tp63 tumor protein p63 multiple interactions
decreases expression
ISO [leptomycin B co-treated with TP53 gene mutant form] results in decreased expression of TP63 mRNA
leptomycin B results in decreased expression of TP63 mRNA
CTD PMID:20803015 NCBI chr11:78,234,853...78,456,559
Ensembl chr11:78,234,800...78,456,501
JBrowse link
G Txndc5 thioredoxin domain containing 5 increases expression
multiple interactions
ISO leptomycin B results in increased expression of TXNDC5 mRNA
1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [leptomycin B results in increased expression of TXNDC5 mRNA]
CTD PMID:24515801 NCBI chr17:26,925,828...26,953,981
Ensembl chr17:26,925,828...26,953,970
JBrowse link
G Wtip WT1 interacting protein decreases localization ISO leptomycin B results in decreased localization of WTIP protein CTD PMID:14736876 NCBI chr 1:89,966,496...89,999,892 JBrowse link
G Xpo1 exportin 1 decreases activity
multiple interactions
ISO leptomycin B results in decreased activity of XPO1 protein
[leptomycin B results in decreased activity of XPO1 protein] which results in decreased export of SMAD4 protein
CTD PMID:26354774 NCBI chr14:108,007,421...108,049,088
Ensembl chr14:108,007,724...108,049,660
JBrowse link
G Xpo4 exportin 4 multiple interactions ISO leptomycin B inhibits the reaction [arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]]; leptomycin B inhibits the reaction [arsenite inhibits the reaction [XPO4 protein results in increased export of SMAD3 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD2 protein]]; leptomycin B inhibits the reaction [monomethylarsonous acid inhibits the reaction [XPO4 protein results in increased export of SMAD3 protein]] CTD PMID:26354774 NCBI chr15:37,835,580...37,926,715
Ensembl chr15:37,835,580...37,926,715
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19816
    chemical entity 19816
      atom 19814
        nonmetal atom 19690
          carbon atom 19597
            organic molecular entity 19597
              lipid 17059
                fatty acid 15990
                  oxo fatty acid 104
                    (12E)-9-hydroxy-10-oxo-12-octadecenoic acid 0
                    (6E,8R,10Z)-8-hydroxy-3-oxohexadeca-6,10-dienoic acid 0
                    (6E,8Z)-5-oxooctadecadienoic acid 0
                    (6E,8Z,10E,12S,14Z)-12-hydroxy-5-oxoicosatetraenoic acid 0
                    (6E,8Z,11Z)-5-oxoicosatrienoic acid 0
                    (6E,8Z,11Z,13E,15S)-15-hydroxy-5-oxoicosatetraenoic acid 0
                    (6E,8Z,11Z,14Z,17Z)-5-oxoicosapentaenoic acid 0
                    (7Z)-14-hydroxy-10,13-dioxoheptadec-7-enoic acid + 0
                    (7Z,10Z,13Z,15E,19Z)-17-oxodocosapentaenoic acid 0
                    (7Z,10Z,14E,16Z,19Z)-13-oxodocosapentaenoic acid 0
                    (8E,10Z,13Z,16Z,19Z)-7-oxodocosapentaenoic acid 0
                    (9R,13R)-1a,1b-dinor-10,11-dihydro-12-oxo-15-phytoenoic acid 0
                    (9Z,11Z,13E,15E)-4-oxooctadecatetraenoic acid 0
                    10,11-dihydro-12-oxoleukotriene B4 0
                    12(13)Ep-9-KODE 0
                    12-dehydro-leukotriene B4 0
                    12-oxo-20-hydroxyleukotriene B4 0
                    12-oxo-6-trans-leukotriene B4 0
                    12-oxo-cis-dodec-9-enoic acid 0
                    12-oxo-trans-10-dodecenoic acid 0
                    13,14-dihydro-15-oxolipoxin A4 0
                    13-oxo-9E,11E-ODE 0
                    15-oxolipoxin A4 0
                    16-hydroxy-10-oxohexadecanoic acid 0
                    16-oxoresolvin D2 0
                    17-oxoresolvin D1 0
                    18-oxoresolvin E1 0
                    2-oxododecanoic acid 0
                    2-oxohexanoic acid 0
                    2-oxopalmitic acid 0
                    3-hydroxy-3-methyl-2-oxopentanoic acid + 0
                    3-oxo fatty acid + 4
                    4-hydroxy-2-oxohexanoic acid + 0
                    5-oxohexanoic acid 0
                    6-\{(1S,5S)-4-oxo-5-[(2Z)-pent-2-en-1-yl]cyclopent-2-en-1-yl\}hexanoic acid + 0
                    7-methyl-3-oxooct-6-enoic acid 0
                    7-oxoresolvin D2 0
                    8-[(1R,2R)-3-oxo-2-\{(Z)-pent-2-en-1-yl\}cyclopentyl]octanoic acid 0
                    8-oxoresolvin D1 0
                    9-OxoOTrE 0
                    OxoEDE + 0
                    alpha-licanic acid 0
                    leptomycin + 74
                    omega-oxo fatty acid + 1
                    oxodocosahexaenoic acid + 0
                    oxoicosatetraenoic acid + 8
                    oxooctadecadienoic acid + 2
                    oxopentanoic acid + 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 19816
    subatomic particle 19814
      composite particle 19814
        hadron 19814
          baryon 19814
            nucleon 19814
              atomic nucleus 19814
                atom 19814
                  main group element atom 19702
                    p-block element atom 19702
                      carbon group element atom 19608
                        carbon atom 19597
                          organic molecular entity 19597
                            organic group 18537
                              organic divalent group 18530
                                organodiyl group 18530
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18114
                                        monocarboxylic acid 17476
                                          fatty acid 15990
                                            oxo fatty acid 104
                                              (12E)-9-hydroxy-10-oxo-12-octadecenoic acid 0
                                              (6E,8R,10Z)-8-hydroxy-3-oxohexadeca-6,10-dienoic acid 0
                                              (6E,8Z)-5-oxooctadecadienoic acid 0
                                              (6E,8Z,10E,12S,14Z)-12-hydroxy-5-oxoicosatetraenoic acid 0
                                              (6E,8Z,11Z)-5-oxoicosatrienoic acid 0
                                              (6E,8Z,11Z,13E,15S)-15-hydroxy-5-oxoicosatetraenoic acid 0
                                              (6E,8Z,11Z,14Z,17Z)-5-oxoicosapentaenoic acid 0
                                              (7Z)-14-hydroxy-10,13-dioxoheptadec-7-enoic acid + 0
                                              (7Z,10Z,13Z,15E,19Z)-17-oxodocosapentaenoic acid 0
                                              (7Z,10Z,14E,16Z,19Z)-13-oxodocosapentaenoic acid 0
                                              (8E,10Z,13Z,16Z,19Z)-7-oxodocosapentaenoic acid 0
                                              (9R,13R)-1a,1b-dinor-10,11-dihydro-12-oxo-15-phytoenoic acid 0
                                              (9Z,11Z,13E,15E)-4-oxooctadecatetraenoic acid 0
                                              10,11-dihydro-12-oxoleukotriene B4 0
                                              12(13)Ep-9-KODE 0
                                              12-dehydro-leukotriene B4 0
                                              12-oxo-20-hydroxyleukotriene B4 0
                                              12-oxo-6-trans-leukotriene B4 0
                                              12-oxo-cis-dodec-9-enoic acid 0
                                              12-oxo-trans-10-dodecenoic acid 0
                                              13,14-dihydro-15-oxolipoxin A4 0
                                              13-oxo-9E,11E-ODE 0
                                              15-oxolipoxin A4 0
                                              16-hydroxy-10-oxohexadecanoic acid 0
                                              16-oxoresolvin D2 0
                                              17-oxoresolvin D1 0
                                              18-oxoresolvin E1 0
                                              2-oxododecanoic acid 0
                                              2-oxohexanoic acid 0
                                              2-oxopalmitic acid 0
                                              3-hydroxy-3-methyl-2-oxopentanoic acid + 0
                                              3-oxo fatty acid + 4
                                              4-hydroxy-2-oxohexanoic acid + 0
                                              5-oxohexanoic acid 0
                                              6-\{(1S,5S)-4-oxo-5-[(2Z)-pent-2-en-1-yl]cyclopent-2-en-1-yl\}hexanoic acid + 0
                                              7-methyl-3-oxooct-6-enoic acid 0
                                              7-oxoresolvin D2 0
                                              8-[(1R,2R)-3-oxo-2-\{(Z)-pent-2-en-1-yl\}cyclopentyl]octanoic acid 0
                                              8-oxoresolvin D1 0
                                              9-OxoOTrE 0
                                              OxoEDE + 0
                                              alpha-licanic acid 0
                                              leptomycin + 74
                                              omega-oxo fatty acid + 1
                                              oxodocosahexaenoic acid + 0
                                              oxoicosatetraenoic acid + 8
                                              oxooctadecadienoic acid + 2
                                              oxopentanoic acid + 26
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.